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Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals
Abstract
The neural systems regulating food intake in obese individuals remain poorly understood. Previous studies applied positron emission tomography and manipulated hunger and satiety to investigate differences in appetitive processing between obese and normal-weight individuals. However, it is not known whether manipulation of stimulus value may yield different neural activity in obese as compared to control subjects when intrinsic physiological states are kept constant. We used functional magnetic resonance imaging to investigate 13 obese and 13 normal-weight subjects and manipulated food motivation by presenting visual food stimuli differing in their caloric content and energy density. In contrast to controls, obese women selectively activated the dorsal striatum while viewing high-caloric foods. Moreover, in the high-calorie condition body mass index (BMI) predicted activation in the dorsal striatum, anterior insula, claustrum, posterior cingulate, postcentral and lateral orbitofrontal cortex. The results indicate that in obese individuals simple visual stimulation with food stimuli activates regions related to reward anticipation and habit learning (dorsal striatum). Additionally, high-calorie food images yielded BMI-dependent activations in regions associated with taste information processing (anterior insula and lateral orbitofrontal cortex), motivation (orbitofrontal cortex), emotion as well as memory functions (posterior cingulate). Collectively, the results suggest that the observed activation is independent of the physiological states of hunger and satiation, and thus may contribute to pathological overeating and obesity. Some of the observed activations (dorsal striatum, orbitofrontal cortex) are likely to be dopamine-mediated.
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“Recent studies that used the conventional blood oxygenation level-dependent fMRI have shown selective overactivity in the nucleus accumbens and related brain areas in obese compared with lean individuals when shown imagines of highly palatable food (6)(7)(8)(9)(10)(11)”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [8]
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
(2005) · CTIT technical reports series · Cited by 5,307
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
Excess Deaths Associated With Underweight, Overweight, and Obesity
Flegal, K. M. (2005) · JAMA · doi:10.1001/jama.293.15.1861 · Cited by 2,811
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864
Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711
The Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595
The functions of the orbitofrontal cortex
Rolls, E. T. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00277-x · Cited by 1,327
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Items 401–500 of 677
Biegon, A. R., Nelly Alia-klein, A., Alexoff, D. L., Fowler, J. S., Kim, S. W., Logan, J., Pareto, D., Preston‐Campbell, R. N., Wang, G., & Hildebrandt, T. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006117117 · Cited by 18
“In humans, the amygdala has been shown to be involved in hunger-enhanced memory for food stimuli, cued appetitive response to food (42), and cognitive inhibition of brain activation elicited by food stimulation (43).”
BackgroundThe Time-Course of Food Representation in the Human Brain
Moerel, D., Psihoyos, J., & Carlson, T. A. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1101-23.2024 · Cited by 27
Functional Magnetic Resonance Imaging and Obesity—Novel Ways to Seen the Unseen
Drelich‐Zbroja, A., Matuszek, M., Kaczor, M., & Kuczyńska, M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123561 · Cited by 17
“In the light of fMRI, it was shown that in particular, the dorsal striatum, a region commonly associated with reward anticipation and habit formation, shows increased activation in response to visual food cues in obese individuals [36].”
BackgroundAlsaadi, H., & Vugt, D. A. V. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0048 · Cited by 17
“HC pictures have been shown to enhance activation of the lateral OFC, insula, hippocampus and cingulate in obese compared to normal weight women [8, 9].”
BackgroundStimulus devaluation induced by action stopping is greater for explicit value representations
Wessel, J. R., Tonnesen, A. L., & Aron, A. R. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01640 · Cited by 19
The impact of a junk-food diet during development on ‘wanting’ and ‘liking’
Lesser, E. N., Arroyo-Ramirez, A., Mi, S. J., & Robinson, M. J. F. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.041 · Cited by 17
McEown, K., Takata, Y., Chérasse, Y., Nagata, N., Aritake, K., & Lazarus, M. (2016) · eLife · doi:10.7554/elife.20269 · Cited by 17
“In addition, obese patients dis- play increased PFC activity in response to high-calorie visual food stimuli; specifically, increased activity in the orbitofrontal and anterior cingulate cortex (Stoeckel et al., 2008; Rothemund et al., 2007).”
BackgroundCentral Modulation of Energy Homeostasis and Cognitive Performance After Bariatric Surgery
Eickhoff, H. (2017) · Advances in neurobiology · doi:10.1007/978-3-319-63260-5_9 · Cited by 17
Central Nervous System and Peripheral Hormone Responses to a Meal in Children
Roth, C. L., Melhorn, S. J., Elfers, C., Scholz, K., Leon, M. R. B. D., Rowland, M. G., Kearns, S., Aylward, E., Grabowski, T. J., Saelens, B. E., et al. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01525 · Cited by 17
To What Extent Memory Could Contribute to Impaired Food Valuation and Choices in Obesity?
