The medial frontal-prefrontal network for altered awareness and control of action in corticobasal syndrome
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The volitional impairments of alien limb and apraxia are a defining feature of the corticobasal syndrome, but a limited understanding of their neurocognitive aetiology has hampered progress towards effective treatments. Here we combined several key methods to investigate the mechanism of impairments in voluntary action in corticobasal syndrome. We used a quantitative measure of awareness of action that is based on well-defined processes of motor control; structural and functional anatomical information; and evaluation against the clinical volitional disorders of corticobasal syndrome. In patients and healthy adults we measured 'intentional binding', the perceived temporal attraction between voluntary actions and their sensory effects. Patients showed increased binding of the perceived time of actions towards their effects. This increase correlated with the severity of alien limb and apraxia, which we suggest share a core deficit in motor control processes, through reduced precision in voluntary action signals. Structural neuroimaging analyses showed the behavioural variability in patients was related to changes in grey matter volume in pre-supplementary motor area, and changes in its underlying white matter tracts to prefrontal cortex. Moreover, changes in functional connectivity at rest between the pre-supplementary motor area and prefrontal cortex were proportional to changes in binding. These behavioural, structural and functional results converge to reveal the frontal network for altered awareness and control of voluntary action in corticobasal syndrome, and provide candidate markers to evaluate new therapies.
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Increased connectivity values were detected in specific FTD variants: parietal lobe connections in bvFTD, frontal lobe in CBS, occipital lobe in PSP, and structural thalamic tract connectivity in bvFTD and svPPA.
“We also detected increased connectivity values in specific FTD variants, for example, in the connections involving the parietal lobe in bvFTD (Meijboom et al., 2017; Whitwell et al., 2011b), the frontal lobe in CBS (Wolpe et al., 2014), occipital lobe in PSP (Whitwell et al., 2011a), and structural thalamic tract connectivity in bvFTD and svPPA.”
From Multiclass characterization of frontotemporal dementia variants via multimodal brain network computational inference (2023) · cites this paper as Wolpe et al., 2014
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Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282 · see citing works
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,010 · see citing works
Kok, J. S., Berg, I. J., & Scherder, E. J. A. (2013) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000353441 · Cited by 20,589 · see citing works
Older Adults' Reasons for Using Technology while Aging in Place
Peek, S. T. M., Luijkx, K. G., Rijnaard, M. D., Nieboer, M. E., van der Voort, C. S., Aarts, S., van Hoof, J., Vrijhoef, H. J., & Wouters, E. (2015) · Gerontology · doi:10.1159/000430949 · Cited by 19,803 · see citing works
Sensitivity and False Alarm Rate of a Fall Sensor in Long-Term Fall Detection in the Elderly
Kangas, M., Korpelainen, R., Vikman, I., Nyberg, L., & Jämsä, T. J. (2014) · Gerontology · doi:10.1159/000362720 · Cited by 19,003 · see citing works
Voxel-Based Morphometry—The Methods
Ashburner, J., & Friston, K. J. (2000) · NeuroImage · doi:10.1006/nimg.2000.0582 · Cited by 8,676 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358 · see citing works
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C., Watkins, K., Ciccarelli, O., Cader, M., Matthews, P., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,035 · see citing works
SMITH, S., & NICHOLS, T. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.03.061 · Cited by 5,250 · see citing works
Functional architecture of basal ganglia circuits: neural substrates of parallel processing
Alexander, G. E., & Crutcher, M. D. (1990) · Trends in Neurosciences · doi:10.1016/0166-2236(90)90107-l · Cited by 4,131 · see citing works
Meeting of minds: the medial frontal cortex and social cognition
