Mismatch negativity potentials and cognitive impairment in schizophrenia
Abstract
Cognitive impairment in schizophrenia is an important predictor of clinical and social outcome. In this preliminary study, the correlation between cognitive status and deficits in mismatch negativity (MMN) generation was explored. The MMN response to tone duration deviants was recorded using a new stimulation protocol with continuously changing ('roving') standard stimuli in order to measure the effect of standard repetitions on MMN (memory trace effect). Cognitive status of the patient group (n=28) was assessed using neuropsychological screening. Healthy participants (n=20) served as age-matched comparison group. In patients, MMN amplitude in frontal electrodes as well as the MMN memory trace effect was diminished compared to controls. While both measures were inversely related to patient's age and disease severity, only the MMN memory trace effect was robustly correlated with the degree of neuropsychological impairment. This suggests that ERP measures of auditory system adaptability more appropriately characterise the pathophysiological processes underlying cognitive impairment in schizophrenia than static measures of ERP magnitude.
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In the roving oddball paradigm, repetition showed no effect on MMN for patients with schizophrenia.
“They found that healthy controls showed larger MMN amplitudes under longer repetition conditions, while repetition showed no effect on MMN for patients with schizophrenia.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [28]
In the roving oddball paradigm, healthy controls showed larger MMN amplitudes under longer repetition conditions.
“They found that healthy controls showed larger MMN amplitudes under longer repetition conditions, while repetition showed no effect on MMN for patients with schizophrenia.”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [28]
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“This suggests that, after one presentation of a new tone, the brain has re-learned the auditory context; in other words, the “standard” is largely learned (c.f. Baldeweg et al., 2004; Dyson et al., 2005; Haenschel et al., 2005).”
InfluentialRepetition effects to sounds: evidence for predictive coding in the auditory system
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“Some studies have suggested that the greater the MMN deficit, the weaker the cognitive or functional status of the patients (also Light and Braff 2005b; Baldeweg et al. 2004; Ka- wakubo et al. 2007; Kiang et al. 2007; Hermens et al. 2010; Kaur et al. 2013).”
BackgroundMaking Sense of Mismatch Negativity
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“MMN amplitude appears to reflect the strength of the memory trace for the standard, increasing with the number of consecutive standards (26, 27, 69, 70), reduced ISI between sounds (71), and is reduced by backward masking the standard (28).”
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“The sample stimuli evoked a P570 component with a mean (SD) latency of 568 (75) milliseconds in controls and 568 (73) milliseconds in patients at the central parietal electrodes (Pz) (Figure 3 and Table 2).”
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“Indeed, previous studies have demonstrated that MMN and P3a are each significantly correlatedwith distinct domains of cognitive (Baldeweg et al., 2004; Näätänen et al., 2011; Light et al., 2007; Kawakubo et al., 2006) and psychosocial functioning (Light and Braff 2005a, 2005b; Kawakubo et al.,…”
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“Other studies of schizophrenia patients have found that MMN is associated with verbal memory deficits (Kawakubo et al., 2006; Baldeweg, Klugman, Gruzelier, & Hirsch, 2004 ), executive functioning (Kiang et al., 2007), and the degree of social skills acquisition following 3-month training program (Kawakubo et al., 2007…”
BackgroundToward a Neurobiologically Plausible Model of Language-Related, Negative Event-Related Potentials
Bornkessel‐Schlesewsky, I., & Schlesewsky, M. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00298 · Cited by 187 · see citing works
“, 1985); • MMN effects emerge via the reduction of ERP amplitudes for standards across a train of repeated presentations, reflecting the continual reduction in post-synaptic sensitivity for prediction error units with increasing predictive precision (Baldeweg et al., 2004)”
BackgroundModelling trial-by-trial changes in the mismatch negativity
Lieder, F., Daunizeau, J., Garrido, M. I., Friston, K. J., & Stephan, K. E. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002911 · Cited by 168 · see citing works
Impaired MMN/P3a complex in first-episode psychosis: cognitive and psychosocial associations
Hermens, D. F., Ward, P. B., Hodge, M. A. R., Kaur, M., Naismith, S. L., & Hickie, I. B. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.019 · Cited by 170 · see citing works
“Unlike P3, MMN deficits are relatively specific to schizophrenia (Catts et al., 1995; Salisbury et al., 2007; Umbricht et al., 2003) and correlate with the symptom severity and poor functional status (Baldeweg et al., 2004; Light and Braff, 2005a; Umbricht and Krljes, 2005).”
