The effect of deviance predictability on mismatch negativity in schizophrenia patients
Abstract
Mismatch negativity (MMN) is an electrophysiological index of prediction error processing and recently has been considered an endophenotype marker in schizophrenia. While the prediction error is a core concept in the MMN generation, predictability of deviance occurrence has rarely been assessed in MMN research and in schizophrenia patients. We investigated the MMN to 12% temporally predictable or unpredictable duration decrement deviant stimuli in two runs in 29 healthy controls and 31 schizophrenia patients. We analyzed MMN amplitudes and latencies and its associations with clinical symptoms at electrode Fz. With a stimulus onset asynchronicity of 500 ms in the regular predictable condition, a deviant occurred every 4s while it varied randomly in the unpredictable condition. In the random condition we found diminished MMN amplitudes in patients which normalized in the regular deviance condition, resulting in an analysis of variance main effect of predictability and a predictability x group interaction. Deviance predictability did not affect the MMN of control subjects and we found no relevant results with regard to MMN latencies. Our results indicate that MMN amplitudes in patients normalize to the level of the control subjects in the case of a temporally fixed regular deviant. In schizophrenia patients the detection of deviance is basically intact. However, the temporal uncertainty of deviance occurrence may be of substantial relevance to the highly replicated MMN deficit in schizophrenia patients.
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Patients with schizophrenia showed a reduction in MMN amplitude in the unpredictable condition but no reduction in MMN amplitude in the predictable condition.
“Patients with schizophrenia showed a reduction in MMN amplitude in the unpredictable condition but no reduction in MMN amplitude in the predictable condition.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [34]
Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378 · see citing works
A new method for off-line removal of ocular artifact
Gratton, G., Coles, M. G. H., & Donchin, E. (1983) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(83)90135-9 · Cited by 5,055 · see citing works
A theory of cortical responses.
Friston, K. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1622 · Cited by 4,578 · see citing works
Early selective-attention effect on evoked potential reinterpreted
Näätänen, R., Gaillard, A. W. K., & Mäntysalo, S. (1978) · Acta Psychologica · doi:10.1016/0001-6918(78)90006-9 · Cited by 2,725 · see citing works
The mismatch negativity (MMN) in basic research of central auditory processing: A review
Näätänen, R., Paavilainen, P., Rinne, T., & Alho, K. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.04.026 · Cited by 2,644 · see citing works
Näätänen, R. (1990) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00078407 · Cited by 1,678 · see citing works
The mismatch negativity: a review of underlying mechanisms
Garrido, M. I., Kilner, J. M., Stephan, K. E., & Friston, K. J. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.11.029 · Cited by 1,441 · cited 2× · see citing works
“system of prediction error generation comprising a lower and a higher level system and thereby contributed to the formulation of the Mismatch Negativity as an index of prediction errors [8, 33].”
BackgroundDuncan, C. C., Barry, R. J., Connolly, J. F., Fischer, C., Michie, P. T., Näätänen, R., Polich, J., Reinvang, I., & Van Petten, C. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.07.045 · Cited by 1,191 · see citing works
Wïttchen, H., Wunderlich, U., Gruschwitz, S., & Zaudig, M. (1997) · Max Planck Institute for Plasma Physics · Cited by 769 · see citing works
Mismatch negativity in schizophrenia: a meta-analysis
Umbricht, D., & Krljes, S. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.12.002 · Cited by 742 · see citing works
A Source Analysis of the Late Human Auditory Evoked Potentials
Scherg, M., Vajsar, J., & Picton, T. W. (1989) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1989.1.4.336 · Cited by 704 · see citing works
Evidence for a hierarchy of predictions and prediction errors in human cortex
Wacongne, C., Labyt, E., van Wassenhove, V., Bekinschtein, T., Naccache, L., & Dehaene, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117807108 · Cited by 560 · see citing works
A neuronal model of predictive coding accounting for the mismatch negativity.
Wacongne, C., Changeux, J.-P., & Dehaene, S. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5003-11.2012 · Cited by 542 · see citing works
Separate Time Behaviors of the Temporal and Frontal Mismatch Negativity Sources
Rinne, T., Alho, K., Ilmoniemi, R. J., Virtanen, J. P., & Näätänen, R. (2000) · NeuroImage · doi:10.1006/nimg.2000.0591 · Cited by 514 · see citing works
Mismatch negativity: An index of a preattentive processing deficit in schizophrenia
Shelley, A. M., Ward, P. B., Catts, S. V., Michie, P. T., Andrews, S., & McConaghy, N. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90126-7 · Cited by 411 · see citing works
The Human Auditory Sensory Memory Trace Persists about 10 sec: Neuromagnetic Evidence
Sams, M. E., Hari, R., Rif, J., & Knuutila, J. (1993) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1993.5.3.363 · Cited by 371 · see citing works
Mismatch negativity potentials and cognitive impairment in schizophrenia
Baldeweg, T., Klugman, A., Gruzelier, J., & Hirsch, S. R. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2003.09.009 · Cited by 321 · cited 1× · see citing works
“Reviews have established these findings to a degree that includes the consideration of MMN amplitude reductions as a biomarker and endophenotype of schizophrenia with relations to symptoms, cognition and global functioning [3, 4, 11, 15, 32].”