Amodio, D. M., & Frith, C. D. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1884 · Cited by 3,782 · see citing works
Specific impairments of planning
Shallice, T. (1982) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1982.0082 · Cited by 3,741 · see citing works
DISCONNEXION SYNDROMES IN ANIMALS AND MAN
Geschwind, N. (1965) · Brain · doi:10.1093/brain/88.2.237 · Cited by 3,419 · see citing works
Unified Parkinson's Disease Rating Scale
(2012) · Springer eBooks · doi:10.1007/springerreference_184495 · Cited by 3,071 · see citing works
Recent developments in Parkinson's disease
Fahn, S., Elton, R., MARSDEN, C. D., Calne, D. B., & Goldstein, M. (1986) · Raven Press eBooks · Cited by 2,306 · see citing works
Mioshi, E., Dawson, K., Mitchell, J., Arnold, R., & Hodges, J. R. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1610 · Cited by 2,016 · see citing works
Functional role of the supplementary and pre-supplementary motor areas
Nachev, P., Kennard, C., & Husain, M. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2478 · Cited by 1,928 · see citing works
Criteria for the diagnosis of corticobasal degeneration
Armstrong, M. J., Litvan, I., Lang, A. E., Bak, T. H., Bhatia, K. P., Borroni, B., Boxer, A. L., Dickson, D. W., Grossman, M., Hallett, M., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e31827f0fd1 · Cited by 1,904 · see citing works
DISCONNEXION SYNDROMES IN ANIMALS AND MAN
Geschwind, N. (1965) · Brain · doi:10.1093/brain/88.3.585 · Cited by 1,823 · see citing works
Distinct patterns of brain activity in young carriers of the <i>APOE</i> -ε4 allele
Filippini, N., MacIntosh, B. J., Hough, M. G., Goodwin, G. M., Frisoni, G. B., Smith, S. M., Matthews, P. M., Beckmann, C. F., & Mackay, C. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811879106 · Cited by 1,613 · see citing works
Voluntary action and conscious awareness
Haggard, P., Clark, S., & Kalogeras, J. (2002) · Nature Neuroscience · doi:10.1038/nn827 · Cited by 1,546 · see citing works
Self-citationWITELSON, S. F. (1989) · Brain · doi:10.1093/brain/112.3.799 · Cited by 1,424 · see citing works
Abnormalities in the awareness and control of action
Frith, C., Blakemore, S., & Wolpert, D. M. (2000) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2000.0734 · Cited by 1,201 · see citing works
Human volition: towards a neuroscience of will
Haggard, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2497 · Cited by 1,134 · see citing works
Self-citationZhou, J., Greicius, M. D., Gennatas, E. D., Growdon, M. E., Jang, J. Y., Rabinovici, G. D., Kramer, J. H., Weiner, M., Miller, B. L., & Seeley, W. W. (2010) · Brain · doi:10.1093/brain/awq075 · Cited by 1,016 · see citing works
SIC Task Force appraisal of clinical diagnostic criteria for parkinsonian disorders
Litvan, I., Bhatia, K. P., Burn, D. J., Goetz, C. G., Lang, A. E., McKeith, I. G., Quinn, N. P., Sethi, K. D., Shults, C. W., & Wenning, G. K. (2003) · Movement Disorders · doi:10.1002/mds.10459 · Cited by 1,006 · see citing works
Farrer, C., & Frith, C. D. (2002) · NeuroImage · doi:10.1006/nimg.2001.1009 · Cited by 949 · see citing works
Abnormalities in the awareness of action.
Blakemore, S.-J., Wolpert, D. M., & Frith, C. D. (2002) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(02)01907-1 · Cited by 947 · see citing works
Parkinson’s Disease and Movement Disorders
Tn, M., & Bhattacharyya, K. (2005) · Jaypee Brothers Medical Publishers (P) Ltd. eBooks · doi:10.5005/jp/books/10587 · Cited by 804 · see citing works
Corticocortical connections of area F3 (SMA‐proper) and area F6 (pre‐SMA) in the macaque monkey
Luppino, G., Matelli, M., Camarda, R., & Rizzolatti, G. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903380109 · Cited by 795 · see citing works
Functional organization of human supplementary motor cortex studied by electrical stimulation
Fried, I., Katz, A., McCarthy, G., Sass, K., Williamson, P., Spencer, S., & Spencer, D. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03656.1991 · Cited by 791 · see citing works
Movement intention after parietal cortex stimulation in humans
Desmurget, M., Reilly, K. T., Richard, N., Szathmari, A., Mottolese, C., & Sirigu, A. (2009) · Science · doi:10.1126/science.1169896 · Cited by 695 · see citing works
