Lutein and Zeaxanthin Influence Brain Function in Older Adults: A Randomized Controlled Trial
Open accessAbstract
Objectives: The present study constitutes the first randomized controlled trial to investigate the relation of lutein (L) and zeaxanthin (Z) to brain function using functional magnetic resonance imaging (fMRI). It was hypothesized that L and Z supplementation in older adults would enhance neural efficiency (i.e., reduce activation) and cognitive performance on a verbal learning task relative to placebo. Methods: A total of 44 community-dwelling older adults (mean age=72 years) were randomly assigned to receive either placebo or L+Z supplementation (12 mg/daily) for 1 year. Neurocognitive performance was assessed at baseline and post-intervention on an fMRI-adapted task involving learning and recalling word pairs. Imaging contrasts of blood-oxygen-level-dependent (BOLD) signal were created by subtracting active control trials from learning and recall trials. A flexible factorial model was employed to investigate the expected group (placebo vs . supplement) by time (baseline vs . post-intervention) interaction in pre-specified regions-of-interest. Results: L and Z appeared to buffer cognitive decline on the verbal learning task (Cohen’s d =.84). Significant interactions during learning were observed in left dorsolateral prefrontal cortex and anterior cingulate cortex ( p < .05, family-wise-error corrected). However, these effects were in the direction of increased rather than decreased BOLD signal. Although the omnibus interaction was not significant during recall, within-group contrasts revealed significant increases in left prefrontal activation in the supplement group only. Conclusions: L and Z supplementation appears to benefit neurocognitive function by enhancing cerebral perfusion, even if consumed for a discrete period of time in late life. ( JINS , 2018, 24 , 77–90)
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Improved cognitive functions were observed in elderly patients supplemented for one year with a mixture of lutein and zeaxanthin (12 mg/day), albeit not significant compared to the placebo group.
“Accordingly, improved cognitive functions were observed in elderly patients supplemented for one year with a mixture of lutein and zeaxanthin (12 mg/day), albeit not significant compared to the placebo group [162,163].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [162]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Faul, F., Erdfelder, E., Lang, A.-G., & Buchner, A. (2007) · Behavior Research Methods · doi:10.3758/bf03193146 · Cited by 65,971 · see citing works
Statistical power analyses using G∗Power 3.1: tests for correlation and regression analyses
Faul, F., Erdfelder, E., Buchner, A., & Lang, A.-G. (2009) · Behavior Research Methods · doi:10.3758/brm.41.4.1149 · Cited by 37,615 · see citing works
Development and validation of a geriatric depression screening scale: a preliminary report
Yesavage, J. A., Brink, T. L., Rose, T. L., Lum, O., Huang, V., Adey, M., & Leirer, V. O. (1982) · Journal of Psychiatric Research · doi:10.1016/0022-3956(82)90033-4 · Cited by 15,025 · see citing works
Neuroinflammation in Alzheimer's disease
Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066 · see citing works
MacDonald, A. W., Cohen, J. D., Stenger, V. A., & Carter, C. S. (2000) · Science · doi:10.1126/science.288.5472.1835 · Cited by 3,666 · see citing works
Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598 · see citing works
The adaptive brain: aging and neurocognitive scaffolding
Park, D. C., & Reuter-Lorenz, P. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093656 · Cited by 2,790 · see citing works
The expected value of control: an integrative theory of anterior cingulate cortex function
Shenhav, A., Botvinick, M. M., & Cohen, J. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.007 · Cited by 2,321 · see citing works
Niendam, T. A., Laird, A. R., Ray, K. L., Dean, Y. M., Glahn, D. C., & Carter, C. S. (2012) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-011-0083-5 · Cited by 1,700 · cited 2× · see citing works
“Anterior cingulate cortex is reliably activated on memory tasks as well, particularly when they are challenging or require a high level of attention (Cabeza & Nyberg, 2000; Niendam et al., 2012; Shenhav, Botvinick, & Cohen, 2013; Weissman, Gopalakrishnan, Hazlett, & Woldorff, 2005).”
