The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Age-related changes in Arc transcription and DNA methylation within the hippocampus
Open accessAbstract
Summary The transcription of genes that support memory processes are likely to be impacted by the normal aging process. Because Arc is necessary for memory consolidation and enduring synaptic plasticity, we examined Arc transcription within the aged hippocampus. Here, we report that Arc transcription is reduced within the aged hippocampus compared to the adult hippocampus during both “off line” periods of rest, and following spatial behavior. This reduction is observed within ensembles of CA1 “place cells”, which make less mRNA per cell, and in the dentate gyrus (DG) where fewer granule cells are activated by behavior. In addition, we present data suggesting that aberrant changes in methylation of the Arc gene may be responsible for age-related decreases in Arc transcription within CA1 and the DG. Given that Arc is necessary for normal memory function, these subregion-specific epigenetic and transcriptional changes may result in less efficient memory storage and retrieval during aging.
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Cites
The adaptive brain: aging and neurocognitive scaffolding
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Dynamics of the Hippocampal Ensemble Code for Space
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MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
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Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
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Self-citationArc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories
Plath, N., Ohana, O., Dammermann, B., Errington, M. L., Schmitz, D., Gross, C., Mao, X., Engelsberg, A., Mahlke, C., Welzl, H., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.024 · Cited by 827
The contribution of sleep to hippocampus-dependent memory consolidation
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Altered hippocampal transcript profile accompanies an age-related spatial memory deficit in mice
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Cited by
Pattern separation in the hippocampus
Yassa, M. A., & Stark, C. E. L. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.006 · Cited by 1,544
Yassa, M. A., Lacy, J. W., Stark, S. M., Albert, M. S., Gallagher, M., & Stark, C. E. L. (2011) · Hippocampus · doi:10.1002/hipo.20808 · Cited by 595
Arc in synaptic plasticity: from gene to behavior
Korb, E., & Finkbeiner, S. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.08.007 · Cited by 388
Epigenetic regulation of gene expression in physiological and pathological brain processes
Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373
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Self-citation
Metadata
- Authors
- Penner, M. R., Roth, T. L., Chawla, M. K., Hoang, L. T., Roth, E. D., Lubin, F. D., Sweatt, J. D., Worley, P. F., & Barnes, C. A.
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 32
- Issue
- 12
- Pages
- 2198-2210
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2051692581
- Cited by
- 215
- References
- 12
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- green
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- Penner, M. R., Roth, T. L., Chawla, M. K., Hoang, L. T., Roth, E. D., Lubin, F. D., Sweatt, J. D., Worley, P. F., & Barnes, C. A. (2011). Age-related changes in Arc transcription and DNA methylation within the hippocampus. Neurobiology of Aging. https://doi.org/10.1016/j.neurobiolaging.2010.01.009
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