Zhang, Z., & Coppin, G. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02523 · Cited by 16
Maurer, L., Mai, K., Krude, H., Haynes, J., Weygandt, M., & Spranger, J. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.08.014 · Cited by 19
“Application of this task showed that areas in the brain reward system including the prefrontal cortex and the striatum contribute to food wanting and that persons with obesity respond stronger to highcalorie food compared to neutral stimuli in these areas than lean persons [22,23].”
BackgroundDecreased self-reported appetite following insular cortex resection in patients with epilepsy
Hébert-Seropian, B., Boucher, O., Citherlet, D., Roy-Côté, F., Gravel, V., Obaïd, S., Bouthillier, A., & Nguyen, D. K. (2021) · Appetite · doi:10.1016/j.appet.2021.105479 · Cited by 17
Hedonics, satiation and satiety
Dalton, M., & Finlayson, G. (2013) · Elsevier eBooks · doi:10.1533/9780857098719.4.221 · Cited by 17
Burke, M. V., & Small, D. M. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.02.036 · Cited by 17
Padilla, M. M., Verdejo‐Román, J., Fernández-Serrano, M. J., del Paso, G. A. R., & Verdejo‐García, A. (2018) · Appetite · doi:10.1016/j.appet.2018.08.031 · Cited by 18
Changes in brain activity after weight loss
van Opstal, A. M., Wijngaarden, M. A., van der Grond, J., & Pijl, H. (2019) · Obesity Science & Practice · doi:10.1002/osp4.363 · Cited by 16
“Although these various changes in brain function have been found in obesity in cross-sectional studies, it remains a question whether and which of these altered brain functions are reversible after significant weight loss (20,21).”
BackgroundWang, H., Chen, Y., Li, X., Wang, J., Zhou, Y., & Zhou, C. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00400 · Cited by 17
Zapparoli, L., Devoto, F., Giannini, G., Zonca, S., Gallo, F., & Paulesu, E. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103179 · Cited by 16
“Specifically, associative mechanisms lead the “tempted brain” to respond also to anticipatory food stimuli (e. g., visual cues), rather than only to food consumption (Rothemund et al., 2007; Stoeckel et al., 2008).”
BackgroundPaolini, B., Laurienti, P. J., Simpson, S. L., Burdette, J. H., Lyday, R. G., & Rejeski, W. J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00070 · Cited by 16
van Golen, L. W., Veltman, D. J., IJzerman, R. G., Deijen, J. B., Heijboer, A. C., Barkhof, F., Drent, M. L., & Diamant, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094483 · Cited by 16
la Fleur, S. E., & Serlie, M. J. M. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.06.001 · Cited by 16
“fMRI studies have shown, for example, that obese individuals show greater responses in caudate, gustatory regions and oral somatosensory regions compared to lean individuals when expecting food [44] as well as greater striatal and amygdalar responses when viewing pictures of palatable food items, that also predict wei…”
BackgroundDietary triglycerides as signaling molecules that influence reward and motivation
Berland, C., Cansell, C., Hnasko, T. S., Magnan, C., & Luquet, S. H. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.03.005 · Cited by 16
Desire for food and the power of mind.
Roefs, A., Houben, K., & Werthmann, J. (2015) · Research Publications (Maastricht University) · Cited by 16
Brede, S., Sputh, A., Hartmann, A.-C., Hallschmid, M., Lehnert, H., & Klement, J. (2017) · Appetite · doi:10.1016/j.appet.2017.07.001 · Cited by 16
Comparison of explicit vs. implicit measurements in predicting food purchases
Kytö, E., Bult, J. H. F., Aarts, E., Wegman, J., Ruijschop, R. M. A. J., & Mustonen, S. (2019) · Food Quality and Preference · doi:10.1016/j.foodqual.2019.103733 · Cited by 16
Homeostatic, reward and executive brain functions after gastric bypass surgery
Hankir, M. K., Al-Bas, S., Rullmann, M., Chakaroun, R., Seyfried, F., & Pleger, B. (2019) · Appetite · doi:10.1016/j.appet.2019.104419 · Cited by 16
Hamm, J. D., Dotel, J., Tamura, S., Shechter, A., Herzog, M., Brunstrom, J. M., Albu, J., Pi-Sunyer, X., Laferrère, B., & Kissileff, H. R. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113001 · Cited by 16
“Additionally, patients with obesity may have neurocognitive deficits regarding visuospatial memory [65], but most studies examining these deficits use shapes and do not use foods, which are likely more stimulating [66].”