Corticodentatonigral Degeneration With Neuronal Achromasia
Rebeiz, J. J., Kolodny, E. H., & Richardson, E. P. (1968) · Archives of Neurology · doi:10.1001/archneur.1968.00470310034003 · Cited by 627 · see citing works
Cortical‐basal ganglionic degeneration
Riley, D. E., Lang, A. E., Lewis, A., Resch, L., Ashby, P., Hornykiewicz, O., & Black, S. E. (1990) · Neurology · doi:10.1212/wnl.40.8.1203 · Cited by 570 · see citing works
Cunnington, R., Windischberger, C., Deecke, L., & Moser, E. (2002) · NeuroImage · doi:10.1006/nimg.2001.0976 · Cited by 546 · see citing works
Lau, H. C., Rogers, R. D., Haggard, P., & Passingham, R. E. (2004) · Science · doi:10.1126/science.1090973 · Cited by 539 · see citing works
Self-citationFried, I., Mukamel, R., & Kreiman, G. (2011) · Neuron · doi:10.1016/j.neuron.2010.11.045 · Cited by 459 · see citing works
Awareness of action: Inference and prediction
Moore, J. W., & Haggard, P. (2007) · Consciousness and Cognition · doi:10.1016/j.concog.2006.12.004 · Cited by 443 · see citing works
Self-citationRecent Developments in Parkinson's Disease
Pearce, J. (1986) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.49.7.850-c · Cited by 435 · see citing works
Deiber, M., Honda, M., Ibañez, V., Sadato, N., & Hallett, M. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.6.3065 · Cited by 423 · see citing works
Corticobasal degeneration: A clinical study of 36 cases
Rinne, J. O., Lee, M. S., Thompson, P. D., & MARSDEN, C. D. (1994) · Brain · doi:10.1093/brain/117.5.1183 · Cited by 407 · see citing works
Altered awareness of action in schizophrenia: a specific deficit in predicting action consequences
Voss, M., Moore, J., Hauser, M., Gallinat, J., Heinz, A., & Haggard, P. (2010) · Brain · doi:10.1093/brain/awq152 · Cited by 366 · see citing works
Self-citationThe fMRI signal, slow cortical potential and consciousness
He, B. J., & Raichle, M. E. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.04.004 · Cited by 324 · see citing works
Parkinson's Disease and Movement Disorders
Goetz, C. G. (1998) · JAMA · doi:10.1001/jama.280.20.1796-a · Cited by 317 · see citing works
Human Medial Frontal Cortex Mediates Unconscious Inhibition of Voluntary Action
Sumner, P., Nachev, P., Morris, P. G., Peters, A. M., Jackson, S. R., Christopher Kennard, C., & Masud Husain, B. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.016 · Cited by 310 · see citing works
Feinberg, T. E., Schindler, R. J., Flanagan, N. G., & Haber, L. D. (1992) · Neurology · doi:10.1212/wnl.42.1.19 · Cited by 308 · see citing works
Volitional control of movement: The physiology of free will
Hallett, M. (2007) · Clinical Neurophysiology · doi:10.1016/j.clinph.2007.03.019 · Cited by 258 · see citing works
Medial frontal cortex: From self-generated action to reflection on one's own performance
Passingham, R. E., Bengtsson, S. L., & Lau, H. C. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2009.11.001 · Cited by 252 · see citing works
Voxel-based morphometry in autopsy proven PSP and CBD
Josephs, K. A., Whitwell, J. L., Dickson, D. W., Boeve, B. F., Knopman, D. S., Petersen, R. C., Parisi, J. E., & Jack, C. R. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.09.019 · Cited by 234 · see citing works
Cunnington, R., Windischberger, C., Deecke, L., & Moser, E. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00291-x · Cited by 233 · see citing works
Action effect anticipation: Neurophysiological basis and functional consequences
Waszak, F., Cardoso-Leite, P., & Hughes, G. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.11.004 · Cited by 231 · see citing works
Who is causing what? The sense of agency is relational and efferent-triggered
Engbert, K., Wohlschläger, A., & Haggard, P. (2007) · Cognition · doi:10.1016/j.cognition.2007.07.021 · Cited by 218 · see citing works
Self-citationDiagnostic criteria for corticobasal syndrome: a comparative study
Mathew, R., Bak, T. H., & Hodges, J. R. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-300875 · Cited by 195 · see citing works
Moore, J. W., Ruge, D., Wenke, D., Rothwell, J. C., & Haggard, P. (2010) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2010.0404 · Cited by 172 · see citing works
Self-citationManipulating the Experienced Onset of Intention after Action Execution