BackgroundLight, G. A., & Swerdlow, N. R. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12730 · Cited by 156 · see citing works
On the role of general system theory for functional neuroimaging
Stephan, K. (2004) · Journal of Anatomy · doi:10.1111/j.0021-8782.2004.00359.x · Cited by 174 · see citing works
Costa‐Faidella, J., Baldeweg, T., Grimm, S., & Escera, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2599-11.2011 · Cited by 151 · see citing works
“Divergences might arise from using inappropriate stimulation paradigms; because AEP repetition effects occur rapidly, using different stimuli with a variable number of repetitions might prove more instructive (e.g., roving standard paradigm) (Baldeweg et al., 2004; Cowan et al., 1993).”
BackgroundMethodCatts, V. S., Lai, Y. L., Weickert, C. S., Weickert, T. W., & Catts, S. V. (2015) · Biological Psychology · doi:10.1016/j.biopsycho.2015.10.013 · Cited by 151 · see citing works
COMT Val108/158Met Modifies Mismatch Negativity and Cognitive Function in 22q11 Deletion Syndrome
Baker, K., Baldeweg, T., Sivagnanasundaram, S., Scambler, P. J., & Skuse, D. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.020 · Cited by 150 · see citing works
Regularity Extraction and Application in Dynamic Auditory Stimulus Sequences
Bendixen, A., Roeber, U., & Schröger, E. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.10.1664 · Cited by 147 · see citing works
“The present results concerning the standard stimulus repetition effects are not in line with those of Baldeweg et al. (2004) and Haenschel et al. (2005) who found an early repetition positivity from 50 to 250 msec, which may reflect an ERP Bendixen, Roeber, and Schröger 1673 correlate of…”
ResultMismatch Negativity in First-Episode Schizophrenia
Haigh, S. M., Coffman, B. A., & Salisbury, D. F. (2016) · Clinical EEG and Neuroscience · doi:10.1177/1550059416645980 · Cited by 145 · see citing works
Outlier Responses Reflect Sensitivity to Statistical Structure in the Human Brain
Garrido, M. I., Sahani, M., & Dolan, R. J. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002999 · Cited by 135 · see citing works
“The oddballs are events that differ from the standards in some physical aspect such as frequency [9–12], duration [13], or amplitude [14].”
BackgroundMusic and Speech Listening Enhance the Recovery of Early Sensory Processing after Stroke
Särkämö, T., Pihko, E., Laitinen, S., Forsblom, A., Soinila, S. O., Mikkonen, M., Autti, T. H., Silvennoinen, H. M., Erkkilä, J., Laine, M., et al. (2009) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21376 · Cited by 132 · see citing works
Music listening after stroke: beneficial effects and potential neural mechanisms
Särkämö, T., & Soto, D. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06405.x · Cited by 131 · see citing works
Nicotinic modulation of human auditory sensory memory: Evidence from mismatch negativity potentials
Baldeweg, T., WONG, D., & Stephan, K. E. (2005) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.07.014 · Cited by 123 · see citing works
“A fronto-central ERP positivity from 50–220 ms post-stimulus increased in amplitude with repetition of each new standard sound (Baldeweg et al., 2004).”
BackgroundInfluentialEvidence for neural encoding of Bayesian surprise in human somatosensation
Ostwald, D., Spitzer, B., Guggenmos, M., Schmidt, T. T., Kiebel, S. J., & Blankenburg, F. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.050 · Cited by 120 · see citing works
“In the framework of the Bayesian brain hypothesis, one way to formally quantify the novelty of sensory input is Bayesian surprise, a recently proposed information theoretic quantity (Baldi and Itti, 2010; Itti and Baldi, 2009).”
Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments
Schmidt, A., Bachmann, R., Kometer, M., Csomor, P. A., Stephan, K. E., Seifritz, E., & Vollenweider, F. X. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.261 · Cited by 121 · see citing works
A Neurocomputational Model of the Mismatch Negativity
Lieder, F., Stephan, K. E., Jean Daunizeau, A., Garrido, M. I., & Friston, K. J. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003288 · Cited by 119 · see citing works
Mismatch Negativity: Translating the Potential
Todd, J., Harms, L. R., Schall, U., & Michie, P. T. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00171 · Cited by 118 · see citing works
“In schizophrenia, the increment in both components is smaller than that in controls (59), but more notably in this study, the positivity in response to standard repetitions failed to increment at all.”
MethodResultTodd, J., Michie, P. T., Schall, U., Ward, P. B., & Catts, S. V. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.10.003 · Cited by 122 · see citing works
“Interestingly, not only do patients show reduced sensitivity to increasing repetition of a new rule (Baldeweg et al., 2004), they also failed to show the nicotineinduced enhancement of MMN observed in the control group (Inami et al., 2007, although a very small sample size of n=10).”
BackgroundERP Repetition Effects and Mismatch Negativity Generation
Baldeweg, T. (2007) · Journal of Psychophysiology · doi:10.1027/0269-8803.21.34.204 · Cited by 115 · see citing works
“, generates topdown predictions), while the temporal component represents an error signal generated in a lower sensory level (Baldeweg et al., 2004; Haenschel et al., 2005).”
BackgroundInfluentialDeviance-related electrophysiological activity in mice: is there mismatch negativity in mice?
Umbricht, D., Vyssotki, D., Латанов, А. В., Nitsch, R. M., & Lipp, H. (2004) · Clinical Neurophysiology · doi:10.1016/j.clinph.2004.08.015 · Cited by 112 · see citing works
Pakarinen, S., Lovio, R., Huotilainen, M., Alku, P., Näätänen, R., & Kujala, T. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.07.008 · Cited by 116 · see citing works
Modeling ketamine effects on synaptic plasticity during the mismatch negativity
Schmidt, A., Diaconescu, A. O., Kometer, M., Friston, K. J., Stephan, K. E., & Vollenweider, F. X. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs238 · Cited by 109 · see citing works
“Beyond cognitive neuroscience and theories of brain function, the MMN has attracted a lot of attention because it is altered in several brain disorders (Naatanen 2003) with, in particular, significant reductions in schizophrenia patients (Baldeweg et al. 2002, 2004; Umbricht and Krljes 2005).”
BackgroundMethodBaldeweg, T., & Hirsch, S. R. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2014.03.008 · Cited by 108 · see citing works
“The data from a first pilot study (Baldeweg et al., 2004) supported this hypothesis, showing a diminution of theMMNmemory trace effect (expressed as the relative increase or slope of MMN amplitude with number of standards) in proportion to the impairment in working memory, assessed neuropsychologically using digit spa…”
BackgroundMethodResultInfluentialMultiple time scales of adaptation in the auditory system as revealed by human evoked potentials
Costa‐Faidella, J., Grimm, S., Slabu, L., Díaz-Santaella, F., & Escera, C. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2010.01144.x · Cited by 104 · see citing works
Application of Electroencephalography to the Study of Cognitive and Brain Functions in Schizophrenia
van der Stelt, O., & Belger, A. (2007) · Schizophrenia Bulletin · doi:10.1093/schbul/sbm016 · Cited by 101 · see citing works
“tal vs temporal sites could reflect impaired coactivation or functional ‘‘disconnection’’ of the temporal and frontal cortical regions involved in auditory change detection and orienting.(125) To disentangle possible temporal and frontal contributions to MMN abnormalities in schizophrenia, detailed topographic studies…”
Backgroundde Bastos-Leite, A. J., Ridgway, G. R., Silveira, C., Norton, A., Reis, S., & Friston, K. J. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu080 · Cited by 99 · see citing works
Mismatch negativity (MMN) as an index of central auditory system plasticity
Näätänen, R. (2008) · International Journal of Audiology · doi:10.1080/14992020802340116 · Cited by 95 · see citing works
“In addition, the MMN amplitude gets larger with an increasing number of standards preceding a deviant (Sams et al, 1983; Baldeweg et al, 2004; Haenschel et al, 2005).”
