Cited by 230Stress Responses and CortisolNeurotransmitter Receptor Influence on BehaviorTryptophan and brain disorders

The DOI matches its Crossref record; 227 of the 229 references it cites were found in a registry or an index.

Defeat stress in rodents: From behavior to molecules

Hammels, Caroline, Pishva, Ehsan, De Vry, Jochen, van den Hove, Daniel L.A., Prickaerts, Jos, van Winkel, Ruud, Selten, Jean-Paul, Lesch, Klaus-Peter, Daskalakis, Nikolaos P., Steinbusch, Harry W.M., van Os, Jim, Kenis, Gunter, Rutten, Bart P.F.·2015·Neuroscience & Biobehavioral Reviews

Abstract

Mood and anxiety disorders are prevalent conditions affecting one out of four people during lifetime. The development of high validity animal models to study these disorders has been a major challenge in the past. When considering experimental approaches for studying affective disorders, the social defeat paradigm has been shown to have etiological, predictive and face validity. Here, we explain the general principle of social defeat stress paradigms, with a strong focus on the resident-intruder model and compare different experimental settings as published to date. We discuss behavioral changes described in defeated animals as well as changes in the animal's physiological parameters. In addition, we provide an overview of the molecular adaptations that are found in animals subjected to defeat stress, with special attention to neural circuits and neuroendocrine signaling. Defeat produces specific behaviors resembling the signs and symptoms of humans with affective disorders, such as anhedonia, social avoidance, despair and anxiety. These can be linked to a wide range of physiological changes-ranging from cardiovascular changes to alterations in the immune system- or by disturbances in specific neurotransmitter systems, in particular serotonin and dopamine. The defeat stress model thus impacts on several functional domains of behavior and may mimic cardinal features of a multitude of psychiatric disorders including depression, post-traumatic stress disorder and schizophrenia. This manuscript critically reviews the core findings, strengths and limitations of the range of animal studies in this field and provides future perspectives.

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Crossref · 10.1016/j.neubiorev.2015.10.006

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Research works printed but not linked: 5

  1. Bailey, 2007, Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway, Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, R1180, 10.1152/ajpregu.00307.2007 · DOI · Paper page
  2. Foster, 2006, Social defeat increases food intake, body mass, and adiposity in Syrian hamsters, Am. J. Physiol. Regul. Integr. Comp. Physiol., 290, R1284, 10.1152/ajpregu.00437.2005 · DOI
  3. Kinn, 2008, A double exposure to social defeat induces sub-chronic effects on sleep and open field behaviour in rats, Physiol. Behav., 95, 553, 10.1016/j.physbeh.2008.07.031 · DOI
  4. Kudryavtseva, 1991, Social model of depression in mice of C57BL/6J strain, Pharmacol. Biochem. Behav., 38, 315, 10.1016/0091-3057(91)90284-9 · DOI · Paper page
  5. Watt, 2009, Adolescent male rats exposed to social defeat exhibit altered anxiety behavior and limbic monoamines as adults, Behav. Neurosci., 123, 564, 10.1037/a0015752 · DOI

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Metadata

Authors
Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., van Os, J., Kenis, G., & Rutten, B. P. F.
Affiliations
  • Maastricht University (NL)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Rutten, Bart P.F.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2015-12
Volume
59
Pages
111-140
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2175484872
Cited by
230
References
229
Citations by year
2026: 9 · 2025: 16 · 2024: 18 · 2023: 12 · 2022: 18 · 2021: 28 · 2020: 50 · 2019: 28 · 2018: 14 · 2017: 17 · 2016: 20
FWCI
1.36
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience & Biobehavioral Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Research Publications (Maastricht University) (publishedVersion)
  • Lirias (submittedVersion)
  • Research Publications (Maastricht University) (submittedVersion)
Funders
  • Netherlands Organisation for Scientific Research (916.11.086)
  • European Community's Seventh Framework Program
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
social defeat stress, depression, post-traumatic stress disorder, schizophrenia, anhedonia, social avoidance, neuroendocrine signaling, serotonin, dopamine, immune system alterations, cardiovascular changes, neural circuits, face validity
MeSH terms
Animals, Anxiety Disorders, Behavior, Animal, Depression, Disease Models, Animal, Humans, Social Behavior, Stress, Psychological

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