Depletion of MAP2 expression and laminar cytoarchitectonic changes in dorsolateral prefrontal cortex in adult autistic individuals
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The neuropathological substrates underlying the characteristic clinical phenotype of autism are unknown. Neuroimaging studies have identified a decrease in task‐related activation in the dorsolateral prefrontal cortex in autism. In the current study, we have analysed the dorsolateral prefrontal cortex in two adult individuals with a clinical diagnosis of autism, using Nissl staining and MAP2 immunohistochemistry. There was unchanged density of both neuronal and glial cell pools, although the autistic individuals had ill‐defined neocortical cellular layers, substantially depleted MAP2 neuronal expression, and reduced dendrite numbers. Further studies on a larger number of individuals with autism are needed to establish the clinical relevance of the described changes, especially to determine whether the loss of dendritic markers is age associated or disease specific.
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ASD hippocampal neurons show reduced dendritic branching compared with controls, and the PFC shows fewer dendrites as detected by microtubule-associated protein 2 immunoreactivity.
“Neurons show reduced dendritic branching in the hippocampus of ASD subjects compared to controls [296] and fewer dendrites as detected by microtubule-associated protein 2 immunoreactivity in the PFC [248].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [248]
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- Authors
- Mukaetova‐Ladinska, E. B., Arnold, H., Jaros, E., Perry, R., & Perry, E.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Mukaetova‐Ladinska, E. B.
- Venue
- Neuropathology and Applied Neurobiology
- Publisher
- Wiley
- Published
- 2004-07-09
- Volume
- 30
- Issue
- 6
- Pages
- 615-623
- ISSN
- 0305-1846 (ISSN-L)
- 1365-2990
- OpenAlex
- W1975216375
- Cited by
- 115
- References
- 56
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 10 · 2022: 6 · 2021: 8 · 2020: 11 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 3 · 2012: 5
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neuropathology and Applied Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, dorsolateral prefrontal cortex, MAP2, cytoarchitecture, neuronal loss, autistic adults, neuropathology, cortical layers
- MeSH terms
- Adult, Autistic Disorder, Brain, Brain Chemistry, Cell Count, Dendrites, Humans, Male, Microtubule-Associated Proteins, Neuroglia, Neurons, Prefrontal Cortex, Fatal Outcome
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