Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice

Ambrée, Oliver; Touma, Chadi; Görtz, Nicole; Keyvani, Kathy; Paulus, Werner; Palme, Rupert; Sachser, Norbert

doi:10.1016/j.neurobiolaging.2005.05.009

Cited by 93Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroscience and Neuropharmacology Research

Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice

Ambrée, Oliver, Touma, Chadi, Görtz, Nicole, Keyvani, Kathy, Paulus, Werner, Palme, Rupert, Sachser, Norbert·2006·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2005.05.009

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Abstract

Alzheimer's disease (AD) is not only characterized by cognitive decline and neuropathological changes, but also by non-cognitive behavioral symptoms like restlessness, sleep disturbance, and wandering. These symptoms are categorized in the "Behavioral and Psychological Symptoms of Dementia" (BPSD). We investigated transgenic and wildtype mice of an APP transgenic mouse model of AD (TgCRND8) with respect to 24 h activity and spontaneous home cage behavior at 30, 60, 90 and 120 days of age. At all test days, transgenic and wildtype animals differed significantly with respect to activity patterns. In addition, activity rhythms changed distinctly in transgenic mice with increasing age. Transgenic mice also clearly showed more stereotypic behavior, which correlated significantly at 90 and 120 days of age with elevated corticosterone metabolite concentrations in fecal samples. Activity patterns in TgCRND8 mice resemble altered rhythms of activity in AD patients. Stereotypic behaviors may be caused by the same mechanisms as non-cognitive behavioral symptoms of AD. Thus, it is likely that analogies to BPSD that precede Abeta pathology are found in APP-overexpressing TgCRND8 mice.

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In TgCRND8 mice, the deficits seem most severe near the end of their wake cycle and less severe at other times of the day.
“For example, in the TgCRND8 mice, the deficits seem most severe near the end of their wake cycle and less severe at other times of the day (Ambree et al., 2006).”
From Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014) · cites this paper as Ambree et al., 2006
Many AD mouse models display increased aggressive behavior.
“Many AD mouse models also display increased aggressive behavior”
From Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models (2014) · cites this paper as Ambree et al., 2006

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“For example, in the TgCRND8 mice, the deﬁcits seem most severe near the end of their wake cycle and less severe at other times of the day (Ambree et al., 2006).”
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Authors: Ambrée, O., Touma, C., Görtz, N., Keyvani, K., Paulus, W., Palme, R., & Sachser, N.
Affiliations: University of Münster (DE)
University Hospital Münster (DE)
University of Veterinary Medicine Vienna (AT)
Corresponding author: Ambrée, Oliver
ORCID: Keyvani, Kathy
Paulus, Werner
Palme, Rupert
Sachser, Norbert
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2006-07
Volume: 27
Issue: 7
Pages: 955-964
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2005.05.009
OpenAlex: W2030336791
Cited by: 93
References: 84
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 8 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 11
FWCI: 2.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: Alzheimer's disease, TgCRND8 mice, APP transgenic mice, behavioral and psychological symptoms of dementia, stereotypy, activity rhythms, circadian activity, amyloid-beta pathology, corticosterone metabolites, restlessness, sleep disorders, wandering
MeSH terms: Adrenal Medulla, Aging, Alzheimer Disease, Animals, Behavior, Animal, Brain, Circadian Rhythm, Corticosterone, Disease Models, Animal, Humans, Male, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Stereotyped Behavior, Tyrosine 3-Monooxygenase, Amyloid beta-Protein Precursor, Mice, Plaque, Amyloid

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Activity changes and marked stereotypic behavior precede Aβ pathology in TgCRND8 Alzheimer mice

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