Inflammation, the complement system and the diseases of aging

Inflammation, Atherosclerosis, and Coronary Artery Disease

Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773 · see citing works

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works

Reactive microglia are positive for HLA‐DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

McGeer, P. L., Itagaki, S., Boyes, B. E., & McGeer, E. G. (1988) · Neurology · doi:10.1212/wnl.38.8.1285 · Cited by 2,990 · see citing works

Complement factor H polymorphism and age-related macular degeneration

Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449 · see citing works

Complement factor H variant increases the risk of age-related macular degeneration

Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424 · see citing works

A common haplotype in the complement regulatory gene factor H ( <i>HF1/CFH</i> ) predisposes individuals to age-related macular degeneration

Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961 · see citing works

The many faces of macrophage activation

Mosser, D. M. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0602325 · Cited by 1,902 · see citing works

A role for local inflammation in the formation of drusen in the aging eye

Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01624-0 · Cited by 1,087 · see citing works

Complement activation by beta-amyloid in Alzheimer disease.

Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817 · see citing works

Nonsteroidal Anti-inflammatory Drugs and the Risk of Parkinson Disease

Chen, H., Zhang, S. M., Hernán, M. Á., Schwarzschild, M. A., Willett, W. C., Colditz, G. A., Speizer, F. E., & Ascherio, A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1059 · Cited by 630 · see citing works

Inflammation and neurodegeneration in Parkinson's disease

McGeer, P. L., & McGeer, E. G. (2004) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2004.01.005 · Cited by 628 · see citing works

Presence of dendritic cells, MCP‐1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

Henkel-Tigges, J., Engelhardt, J., Siklós, L., Simpson, E. P., Kim, S. H., Pan, T., Goodman, J. C., Siddique, T., Beers, D. R., & Appel, S. H. (2003) · Annals of Neurology · doi:10.1002/ana.10805 · Cited by 554 · see citing works

Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue.

Kawamata, T., Akiyama, H., Yamada, T., & McGeer, P. L. (1992) · PubMed Central · Cited by 546 · see citing works

Inflammation and the Degenerative Diseases of Aging

McGeer, P. L., & McGeer, E. G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.007 · Cited by 519 · see citing works

C-Reactive Protein: A Simple Test to Help Predict Risk of Heart Attack and Stroke

Ridker, P. M. (2003) · Circulation · doi:10.1161/01.cir.0000093381.57779.67 · Cited by 448 · see citing works

Brain microglia constitutively express β-2 integrins

Akiyama, H., & McGeer, P. L. (1990) · Journal of Neuroimmunology · doi:10.1016/0165-5728(90)90055-r · Cited by 430 · see citing works

Brain protein oxidation in age-related neurodegenerative disorders that are associated with aggregated proteins

Butterfield, D. A., & Kański, J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00249-4 · Cited by 418 · see citing works

Presence of reactive microglia in monkey substantia nigra years after 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine administration

McGeer, P. L., Schwab, C., Parent, A., & Doudet, D. (2003) · Annals of Neurology · doi:10.1002/ana.10728 · Cited by 400 · see citing works

Association Between C-Reactive Protein and Age-Related Macular Degeneration

Keenan, T. D. L., & Chew, E. Y. (2017) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2017.2210 · Cited by 378 · see citing works

Association between C-reactive protein and age-related macular degeneration

Seddon, J. M. (2004) · JAMA · doi:10.1001/jama.291.6.704 · Cited by 376 · see citing works

Activated microglia in the human glaucomatous optic nerve head

Yuan, L., & Neufeld, A. H. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.1104 · Cited by 348 · see citing works

Critical Role for Microglial NADPH Oxidase in Rotenone-Induced Degeneration of Dopaminergic Neurons

Gao, H., Liu, B., & Hong, J. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06181.2003 · Cited by 338 · see citing works

High dietary fat induces NADPH oxidase-associated oxidative stress and inflammation in rat cerebral cortex

ZHANG, X., Dong, F., Ren, J. T., Driscoll, M., & Culver, B. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.10.011 · Cited by 280 · see citing works

IL-4, IL-10 and IL-13 modulate Aβ(1–42)-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line

Szczepanik, A. M. (2001) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00404-5 · Cited by 243 · see citing works

Complement factor H polymorphism in age-related macular degeneration

Klein, R. J., Zeiss, C. J., Chew, E. Y., Tsai, J. –., Sackler, R. S., Haynes, C. M., Henning, A. K., SanGiovanni, J. P., Manne, S., Mayne, S. T., et al. (2005) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2005.06.004 · Cited by 213 · see citing works

Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure

Barcia, C., Sánchez-Bahíllo, A., Fernández‐Villalba, E., Bautista‐Hernández, V., Poza, M., Fernández-Barreiro, A., Hirsch, É. C., & Herrero, M. T. (2004) · Glia · doi:10.1002/glia.20015 · Cited by 206 · see citing works

Immunological aspects of microglia: relevance to Alzheimer's disease

Benveniste, E. N., Nguyen, V. T., & O'Keefe, G. M. (2001) · Neurochemistry International · doi:10.1016/s0197-0186(01)00045-6 · Cited by 188 · see citing works

Human Heart Generates Complement Proteins That Are Upregulated and Activated After Myocardial Infarction

Yasojima, K., Schwab, C., McGeer, E. G., & McGeer, P. L. (1998) · Circulation Research · doi:10.1161/01.res.83.8.860 · Cited by 161 · see citing works

Major histocompatibility complex antigen expression on rat microglia following epidural kainic acid lesions

Akiyama, H., Itagaki, S., & McGeer, P. L. (1988) · Journal of Neuroscience Research · doi:10.1002/jnr.490200202 · Cited by 160 · see citing works

Microglia and the Process of Phagocytosis in Gliomas.

Penfield, W. G. (1925) · Europe PMC (PubMed Central) · Cited by 153 · see citing works

Inflammation and degeneration in multiple sclerosis

Brück, W., & Stadelmann, C. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0170-7 · Cited by 130 · see citing works

Detection of complement alternative pathway mRNA and proteins in the Alzheimer’s disease brain

Strohmeyer, R., Shen, Y., & Rogers, J. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00149-2 · Cited by 114 · see citing works

Atypical Antiinflammatory Activation of Microglia Induced by Apoptotic Neurons: Possible Role of Phosphatidylserine–Phosphatidylserine Receptor Interaction

Simone, R. D., Ajmone‐Cat, M. A., & Minghetti, L. (2004) · Molecular Neurobiology · doi:10.1385/mn:29:2:197 · Cited by 88 · see citing works

Pharmacologic Approaches to the Treatment of Amyotrophic Lateral Sclerosis

McGeer, E. G., & McGeer, P. L. (2005) · BioDrugs · doi:10.2165/00063030-200519010-00004 · Cited by 75 · see citing works

Interleukin‐4, interleukin‐10, and interleukin‐1‐receptor antagonist but not transforming growth factor‐β induce ramification and reduce adhesion molecule expression of rat microglial cells

Wirjatijasa, F., Dehghani, F., Blaheta, R. A., Korf, H., & Hailer, N. P. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10254 · Cited by 52 · see citing works

Sparing of age-related macular degeneration in rheumatoid arthritis

McGeer, P. L., & Sibley, J. T. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.02.003 · Cited by 51 · see citing works

Modulation of human microglia and THP-1 cell toxicity by cytokines endogenous to the nervous system

Klegeris, A., Bissonnette, C. J., & McGeer, P. L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.06.012 · Cited by 50 · see citing works

Neuroprotection from Complement‐Mediated Inflammatory Damage

Kulkarni, A. P., Kellaway, L. A., Lahiri, D. K., & Kotwal, G. J. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.010 · Cited by 50 · see citing works

Tumour necrosis factor-α blockade: a new era for effective management of rheumatoid arthritis

Hamilton, K., & Clair, E. W. S. T. (2000) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.1.5.1041 · Cited by 39 · see citing works

Chymotrypsin‐like proteases contribute to human monocytic THP‐1 cell as well as human microglial neurotoxicity

Klegeris, A., & McGeer, P. L. (2005) · Glia · doi:10.1002/glia.20186 · Cited by 22 · see citing works

Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure

Langston, J. W., Forno, L. S., Tetrud, J., Reeves, A. G., Kaplan, J. A., & Karluk, D. (1999) · Annals of Neurology · doi:10.1002/1531-8249(199910)46:4 · Cited by 1 · see citing works

Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration

Qin, L., Wu, X., Block, M. L., Liu, Y., Breese, G. R., Hong, J., Knapp, D. J., & Crews, F. T. (2007) · Glia · doi:10.1002/glia.20467 · Cited by 2,144 · see citing works

Microglial Activation and Chronic Neurodegeneration

Lull, M. E., & Block, M. L. (2010) · Neurotherapeutics · doi:10.1016/j.nurt.2010.05.014 · Cited by 1,047 · see citing works

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045 · see citing works

Blood–brain Barrier: Structural Components and Function Under Physiologic and Pathologic Conditions

