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Harmine is an ATP-competitive inhibitor for dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A)

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Minibrain/Dyrk1a Regulates Food Intake through the Sir2-FOXO-sNPF/NPY Pathway in Drosophila and Mammals

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Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

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A chemical with proven clinical safety restores Down syndrome-related phenotypes via DYRK1A inhibition

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Effects of long-term memantine on memory and neuropathology in Ts65Dn mice, a model for Down syndrome

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DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesis

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Dyrk1A‐mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer’s disease

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Mental retardation in Down syndrome: From gene dosage imbalance to molecular and cellular mechanisms

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Autism spectrum disorders: The quest for genetic syndromes

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Dysfunction of the corticostriatal pathway in autism spectrum disorders

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Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and Neuromorphological alterations found in a mouse model of down syndrome

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Mental retardation and associated neurological dysfunctions in Down syndrome: A consequence of dysregulation in critical chromosome 21 genes and associated molecular pathways

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A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

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Normalizing the gene dosage of Dyrk1A in a mouse model of down syndrome rescues several Alzheimer’s disease phenotypes

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DYRK1A (Dual-Specificity Tyrosine-Phosphorylated and -Regulated Kinase 1A): A Gene with Dosage Effect During Development and Neurogenesis

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Impaired Spatial Learning Strategies and Novel Object Recognition in Mice Haploinsufficient for the Dual Specificity Tyrosine-Regulated Kinase-1A (Dyrk1A)

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Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn down syndrome mice

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Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons.

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Dyrk1A Influences Neuronal Morphogenesis Through Regulation of Cytoskeletal Dynamics in Mammalian Cortical Neurons

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Down syndrome: Neurobiological alterations and therapeutic targets

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Possible Compensatory Events in Adult Down Syndrome Brain Prior to the Development of Alzheimer Disease Neuropathology: Targets for Nonpharmacological Intervention

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Regulation of RCAN1 Protein Activity by Dyrk1A Protein-mediated Phosphorylation

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Aberrant phosphorylation in the pathogenesis of Alzheimer's disease

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Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A

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Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1

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The spatio‐temporal and subcellular expression of the candidate Down syndrome gene <i>Mnb/Dyrk1A</i> in the developing mouse brain suggests distinct sequential roles in neuronal development

Hämmerle, B., Elizalde, C., & Tejedor, F. J. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06092.x · Cited by 82 · see citing works

Prospects for Improving Brain Function in Individuals with Down Syndrome

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Animal models reveal role for tau phosphorylation in human disease

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Negative Feedback Inhibition of NFATc1 by DYRK1A Regulates Bone Homeostasis

Lee, Y., Ha, J., Kim, H. J., Kim, Y.-S., Chang, E., Song, W., & Kim, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.042234 · Cited by 73 · see citing works

Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development

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Activity-dependent facilitation of Synaptojanin and synaptic vesicle recycling by the Minibrain kinase

Chen, C., Brégère, C., Paluch, J., Lu, J. F., Dickman, D. K., & Chang, K. T. (2014) · Nature Communications · doi:10.1038/ncomms5246 · Cited by 77 · see citing works

DYRK1A Protein, A Promising Therapeutic Target to Improve Cognitive Deficits in Down Syndrome

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Is it possible to improve neurodevelopmental abnormalities in Down syndrome?

Bartesaghi, R., Guidi, S., & Ciani, E. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.037 · Cited by 74 · see citing works

Environmental enrichment rescues DYRK1A activity and hippocampal adult neurogenesis in TgDyrk1A

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Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)

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Phosphorylation and Inactivation of Glycogen Synthase Kinase 3β (GSK3β) by Dual-specificity Tyrosine Phosphorylation-regulated Kinase 1A (Dyrk1A)

Song, W., Song, E. C., Jung, M., Choi, S., Baik, H.-H., Jin, B. K., Kim, J. H., & Chung, S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.594952 · Cited by 72 · see citing works

DYRK1A Kinase Inhibitors with Emphasis on Cancer

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Targeting Dyrk1A with AAVshRNA Attenuates Motor Alterations in TgDyrk1A, a Mouse Model of Down Syndrome

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Using mouse models to explore genotype–phenotype relationship in Down syndrome

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Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1

Schneider, P., Bayo, J., Singh, R. K., Dhanyamraju, P. K., Holz, P. S., Baier, A., Fendrich, V., Ramaswamy, A., Baumeister, S., Martínez, E. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms9023 · Cited by 65 · see citing works

DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation

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Influence of prenatal EGCG treatment andDyrk1adosage reduction on craniofacial features associated with Down syndrome

McElyea, S. D., Starbuck, J. M., Tumbleson, D. M., Harrington, E., Blazek, J. D., Ghoneima, A. A. M., Kula, K. S., & Roper, R. J. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw309 · Cited by 59 · see citing works

Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of down syndrome

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Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801

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DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

Menon, V., Ananthapadmanabhan, V., Swanson, S. K., Saini, S., Sesay, F. F., Yakovlev, V. A., Florens, L. A., DeCaprio, J. A., Washburn, M. P., Dozmorov, M. G., et al. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1577525 · Cited by 53 · see citing works

Clinical manifestations of the deletion of Down syndrome critical region including DYRK1A and KCNJ6

