Social cognitive deficits and their neural correlates in progressive supranuclear palsy
Open accessAbstract
Although progressive supranuclear palsy is defined by its akinetic rigidity, vertical supranuclear gaze palsy and falls, cognitive impairments are an important determinant of patients' and carers' quality of life. Here, we investigate whether there is a broad deficit of modality-independent social cognition in progressive supranuclear palsy and explore the neural correlates for these. We recruited 23 patients with progressive supranuclear palsy (using clinical diagnostic criteria, nine with subsequent pathological confirmation) and 22 age- and education-matched controls. Participants performed an auditory (voice) emotion recognition test, and a visual and auditory theory of mind test. Twenty-two patients and 20 controls underwent structural magnetic resonance imaging to analyse neural correlates of social cognition deficits using voxel-based morphometry. Patients were impaired on the voice emotion recognition and theory of mind tests but not auditory and visual control conditions. Grey matter atrophy in patients correlated with both voice emotion recognition and theory of mind deficits in the right inferior frontal gyrus, a region associated with prosodic auditory emotion recognition. Theory of mind deficits also correlated with atrophy of the anterior rostral medial frontal cortex, a region associated with theory of mind in health. We conclude that patients with progressive supranuclear palsy have a multimodal deficit in social cognition. This deficit is due, in part, to progressive atrophy in a network of frontal cortical regions linked to the integration of socially relevant stimuli and interpretation of their social meaning. This impairment of social cognition is important to consider for those managing and caring for patients with progressive supranuclear palsy.
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The basal ganglia, insula, and amygdala are implicated in recognition of predominantly negative emotions, and these neuropsychological functions are abnormal in PSP.
“Basal ganglia, insula and amygdala have been reported to be implicated in the recognition of predominately negative emotions, and these neuropsychological function is abnormal in PSP43,46.”
From Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy (2020) · cites this paper as [46]
Previous studies have implicated the medial temporal lobe and limbic structures in basic emotional recognition, which is impaired in PSP, alongside theory of mind and social cognition.
“Previous studies have implicated the medial temporal lobe and limbic structures in basic emotional recognition, which is in turn found to be impaired in PSP, alongside theory of mind and social cognition45,46.”
From Neuroinflammation and Tau Colocalize in vivo in Progressive Supranuclear Palsy (2020) · cites this paper as [46]
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Redefining the multidimensional clinical phenotypes of frontotemporal lobar degeneration syndromes
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Self-citation
- Authors
- Ghosh, B. C. P., Calder, A. J., Peers, P. V., Lawrence, A. D., Acosta-Cabronero, J., Pereira, J. M., Hodges, J. R., & Rowe, J. B.
- Affiliations
- University of Cambridge (GB)
- MRC Cognition and Brain Sciences Unit (GB)
- Cardiff University (GB)
- Neuroscience Research Australia (AU)
- Corresponding author
- Ghosh, Boyd C. P.
- ORCID
- Venue
- Brain
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05-25
- Volume
- 135
- Issue
- 7
- Pages
- 2089-2102
- ISSN
- 0006-8950 (ISSN-L)
- 1460-2156
- PMC
- PMC3381722
- OpenAlex
- W2163975394
- Cited by
- 123
- References
- 145
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 26 · 2019: 6 · 2018: 10 · 2017: 11 · 2016: 8 · 2015: 8 · 2014: 9 · 2013: 10
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Brain (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (088324)
- Parkinson's UK (G-0603)
- Guarantors of Brain
- Medical Research Council (G0700503)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- progressive supranuclear palsy, social cognition, voice emotion recognition, theory of mind, gray matter atrophy, inferior frontal gyrus, frontal cortex, cognitive impairment, neural correlates
- MeSH terms
- Aged, Atrophy, Brain Mapping, Cognition Disorders, Emotions, Female, Frontal Lobe, Humans, Magnetic Resonance Imaging, Male, Nerve Fibers, Myelinated, Neuropsychological Tests, Social Perception, Supranuclear Palsy, Progressive, Case-Control Studies, Recognition, Psychology, Nerve Fibers, Unmyelinated, Theory of Mind
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