Persidsky, Y., Ramirez, S. H., Haorah, J., & Kanmogne, G. D. (2006) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-006-9025-3 · Cited by 922 · see citing works

Para-Inflammation in the Aging Retina

Xu, H., Chen, M., & Forrester, J. V. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.001 · Cited by 659 · see citing works

Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis

Gralinski, L. E., Sheahan, T. P., Morrison, T. E., Menachery, V. D., Jensen, K., Leist, S. R., Whitmore, A. C., Heise, M. T., & Baric, R. S. (2018) · mBio · doi:10.1128/mbio.01753-18 · Cited by 656 · see citing works

Synuclein activates microglia in a model of Parkinson's disease

Su, X., Maguire-Zeiss, K. A., Giuliano, R., Prifti, L., Venkatesh, K., & Federoff, H. J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.006 · Cited by 474 · see citing works

Parkinson’s Disease

Mhyre, T. R., Boyd, J. T., Hamill, R. W., & Maguire‐Zeiss, K. A. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-5416-4_16 · Cited by 442 · see citing works

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

Bureau, G., Longpré, F., & Martinoli, M. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21503 · Cited by 336 · see citing works

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

Daniele, S. G., Béraud, D., Davenport, C., Cheng, K., Yin, H., & Maguire-Zeiss, K. A. (2015) · Science Signaling · doi:10.1126/scisignal.2005965 · Cited by 303 · see citing works

Genetic Analysis of Pathways to Parkinson Disease

Hardy, J. (2010) · Neuron · doi:10.1016/j.neuron.2010.10.014 · Cited by 270 · see citing works

Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa

Yoshida, N., Ikeda, Y., Notomi, S., Ishikawa, K., Murakami, Y., Hisatomi, T., Enaida, H., & Ishibashi, T. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2012.07.006 · Cited by 262 · see citing works

Crosstalk between reactive oxygen species and pro-inflammatory markers in developing various chronic diseases: a review

Ranneh, Y., Ali, F., Akim, A. M., Hamid, H. A., Khaza’ai, H., & Fadel, A. (2017) · Applied Biological Chemistry · doi:10.1007/s13765-017-0285-9 · Cited by 258 · see citing works

Complement activation in experimental and human temporal lobe epilepsy

Aronica, E., Boer, K., van Vliet, E. A., Redeker, S., Baayen, J. C., Spliet, W. G. M., van Rijen, P. C., Troost, D., Lopes, F. H. D. S., Wadman, W. J., et al. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.01.015 · Cited by 228 · see citing works

Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites

Brouwers, N., Van Cauwenberghe, C., Engelborghs, S., Lambert, J.-C., Bettens, K., Le Bastard, N., Pasquier, F., Montoya, A. G., Peeters, K., Mattheijssens, M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.24 · Cited by 227 · see citing works

Chronic Neuron-Specific Tumor Necrosis Factor-Alpha Expression Enhances the Local Inflammatory Environment Ultimately Leading to Neuronal Death in 3xTg-AD Mice

Janelsins, M. C., Mastrangelo, M. A., Park, K. M., Sudol, K. L., Narrow, W. C., Oddo, S., LaFerla, F. M., Callahan, L. M., Federoff, H. J., & Bowers, W. J. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.080528 · Cited by 220 · see citing works

Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6‐hydroxydopamine model of Parkinson’s disease

Marinova‐Mutafchieva, L., Sadeghian, M., Broom, L., Davis, J. B., Medhurst, A. D., & Dexter, D. T. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06189.x · Cited by 217 · see citing works

Amyloid pathology is associated with progressive monoaminergic neurodegeneration in a transgenic mouse model of Alzheimer’s disease

Liu, Y., Yoo, M.-J., Savonenko, A., Stirling, W., Price, D. L., Borchelt, D. R., Mamounas, L., Lyons, W. E., Blue, M. E., & Lee, M. K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4218-08.2008 · Cited by 206 · see citing works

Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment

Singhal, G., Jaehne, E. J., Corrigan, F., & Baune, B. T. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00097 · Cited by 186 · see citing works

REVIEW: Pin1 in Alzheimer's disease

Butterfield, D. A., Abdul, H. M., Opii, W. O., Newman, S. F., Gururaj Joshi, A., Ansari, M. A., & Rukhsana Sultana, A. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03995.x · Cited by 179 · see citing works

The Effects of Age on Pain Sensitivity: Preclinical Studies

Yezierski, R. P. (2012) · Pain Medicine · doi:10.1111/j.1526-4637.2011.01311.x · Cited by 177 · see citing works

Targeted delivery of siRNA to macrophages for anti-inflammatory treatment.

