Cited by 210Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsCancer-related cognitive impairment studies

The DOI matches its Crossref record; 84 of the 85 references it cites were found in a registry or an index.

Functional implications of hippocampal volume and diffusivity in mild cognitive impairment

Abstract

Hippocampal atrophy has been related to mild cognitive impairment (MCI) and early Alzheimer disease (AD), but the diagnostic significance of cross-sectionally determined hippocampal volumes is still ambiguous. Diffusion-Tensor-Imaging (DTI) in MCI patients revealed an association of microstructural changes in hippocampal areas with verbal memory decline. MRI volumetry and DTI were combined to investigate 18 MCI patients attending a memory clinic, and 18 carefully age- and gender-matched healthy controls. Neuropsychological testing, high resolution T1-weighted volume MRI scans, and DTI scans with regions-of-interest in hippocampal areas were applied. Left hippocampal volume was significantly lower (-11%, P = 0.02) in MCI patients than in control subjects. No significant differences were found for the right hippocampus (-4%). Mean diffusivity (MD) was significantly elevated in MCI patients vs. controls in left (+10%, P = 0.002) and right hippocampal areas (+13%, P = 0.02). Hippocampal volume and MD values were not significantly correlated. Combining left hippocampal volume and MD measures showed that lower left hippocampal volumes were associated with poor verbal memory performance particularly when co-occurring with high MD values. No comparable associations could be found regarding the right hippocampal formation and with respect to non-verbal memory function. The results demonstrate that microstructural abnormalities as revealed by DTI are very sensitive early indicators of…

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Crossref · 10.1016/j.neuroimage.2005.06.029

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Research works printed but not linked: 1

  1. Thalmann, 1998, CERAD neuropsychological battery: a minimal data set to be used as a common assessment tool of dementia, Neurobiol. Aging, 19, S9

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Metadata

Authors
Müller, M. J., Greverus, D., Dellani, P. R., Weibrich, C., Wille, P. R., Scheurich, A., Stoeter, P., & Fellgiebel, A.
Affiliations
Johannes Gutenberg University Mainz (DE)
Corresponding author
Müller, Matthias J.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2005-12
Volume
28
Issue
4
Pages
1033-1042
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2045333811
Cited by
210
References
85
Citations by year
2026: 7 · 2025: 8 · 2024: 12 · 2023: 6 · 2022: 10 · 2021: 8 · 2020: 14 · 2019: 6 · 2018: 10 · 2017: 17 · 2016: 7 · 2015: 9 · 2014: 7 · 2013: 8 · 2012: 11
FWCI
7.02
Type
journal article
Language
en
Open access
closed
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
Keywords
mild cognitive impairment, hippocampal volume, hippocampal atrophy, mean diffusivity, diffusion tensor imaging, verbal memory, hippocampal asymmetry, early detection of neurodegeneration, Alzheimer's disease
MeSH terms
Aged, Atrophy, Cognition Disorders, Female, Hippocampus, Humans, Male, Memory, Psychomotor Performance, Mental Recall, Reproducibility of Results, Infarction, Middle Cerebral Artery, Diffusion Magnetic Resonance Imaging

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