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Cited by 49Nicotinic Acetylcholine Receptors StudySmoking Behavior and CessationNeuroscience and Neuropharmacology Research

Decreased anxiety-like behavior in beta3 nicotinic receptor subunit knockout mice

Booker, T.K., Butt, Christopher M., Wehner, Jeanne M., Heinemann, Stephen F., Collins, Allan C.·2007·Pharmacology Biochemistry and Behavior
DOI 10.1016/j.pbb.2007.04.011
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Abstract

Nicotine, via a family of nicotinic acetylcholine receptors, elicits many physiological responses, including alterations in anxiety. Studies suggest that the effects of nicotine on anxiety may support smoking behaviors. We reported previously that mice lacking the beta3 nicotinic receptor subunit demonstrate increased activity in the open field arena. Open field activity has been shown to be a composite of anxiety and locomotor activity, behaviors that are both altered by nicotine. We therefore sought to differentiate the role(s) of beta3-containing receptors in anxiety and locomotor activity. Anxiety behaviors were examined in the elevated plus maze, the black/white box and the mirrored chamber. Beta3 null mutant mice demonstrated decreased anxiety with more time spent on the open arm of the elevated plus maze than their wildtype littermates. No significant differences were observed with the black/white box or the mirrored chamber. Levels of the stress hormone, corticosterone, were significantly higher in the beta3 null mutant mice at baseline and following exposure to stress. Increased locomotor activity in the Y-maze was also observed for the beta3 null mutant mice, but only following exposure to stress. These findings strongly suggest that beta3-containing nicotinic receptors influence anxiety and may be critical for the continuation of smoking behaviors.

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Crossref · 10.1016/j.pbb.2007.04.011

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  • β3 knockout mice have altered hypothalamic-pituitary-adrenal axis responses, as also reported for α5 knockout mice.

    “As reported for the α5 KO mice (Gangitano et al. 2009), β3 KO mice have altered hypothalamic pituitary adrenal axis responses (Booker et al. 2007).”

    From Nicotine Withdrawal (2015) · cites this paper as Booker et al. 2007

  • β3 knockout mice show lower baseline anxiety-related behavior across three paradigms.

    “β3 KO mice exhibit lower baseline levels of anxiety-related behavior in three different paradigms (Booker et al. 2007).”

    From Nicotine Withdrawal (2015) · cites this paper as Booker et al. 2007

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Authors
Booker, T. K., Butt, C. M., Wehner, J. M., Heinemann, S. F., & Collins, A. C.
Affiliations
  • Salk Institute for Biological Studies (US)
  • West Virginia School of Osteopathic Medicine (US)
  • University of Colorado Boulder (US)
Corresponding author
Booker, T.K.
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2007-05
Volume
87
Issue
1
Pages
146-157
ISSN
0091-3057 (ISSN-L)
DOI
10.1016/j.pbb.2007.04.011
OpenAlex
W2082897552
Cited by
49
References
100
Citations by year
2023: 2 · 2022: 1 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 6 · 2014: 1 · 2013: 5 · 2012: 3
FWCI
2.78
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5p01da010156-05)
  • National Institute on Alcohol Abuse and Alcoholism (AA13018, R01AA013018)
  • National Institute on Drug Abuse (P30DA015663, DA15663, DA10156)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
  • Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
nicotinic acetylcholine receptors, anxiety-like behavior, knockout mice, nicotine, locomotor activity, corticosterone, stress response, elevated plus maze, smoking behavior, Y-maze
MeSH terms
Animals, Anxiety, Corticosterone, Memory, Mice, Inbred C57BL, Motor Activity, Receptors, Nicotinic, Stress, Psychological, Mice, Knockout, Protein Subunits, Mice

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