Lau, H. C., Rogers, R. D., & Passingham, R. E. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.1.81 · Cited by 165 · see citing works
Disentangling the Alien and Anarchic Hand
Marchetti, C. (1998) · Cognitive Neuropsychiatry · doi:10.1080/135468098396143 · Cited by 151 · see citing works
The Alien Hand: Cases, Categorizations, and Anatomical Correlates
Scepkowski, L. A., & Cronin‐Golomb, A. (2003) · Behavioral and Cognitive Neuroscience Reviews · doi:10.1177/1534582303260119 · Cited by 145 · see citing works
Wheaton, L. A., & Hallett, M. (2007) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2007.04.014 · Cited by 140 · see citing works
Cue integration and the perception of action in intentional binding
Wolpe, N., Haggard, P., Siebner, H. R., & Rowe, J. B. (2013) · Experimental Brain Research · doi:10.1007/s00221-013-3419-2 · Cited by 132 · see citing works
Self-citationRowe, J. B. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh111 · Cited by 130 · see citing works
Self-citationVISUAL AFFORDANCES DIRECT ACTION: NEUROPSYCHOLOGICAL EVIDENCE FROM MANUAL INTERFERENCE
Riddoch, M. J., Edwards, M., Humphreys, G. W., West, R., & Heafield, T. (1998) · Cognitive Neuropsychology · doi:10.1080/026432998381041 · Cited by 124 · see citing works
Dopaminergic medication boosts action–effect binding in Parkinson's disease
Moore, J. W., Schneider, S. A., Schwingenschuh, P., Moretto, G., Bhatia, K. P., & Haggard, P. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.12.014 · Cited by 114 · see citing works
Self-citationAcosta‐Cabronero, J., Williams, G. B., Pereira, J., Pengas, G., & Nestor, P. J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.10.051 · Cited by 107 · see citing works
White Matter Changes in Corticobasal Degeneration Syndrome and Correlation With Limb Apraxia
Borroni, B., Garibotto, V., Agosti, C., Brambati, S. M., Bellelli, G., Gasparotti, R., Padovani, A., & Perani, D. (2008) · Archives of Neurology · doi:10.1001/archneur.65.6.796 · Cited by 92 · see citing works
Morphometric fingerprint of asymptomatic Parkin and PINK1 mutation carriers in the basal ganglia
Binkofski, F., Reetz, K., Christian Gaser, B., Hilker, R., Hagenah, J., Hedrich, K., van Eimeren, T., Thiel, A., Büchel, C., Pramstaller, P. P., et al. (2007) · Neurology · doi:10.1212/01.wnl.0000267844.72421.6c · Cited by 76 · see citing works
Reetz, K., Christian Gaser, B., Klein, C., Hagenah, J. M., Büchel, C., Gottschalk, S., Pramstaller, P. P., Siebner, H. R., & Binkofski, F. (2008) · Movement Disorders · doi:10.1002/mds.22333 · Cited by 61 · see citing works
Cortical‐basal ganglionic degeneration
Okuda, B., & Tachibana, H. (1995) · Neurology · doi:10.1212/wnl.45.5.1033-b · Cited by 58 · see citing works
The Where and When of Intention
Eagleman, D. M. (2004) · Science · doi:10.1126/science.1095331 · Cited by 57 · see citing works
Exaggerated object affordance and absent automatic inhibition in alien hand syndrome
McBride, J. M., Sumner, P., Jackson, S. R., Bajaj, N. P. S., & Masud Husain, B. (2013) · Cortex · doi:10.1016/j.cortex.2013.01.004 · Cited by 54 · see citing works
Alien Hand Syndrome: Neural Correlates of Movements without Conscious Will
Schaefer, M., Heinze, H. J., & Galazky, I. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015010 · Cited by 45 · see citing works
Gibb, W., Luthert, P., & Marsden, C. (1989) · Brain : a journal of neurology · doi:10.1093/brain/112.5.1171 · Cited by 39 · see citing works
Action, prediction, and temporal awareness
Walsh, E., & Haggard, P. (2013) · Acta Psychologica · doi:10.1016/j.actpsy.2012.11.014 · Cited by 22 · see citing works
Self-citation
Flagged first, then by citations
1 of the 74 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Sarubbo, S., Tate, M., De Benedictis, A., Merler, S., Moritz-Gasser, S., Herbet, G., & Duffau, H. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2019.116237 · Cited by 206 · see citing works
Towards a functional atlas of human white matter
Sarubbo, S., Benedictis, A. D., Merler, S., Mandonnet, E., Balbi, S., Granieri, E., & Duffau, H. (2015) · Human Brain Mapping · doi:10.1002/hbm.22832 · Cited by 168 · see citing works
Cognition in corticobasal syndrome and progressive supranuclear palsy: A review
