Progesterone modulation of α5 nAChR subunits influences anxiety‐related behavior during estrus cycle
Open accessAbstract
Smokers often report an anxiolytic effect of cigarettes. In addition, stress‐related disorders such as anxiety, post‐traumatic stress syndrome and depression are often associated with chronic nicotine use. To study the role of the α5 nicotinic acetylcholine receptor subunit in anxiety‐related responses, control and α5 subunit null mice (α5 −/− ) were subjected to the open field activity (OFA), light–dark box (LDB) and elevated plus maze (EPM) tests. In the OFA and LDB, α5 −/− behaved like wild‐type controls. In the EPM, female α5 −/− mice displayed an anxiolytic‐like phenotype, while male α5 −/− mice were undistinguishable from littermate controls. We studied the hypothalamus–pituitary–adrenal axis by measuring plasma corticosterone and hypothalamic corticotropin‐releasing factor. Consistent with an anxiolytic‐like phenotype, female α5 −/− mice displayed lower basal corticosterone levels. To test whether gonadal steroids regulate the expression of α5, we treated cultured NTera 2 cells with progesterone and found that α5 protein levels were upregulated. In addition, brain levels of α5 mRNA increased upon progesterone injection into ovariectomized wild‐type females. Finally, we tested anxiety levels in the EPM during the estrous cycle. The estrus phase (when progesterone levels are low) is anxiolytic‐like in wild‐type mice, but no cycle‐dependent fluctuations in anxiety levels were found in α5 −/− females. Thus, α5‐containing neuronal nicotinic acetylcholine receptors may be mediators of anxiogenic responses, and progesterone‐dependent modulation of α5 expression may contribute to fluctuations in anxiety levels during the ovarian cycle.
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The reduced anxiety-like behavior in female α5 knockout mice may be related to progesterone effects on α5 subunit expression.
“and this may be related to progesterone effects on α5 subunit expression (Gangitano et al. 2009)”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Gangitano et al. 2009
Female but not male mice lacking the α5 nAChR subunit show reduced anxiety-like behavior.
“female, but not male, knockout mice lacking the α5 subunit showed reduced anxiety-like behavior”
From Mechanisms of Nicotine Addiction (2021) · cites this paper as Gangitano et al. 2009
β3 knockout mice have altered hypothalamic-pituitary-adrenal axis responses, as also reported for α5 knockout mice.
“As reported for the α5 KO mice (Gangitano et al. 2009), β3 KO mice have altered hypothalamic pituitary adrenal axis responses (Booker et al. 2007).”
From Nicotine Withdrawal (2015) · cites this paper as Gangitano et al. 2009
α5 knockout animals showed altered hypothalamus-pituitary-adrenal axis function with lower basal corticosterone levels.
“Gangitano, Salas, Teng, Perez, and De Biasi (2009) demonstrated that α5 KO animals showed altered hypothalamus–pituitary–adrenal axis function as they were shown to have lower basal corticosterone levels.”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Gangitano et al. (2009)
α5 knockout animals showed no behavioral changes in the open field and light-dark box paradigms, while female knockout mice, but not male mice, showed reduced anxiety-like behavior in the elevated plus maze.
“while α5 KO animals showed no behavioral changes in the OF and light–dark box paradigms, female KO mice, but not male mice, showed reduced anxiety-like behavior in the EPM.”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Gangitano et al. (2009)
Female but not male α5 knockout mice showed a reduced depressive-like behavioral phenotype.
“Gangitano et al. (2009) found that female but not male α5 KO mice showed reduced depressive-like behavioral phenotype.”
From Nicotine addiction and psychiatric disorders (2015) · cites this paper as Gangitano et al. (2009)
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- Authors
- Gangitano, D., Salas, R., Teng, Y., Perez, E., & De Biasi, M.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2009-06
- Volume
- 8
- Issue
- 4
- Pages
- 398-406
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC2712346
- OpenAlex
- W2008372059
- Cited by
- 76
- References
- 74
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 7
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (R01DA017173, DA17173)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- progesterone, anxiety-like behavior, estrous cycle, corticosterone, hypothalamic-pituitary-adrenal axis, corticotropin-releasing factor, sex differences, neuronal nicotinic acetylcholine receptors, ovariectomy
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Cells, Cultured, Corticosterone, Corticotropin-Releasing Hormone, Depression, Diestrus, Female, Genotype, Hypothalamo-Hypophyseal System, Hypothalamus, Male, Mice, Inbred C57BL, Motor Activity, Pituitary-Adrenal System, Progesterone, Receptors, Nicotinic, Mice, Knockout, Hindlimb Suspension, Reverse Transcriptase Polymerase Chain Reaction, Estrous Cycle, Mice
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