Kim, S.-S., Ye, C., Kumar, P., Chiu, I., Subramanya, S., Wu, H., Shankar, P., & Manjunath, N. (2010) · Molecular Therapy · doi:10.1038/mt.2010.27 · Cited by 164 · see citing works

Laboratory Evidence of Sustained Chronic Inflammatory Reaction in Retinitis Pigmentosa

Yoshida, N., Ikeda, Y., Notomi, S., Ishikawa, K., Murakami, Y., Hisatomi, T., Enaida, H., & Ishibashi, T. (2012) · Ophthalmology · doi:10.1016/j.ophtha.2012.07.008 · Cited by 174 · see citing works

Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

Huang, Q., & Figueiredo‐Pereira, M. E. (2010) · APOPTOSIS · doi:10.1007/s10495-010-0466-z · Cited by 171 · see citing works

IFN‐γ enhances neurogenesis in wild‐type mice and in a mouse model of Alzheimer's disease

Baron, R., Nemirovsky, A., Harpaz, I., Cohen, H., Owens, T., & Monsonego, A. (2008) · The FASEB Journal · doi:10.1096/fj.08-105866 · Cited by 166 · see citing works

Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)

Ramkumar, H. L., Zhang, J., & Chan, C.-C. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.02.002 · Cited by 163 · see citing works

Alzheimers Disease and Retinal Neurodegeneration

Guo, L., Duggan, J., & Cordeiro, M. F. (2010) · Current Alzheimer Research · doi:10.2174/156720510790274491 · Cited by 161 · see citing works

Mutant α-Synuclein Overexpression Mediates Early Proinflammatory Activity

Su, X., Federoff, H. J., & Maguire-Zeiss, K. A. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9053-x · Cited by 145 · see citing works

Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents

Jan, M. S., Ahmad, S., Hussain, F., Ahmad, A., Mahmood, F., Rashid, U., Abid, O., Ullah, F., Ayaz, M., & Sadiq, A. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111863 · Cited by 138 · see citing works

Age-related macular degeneration and the immune response: implications for therapy

Nussenblatt, R. B., & Ferris, F. (2007) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2007.06.025 · Cited by 130 · see citing works

Vitamin B-6 Intake Is Inversely Related to, and the Requirement Is Affected by, Inflammation Status

Morris, M. S., Sakakeeny, L., Jacques, P. F., Picciano, M. F., & Selhub, J. (2009) · Journal of Nutrition · doi:10.3945/jn.109.114397 · Cited by 130 · see citing works

Microglia in Aging and Alzheimer’s Disease: A Comparative Species Review

Edler, M. K., Mhatre-Winters, I., & Richardson, J. R. (2021) · Cells · doi:10.3390/cells10051138 · Cited by 126 · see citing works

Complement 3 and Factor H in Human Cerebrospinal Fluid in Parkinson's Disease, Alzheimer's Disease, and Multiple-System Atrophy

Wang, Y., Hancock, A. M., Bradner, J. M., Chung, K. A., Quinn, J. F., Peskind, E. R., Galasko, D. R., Jankovic, J. J., Zabetian, C. P., Kim, H. M., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.01.006 · Cited by 121 · see citing works

Pathogenic Upregulation of Glial Lipocalin-2 in the Parkinsonian Dopaminergic System

Kim, B.-W., Jeong, K. H., Kim, J., Jin, M., Kim, J., Lee, M., Choi, D., Won, S.-Y., McLean, C., Jeon, M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4261-15.2016 · Cited by 118 · see citing works

The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration

Hadziahmetovic, M., Song, Y., Wolkow, N., Iacovelli, J., Grieco, S. F., Lee, J., Lyubarsky, A., Praticò, D., Connelly, J., Spino, M., et al. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6207 · Cited by 117 · see citing works

Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation

Helbling, P. M., Piñeiro-Yáñez, E., Gerosa, R., Boettcher, S., Al-Shahrour, F., Manz, M. G., & Nombela-Arrieta, C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.004 · Cited by 116 · see citing works

Regulator of G-Protein Signaling 10 Promotes Dopaminergic Neuron Survival via Regulation of the Microglial Inflammatory Response

Lee, J., McCoy, M. K., Harms, A. S., Ruhn, K. A., Gold, S. J., & Tansey, M. G. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1806-08.2008 · Cited by 113 · see citing works

Notch signaling modulates the activation of microglial cells

Grandbarbe, L., Michelucci, A., Heurtaux, T., Hemmer, K., Morga, E., & Heuschling, P. (2007) · Glia · doi:10.1002/glia.20553 · Cited by 110 · see citing works