Burrell, J. R., Hodges, J. R., & Rowe, J. B. (2014) · Movement Disorders · doi:10.1002/mds.25872 · Cited by 177 · see citing works
Self-citationThe sense of agency in perception, behaviour and human–machine interactions
Wen, W., & Imamizu, H. (2022) · Nature Reviews Psychology · doi:10.1038/s44159-022-00030-6 · Cited by 155 · see citing works
Wolpe, N., Ingram, J. N., Tsvetanov, K. A., Geerligs, L., Kievit, R., Henson, R. N., Wolpert, D. M., Cam-CAN, TYLER, L. K., Brayne, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms13034 · Cited by 154 · see citing works
Self-citationEvidence for causal top-down frontal contributions to predictive processes in speech perception
Cope, T., Sohoglu, E., Sedley, W., Patterson, K. E., Jones, P. S., Wiggins, J., Dawson, C., Grube, M., Carlyon, R. P., Griffiths, T. D., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01958-7 · Cited by 150 · see citing works
Self-citationApathy and impulsivity in frontotemporal lobar degeneration syndromes
Lansdall, C. J., Coyle-Gilchrist, I. T. S., Jones, P. S., Rodríguez, P. V., Wilcox, A., Wehmann, E., Dick, K. M., Robbins, T. W., & Rowe, J. B. (2017) · Brain · doi:10.1093/brain/awx101 · Cited by 136 · see citing works
Self-citationDevelopmental coordination disorder: core sensori-motor deficits, neurobiology and etiology
Gomez, A., & Angela Sirigu, B. (2015) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2015.09.032 · Cited by 118 · see citing works
Resting‐state Functional MRI in Parkinsonian Syndromes
Filippi, M., Sarasso, E., & Agosta, F. (2019) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12730 · Cited by 96 · see citing works
Saito, N., Takahata, K., Murai, T., & Takahashi, H. (2015) · Consciousness and Cognition · doi:10.1016/j.concog.2015.07.011 · Cited by 96 · see citing works
Holland, N., Jones, P. S., Savulich, G., Wiggins, J. K., Hong, Y. T., Fryer, T. D., Manavaki, R., Sephton, S. M., Boros, I., Malpetti, M., et al. (2020) · Movement Disorders · doi:10.1002/mds.28188 · Cited by 93 · see citing works
Self-citationHassan, A., & Josephs, K. A. (2016) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-016-0676-z · Cited by 88 · see citing works
A Bayesian Account of the Sensory-Motor Interactions Underlying Symptoms of Tourette Syndrome
Rae, C. L., Critchley, H., & Seth, A. K. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00029 · Cited by 69 · see citing works
Self-citationThe acute brain response to levodopa heralds dyskinesias in Parkinson disease
Herz, D. M., Haagensen, B. N., Christensen, M. S., Madsen, K. H., Rowe, J. B., Løkkegaard, A., & Siebner, H. R. (2014) · Annals of Neurology · doi:10.1002/ana.24138 · Cited by 69 · see citing works
Self-citationPyasik, M. M., Burin, D., & Pia, L. (2018) · Acta Psychologica · doi:10.1016/j.actpsy.2018.03.001 · Cited by 63 · see citing works
Beyond the “urge to move”: objective measures for the study of agency in the post-Libet era
Wolpe, N., & Rowe, J. B. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00450 · Cited by 58 · see citing works
Self-citationCorticobasal syndrome: A diagnostic conundrum
Parmera, J. B., Rodriguez, R. D., Studart‐Neto, A., Nitríni, R., & Brucki, S. M. D. (2016) · Dementia & Neuropsychologia · doi:10.1590/s1980-5764-2016dn1004003 · Cited by 57 · see citing works
The neural basis of consciousness
Frith, C. (2019) · Psychological Medicine · doi:10.1017/s0033291719002204 · Cited by 57 · see citing works
Anticipating conflict: Neural correlates of a Bayesian belief and its motor consequence
Hu, S., Ide, J. S., Zhang, S., & Li, C. R. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.06.032 · Cited by 59 · see citing works
Sensory attenuation in Parkinson’s disease is related to disease severity and dopamine dose
Wolpe, N., Zhang, J., Nombela, C., Ingram, J. N., Wolpert, D. M., Cam-CAN, TYLER, L. K., Brayne, C., Bullmore, E. T., Calder, A. C., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-33678-3 · Cited by 48 · see citing works
Self-citationThe Representation of Objects in Apraxia: From Action Execution to Error Awareness
Canzano, L., Scandola, M., Gobbetto, V., Moretto, G., D’Imperio, D., & Moro, V. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00039 · Cited by 45 · see citing works
A Predictive Processing Model of Perception and Action for Self-Other Distinction