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DYRK1A-haploinsufficiency in mice causes autistic-like features and febrile seizures

Raveau, M., Shimohata, A., Amano, K., Miyamoto, H., & Yamakawa, K. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.12.003 · Cited by 49 · see citing works

Mouse Models for Down Syndrome-Associated Developmental Cognitive Disabilities

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Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome

Laguna, A., Barallobre, M. J., Marchena, M., Mateus, C., Ramírez, E., Martínez‐Cué, C., Delabar, J. M., Castelo-Branco, M. S., de la Villa, P., & Arbonés, M. L. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt125 · Cited by 54 · see citing works

Pathways to cognitive deficits in Down syndrome

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Developmental Defects in Trisomy 21 and Mouse Models

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DYRK1A-mediated phosphorylation of GluN2A at Ser1048 regulates the surface expression and channel activity of GluN1/GluN2A receptors

Grau, C. J. A., Arató, K., Fernández‐Fernández, J. M., Valderrama, A., Sindreu, C. B., Fillat, C., Ferrer, I., de la Luna, S., & Altafaj, X. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00331 · Cited by 46 · see citing works

Modeling human neurodevelopmental diseases with brain organoids

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Targeting trisomic treatments: optimizing Dyrk1a inhibition to improve Down syndrome deficits

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QSAR analysis of pyrazolidine-3,5-diones derivatives as Dyrk1A inhibitors

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Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP

Park, J., Sung, J. Y., Park, J., Song, W., Chang, S., & Chung, K. C. (2012) · Journal of Cell Science · doi:10.1242/jcs.086124 · Cited by 44 · see citing works

Chronic Dyrk1 Inhibition Delays the Onset of AD-Like Pathology in 3xTg-AD Mice

Velázquez, R., Meechoovet, B., Ow, A., Foley, C., Shaw, A. Y., Smith, B. E., Oddo, S., Hulme, C., & Dunckley, T. L. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01684-9 · Cited by 43 · see citing works

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome

Brault, V., Nguyen, T. L., Gutiérrez, J. F., Iacono, G. L., Birling, M., Lalanne, V., Méziane, H., Manousopoulou, A., Pavlovic, G., Lindner, L., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009777 · Cited by 41 · see citing works

Function and inhibition of DYRK1A: Emerging roles of treating multiple human diseases

Yang, Y., Fan, X., Liu, Y., Ye, D., Liu, C., Yang, H., Su, Z., Zhang, Y., & Liu, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115521 · Cited by 43 · see citing works

The E3 ligase APC/C–Cdh1 is required for associative fear memory and long-term potentiation in the amygdala of adult micePreprint

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DYRK3 Dual-specificity Kinase Attenuates Erythropoiesis during Anemia

Bogacheva, O., Bogachev, O., Menon, M. P., Dev, A., Houde, E., Valoret, E. I., Prosser, H. M., Creasy, C. L., Pickering, S. J., Grau, E., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807844200 · Cited by 42 · see citing works

Molecular and cellular mechanisms elucidating neurocognitive basis of functional impairments associated with intellectual disability in Down syndrome.

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Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice

Mazur‐Kolecka, B., Golabek, A. A., Kida, E., Rabe, A., Hwang, Y., Adayev, T., Węgiel, J., Flory, M. J., Kaczmarski, W., Marchi, E. J., et al. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.23007 · Cited by 38 · see citing works

Modeling Down syndrome in animals from the early stage to the 4.0 models and next

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Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome

Altafaj, X., Ortiz-Abalia, J., Fernández, M., Potier, M., Laffaire, J., Andreu, N., Dierssen, M., González-García, C., Ceña, V., Martı́, E., et al. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.07.024 · Cited by 38 · see citing works

Perturbation of dendritic protrusions in intellectual disability

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Cannabinoid type-1 receptor blockade restores neurological phenotypes in two models for Down syndrome

Navarro-Romero, A., Vázquez‐Oliver, A., Gomis‐González, M., Garzón-Montesinos, C., Falcón‐Moya, R., Pastor, A., Martín‐García, E., Pizarro, N., Busquets-García, A., Revest, J., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.014 · Cited by 35 · see citing works

Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome

Altafaj, X. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.18.1915 · Cited by 396 · see citing works

Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome

Brault, V., Nguyen, T. L., Gutiérrez, J. F., Iacono, G. L., Birling, M., Lalanne, V., Méziane, H., Manousopoulou, A., Pavlovic, G., Lindner, L., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009777 · Cited by 41 · see citing works

Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate GeneDyrk1a

Thomazeau, A., Lassalle, O., Iafrati, J., Souchet, B., Guedj, F., Janel, N., Chavis, P., Delabar, J. M., & Manzoni, O. J. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2852-13.2014 · Cited by 93 · see citing works

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

Souchet, B., Guedj, F., Sahún, I., Duchon, A., Daubigney, F., Badel, A., Yanagawa, Y., Barallobre, M. J., Dierssen, M., Yu, E. Y., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.04.016 · Cited by 112 · see citing works

DYRK1A up-regulation specifically impairs a presynaptic form of long-term potentiationPreprint

Lepagnol-Bestel, A.-M., Haziza, S., Viard, J., Salin, P. A., Crépel, V., Duchon, A., Hérault, Y., & Simonneau, M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/645200