BackgroundPatterns of Brain Activation in People at Risk for Alzheimer's Disease
Bookheimer, S. Y., Strojwas, M. H., Cohen, M. S., Saunders, A. M., Pericak-Vance, M. A., Mazziotta, J. C., & Small, G. W. (2000) · New England Journal of Medicine · doi:10.1056/nejm200008173430701 · Cited by 1,328 · see citing works
Memory aging and brain maintenance
Nyberg, L. H., Lövdén, M., Riklund, K., Lindenberger, U., & Bäckman, L. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.04.005 · Cited by 1,220 · see citing works
Mikkilä, V., Räsänen, L., Raitakari, O. T., Pietinen, P., & Viikari, J. S. A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051418 · Cited by 983 · see citing works
How Does it STAC Up? Revisiting the Scaffolding Theory of Aging and Cognition
Reuter‐Lorenz, P. A., & Park, D. C. (2014) · Neuropsychology Review · doi:10.1007/s11065-014-9270-9 · Cited by 955 · see citing works
Dorsolateral prefrontal contributions to human working memory
Barbey, A. K., Koenigs, M., & Grafman, J. (2013) · Cortex · doi:10.1016/j.cortex.2012.05.022 · Cited by 940 · see citing works
Precentral gyrus discrepancy in electronic versions of the Talairach atlas
Maldjian, J. A., Laurienti, P. J., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.032 · Cited by 868 · see citing works
Alterations in the BOLD fMRI signal with ageing and disease: a challenge for neuroimaging
D’Esposito, M., Deouell, L. Y., & Gazzaley, A. H. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1246 · Cited by 852 · see citing works
Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study
Ruitenberg, A., den Heijer, T., Bakker, S. L. M., van Swieten, J. C., Koudstaal, P. J., Hofman, A., & Breteler, M. M. B. (2005) · Annals of Neurology · doi:10.1002/ana.20493 · Cited by 733 · see citing works
(2004) · doi:10.1007/978-3-0348-7836-4 · Cited by 652 · see citing works
The role of oxidative damage and stress in aging
Bokov, A. F., Chaudhuri, A. R., & Richardson, A. G. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.009 · Cited by 621 · see citing works
Preliminary identification of the human macular pigment
Bone, R. A., Landrum, J. T., & Tarsis, S. L. (1985) · Vision Research · doi:10.1016/0042-6989(85)90123-3 · Cited by 462 · see citing works
A One Year Study of the Macular Pigment: The Effect of 140 Days of a Lutein Supplement
Landrum, J. T., Bone, R. A., JOA, H., Kilburn, M. D., MOORE, L. L., & Sprague, K. E. (1997) · Experimental Eye Research · doi:10.1006/exer.1997.0309 · Cited by 453 · see citing works
Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan
Johnson, E. J. (2014) · Nutrition Reviews · doi:10.1111/nure.12133 · Cited by 444 · see citing works
Dietary modification of human macular pigment density.
Hammond, B. R., Johnson, E. J., Russell, R. M., Krinsky, N. I., Yeum, K., Edwards, R. B., & Snodderly, D. M. (1997) · PubMed · Cited by 411 · see citing works
Self-citationAssociations of vegetable and fruit consumption with age-related cognitive change
Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., & Wilson, R. S. (2006) · Neurology · doi:10.1212/01.wnl.0000240224.38978.d8 · Cited by 404 · see citing works
Blumenfeld, R. S., & Ranganath, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2353-05.2006 · Cited by 383 · see citing works
Identification and Quantitation of Carotenoids and their Metabolites in the Tissues of the Human Eye
Bernstein, P. S., Khachik, F., Carvalho, L. S., Muir, G. J., Zhao, D.-Y., & Katz, N. B. (2001) · Experimental Eye Research · doi:10.1006/exer.2000.0954 · Cited by 366 · see citing works
Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults
Brickman, A. M., Khan, U., Provenzano, F. A., Yeung, L., SUZUKI, W. A., Schroeter, H., Wall, M. M., Sloan, R. P., & Small, S. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3850 · Cited by 349 · see citing works
Fruit and vegetable consumption and cognitive decline in aging women
Kang, J. H., Ascherio, A., & Grodstein, F. (2005) · Annals of Neurology · doi:10.1002/ana.20476 · Cited by 300 · see citing works
Butterfield, D. A., Lange, M. L. B., & Rukhsana Sultana, A. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.02.005 · Cited by 298 · see citing works