Kahl, S., & Kopp, S. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02421 · Cited by 45 · see citing works
Neural underpinnings of the ‘agent brain’: new evidence from transcranial direct current stimulation
Cavazzana, A., Penolazzi, B., Begliomini, C., & Bisiacchi, P. S. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.12937 · Cited by 40 · see citing works
Lush, P., Roseboom, W., Axel Cleeremans, B., Scott, R. B. Y., Seth, A. K., & Dienes, Z. P. (2019) · Journal of Experimental Psychology Human Perception & Performance · doi:10.1037/xhp0000661 · Cited by 39 · see citing works
Pathophysiology and Treatment of Alien Hand Syndrome
Sarva, H., Deik, A., & Severt, W. (2014) · PubMed Central · doi:10.7916/d8vx0f48 · Cited by 39 · see citing works
Altered awareness of action in Parkinson’s disease: evaluations by explicit and implicit measures
Saito, N., Takahata, K., Yamakado, H., Sawamoto, N., Saitô, S., Takahashi, R., Murai, T., & Takahashi, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-08482-0 · Cited by 36 · see citing works
Lush, P., Caspar, É. A., Cleeremans, A., Haggard, P., da Gama, P. A. M. D. S., & Dienes, Z. P. (2017) · Psychological Science · doi:10.1177/0956797616687015 · Cited by 36 · see citing works
Self-citationThe pre-supplementary motor area achieves inhibitory control by modulating response thresholds
Wolpe, N., Hezemans, F. H., Rae, C. L., Zhang, J., & Rowe, J. B. (2022) · Cortex · doi:10.1016/j.cortex.2022.03.018 · Cited by 35 · see citing works
Self-citationIntentional binding effect in children: insights from a new paradigm
Cavazzana, A., Begliomini, C., & Bisiacchi, P. S. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00651 · Cited by 33 · see citing works
Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing
Chang, A., Ide, J. S., Li, H.-H., Chen, C., & Li, C.-S. R. (2017) · eNeuro · doi:10.1523/eneuro.0061-17.2017 · Cited by 31 · see citing works
The sense of agency for brain disorders: A comprehensive review and proposed framework
Malik, R. A., Galang, C. M., & Finger, E. C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104759 · Cited by 29 · see citing works
Pazzaglia, M., & Galli, G. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00751 · Cited by 28 · see citing works
Ricciardi, L., Haggard, P., de Boer, L., Sorbera, C., Stenner, M., Morgante, F., & Edwards, M. J. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.04.011 · Cited by 28 · see citing works
Self-citationSeghezzi, S., & Zapparoli, L. (2020) · Brain Science · doi:10.3390/brainsci10110825 · Cited by 20 · see citing works
Sense of agency disturbances in movement disorders: A comprehensive review
Seghezzi, S., Convertino, L., & Zapparoli, L. (2021) · Consciousness and Cognition · doi:10.1016/j.concog.2021.103228 · Cited by 26 · see citing works
Moccia, L., Luzio, M. D., Conte, E., Modica, M., Ambrosecchia, M., Ardizzi, M., Lanzotti, P., Kotzalidis, G. D., Janiri, D., Nicola, M. D., et al. (2023) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13601 · Cited by 27 · see citing works
The Role of Body-Related Afferent Signals in Human Sense of Agency
Pyasik, M. M., Furlanetto, T., & Pia, L. (2019) · Journal of Experimental Neuroscience · doi:10.1177/1179069519849907 · Cited by 26 · see citing works
Galang, C. M., Malik, R. A., Kinley, I., & Obhi, S. S. (2021) · Consciousness and Cognition · doi:10.1016/j.concog.2021.103217 · Cited by 24 · see citing works
Lewis‐Smith, D., Wolpe, N., Ghosh, B. C. P., & Rowe, J. B. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09672-8 · Cited by 24 · see citing works
Self-citationCortical response to levodopa in Parkinson's disease patients with dyskinesias
Turco, F., Canessa, A., Olivieri, C., Pozzi, N. G., Palmisano, C., Arnulfo, G., Marotta, G., Volkmann, J., Pezzoli, G., & Isaias, I. U. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14114 · Cited by 22 · see citing works
Alien limb syndrome: A Bayesian account of unwanted actions
Wolpe, N., Hezemans, F. H., & Rowe, J. B. (2020) · Cortex · doi:10.1016/j.cortex.2020.02.002 · Cited by 20 · see citing works
Self-citationRelationship between Attention Deficit Hyperactivity Disorder and epilepsy: a literature review
Ahmed, G. K., Darwish, A. M., Khalifa, H., & Haridy, N. A. (2022) · The Egyptian Journal of Neurology Psychiatry and Neurosurgery · doi:10.1186/s41983-022-00482-w · Cited by 18 · see citing works