BackgroundPerez, V. B., Tarasenko, M., Miyakoshi, M., Pianka, S. T., Makeig, S. D., Braff, D. L., Swerdlow, N. R., & Light, G. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.25 · Cited by 94 · see citing works
“Furthermore, as larger MMN amplitude in SZ patients is associated with better cognitive performance (Baldeweg et al, 2004; Jahshan et al, 2012; Javitt et al, 1995; Thomas et al, 2017; Wynn et al, 2010), we hypothesized that larger pretraining MMN amplitude would be associated with greater gains in…”
BackgroundFelipo, V., Ordoño, J. F., Urios, A., Mlili, N. E., Giménez‐Garzó, C., Aguado, C., González‐López, O., Giner‐Durán, R., Serra, M. Á., Wassel, A., et al. (2011) · Hepatology · doi:10.1002/hep.24704 · Cited by 94 · see citing works
Kocsis, B., Brown, R. E., McCarley, R. W., & Hajós, M. (2013) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12081 · Cited by 93 · see citing works
“Impaired generation of both MMN and P300 has been observed after ketamine treatment in humans [75–79], resembling deficits present in patients with schizophrenic [80,81].”
Khouri, L., & Nelken, I. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.08.003 · Cited by 84 · see citing works
Meta-analysis of mismatch negativity to simple versus complex deviants in schizophrenia
Avissar, M., Xie, S., Vail, B., López‐Calderón, J., Wang, Y., & Javitt, D. C. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.009 · Cited by 81 · see citing works
Sensory prediction errors in the continuum of psychosis
Randeniya, R., Oestreich, L. K. L., & Garrido, M. I. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.019 · Cited by 78 · see citing works
“However, findings show that duration MMN amplitude decreases as illness progresses and is nearly abolished in chronic schizophrenia (Baldeweg et al., 2004).”
BackgroundCortical Mapping of Mismatch Negativity with Deviance Detection Property in Rat
Shiramatsu, T. I., Kanzaki, R., & Takahashi, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082663 · Cited by 71 · see citing works
“This finding in rodents may have significant implication in higher animals, in which MMNp is highly likely conserved during evolution, and stimulates further animal studies to investigate neural mechanisms of MMN-related clinical findings [19–27].”
Tone duration mismatch negativity deficits predict impairment of executive function in schizophrenia
Toyomaki, A., Kusumi, I., Matsuyama, T., Kako, Y., Ito, K., & Koyama, T. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.07.020 · Cited by 75 · see citing works
Primary Auditory Cortex is Required for Anticipatory Motor Response
Li, J., Liao, X., Zhang, J., Wang, M., Yang, N., Zhang, J., Lv, G., Li, H., Lu, J., Ding, R., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx079 · Cited by 73 · see citing works
Weber, L. A. E., Diaconescu, A. O., Mathys, C. D., Schmidt, A., Kometer, M., Vollenweider, F. X., & Stephan, K. E. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.3069-19.2020 · Cited by 73 · see citing works
Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia
Kawakubo, Y., Kasai, K., Kudo, N., Rogers, M. A., Nakagome, K., Itoh, K., & Kato, N. (2006) · Neuroreport · doi:10.1097/01.wnr.0000221828.10846.ba · Cited by 72 · see citing works
“[11] reported that, while toneduration MMN amplitude itself did not correlate with performance on the Rivermead Behavioural Memory Test (RBMT), MMN memory trace effect was significantly predicted by total profile scores of RBMT as revealed by regression analysis.”
ResultHamilton, H., Roach, B. J., Bachman, P., Belger, A., Carrión, R. E., Duncan, E., Johannesen, J., Light, G. A., Niznikiewicz, M. A., Addington, J., et al. (2022) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2022.1417 · Cited by 72 · see citing works
Bendixen, A., & Schröger, E. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.03.005 · Cited by 72 · see citing works
“Such protocols have previously been employed with concrete rules (Baldeweg et al., 2004; Bendixen et al., 2007; Cowan et al., 1993; Haenschel et al., 2005; Huotilainen et al., 2001; Winkler et al., 1996a).”
