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Cited by 65Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchAdvanced Proteomics Techniques and Applications

Synaptic proteins associated with cognitive performance and neuropathology in older humans revealed by multiplexed fractionated proteomics

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Carlyle, Becky C., Kandigian, Savannah E., Kreuzer, Johannes, Das, Sudeshna, Trombetta, Bianca A., Kuo, Yikai, Bennett, David A., Schneider, Julie A. +7 more·2021·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2021.04.012PMC PMC8338777
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Abstract

Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau neuropathology. While this neuropathology is necessary for AD diagnosis, it is not sufficient for causing cognitive impairment. Up to one third of community dwelling older adults harbor intermediate to high levels of AD neuropathology at death yet demonstrate no significant cognitive impairment. Conversely, there are individuals who exhibit dementia with no gross explanatory neuropathology. In prior studies, synapse loss correlated with cognitive impairment. To understand how synaptic composition changes in relation to neuropathology and cognition, multiplexed liquid chromatography mass-spectrometry was used to quantify enriched synaptic proteins from the parietal association cortex of 100 subjects with contrasting levels of AD pathology and cognitive performance. 123 unique proteins were significantly associated with diagnostic category. Functional analysis showed enrichment of serotonin release and oxidative phosphorylation categories in normal (cognitively unimpaired, low neuropathology) and "resilient" (unimpaired despite AD pathology) individuals. In contrast, frail individuals, (low pathology, impaired cognition) showed a metabolic shift towards glycolysis and increased presence of proteasome subunits.

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  • Omics and large cohort dataset analyses have identified potential cell signatures and molecular mechanisms of resilience, including high processing of energetic pathways involving mitochondrial metabolism and glycolysis, axonal and dendritic growth, and a general increase in protein processing.

    “Advancements in omics and large cohort dataset analyses have enabled the identification of potential cell signatures and molecular mechanisms of resilience, including high processing of energetic pathways involving mitochondrial metabolism and glycolysis, axonal and dendritic growth, and a general increase in protein processing [11, 90, 91].”

    From Enhanced microglial dynamics and a paucity of tau seeding in the amyloid plaque microenvironment contribute to cognitive resilience in Alzheimer’s disease (2024) · cites this paper as [11]

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Cited by

Sorted by citations

Authors
Carlyle, B. C., Kandigian, S. E., Kreuzer, J., Das, S., Trombetta, B. A., Kuo, Y., Bennett, D. A., Schneider, J. A., Petyuk, V. A., Kitchen, R. R., Morris, R., Nairn, A. C., Hyman, B. T., Haas, W., & Arnold, S. E.
Affiliations
  • Harvard University (US)
  • Rush University Medical Center (US)
  • Pacific Northwest National Laboratory (US)
  • Yale University (US)
Corresponding author
Carlyle, Becky C.
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2021-09
Volume
105
Pages
99-114
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2021.04.012
PMC
PMC8338777
OpenAlex
W3159512994
Cited by
65
References
21
Citations by year
2026: 9 · 2025: 11 · 2024: 16 · 2023: 17 · 2022: 9 · 2021: 3
FWCI
7.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Neurobiology of Aging (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion, cc-by-nc-nd)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders
  • National Institute on Aging (R01 AG17917, P30 AG20262, R01 AG039478, R01 AG15819, P50 AG047270, P30 AG066508, U01 AG61356, R01 AG062306, P30 AG062421)
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Physical Sciences › Chemistry › Spectroscopy › Advanced Proteomics Techniques and Applications
Keywords
Alzheimer's disease, synaptic proteins, cognitive impairment, amyloid-beta, tau pathology, synaptic loss, parietal association cortex, frailty, glycolysis, oxidative phosphorylation, serotonin release, proteasome subunits, metabolic switch
MeSH terms
Aged, Aged, 80 and over, Aging, Alzheimer Disease, Chromatography, Liquid, Cognition, Female, Glycolysis, Humans, Male, Parietal Lobe, Phosphorylation, Serotonin, Mass Spectrometry, Synapses, Proteomics, Proteasome Endopeptidase Complex, Independent Living

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