The Ubiquitin–Proteasome System in Retinal Health and Disease

Campello, L., Esteve-Rudd, J., Cuenca, N., & Martín‐Nieto, J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-012-8391-5 · Cited by 104 · see citing works

Marked microglial reaction in normal aging human substantia nigra: correlation with extraneuronal neuromelanin pigment deposits

Beach, T. G., Sue, L. I., Walker, D. G., Lue, L. F., Connor, D. J., Caviness, J. N., Sabbagh, M. N., & Adler, C. H. (2007) · Acta Neuropathologica · doi:10.1007/s00401-007-0250-5 · Cited by 101 · see citing works

Emerging roles of microglial activation and non-motor symptoms in Parkinson's disease

Doorn, K. J., Lucassen, P. J., Boddeke, H. W. G. M., Prins, M., Berendse, H. W., Drukarch, B., & van Dam, A. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.06.005 · Cited by 97 · see citing works

Systemic administration of the iron chelator deferiprone protects against light-induced photoreceptor degeneration in the mouse retina

Song, D., Song, Y., Hadziahmetovic, M., Zhong, Y., & Dunaief, J. L. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.04.020 · Cited by 96 · see citing works

Age-Dependent Retinal Iron Accumulation and Degeneration in Hepcidin Knockout Mice

Hadziahmetovic, M., Song, Y., Ponnuru, P., Iacovelli, J., Hunter, A. A., Haddad, N., Beard, J., Connor, J. R., Vaulont, S., & Dunaief, J. L. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6113 · Cited by 98 · see citing works

Effect of Complement CR1 on Brain Amyloid Burden During Aging and Its Modification by APOE Genotype

Thambisetty, M., An, Y., Nalls, M., Sojkova, J., Swaminathan, S., Zhou, Y., Singleton, A. B., Wong, D. F., Ferrucci, L., Saykin, A. J., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.08.015 · Cited by 90 · see citing works

Interferon γ–Inducible Protein-10 (IP-10) and Eotaxin as Biomarkers in Age-Related Macular Degeneration

Mo, F. M., Proia, A. D., Johnson, W. H., Cyr, D., & Lashkari, K. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3910 · Cited by 96 · see citing works

Inflammation in transgenic mouse models of neurodegenerative disorders

Schwab, C., Klegeris, A., & McGeer, P. L. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.10.013 · Cited by 97 · see citing works

The Complement System, Aging, and Aging-Related Diseases

Zheng, R., Zhang, Y., Zhang, K., Yuan, Y., Jia, S., & Liu, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158689 · Cited by 94 · see citing works

Immunological outcomes of exercise in older adults

Senchina, D. S., & Kohut, M. L. (2007) · Clinical Interventions in Aging · doi:10.2147/ciia.2007.2.1.3 · Cited by 91 · see citing works

Curcumin Protects Dopaminergic Neuron Against LPS Induced Neurotoxicity in Primary Rat Neuron/Glia Culture

Yang, S., Zhang, D., Yang, Z., Hu, X., Qian, S. Y., Liu, J., Wilson, B. C., Block, M. L., & Hong, J. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9675-z · Cited by 93 · see citing works

Regulator of G-Protein Signaling-10 Negatively Regulates NF-κB in Microglia and Neuroprotects Dopaminergic Neurons in Hemiparkinsonian Rats

Lee, J., Chung, J., McAlpine, F. E., & Tansey, M. G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1002-11.2011 · Cited by 88 · see citing works

Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice

Okuyama, S., Minami, S., Shimada, N., Makihata, N., Nakajima, M., & Furukawa, Y. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.11.043 · Cited by 88 · see citing works

Metabolism, mood and cognition in aging: the importance of lifestyle and dietary intervention

Hendrickx, H., McEwen, B. S., & Ouderaa, F. V. D. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.10.005 · Cited by 83 · see citing works

Inflammation and the pathogenesis of age-related macular degeneration

Augustin, A. J., & Kirchhof, J. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220902942322 · Cited by 83 · see citing works

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

Chavarría, C., Rodríguez-Bottero, S., Quijano, C., Cassina, P., & Souza, J. M. (2018) · Biochemical Journal · doi:10.1042/bcj20180297 · Cited by 82 · see citing works

Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration

Lueck, K., Wasmuth, S., Williams, J., Hughes, T. R., Morgan, B. P., Lommatzsch, A., Greenwood, J., Moss, S. E., & Pauleikhoff, D. (2011) · Eye · doi:10.1038/eye.2011.109 · Cited by 80 · see citing works

Mendelian disorders and multifactorial traits: the big divide or one for all?