Lee, S., Sung, K., Lee, K.-S., Moon, E., & Kim, C.-G. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.010 · Cited by 69 · see citing works
“However, other studies have shown no significant correlations between MMN and neuropsychological test scores in healthy controls (Baldeweg et al., 2004; Kasai et al., 2002; Light et al., 2007).”
The effects of glycine on auditory mismatch negativity in schizophrenia
Greenwood, L., Leung, S., Michie, P. T., Green, A. E., Nathan, P. J., Fitzgerald, P. B., Johnston, P., Solowij, N., Kulkarni, J., & Croft, R. J. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.05.031 · Cited by 69 · see citing works
“…NMDAR deficit severity in SCZ and has been associated with impaired executive function (Toyomaki et al., 2008), daily functioning (Light and Braff, 2005), cognitive performance (Baldeweg et al., 2004) and in some studies with increased clinical symptoms (Catts et al., 1995; Schall et al., 1999).”
A predictive coding account of MMN reduction in schizophrenia
Wacongne, C. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2015.10.011 · Cited by 68 · see citing works
Enhanced mismatch negativity in adolescents with posttraumatic stress disorder (PTSD)
Ge, Y., Wu, J., Sun, X., & Zhang, K. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.10.012 · Cited by 68 · see citing works
Duerler, P., Brem, S., González, G. F., Neef, T., Allen, M., Zeidman, P., Stämpfli, P., Vollenweider, F. X., & Preller, K. H. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab202 · Cited by 66 · see citing works
“Clinical studies have linked a reduced MMN amplitude to aberrant perceptual learning, e.g. in patients with alterations of sensory information processing such as schizophrenia (Umbricht and Krljes 2005; Baldeweg et al. 2004).”
BackgroundDima, D., Frangou, S., Burge, L., Braeutigam, S., & James, A. C. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2011.12.024 · Cited by 65 · see citing works
“Additionally Baldeweg et al. (2004) reported that patients with schizophrenia do not benefit from experimental manipulations known to strengthen sensory memory as they did not evidence MMN enhancement with increasing length of standard tone trains.”
Oranje, B., Jensen, K. S., Wienberg, M., & Glenthoj, B. Y. (2007) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008176 · Cited by 64 · see citing works
“…be negatively correlated with psychomotor activity, while the slope of the MMN seems positively correlated with cognitive variables such as digit span backward and forward, MMSE score and verbal fluency score, but only in patients with schizophrenia, not in healthy controls (Baldeweg et al., 2004).”
Overcoming Rest–Task Divide—Abnormal Temporospatial Dynamics and Its Cognition in Schizophrenia
Northoff, G., & Gómez‐Pilar, J. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa178 · Cited by 61 · see citing works
Leung, S., Croft, R. J., Guille, V., Scholes‐Balog, K. E., O’Neill, B. V., Phan, K. L., & Nathan, P. J. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1723-0 · Cited by 62 · see citing works
Hochberger, W. C., Joshi, Y. B., Thomas, M. L., Zhang, W., Bismark, A. W., Treichler, E. B. H., Tarasenko, M. A., Nungaray, J. A., Sprock, J., Cardoso, L., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0256-9 · Cited by 62 · see citing works
Magnetoencephalographic signatures of conscious processing before birth
Moser, J., Schleger, F., Weiss, M., Sippel, K., Semeia, L., & Preissl, H. (2021) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2021.100964 · Cited by 61 · see citing works
“In fact, children were able to learn the hierarchical rules, as can be observed in the neuronal responses following the adequate temporal resolution (Basirat et al., 2014).”
InfluentialCsukly, G., Stefanics, G., Komlósi, S., Czigler, I., & Czobor, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075444 · Cited by 60 · see citing works
“Earlier studies showed that auditory MMN impairments can be linked to cognitive [55] and everyday functioning [56].”
BackgroundMismatch Negativity Latency and Cognitive Function in Schizophrenia
Kärgel, C., Sartory, G., Kariofillis, D., Wiltfang, J., & Müller, B. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0084536 · Cited by 60 · see citing works
“immediately before the occurrence of the deviant event [4].”
