β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans

Gearing, M; Tigges, J; Mori, H; Mirra, S.S

doi:10.1016/s0197-4580(97)00012-2

Cited by 130Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans

Gearing, M, Tigges, J, Mori, H, Mirra, S.S·1997·Neurobiology of Aging

DOI 10.1016/s0197-4580(97)00012-2

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Abstract

While aged monkeys of several species show cerebral amyloid deposition in senile plaques and blood vessels similar to that seen in human aging and Alzheimer's disease (AD), studies of great apes have been limited. Using histological and immunohistochemical methods, we examined the brains of four orangutans aged 10, 28, 31, and 36 years. We encountered sparse beta-amyloid (A beta)-immunoreactive, silver-negative plaque-like structures in the brains of the three older apes. The 36-year-old orangutan also evidenced small A beta-positive deposits in subcortical white matter and sparse vascular amyloid deposition, primarily in meningeal vessels. Neurofibrillary tangles were not detected on silver stains or on tau or ubiquitin immunohistochemistry. Many of the A beta-positive plaque-like deposits in the orangutans were apolipoprotein E-immunoreactive, as we have previously reported in aged rhesus monkeys and an aged chimpanzee. Also, paralleling our earlier findings in these nonhuman primates, A beta 40 in plaques was more prominent in the orangutan than is typically seen in human aging, AD, and Down syndrome. These intriguing species differences may provide clues to the mechanisms of amyloid deposition and the development of neuropathologic changes in AD.

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Authors: Gearing, M., Tigges, J., Mori, H., & Mirra, S. S.
Affiliations: Emory University (US)
Tokyo Institute of Psychiatry (JP)
Corresponding author: Mirra, S.S
ORCID: Gearing, M
Mori, H
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 1997-03
Volume: 18
Issue: 2
Pages: 139-146
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/s0197-4580(97)00012-2
OpenAlex: W2088004915
Cited by: 130
References: 42
Citations by year: 2026: 1 · 2025: 8 · 2024: 8 · 2023: 7 · 2022: 3 · 2021: 9 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 11 · 2015: 2 · 2014: 6 · 2013: 8 · 2012: 3
FWCI: 1.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
National Institutes of Health
National Institute on Aging (P30AG010130, AG-10130, 2 P01-AG 00001, P01AG000001)
National Center for Research Resources (RR-00 165, P51RR000165)
Topics: Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: amyloid-beta deposition, orangutans, aging, Alzheimer's disease, apolipoprotein E, Aβ40, vascular amyloid, neurofibrillary tangles, great apes, species differences, non-human primates, meningeal vessels
MeSH terms: Aging, Animals, Brain, Brain Chemistry, Cerebral Cortex, Coloring Agents, Female, Immunohistochemistry, Male, Pongo pygmaeus, Amyloid beta-Peptides, Neurofibrillary Tangles

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β-Amyloid (Aβ) Deposition in the Brains of Aged Orangutans

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