Weissman, D. H. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh125 · Cited by 296 · see citing works
Johnson, E. J., McDonald, K. Q., Caldarella, S. M., Chung, H.-Y., Troen, A. M., & Snodderly, D. M. (2008) · Nutritional Neuroscience · doi:10.1179/147683008x301450 · Cited by 292 · see citing works
Carotenoids in Health and Disease
Krinsky, N. I., Mayne, S. T., & Sies, H. (2004) · CRC Press eBooks · doi:10.1201/9780203026649 · Cited by 272 · see citing works
Johnson, E. J., Vishwanathan, R., Johnson, M. A., Hausman, D. B., Davey, A., Scott, T. M., Green, R. C., Miller, L. S., Gearing, M., Woodard, J. L., et al. (2013) · Journal of Aging Research · doi:10.1155/2013/951786 · Cited by 268 · see citing works
Self-citationEffects of omega-3 fatty acids on cognitive performance: a meta-analysis
Mazereeuw, G., Lanctôt, K. L., Chau, S. A., Swardfager, W., & Herrmann, N. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.014 · Cited by 253 · see citing works
Khachik, F., Beecher, G. R., Goli, M. B., & Lusby, W. R. (1991) · Pure and Applied Chemistry · doi:10.1351/pac199163010071 · Cited by 241 · see citing works
Localization of function in anterior cingulate cortex: From psychosurgery to functional neuroimaging
Gasquoine, P. G. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.01.002 · Cited by 240 · see citing works
Acute effect of a high nitrate diet on brain perfusion in older adults
Presley, T. D., Morgan, A. R., Bechtold, E., Clodfelter, W., Dove, R. W., Jennings, J. M., Kraft, R. A., Bruce King, S., Laurienti, P. J., Jack Rejeski, W., et al. (2011) · Nitric Oxide · doi:10.1016/j.niox.2010.10.002 · Cited by 238 · see citing works
Ma, L., Dou, H.-L., Wu, Y.-Q., Huang, Y.-M., Huang, Y.-B., Xu, X.-R., Zou, Z.-Y., & Lin, X.-M. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511004260 · Cited by 237 · see citing works
Fleck, M. S. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj097 · Cited by 228 · see citing works
The relevance of behavioural measures for functional-imaging studies of cognition
Wilkinson, D. T., & Halligan, P. W. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1302 · Cited by 222 · see citing works
Carotenoid, tocopherol, and retinol concentrations in elderly human brain.
Craft, N. E., Haitema, T., Garnett, K., Fitch, K. A., & Dorey, C. K. (2004) · PubMed · Cited by 221 · see citing works
Cholinergic enhancement of frontal lobe activity in mild cognitive impairment
Saykin, A. J., Wishart, H. A., Rabin, L. A., Flashman, L. A., McHugh, T., Mamourian, A. C., & Santulli, R. B. (2004) · Brain · doi:10.1093/brain/awh177 · Cited by 213 · see citing works
Blumenfeld, R. S., Parks, C. M., Yonelinas, A. P., & Ranganath, C. (2011) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2010.21459 · Cited by 209 · see citing works
Carotenoids and Gene Regulation
Bertram, J. S. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1999.tb06941.x · Cited by 207 · see citing works
A possible role for lutein and zeaxanthin in cognitive function in the elderly
Johnson, E. J. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.034611 · Cited by 207 · see citing works
The Statistical Analysis of Functional MRI Data
Lazar, N. A. (2008) · Statistics in the health sciences · doi:10.1007/978-0-387-78191-4 · Cited by 196 · see citing works
Macular Pigment and Visual Performance Under Glare Conditions
Stringham, J. M., & Hammond, B. R. (2008) · Optometry and Vision Science · doi:10.1097/opx.0b013e318162266e · Cited by 183 · see citing works
Self-citationMacular lutein and zeaxanthin are related to brain lutein and zeaxanthin in primates
Vishwanathan, R., Neuringer, M., Snodderly, D. M., Schalch, W., & Johnson, E. J. (2012) · Nutritional Neuroscience · doi:10.1179/1476830512y.0000000024 · Cited by 163 · see citing works
Weigert, G., Kaya, S., Pemp, B., Sacu, S., Lasta, M., Werkmeister, R. M., Dragostinoff, N., Simader, C., Garhöfer, G., Schmidt-Erfurth, U. M., et al. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7522 · Cited by 160 · see citing works
Diet-related macular anomalies in monkeys.
