Oxytocin facilitates the induction of long-term potentiation in the accessory olfactory bulb
Open accessAbstract
When female mice are mated, they form a memory to the pheromonal signal of their male partner. Several lines of evidence indicate that the neural changes underlying this memory occur in the accessory olfactory bulb (AOB) at the first stage of the vomeronasal system. The formation of this memory depends on the mating-induced release of noradrenaline in the AOB. In addition to noradrenaline, the neuropeptide oxytocin (OT) is also released within the central nervous system during mating. Because OT has been implicated in social memory and its receptors are expressed in the AOB, we hypothesized that OT might promote the strength of synaptic transmission from mitral to granule cells in the AOB. To test this hypothesis, we analyzed the lateral olfactory tract-evoked field potential that represents the granule cell response to mitral cell activation and its plasticity in parasagittal slices of the AOB. Of the 10-, 20-, 50-, and 100-Hz stimulations tested, the 100-Hz stimulation was optimal for inducing long-term potentiation (LTP). OT paired with 100-Hz stimulation that only produced short-term potentiation enhanced LTP induction in a dose-dependent manner. OT-paired LTP was blocked by both the selective OT antagonist desGly-NH(2),d(CH(2))(5)[Tyr(Me)(2),Thr(4)]-ornithine vasotocin and the N-methyl-d-aspartate (NMDA) receptor antagonist dl-2-amino-5-phosphonovaleric acid. These results indicate that OT can function as a gate to modulate the establishment of NMDA receptor-dependent LTP at the mitral-to-granule cell synapse in the AOB.
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Oxytocin lowers the threshold for depolarizing inputs to induce long-term potentiation (LTP) in hippocampal CA2 and olfactory bulb.
“For example, oxytocin lowers the threshold for depolarizing inputs to induce long-term potentiation (LTP) in hippocampal CA2 (Pagani et al. 2015, Carstens & Dudek 2019) and olfactory bulb (Fang et al. 2008).”
From Oxytocin, Neural Plasticity, and Social Behavior (2021) · cites this paper as Fang et al. 2008
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- Authors
- Fang, L.-Y., Quan, R.-D., & Kaba, H.
- Affiliations
- Yanbian University (CN)
- National Institute for Physiological Sciences (JP)
- Corresponding author
- Kaba, Hideto
- ORCID
- Kaba, Hideto
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 438
- Issue
- 2
- Pages
- 133-137
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2067997599
- Cited by
- 57
- References
- 46
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 4 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 3
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- green
- kochi.repo.nii.ac.jp
- Licence
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kochi University Digital Repository for Academic Resources (Kochi University) (submittedVersion, cc-by-nc-nd)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Kochi University
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- oxytocin, long-term potentiation, accessory olfactory bulb, vomeronasal system, NMDA receptor, social memory, norepinephrine, synaptic plasticity
- MeSH terms
- Animals, Electric Stimulation, Female, Male, Memory, Mice, Inbred BALB C, Synaptic Transmission, Neurons, Olfactory Bulb, Olfactory Pathways, Organ Culture Techniques, Oxytocin, Sex Attractants, Sexual Behavior, Animal, Synapses, Vasotocin, Signal Transduction, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Excitatory Amino Acid Antagonists, Vomeronasal Organ, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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