Ridley, B., Beltramone, M., Wirsich, J., Troter, A. L., Tramoni, E., Aubert, S., Achard, S., Ranjeva, J., Guye, M., & Félician, O. (2016) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2016.00307 · Cited by 18 · see citing works
Nobusako, S., Ishibashi, R., Takamura, Y., Oda, E., Tanigashira, Y., Kouno, M., Tominaga, T., Ishibashi, Y., Okuno, H., Nobusako, K., et al. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00709 · Cited by 18 · see citing works
Functional MRI in Atypical Parkinsonisms
Agosta, F., Sarasso, E., & Filippi, M. (2018) · International review of neurobiology · doi:10.1016/bs.irn.2018.09.002 · Cited by 17 · see citing works
Intentional binding as a marker of agency across the lifespan
Cavazzana, A., Begliomini, C., & Bisiacchi, P. S. (2017) · Consciousness and Cognition · doi:10.1016/j.concog.2017.04.016 · Cited by 16 · see citing works
Hanganu, A., Muthuraman, M., Chirumamilla, V. C., Koirala, N., Paktas, B., Deuschl, G., Zeuner, K. E., & Groppa, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168652 · Cited by 15 · see citing works
Illusory Temporal Binding in Meditators
Lush, P., Parkinson, J., & Dienes, Z. P. (2016) · Mindfulness · doi:10.1007/s12671-016-0583-z · Cited by 14 · see citing works
Elevated representational similarity of voluntary action and inhibition in Tourette syndrome
Rae, C. L., Raykov, P., Ambridge, E. M., Colling, L. J., van Praag, C. G., Bouyagoub, S., Polanski, L., Larsson, D. E. O., & Critchley, H. (2023) · Brain Communications · doi:10.1093/braincomms/fcad224 · Cited by 12 · see citing works
Self-citationKim, I. H., Lee, S., Lee, C.-Y., & Lee, D. G. (2014) · Annals of Rehabilitation Medicine · doi:10.5535/arm.2014.38.6.871 · Cited by 11 · see citing works
A reduction in the implicit sense of agency during adolescence compared to childhood and adulthood
Aytemür, A., & Levita, L. (2020) · Consciousness and Cognition · doi:10.1016/j.concog.2020.103060 · Cited by 11 · see citing works
Gonzalez-Gomez, R., Ibañez, A., & Moguilner, S. (2023) · Network Neuroscience · doi:10.1162/netn_a_00285 · Cited by 10 · see citing works
García-Guáqueta, D. P., Botha, H., Utianski, R. L., Duffy, J. R., Clark, H. M., Goodrich, A. W., Pham, N. T. T., Machulda, M. M., Baker, M. C., Rademakers, R., et al. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12344-x · Cited by 9 · see citing works
Cortical Activation During Levitation and Tentacular Movements of Corticobasal Syndrome
ONOFRJ, M. C., Bonanni, L., Pizzi, S. D., Caulo, M., Onofrj, V., Thomas, A., Tartaro, A., & Franciotti, R. (2015) · Medicine · doi:10.1097/md.0000000000001977 · Cited by 9 · see citing works
Pietro, M. D., Russo, M., Dono, F., Carrarini, C., Thomas, A., Stefano, V. D., Telese, R., Bonanni, L., Sensi, S. L., ONOFRJ, M. C., et al. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.661130 · Cited by 8 · see citing works
Dentatorubrothalamic tract reduction using fixel-based analysis in corticobasal syndrome
Sakamoto, S., Kimura, T., Kajiyama, K., Ando, K., Takeda, M., & Yoshikawa, H. (2020) · Neuroradiology · doi:10.1007/s00234-020-02559-w · Cited by 9 · see citing works
Case Report: Good Prognosis of Mixed Alien Hand Syndrome by Verbal-Cue Rehabilitation Exercise
Qu, K., Gan, L., Jiang, W., Yu, P., & Dong, M. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.718706 · Cited by 7 · see citing works
Alien Limb Syndrome Responsive to Amantadine in a Patient with Corticobasal Syndrome
Movements, T. A. O. H. (2025) · PubMed Central · doi:10.7916/d83fanq7 · Cited by 7 · see citing works
Wolpe, N., Harlev, D., Bergmann, E., Cam-CAN, & Henson, R. N. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0386-25.2025 · Cited by 6 · see citing works
Self-citationThe sense of agency and the attribution of responsibility in human behavior
Gu, J., Zhao, K., & Fu, X. (2020) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2019-0715 · Cited by 5 · see citing works
A Psychophysical Window onto the Subjective Experience of Compulsion
Schmidt, S., Wagner, G., Walter, M., & Stenner, M. (2021) · Brain Sciences · doi:10.3390/brainsci11020182 · Cited by 5 · see citing works
Is There Really a Loss of Agency in Patients With Apraxia of Tool Use?