Malinow, M. R., Feeney-Burns, L., Peterson, L. H., Klein, M. L., & Neuringer, M. D. (1980) · PubMed · Cited by 156 · see citing works
Wechsler Memory Scale—Fourth Edition (WMS-IV)
Bortnick, K. (2024) · Routledge eBooks · doi:10.4324/9781003525288-74 · Cited by 137 · see citing works
Feeney, J., Finucane, C., Savva, G. M., Cronin, H., Beatty, S., Nolan, J. M., & Kenny, R. A. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.05.007 · Cited by 135 · see citing works
Mares, J. A., LaRowe, T. L., Snodderly, D. M., Moeller, S. M., Gruber, M. J., Klein, M. L., Wooten, B. R., Johnson, E. J., & Chappell, R. J. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.5.1107 · Cited by 132 · see citing works
Macular pigment optical density is related to cognitive function in older people
Vishwanathan, R., Iannaccone, A., Scott, T. M., Kritchevsky, S. B., Jennings, B., Carboni, G., Forma, G., Satterfield, S., Harris, T. B., Johnson, K., et al. (2014) · Age and Ageing · doi:10.1093/ageing/aft210 · Cited by 131 · see citing works
Self-citationAkbaraly, N. T., Faure, H., Gourlet, V., Favier, A., & Berr, C. (2007) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/62.3.308 · Cited by 130 · see citing works
Beatty, S., Nolan, J. M., Kavanagh, H., & O’Donovan, Ó. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.03.015 · Cited by 124 · see citing works
Serum Lycopene, Lutein and Zeaxanthin, and the Risk of Alzheimer's Disease Mortality in Older Adults
Min, J., & Min, K. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000356486 · Cited by 124 · see citing works
Challenging the cholinergic system in mild cognitive impairment: a pharmacological fMRI study
Goekoop, R., Rombouts, S. A. R. B., Jonker, C., Hibbel, A., Knol, D. L., Truyen, L., Barkhof, F., & Scheltens, P. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.006 · Cited by 122 · see citing works
Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance
Kvansakul, J. G. S., Rodríguez‐Carmona, M., Edgar, D. F., Barker, F. M., Köpcke, W., Schalch, W., & Barbur, J. L. (2006) · Ophthalmic and Physiological Optics · doi:10.1111/j.1475-1313.2006.00387.x · Cited by 120 · see citing works
Antioxidant Carbon Particles Improve Cerebrovascular Dysfunction Following Traumatic Brain Injury
Bitner, B. R., Marcano, D. C., Berlin, J. M., Fabian, R. H., Cherian, L., Culver, J. C., Dickinson, M. E., Robertson, C. S., Pautler, R. G., Kent, T. A., et al. (2012) · ACS Nano · doi:10.1021/nn302615f · Cited by 114 · see citing works
Murray, I. J., Makridaki, M., van der Veen, R. L. P., Carden, D. E., Parry, N. R. A., & Berendschot, T. T. J. M. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10715 · Cited by 113 · see citing works
Rosano, C., Marsland, A. L., & Gianaros, P. J. (2012) · Europe PMC (PubMed Central) · Cited by 109 · see citing works
Erdman, J. W., Smith, J. W., Kuchan, M. J., Mohn, E. S., Johnson, E. J., Rubakhin, S. S., Wang, L., Sweedler, J. V., & Neuringer, M. D. (2015) · Foods · doi:10.3390/foods4040547 · Cited by 107 · see citing works