Antonarakis, S. E., Chakravarti, A., Cohen, J. C., & Hardy, J. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2793 · Cited by 80 · see citing works

Inflammation in Dry Age-Related Macular Degeneration

Rodrigues, E. B. (2007) · Ophthalmologica · doi:10.1159/000099293 · Cited by 73 · see citing works

Brain progranulin expression in GRN-associated frontotemporal lobar degeneration

Chen‐Plotkin, A. S., Xiao, J., Geser, F., Martinez‐Lage, M., Grossman, M., Unger, T. L., Wood, E. M., Deerlin, V. M. V., Trojanowski, J. Q., & Lee, V. M. ‐. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0576-2 · Cited by 71 · see citing works

CD 4 T cells in immunity and immunotherapy of A lzheimer's disease

Monsonego, A., Nemirovsky, A., & Harpaz, I. (2013) · Immunology · doi:10.1111/imm.12103 · Cited by 71 · see citing works

Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells

Fernandes, A. F., Zhou, J., Zhang, X., Bian, Q., Sparrow, J. R., Taylor, A., Pereira, P., & Shang, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800268200 · Cited by 69 · see citing works

Modulation by Astrocytes of Microglial Cell-Mediated Neuroinflammation: Effect on the Activation of Microglial Signaling Pathways

Tichauer, J. E., Saud, K., & Rommy von Bernhardi, M. (2007) · NeuroImmunoModulation · doi:10.1159/000110642 · Cited by 68 · see citing works

Induction of microglial toll-like receptor 4 by prothrombin kringle-2: a potential pathogenic mechanism in Parkinson’s disease

Shin, W.-H., Jeon, M., Leem, E., Won, S.-Y., Jeong, K. H., Park, S., McLean, C., Lee, S. J., Jin, B. K., Jung, U. J., et al. (2015) · Scientific Reports · doi:10.1038/srep14764 · Cited by 65 · see citing works

Role of Complement Cascade in Abdominal Aortic Aneurysms

Hinterseher, I., Erdman, R., Donoso, L. A., Vrabec, T. R., Schworer, C. M., Lillvis, J. H., Boddy, A. M., Derr, K., Golden, A. M., Bowen, W. D., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.227652 · Cited by 62 · see citing works

Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis

Iannaccone, A., Giorgianni, F., New, D. D., Hollingsworth, T., Umfress, A. C., Alhatem, A., Neeli, I., Lenchik, N. I., Jennings, B., Calzada, J. I., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145323 · Cited by 59 · see citing works

Loss of P2Y2 Nucleotide Receptors Enhances Early Pathology in the TgCRND8 Mouse Model of Alzheimer's Disease

Ajit, D., Woods, L. T., Camden, J. M., Thebeau, C. N., El-Sayed, F. G., Greeson, G. W., Erb, L., Petris, M. J., Miller, D. C., Sun, G. Y., et al. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8577-5 · Cited by 58 · see citing works

Bioprospecting of brown seaweeds for biotechnological applications: Phlorotannin actions in inflammation and allergy network

Barbosa, M., Lopes, G., Andrade, P. B., & Valentão, P. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.02.037 · Cited by 58 · see citing works

Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response

Mendes-Pinheiro, B., Soares‐Cunha, C., Marote, A., Loureiro‐Campos, E., Campos, J., Barata‐Antunes, S., Monteiro‐Fernandes, D., Santos, D. J., Duarte‐Silva, S., Pinto, L., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111530 · Cited by 55 · see citing works

Inflammation in Lafora Disease: Evolution with Disease Progression in Laforin and Malin Knock-out Mouse Models

López‐González, I., Viana, R., Sanz, P., & Ferrer, I. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9884-4 · Cited by 54 · see citing works

C4b-binding protein in Alzheimer's disease: Binding to Aβ1–42 and to dead cells

Trouw, L. A., Nielsen, H. M., Minthon, L., Londos, E., Landberg, G., Veerhuis, R., Janciauskiene, S. M., & Blom, A. M. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.04.025 · Cited by 53 · see citing works

Nanoceutical Adjuvants as Wound Healing Material: Precepts and Prospects

Banerjee, K., Madhyastha, R., Nakajima, Y., Maruyama, M., & Madhyastha, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094748 · Cited by 52 · see citing works