Osiurak, F., Lesourd, M., Rossetti, Y., & Baumard, J. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.00087 · Cited by 4 · see citing works
Zalyalova, Z. A. (2021) · Neurology neuropsychiatry Psychosomatics · doi:10.14412/2074-2711-2021-1-119-125 · Cited by 4 · see citing works
Evidence and implications of abnormal predictive coding in dementia
Kocagoncu, E., Klimovich-Gray, A., Hughes, L. E., & Rowe, J. B. (2021) · Brain · doi:10.1093/brain/awab254 · Cited by 3 · see citing works
Self-citationNobusako, S., Takamura, Y., Koge, K., Osumi, M., Maeda, T., & Morioka, S. (2024) · Cognitive Development · doi:10.1016/j.cogdev.2024.101503 · Cited by 4 · see citing works
Adaptability of the Sense of Agency in Healthy Young Adults in Sensorimotor Tasks for a Short Term
Mishima, M., Hayashida, K., Fukasaku, Y., Ogata, R., Ohsawa, K., Iwai, K., Wen, W., & Morioka, S. (2023) · Behavioral Sciences · doi:10.3390/bs13020132 · Cited by 3 · see citing works
Subliminal modulation of voluntary action experience: A neuropsychological investigation
Khalighinejad, N., Kunnumpurath, A., Bertini, C., Làdavas, E., & Haggard, P. (2017) · Cortex · doi:10.1016/j.cortex.2017.02.012 · Cited by 2 · see citing works
Self-citationNobusako, S., Ishibashi, R., Maeda, T., Shimada, S., & Morioka, S. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1597200 · Cited by 1 · see citing works
Acute academic stress impairs inhibitory control in early primary school children
Yang, Q., Liu, Y., Zhang, H., & Sun, M. (2025) · Journal of Experimental Child Psychology · doi:10.1016/j.jecp.2025.106415 · Cited by 1 · see citing works
Increased temporal binding during voluntary motor task under local anesthesia
Driller, K. K., Fradet, C., Mathijssen, N. M. C., Kraan, G. A., Goossens, R., Vincent Hayward, B., & Hartcher-O’Brien, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-40591-x · Cited by 1 · see citing works
Abbate, C., Trimarchi, P., Manzoni, L., Quarenghi, A., Salvi, G., Inglese, S., Giunco, F., Bagarolo, R., Mari, D., & Arosio, B. (2018) · Cogent Psychology · doi:10.1080/23311908.2018.1452868 · Cited by 1 · see citing works
The spatiotemporal markers for the sense of agency in the human brain
Zhao, K., Gu, J., HUANG, G., ZHENG, S., & Fu, X. (2021) · Advances in Psychological Science · doi:10.3724/sp.j.1042.2021.01901 · Cited by 1 · see citing works
Goldberg, G., & Goodwin, M. E. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_1877 · Cited by 1 · see citing works
Distinguishing minds in interaction: Modeling self-other distinction in the motor system
Kahl, S., & Kopp, S. (2017) · PUB – Publications at Bielefeld University (Bielefeld University)
Quantifying the subjective experience of initiating and monitoring actions, in health and disease
Costa, S. D. (2017) · UCL Discovery (University College London)
Hypnotically induced changes in temporal bindingPreprint
Lush, P. (2016) · OSF Preprints (OSF Preprints)
Goldberg, G., & Goodwin, M. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-56782-2_1877-3
Goldberg, G., & Goodwin, M. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-56782-2_1877-2
Motor beta oscillations contribute to the temporal binding effect
Ulloa, J. L., Vastano, R., Jensen, O. B., & Braß, M. (2025) · Brain and Cognition · doi:10.1016/j.bandc.2025.106362
Characterizing brain networks in focal epilepsies in the interictal "resting-state"
Ridley, B. (2016) · theses.fr (ABES) · doi:10.70675/73fb74fbz90bez4d7cz8eb1z9a4f97b87161
TMS to preSMA, but not rIFG, impacts strategy use in multi-attribute choice
Witkowska, M., Cacek, J., Hobot, J., Bielski, K., Szymanek, K., Lejeune, T. A. –., Folmer, M., Dec‐Ćwiek, M., Słowik, A., Wierzchoń, M., et al. (2026) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2026.109474
Hayashida, K., Mishima, M., Ohnishi, M., Iyanaga, D., Wen, W., & Morioka, S. (2026) · Acta Psychologica · doi:10.1016/j.actpsy.2026.107095
Kumar, D., & Srinivasan, N. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-29258-3.00064-1
- Authors
- Wolpe, N., Moore, J. W., Rae, C. L., Rittman, T., Altena, E., Haggard, P., & Rowe, J. B.
- Affiliations
- MRC Cognition and Brain Sciences Unit (GB)
- University College London (GB)
- University of Cambridge (GB)
- Corresponding author
- Wolpe, Noham
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-11-29
- Volume
- 137
- Issue
- 1
- Pages
- 208-220
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC3891444
- OpenAlex
- W2105407889
- Cited by
- 86
- References
- 74
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 10 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 12 · 2016: 9 · 2015: 6 · 2014: 7
- FWCI
- 4.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Brain (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Goldsmiths Research Online (acceptedVersion)
- HAL (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- James S. McDonnell Foundation
- Wellcome Trust (088324)
- National Institute for Health and Care Research
- Cambridge University Hospitals
- Medical Research Council (MC_US_A060_0016)
- Economic and Social Research Council (ES/J023140/1)
- NIHR Cambridge Biomedical Research Centre
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- corticobasal syndrome, apraxia, intentional binding, pre-supplementary motor area, prefrontal cortex, functional connectivity, gray matter volume, white matter tracts
- MeSH terms
- Aged, Aged, 80 and over, Apraxias, Awareness, Female, Frontal Lobe, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Movement Disorders, Nerve Net, Neuropsychological Tests, Psychomotor Performance, Syndrome, Prefrontal Cortex, Diffusion Magnetic Resonance Imaging, Alien Limb Phenomenon
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