Stringham, J. M., Hammond, B. R., Nolan, J. M., Wooten, B. R., Mammen, A., Smollon, W. E., & Snodderly, D. M. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.08.005 · Cited by 105 · see citing works
Self-citationNolan, J. M., Loskutova, E., Howard, A. N., Moran, R., Mulcahy, R., Stack, J., Bolger, M., Dennison, J. L., Akuffo, K. O., Owens, N., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140507 · Cited by 102 · see citing works
Macular pigment carotenoids in the retina and occipital cortex are related in humans
Vishwanathan, R., Schalch, W., & Johnson, E. J. (2015) · Nutritional Neuroscience · doi:10.1179/1476830514y.0000000141 · Cited by 98 · see citing works
Renzi‐Hammond, L. M., Dengler, M. J., Puente, A. N., Miller, L. S., & Hammond, B. R. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.024 · Cited by 97 · see citing works
Self-citationCarotenoid-rich dietary patterns during midlife and subsequent cognitive function
Kesse‐Guyot, E., Andreeva, V. A., Ducros, V., Jeandel, C., Julia, C., Herçberg, S., & Galan, P. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513003188 · Cited by 94 · see citing works
Bookheimer, S. Y., Renner, B., Ekstrom, A. D., Li, Z., Henning, S. M., Brown, J. A., Jones, M., Moody, T. D., & Small, G. W. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/946298 · Cited by 93 · see citing works
The relation between the macular carotenoids, lutein and zeaxanthin, and temporal vision
Renzi‐Hammond, L. M., & Hammond, B. R. (2010) · Ophthalmic and Physiological Optics · doi:10.1111/j.1475-1313.2010.00720.x · Cited by 93 · see citing works
Self-citationEducation Attenuates the Association between Dietary Patterns and Cognition
Akbaraly, T. N., Singh-Manoux, A., Marmot, M. G., & Brunner, E. J. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000199235 · Cited by 90 · see citing works
Assessment of the Validity of in Vivo Methods of Measuring Human Macular Pigment Optical Density
Hammond, B. R., Wooten, B. R., & Smollon, B. (2005) · Optometry and Vision Science · doi:10.1097/01.opx.0000162652.85875.d2 · Cited by 90 · see citing works
Self-citationASSESSMENT OF THE VALIDITY OF IN VIVO METHODS OF MEASURING HUMAN MACULAR PIGMENT OPTICAL DENSITY
Gellermann, W., & Bernstein, P. S. (2006) · Optometry and Vision Science · doi:10.1097/01.opx.0000214591.07685.93 · Cited by 88 · see citing works
Plasma Carotenoids Are Inversely Associated With Dementia Risk in an Elderly French Cohort
Féart, C., Letenneur, L., Helmer, C., Samieri, C., Schalch, W., Etheve, S., Delcourt, C., Dartigues, J., & Barberger‐Gateau, P. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv135 · Cited by 86 · see citing works
Nutritional Cognitive Neuroscience: Innovations for Healthy Brain Aging
Zamroziewicz, M. K., & Barbey, A. K. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00240 · Cited by 78 · see citing works
Why has Nature Chosen Lutein and Zeaxanthin to Protect the Retina?