Paeonol Suppresses Neuroinflammatory Responses in LPS-Activated Microglia Cells

He, L. X., Tong, X., Zeng, J., Tu, Y., Wu, S., Li, M., Deng, H., Zhu, M., Li, X., Nie, H., et al. (2016) · Inflammation · doi:10.1007/s10753-016-0426-z · Cited by 51 · see citing works

Developmental roles of microglia: A window into mechanisms of disease

Anderson, S., & Vetter, M. L. (2018) · Developmental Dynamics · doi:10.1002/dvdy.1 · Cited by 50 · see citing works

Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease

Tang, Y.-W., Shi, C., Yang, H., Cai, P., Liu, Q., Yang, X., Kong, L., & Wang, X. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.11.040 · Cited by 51 · see citing works

Tumor necrosis factor receptor-associated death domain mediated neuronal death contributes to the glial activation and subsequent neuroinflammation in Japanese encephalitis

Swarup, V., Ghosh, J., Das, S., & Basu, A. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.01.014 · Cited by 48 · see citing works

Differential expression of interferon-γ receptor on human glial cells in vivo and in vitro

Hashioka, S., Klegeris, A., Schwab, C., Yu, S. Y., & McGeer, P. L. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.04.023 · Cited by 47 · see citing works

Proteomics of Alzheimer’s disease: understanding mechanisms and seeking biomarkers

Lovestone, S., Güntert, A., Hye, A., Lynham, S., Thambisetty, M., & Ward, M. A. (2007) · Expert Review of Proteomics · doi:10.1586/14789450.4.2.227 · Cited by 46 · see citing works

Targeting complement in neurodegeneration: challenges, risks, and strategies

Zelek, W. M., & Morgan, B. P. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.02.006 · Cited by 44 · see citing works

Complement in Neurologic Disease

Propson, N. E., Gedam, M., & Zheng, H. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-031620-113409 · Cited by 43 · see citing works

Tumor Necrosis Factor-α Potentiates Intraneuronal Ca2+ Signaling via Regulation of the Inositol 1,4,5-Trisphosphate Receptor

Park, K. M., Yule, D. I., & Bowers, W. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802209200 · Cited by 44 · see citing works

P2Y receptors in Alzheimer's disease

Erb, L., Chen, C., Ajit, D., & Weisman, G. A. (2014) · Biology of the Cell · doi:10.1111/boc.201400043 · Cited by 43 · see citing works

The Oral Iron Chelator Deferiprone Protects Against Retinal Degeneration Induced through Diverse Mechanisms

Hadziahmetovic, M., Pajić, M., Grieco, S. F., Song, Y., Song, D., Li, Y., Cwanger, A., Iacovelli, J., Chu, S., Ying, G., et al. (2012) · Translational Vision Science & Technology · doi:10.1167/tvst.1.3.2 · Cited by 43 · see citing works

Auraptene in the Peels of Citrus kawachiensis (Kawachi Bankan) Ameliorates Lipopolysaccharide‐Induced Inflammation in the Mouse Brain

Okuyama, S., Yamamoto, K., Mori, H., Toyoda, N., Yoshimura, M., Amakura, Y., Yoshida, T., Sugawara, K., Sudo, M., Nakajima, M., et al. (2014) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2014/408503 · Cited by 42 · see citing works

Neuronal nicotinic receptors as novel targets for inflammation and neuroprotection: mechanistic considerations and clinical relevance

Bencherif, M. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.37 · Cited by 44 · see citing works

The Senescence Hypothesis of Disease Progression in Alzheimer Disease: an Integrated Matrix of Disease Pathways for FAD and SAD

Hunter, S., Arendt, T., & Brayne, C. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8445-3 · Cited by 41 · see citing works

Squamosamide derivative FLZ protects dopaminergic neurons against inflammation-mediated neurodegeneration through the inhibition of NADPH oxidase activity

Zhang, D., Hu, X., Wei, S., Liu, J., Gao, H., Li, Q., Wilson, B. C., Liu, G.-T., & Hong, J. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-21 · Cited by 40 · see citing works

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity

Chung, J.-Y., Park, H. R., Lee, S. J., Lee, S., Kim, J.-S., Jung, Y., Hwang, S., Ha, N., Seol, W., Lee, J., et al. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.60 · Cited by 40 · see citing works

Chemiexcitation and Its Implications for Disease

Brash, D. E., Gonçalves, L. C. P., & Bechara, E. J. H. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.004 · Cited by 36 · see citing works

Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration

Amadoro, G., Latina, V., Balzamino, B. O., Squitti, R., Varano, M., Calissano, P., & Micera, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.735928 · Cited by 40 · see citing works

