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Cited by 246Heart Rate Variability and Autonomic ControlCardiac Health and Mental HealthCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 112 of the 114 references it cites were found in a registry or an index.

Heart rate variability in the prediction of mortality: A systematic review and meta-analysis of healthy and patient populations

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Jarczok, Marc N., Weimer, Katja, Braun, Christin, Williams, DeWayne P., Thayer, Julian F., Gündel, Harald O., Balint, Elisabeth M.·2022·Neuroscience & Biobehavioral Reviews
DOI 10.1016/j.neubiorev.2022.104907
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Abstract

Measures of heart rate variability (HRV) as a predictor of risk of disease and mortality have been investigated from various perspectives for more than six decades. The aim of the present comprehensive meta-analysis is to examine eight different HRV parameters to determine their association with all-cause and cardiac mortality. A total of 32 studies and two individual participant datasets (IPD) with 37 samples and 38,008 participants were included. Lower HRV parameter values were significant predictors of higher mortality across different ages, sex, continents, populations and recording lengths. Most of the examined parameters showed comparable hazard ratios (HR). IPD sub-analysis for heart rate corrected HRV parameters confirmed the strong association between HRV and all-cause mortality. Meta-regressions revealed no effect modifier for HRs extracted from covariate-adjusted studies. Sub-analyses of studies comparing the lowest quartile of 5-min root mean square of successive differences (RMSSD) vs. the other quartiles yielded a combined HR of 1.56 (95% CI: 1.32-1.85). The applicability of HRV measurement in preventive settings is discussed.

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Crossref · 10.1016/j.neubiorev.2022.104907

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  1. Ryff, Carol D., Almeida, David M., Ayanian, John Z., Carr, Deborah S., Cleary, Paul D., Coe, Christopher, … Williams, David R, 2021. Midlife in the United States (MIDUS 2), 2004-2006. Inter-university Consortium for Political and Social Research [distributor], 2021-09-15. https://doi.org/10.3886/ICPSR04652.v8. · DOI

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Metadata

Authors
Jarczok, M. N., Weimer, K., Braun, C., Williams, D. P., Thayer, J. F., Gündel, H. O., & Balint, E. M.
Affiliations
  • Universität Ulm (DE)
  • University of California, Irvine (US)
Corresponding author
Jarczok, Marc N.
ORCID
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2022-12
Volume
143
Pages
104907
ISSN
0149-7634 (ISSN-L)
DOI
10.1016/j.neubiorev.2022.104907
OpenAlex
W4304943826
Cited by
246
References
114
Citations by year
2026: 74 · 2025: 71 · 2024: 76 · 2023: 23 · 2022: 1
FWCI
8.70
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuroscience & Biobehavioral Reviews (acceptedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (R01AG013196, R01HL36310)
  • U.S. Department of Health and Human Services
  • National Institute on Aging (5-PO1-AG20166-04)
  • Medical Research Council (G0902037, MR/K013351/1)
  • British Heart Foundation (RG/13/2/30098)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
heart rate variability, mortality prediction, all-cause mortality, cardiac mortality, RMSSD, heart rate correction, risk prediction, healthy population, individual patient data
MeSH terms
Heart, Heart Rate, Humans, Proportional Hazards Models

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