Widomska, J. (2014) · Journal of Clinical & Experimental Ophthalmology · doi:10.4172/2155-9570.1000326 · Cited by 77 · see citing works
Boespflug, E. L., McNamara, R. K., Eliassen, J. C., Shidler, M. D., & Krikorian, R. (2015) · The journal of nutrition health & aging · doi:10.1007/s12603-015-0609-6 · Cited by 72 · see citing works
Effects of carotenoids and retinoids on gap junctional communication
Stahl, W., & Sies, H. (2001) · BioFactors · doi:10.1002/biof.5520150209 · Cited by 69 · see citing works
Lee, Y., Kim, J., & Back, J. H. (2008) · Preventive Medicine · doi:10.1016/j.ypmed.2008.10.021 · Cited by 67 · see citing works
SanGiovanni, J. P., & Neuringer, M. D. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.038240 · Cited by 67 · see citing works
Clément, F., & Belleville, S. (2009) · Human Brain Mapping · doi:10.1002/hbm.20827 · Cited by 65 · see citing works
The Statistical Analysis of Functional MRI Data
Achard, S. (2009) · Journal of Statistical Software · doi:10.18637/jss.v029.b03 · Cited by 62 · see citing works
Lindbergh, C. A., Mewborn, C. M., Hammond, B. R., Renzi‐Hammond, L. M., Curran‐Celentano, J., & Miller, L. S. (2016) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617716000850 · Cited by 58 · see citing works
Self-citationKelly, D., Coen, R. F., Akuffo, K. O., Beatty, S., Dennison, J. L., Moran, R., Stack, J., Howard, A. N., Mulcahy, R., & Nolan, J. M. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150199 · Cited by 57 · see citing works
Simone, A. N., Bedard, A., Marks, D. J., & Halperin, J. M. (2015) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617715001010 · Cited by 50 · see citing works
Ma, L., Lin, X.-M., Zou, Z., Xu, X., Li, Y., & Xu, R. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114508163000 · Cited by 49 · see citing works
Nolan, J. M., Stack, J., Mellerio, J., Godhinio, M., O’Donovan, Ó., Neelam, K., & Beatty, S. (2006) · Current Eye Research · doi:10.1080/02713680500514677 · Cited by 44 · see citing works
Entorhinal cortex structure and functional MRI response during an associative verbal memory task
Braskie, M. N., Small, G. W., & Bookheimer, S. Y. (2009) · Human Brain Mapping · doi:10.1002/hbm.20823 · Cited by 42 · see citing works
Hassevoort, K. M., Khazoum, S. E., Walker, J. A., Barnett, S. M., Raine, L. B., Hammond, B. R., Renzi‐Hammond, L. M., Kramer, A. F., Khan, N. A., Hillman, C. H., et al. (2017) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2017.01.016 · Cited by 36 · see citing works
Self-citationHuang, S., Du, F., Shih, Y. I., et al. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.01.027 · Cited by 35 · see citing works
The effect of lutein supplementation on visual fatigue: A psychophysiological analysis
Yagi, A., Fujimoto, K., Michihiro, K., et al. (2009) · Applied Ergonomics · doi:10.1016/j.apergo.2009.04.013 · Cited by 32 · see citing works
Renzi‐Hammond, L. M., Iannaccone, A., Johnson, E., & Kritchevsky, S. B. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.877.5 · Cited by 13 · see citing works
Self-citationThe role of lutein in brain health and function
Maci, S., Fonseca, B. M., & Zhu, Y. (2016) · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Effect of Lutein on Eye and Extra-Eye Health
Buscemi, S., Corleo, D., Di Pace, F., Petroni, M. L., Satriano, A., & Marchesini, G. (2018) · Nutrients · doi:10.3390/nu10091321 · Cited by 260 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
Mewborn, C. M., Lindbergh, C. A., Hammond, B. R., Renzi-Hammond, L. M., & Miller, L. S. (2019) · Journal of Aging Research · doi:10.1155/2019/3709402 · Cited by 20 · see citing works
Self-citation
- Authors
- Lindbergh, C. A., Renzi-Hammond, L. M., Hammond, B. R., Terry, D. P., Mewborn, C. M., Puente, A. N., & Miller, L. S.
- Affiliations
- University of Georgia (US)
- Corresponding author
- Miller, L. Stephen
- Venue
- Journal of the International Neuropsychological Society
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-07-11
- Volume
- 24
- Issue
- 1
- Pages
- 77-90
- ISSN
- 1355-6177 (ISSN-L)
- 1469-7661
- OpenAlex
- W2734963879
- Cited by
- 94
- References
- 94
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 10 · 2022: 8 · 2021: 15 · 2020: 11 · 2019: 12 · 2018: 11 · 2017: 2
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the International Neuropsychological Society (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Georgia
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- lutein, zeaxanthin, carotenoid supplementation, brain function, older adults, cognitive decline, verbal learning, neural efficiency, dorsolateral prefrontal cortex, anterior cingulate cortex, cerebral perfusion, BOLD signal, neuropsychological performance
- MeSH terms
- Aged, Aged, 80 and over, Aging, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Verbal Learning, Lutein, Prefrontal Cortex, Dietary Supplements, Independent Living, Cognitive Dysfunction, Zeaxanthins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