Opposite Effects of Bone Marrow-Derived Cells Transplantation in MPTP-rat Model of Parkinson's Disease: A Comparison Study of Mononuclear and Mesenchymal Stem Cells

Capitelli, C. S., Lopes, C. S., Alves, A. C., Barbiero, J. K., de Oliveira, L. F., da Silva, V. J. D., & Vital, M. A. B. F. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.8182 · Cited by 36 · see citing works

Culture and Characterization of Microglia from the Adult Murine Retina

Devarajan, G., Chen, M., Muckersie, E., & Xu, H. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/894368 · Cited by 35 · see citing works

Complement activation by islet amyloid polypeptide (IAPP) and α-synuclein 112

Klegeris, A., & McGeer, P. L. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.04.055 · Cited by 33 · see citing works

Dihydropyrimidinase-like 3 regulates the inflammatory response of activated microglia

Manivannan, J., Tay, S. S. W., Ling, E.-A., & Dheen, S. T. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.023 · Cited by 33 · see citing works

Complement Factor H polymorphism Y402H associates with inflammation, visual acuity, and cardiovascular mortality in the elderly population at large

Mooijaart, S. P., Koeijvoets, K. C. M. C., Sijbrands, E. J. G., Daha, M. R., & Westendorp, R. G. J. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.08.001 · Cited by 32 · see citing works

Proteasome Inactivation Promotes p38 Mitogen-activated Protein Kinase-dependent Phosphatidylinositol 3-kinase Activation and Increases Interleukin-8 Production in Retinal Pigment Epithelial Cells

Fernandes, A. F., Bian, Q., Jiang, J., Thomas, C. J., Taylor, A., Pereira, P., & Shang, F. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-10-1068 · Cited by 31 · see citing works

The effects of anti‐VEGF and kinin B1 receptor blockade on retinal inflammation in laser‐induced choroidal neovascularization

Hachana, S., Fontaine, O., Sapieha, P. S., Lesk, M. R., Couture, R., & Vaucher, E. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14962 · Cited by 30 · see citing works

Lack of association between IL-1β, TNF-α, and IL-10 gene polymorphisms and sporadic Parkinson’s disease in an Italian cohort

Pascale, E., Passarelli, E., Purcaro, C., Vestri, A. R., Fakeri, A., Guglielmi, R., Passarelli, F., & Meco, G. (2010) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2010.01441.x · Cited by 30 · see citing works

Poor Diet, Stress, and Inactivity Converge to Form a “Perfect Storm” That Drives Alzheimer’s Disease Pathogenesis

Pacholko, A. G., Wotton, C. A., & Bekar, L. K. (2019) · Neurodegenerative Diseases · doi:10.1159/000503451 · Cited by 29 · see citing works

Restriction of sulfur-containing amino acids alters claudin composition and improves tight junction barrier function

Skrovanek, S. M., Valenzano, M. C., & Mullin, J. M. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00072.2007 · Cited by 29 · see citing works

IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer’s disease mouse model

Lonnemann, N., Hosseini, S., Ohm, M., Geffers, R., Hiller, K., Dinarello, C. A., & Körte, M. (2022) · eLife · doi:10.7554/elife.75889 · Cited by 28 · see citing works

In vitro scavenging activity for reactive oxygen species by N‐substituted indole‐2‐carboxylic acid esters

Kruk, I., Aboul-Enein, H. Y., Michalska, T., Lichszteld, K., Kubasik-Kładna, K., & Ölgen, S. (2007) · Luminescence · doi:10.1002/bio.974 · Cited by 28 · see citing works

Complement, neuroinflammation and neuronal degeneration in Alzheimer disease

McGeer, P. L., McGeer, E. G., & Yasojima, K. (2001) · Birkhäuser Basel eBooks · doi:10.1007/978-3-0348-8225-5_2 · Cited by 1 · see citing works

Inflammation and the Degenerative Diseases of Aging

McGeer, P. L., & McGeer, E. G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1332.007 · Cited by 519 · see citing works

Role of complement in neurodegeneration and neuroinflammation

Bonifati, D. M., & Kishore, U. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.007 · Cited by 310 · see citing works

Microglial Cell Dysregulation in the Aged Brain and Neurodegeneration

Triolo-Mieses, M., Fadić, R., & Rommy von Bernhardi, M. (2022) · Springer eBooks · doi:10.1007/978-3-031-15080-7_180 · Cited by 1 · see citing works

Innate Immunity, Local Inflammation, and Degenerative Disease

McGeer, P. L., & McGeer, E. G. (2002) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.29.re3 · Cited by 76 · see citing works