BackgroundLight, G. A., Swerdlow, N. R., Rissling, A. J., Radant, A. D., Sugar, C. A., Sprock, J., Pela, M., Geyer, M. A., & BRAFF, D. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039434 · Cited by 189 · see citing works
Todd, J., Michie, P. T., Schall, U., Ward, P. B., & Catts, S. V. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.10.003 · Cited by 122 · see citing works
Müller, B. W., Jüptner, M., Jentzen, W., & Müller, S. P. (2002) · NeuroImage · doi:10.1006/nimg.2002.1176 · Cited by 112 · see citing works
Integration and segregation in auditory scene analysis
Sussman, E. S. (2005) · The Journal of the Acoustical Society of America · doi:10.1121/1.1854312 · Cited by 111 · see citing works
Predictability of stimulus deviance and the mismatch negativity
Sussman, E. S., Ritter, W., & Vaughan, H. G. (1998) · Neuroreport · doi:10.1097/00001756-199812210-00031 · Cited by 111 · see citing works
Organization of sequential sounds in auditory memory
Sussman, E. S., & Gumenyuk, V. (2005) · Neuroreport · doi:10.1097/01.wnr.0000177002.35193.4c · Cited by 85 · see citing works
Processing of auditory stimuli during visual attention in patients with schizophrenia
Alain, C., Hargrave, R., & Woods, D. L. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00478-2 · Cited by 81 · see citing works
Butler, P. D., Chen, Y., Ford, J. M., Geyer, M. A., Silverstein, S. M., & Green, M. F. (2011) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr106 · Cited by 63 · see citing works
Mismatch Negativity Latency and Cognitive Function in Schizophrenia
Kärgel, C., Sartory, G., Kariofillis, D., Wiltfang, J., & Müller, B. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084536 · Cited by 60 · see citing works
Modulation of mismatch negativity by stimulus deviance and modality of attention
̈ller, B. W. M., Achenbach, C., Oades, R. D., Bender, S., & Schall, U. (2002) · Neuroreport · doi:10.1097/00001756-200207190-00021 · Cited by 44 · see citing works
Novelty-elicited mismatch negativity in patients with schizophrenia on admission and discharge.
Grzella, I., Müller, B. W., Oades, R. D., Bender, S., Schall, U., Zerbin, D., Wolstein, J., & Sartory, G. (2001) · PubMed Central · Cited by 41 · see citing works
Schall, U., Müller, B. W., Kärgel, C., & Güntürkün, O. (2015) · Neuroreport · doi:10.1097/wnr.0000000000000323 · Cited by 34 · see citing works
Event-related potentials reveal modelling of auditory repetition in the brain
Cooper, R. J., Atkinson, R. J., Clark, R. A., & Michie, P. T. (2013) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2013.02.003 · Cited by 30 · see citing works
What's intact and what's not within the mismatch negativity system in schizophrenia
Todd, J., Whitson, L., Ellen, S., Michie, P. T., Schall, U., & Ward, P. B. (2014) · Psychophysiology · doi:10.1111/psyp.12181 · Cited by 27 · see citing works
Koppe, G., Gruppe, H., Sammer, G., Gallhofer, B., Kirsch, P., & Lis, S. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.07.008 · Cited by 22 · see citing works
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Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia
Avissar, M., Xie, S., Vail, B., López‐Calderón, J., Wang, Y., & Javitt, D. C. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.009 · Cited by 81 · see citing works
Sensory prediction errors in the continuum of psychosis
Randeniya, R., Oestreich, L. K. L., & Garrido, M. I. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.019 · Cited by 78 · see citing works
A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia
Kirihara, K., Tada, M., Koshiyama, D., Fujioka, M., Usui, K., Araki, T., & Kasai, K. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00660 · Cited by 51 · see citing works
“investigated MMN in predictable and unpredictable conditions (Figure 2C) (34).”
BackgroundGiersch, A., & Mishara, A. L. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.01659 · Cited by 46 · see citing works
Wolff, A., & Northoff, G. (2024) · Molecular Psychiatry · doi:10.1038/s41380-023-02337-z · Cited by 41 · see citing works
Wiens, S., Szychowska, M., Eklund, R., & van Berlekom, E. (2018) · Psychophysiology · doi:10.1111/psyp.13280 · Cited by 31 · see citing works
The distinction between temporal order and duration processing, and implications for schizophrenia
Coull, J. T., & Giersch, A. (2022) · Nature Reviews Psychology · doi:10.1038/s44159-022-00038-y · Cited by 25 · see citing works
Mismatch negativity to pitch pattern deviants in schizophrenia
Haigh, S. M., Matteis, M. D., Coffman, B. A., Murphy, T. K., Butera, C. D., Ward, K. L., Leiter‐McBeth, J. R., & Salisbury, D. F. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13660 · Cited by 20 · see citing works
The effect of auditory and visual training on the mismatch negativity in schizophrenia
Kärgel, C., Sartory, G., Kariofillis, D., Wiltfang, J., & Müller, B. W. (2016) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2016.03.003 · Cited by 10 · see citing works
- Authors
- Horacek, M., Kärgel, C., Scherbaum, N., & Müller, B. W.
- Affiliations
- University of Wuppertal (DE)
- University of Duisburg-Essen (DE)
- Corresponding author
- Müller, Bernhard W.
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 617
- Pages
- 76-81
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2271994439
- Cited by
- 9
- References
- 32
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2018: 1 · 2017: 4 · 2016: 1
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- mismatch negativity, schizophrenia, temporal uncertainty, endophenotypes, deviance detection, stimulus onset asynchrony
- MeSH terms
- Acoustic Stimulation, Adult, Electroencephalography, Evoked Potentials, Auditory, Female, Humans, Male, Middle Aged, Reaction Time, Schizophrenia, Case-Control Studies
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