Hippocampus in autism: a Golgi analysis
Abstract
Autism is a behaviorally defined syndrome in which neuropathological abnormalities have been identified in the limbic system and cerebellum. The morphology of hippocampal neurons in two cases of infantile autism was studied and compared to age-matched controls. CA4 neurons in autistic children were smaller in perikaryon area and dendritic branching of both CA4 and CA1 neurons was less than in controls. These findings are consistent with previous studies and suggest a curtailment in maturation in the pathogenesis of autism.
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Reduced growth of neuronal cell size and dendritic arbors in ASD postmortem cases have long been reported and are now recognized as an important neuropathological attribute of ASD cortex; neuron size reduction varies from −4% in occipital to −18% in prefrontal cortex.
“Reduced growth of neuronal cell size and dendritic arbors in ASD postmortem cases have long been reported [25, 52] and are now recognized as an important neuropathological attribute of ASD cortex [46]; neuron size reduction varies from −4% in occipital to −18% in prefrontal cortex [24, 40, 53].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [52]
ASD hippocampal neurons show reduced dendritic branching compared with controls, and the PFC shows fewer dendrites as detected by microtubule-associated protein 2 immunoreactivity.
“Neurons show reduced dendritic branching in the hippocampus of ASD subjects compared to controls [296] and fewer dendrites as detected by microtubule-associated protein 2 immunoreactivity in the PFC [248].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [296]
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- Authors
- Raymond, G. V., Bauman, M. L., & Kemper, T. L.
- Affiliations
- Kennedy Krieger Institute (US)
- Massachusetts General Hospital (US)
- Venue
- Acta Neuropathologica
- Published
- 1995-12-01
- Volume
- 91
- Issue
- 1
- Pages
- 117-119
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- OpenAlex
- W2081713212
- Cited by
- 387
- References
- 0
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 17 · 2023: 14 · 2022: 9 · 2021: 13 · 2020: 21 · 2019: 13 · 2018: 13 · 2017: 19 · 2016: 12 · 2015: 19 · 2014: 13 · 2013: 17 · 2012: 19
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- autism spectrum disorder, hippocampus, hippocampal neurons, CA4, CA1, neuronal morphology, dendritic branching, neuron size, limbic system, neuropathology, infantile autism, neuronal maturation
- MeSH terms
- Adolescent, Autistic Disorder, Child, Child, Preschool, Dendrites, Female, Golgi Apparatus, Hippocampus, Humans, Male, Staining and Labeling, Fatal Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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