BackgroundInvestigating the Functional Role of Callosal Connections with Dynamic Causal Models
Stephan, K. E., Penny, W. D., Marshall, J. C., Fink, G. R., & Friston, K. J. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1340.008 · Cited by 60 · see citing works
Komatsu, M., Takaura, K., & Fujii, N. (2015) · Scientific Reports · doi:10.1038/srep15006 · Cited by 57 · see citing works
Mismatch Negativity But Not P300 Is Associated With Functional Disability in Schizophrenia
Hamilton, H., Perez, V. B., Ford, J. M., Roach, B. J., Jaeger, J., & Mathalon, D. H. (2017) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx104 · Cited by 58 · see citing works
Leung, S., Croft, R. J., Baldeweg, T., & Nathan, P. J. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0865-1 · Cited by 81 · see citing works
“Recently, MMN deficits have also been shown to be highly associated with both poor functional status (Light and Braff 2005) and cognitive dysfunction (Baldeweg et al. 2004) in patients with chronic schizophrenia.”
BackgroundMismatch negativity in preclinical models of schizophrenia
Featherstone, R. E., Melnychenko, O., & Siegel, S. J. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.039 · Cited by 59 · see citing works
“…to a deviant varies as a function of number of standard presentations, with a greater magnitude of response occurring following a higher number of standards (standards and deviants vary across subsequent trials) (Baldeweg et al., 2004) or as a function of deviant probability (Javitt et al., 1998).”
BackgroundMenning, H., Renz, A., Seifert, J., & Maercker, A. (2008) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2007.12.003 · Cited by 56 · see citing works
“, 1999), schizophrenia (e.g. Michie 2001; Korostenskaja et al., 2003; Umbricht et al., 2003; Baldeweg et al., 2004) and depression (e.”
BackgroundInfluentialMismatch Negativity in Recent-Onset and Chronic Schizophrenia: A Current Source Density Analysis
Fulham, W. R., Michie, P. T., Ward, P. B., Rasser, P. E., Todd, J., Johnston, P., Thompson, P. M., & Schall, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100221 · Cited by 56 · see citing works
Näätänen, R., Kujala, T., & Light, G. A. (2019) · doi:10.1093/oso/9780198705079.001.0001 · Cited by 83 · see citing works
A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia
Kirihara, K., Tada, M., Koshiyama, D., Fujioka, M., Usui, K., Araki, T., & Kasai, K. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00660 · Cited by 51 · see citing works
“While several studies have shown no difference in repetition effects between healthy individuals and patients with schizophrenia, others reported an association of repetition effects with cognitive impairments (28) and hallucinations (32).”
BackgroundMethodRecasens, M., Leung, S., Grimm, S., Nowak, R., & Escera, C. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.12.031 · Cited by 53 · see citing works
“…and greatly contributes to the “MMN memory trace effect” (Näätänen, 1992; Javitt et al., 1998), that is, the increase of the MMN amplitude as a function of the preceding number of standards (Baldeweg et al., 2004; Haenschel et al., 2005; Costa-Faidella et al., 2011a; Cooper et al., 2013).”
InfluentialNeurophysiological biomarkers support bipolar-spectrum disorders within psychosis cluster
Kaur, M., Battisti, R. A., Lagopoulos, J., Ward, P. B., Hickie, I. B., & Hermens, D. F. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.110081 · Cited by 52 · see citing works
Mowszowski, L., Hermens, D. F., Diamond, K., Norrie, L. M., Hickie, I. B., Lewis, S. J. G., & Naismith, S. L. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-111868 · Cited by 51 · see citing works
Focal cortical damage parallels cognitive impairment in minimal hepatic encephalopathy
Montoliu, C., González‐Escamilla, G., Atienza, M., Urios, A., Gonzalez, O., Wassel, A., Aliaga, R., Giner‐Durán, R., Serra, M. Á., Rodrigo, J. M., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.041 · Cited by 52 · see citing works
“Schizophrenic patients showed a reduced area under theMMNwave over frontal electrodes, and this area further correlated with the degree of cognitive impairment (Baldeweg et al., 2004).”
