Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults
Open accessAbstract
There is widespread evidence that memory deteriorates with aging, however the exact mechanisms that underlie these changes are not well understood. Given the growing size of the aging population, there is an imperative to study age‐related neurocognitive changes in order to better parse healthy from pathological aging. Using a behavioral paradigm that taxes pattern separation (the ability to differentiate novel yet similar information from previously learned information and thus avoid interference), we investigated age‐related neural changes in the human hippocampus using high‐resolution (1.5 mm isotropic) blood‐oxygenation level‐dependent fMRI. Recent evidence from animal studies suggests that hyperactivity in the CA3 region of the hippocampus may underlie behavioral deficits in pattern separation in aged rats. Here, we report evidence that is consistent with findings from the animal studies. We found a behavioral impairment in pattern separation in a sample of healthy older adults compared with young controls. We also found a related increase in CA3/dentate gyrus activity levels during an fMRI contrast that stresses pattern separation abilities. In a detailed analysis of behavior, we also found that the pattern of impairment was consistent with the predictions of the animal model, where larger changes in the input (greater dissimilarity) were required in order for elderly adults to successfully encode new information as distinct from previously learned information. These findings are also consistent with recent fMRI and behavioral reports in healthy aging, and further suggest that a specific functional deficit in the CA3/dentate network contributes to memory difficulties with aging. © 2010 Wiley‐Liss, Inc.
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Greater hippocampal activation during encoding tasks is associated with worse task performance in MCI and AD patients.
“Greater hippocampal activation during encoding tasks is associated with worse task performance [176] in MCI and AD patients [172, 177]”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [176]
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- Authors
- Yassa, M. A., Lacy, J. W., Stark, S. M., Albert, M. S., Gallagher, M., & Stark, C. E. L.
- Affiliations
- University of California, Irvine (US)
- Johns Hopkins University (US)
- Corresponding author
- Stark, Craig E.L.
- ORCID
- Venue
- Hippocampus
- Publisher
- Wiley
- Published
- 2011-08-23
- Volume
- 21
- Issue
- 9
- Pages
- 968-979
- ISSN
- 1050-9631 (ISSN-L)
- 1098-1063
- PMC
- PMC3010452
- OpenAlex
- W2067065650
- Cited by
- 595
- References
- 72
- Citations by year
- 2026: 32 · 2025: 44 · 2024: 49 · 2023: 39 · 2022: 30 · 2021: 54 · 2020: 40 · 2019: 38 · 2018: 53 · 2017: 48 · 2016: 29 · 2015: 44 · 2014: 28 · 2013: 28 · 2012: 22
- FWCI
- 12.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hippocampus (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (2 P01 AG09973, P50AG005146, P01AG009973, P50AG05146)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- pattern separation, hippocampal CA3, dentate gyrus, healthy aging, age-related memory decline, hippocampal hyperactivity, older adults, neural correlates of memory
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Animals, Brain Mapping, Discrimination, Psychological, Female, Humans, Magnetic Resonance Imaging, Male, Memory, Models, Biological, Nerve Net, Oxygen, Pattern Recognition, Visual, Reaction Time, Temporal Lobe, Transfer, Psychology, Dentate Gyrus, Rats, CA3 Region, Hippocampal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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