InfluentialThe neurobiology of MMN and implications for schizophrenia
Michie, P. T., Malmierca, M. S., Harms, L. R., & Todd, J. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2016.01.011 · Cited by 52 · see citing works
Neurophysiological Biomarkers in Schizophrenia—P50, Mismatch Negativity, and TMS-EMG and TMS-EEG
Kim, H. K., Blumberger, D. M., & Daskalakis, Z. J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00795 · Cited by 53 · see citing works
Naismith, S. L., Mowszowski, L., Ward, P. B., Diamond, K., Paradise, M., Kaur, M., Lewis, S. J. G., Hickie, I. B., & Hermens, D. F. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.12.028 · Cited by 51 · see citing works
“MMN deficits have also been shown to correlate with global functioning (Light and Braff, 2005), symptom severity (Baldeweg et al., 2004; Naatanen and Kahkonen, 2009), cognitive dysfunction (Baldeweg et al.”
BackgroundDale, C. L., Findlay, A. M., Adcock, R. A., Vertinski, M., Fisher, M., Genevsky, A., Aldebot, S., Subramaniam, K., Luks, T. L., & Simpson, G. V. (2009) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2009.10.009 · Cited by 51 · see citing works
“In schizophrenia, various experimental paradigms have shown abnormalities in the early neural response to an “unexpected” or “unpredicted” auditory stimulus that follows a previous stimuli set, such as occurs during mismatch negativity tasks (e.g., Näätänen and Kähkönen, 2009; Javitt et al., 2000; Baldeweg et al., 200…”
BackgroundNilsson, S. R. O., Celada, P., Fejgin, K., Thelin, J., Nielsen, J., Santana, N., Heath, C. J., Larsen, P. H., Nielsen, V., Kent, B. A., et al. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4265-2 · Cited by 50 · see citing works
“…dysfunctions in passive sensory stimulation paradigms (2012) such as pre-attentative measures of mismatch negativity and repetition positivity (Baldeweg et al. 2004) and N100 amplitudes (Michie et al. 1990) as well as suppressed P50 gating (Adler et al. 1982), a phenomenon involving α7nAChRs…”
BackgroundRole of N-Methyl D-aspartate receptors in action-based predictive coding deficits in schizophrenia
Kort, N. S., Ford, J. M., Roach, B. J., Gunduz-Bruce, H., Krystal, J. H., Jaeger, J., Reinhart, R. M. G., & Mathalon, D. H. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.06.019 · Cited by 48 · see citing works
“While these findings support deficits in cortical modulation of sensory responses to self-generated actions in schizophrenia, a broader range of studies implicate deficits in predictive coding based on recent sensory contextual information (37, 43-48).”
Hamilton, H., D’Souza, D. C., Ford, J. M., Roach, B. J., Kort, N. S., Ahn, K.-H., Bhakta, S. G., Ranganathan, M., & Mathalon, D. H. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.06.040 · Cited by 49 · see citing works
“Although MMN is elicited pre-attentively (Näätänen and Kähkönen, 2009), it correlates with higher-order cognition and functional outcomes in schizophrenia patients (Baldeweg et al., 2004; Hamilton et al., in revision; Light and Braff, 2005; Wynn et al., 2010) and healthy individuals (Light et al.”
Background
- Authors
- Baldeweg, T., Klugman, A., Gruzelier, J., & Hirsch, S. R.
- Affiliations
- Great Ormond Street Hospital (GB)
- Charing Cross Hospital (GB)
- Corresponding author
- Baldeweg, Torsten
- ORCID
- Baldeweg, Torsten
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 69
- Issue
- 2-3
- Pages
- 203-217
- ISSN
- 0920-9964 (ISSN-L)
- OpenAlex
- W2142009972
- Cited by
- 321
- References
- 64
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 19 · 2023: 12 · 2022: 17 · 2021: 20 · 2020: 27 · 2019: 27 · 2018: 10 · 2017: 16 · 2016: 10 · 2015: 16 · 2014: 16 · 2013: 16 · 2012: 14
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- mismatch negativity, schizophrenia
- MeSH terms
- Acoustic Stimulation, Adult, Brain Mapping, Cognition, Cognition Disorders, Contingent Negative Variation, Electroencephalography, Electrooculography, Evoked Potentials, Auditory, Female, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Schizophrenia, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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