BackgroundProblematic eating as an issue of habitual control
Pierce-Messick, Z. J., & Corbit, L. H. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110294 · Cited by 16
Poessel, M., Morys, F., Breuer, N., Villringer, A., Hummel, T. R., & Horstmann, A. (2021) · Appetite · doi:10.1016/j.appet.2021.105774 · Cited by 16
Relationship between Parental Feeding Practices and Neural Responses to Food Cues in Adolescents
Allen, H. A., Chambers, A., Blissett, J. M., Chechlacz, M., Barrett, T. G., Higgs, S., & Nouwen, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157037 · Cited by 16
Shorter-lived neural taste representations in obese compared to lean individuals
Hardikar, S., Wallroth, R., Villringer, A., & Ohla, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-28847-3 · Cited by 16
Kaurijoki, S., Kuikka, J. T., Niskanen, E. I., Carlson, S., Pietiläinen, K. H., Pesonen, U., Kaprio, J. A., Rissanen, A., Tiihonen, J., & Karhunen, L. J. (2008) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2008.00804.x · Cited by 16
“…role also in the regulation of eating behaviour; the PCC activation has been seen in response to presentation of visual food (Killgore et al., 2003; Rothemund et al., 2007), taste stimuli (Small et al., 2001; Del Parigi et al., 2004) and in the recovery process of anorexia nervosa (Matsumoto et…”
BackgroundChild neurobiology impacts success in family-based behavioral treatment for children with obesity
Schur, E. A., Melhorn, S. J., Scholz, K., Leon, M. R. B. D., Elfers, C., Rowland, M. G., Saelens, B. E., & Roth, C. L. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0644-1 · Cited by 16
Zhang, P., Liu, Y., Yu, F., Wu, G., Li, M., Wang, Z., Ding, H., Wang, L., Zhao, K., Zhang, Z.-Y., et al. (2020) · Appetite · doi:10.1016/j.appet.2020.105055 · Cited by 15
Is the habit system altered in individuals with obesity? A systematic review
Ciria, L. F., Watson, P., Vadillo, M. A., & Luque, D. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.07.006 · Cited by 18
Öyekçin, D. G., & Deveci, A. (2012) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.5455/cap.20120409 · Cited by 15
Establishing links between abnormal eating behaviours and semantic deficits in dementia.
Vignando, M., Rumiati, R., Manganotti, P., Cattaruzza, T., & Aiello, M. (2019) · Journal of Neuropsychology · doi:10.1111/jnp.12195 · Cited by 11
Derman, R. C., & Ferrario, C. R. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112318 · Cited by 17
Implicit and explicit safety evaluation of foods: The importance of food processing
Coricelli, C., Rumiati, R. I., & Rioux, C. (2022) · Appetite · doi:10.1016/j.appet.2022.106062 · Cited by 14
More complex than you might think: Neural representations of food reward value in obesity
Pimpini, L., Kochs, S., Franssen, S., van den Hurk, J., Valente, G., Roebroeck, A. F., Jansen, A. T. M., & Roefs, A. (2022) · Appetite · doi:10.1016/j.appet.2022.106164 · Cited by 16
Hetzer, S., Hirsch, S., Braun, J., Sack, I., & Weygandt, M. (2019) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00200-w · Cited by 14
Jones, S., LUO, S. H., Dorton, H. M., Yunker, A. G., ANGELO, B. C., DEFENDIS, A. W., Monterosso, J. R., & Page, K. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.638504 · Cited by 14
Recompensa alimentar: mecanismos envolvidos e implicações para a obesidade
Ribeiro, G., & Santos, O. (2013) · Revista Portuguesa de Endocrinologia Diabetes e Metabolismo · doi:10.1016/j.rpedm.2013.09.001 · Cited by 16
Overweight in adolescent, psychiatric inpatients: A problem of general or food-specific impulsivity?
Deux, N., Schlarb, A. A., Martin, F., Holtmann, M. H., Hebebrand, J., & Legenbauer, T. (2017) · Appetite · doi:10.1016/j.appet.2017.01.031 · Cited by 16
Neural Mechanisms of Food Decision-Making in Children
Ha, O., Lim, S.-L., & Bruce, A. S. (2020) · Current Nutrition Reports · doi:10.1007/s13668-020-00321-5 · Cited by 14
Food Perception and Categorization
Foroni, F., & Rumiati, R. I. (2017) · Handbook of Categorization in Cognitive Science · doi:10.1016/b978-0-08-101107-2.00012-9 · Cited by 13
Efraim, M., Kirwan, C. B., Muncy, N. M., Tucker, L. A., Kwon, S., & Bailey, B. W. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00244-y · Cited by 15
Metabolic neuroimaging of the brain in diabetes mellitus and hypoglycaemia
Cheah, Y. S., & Amiel, S. A. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.97 · Cited by 13
Harb, M. R., & Almeida, O. F. X. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.28 · Cited by 13
What Twin Studies Tell Us About Brain Responses to Food Cues
Schur, E. A., & Carnell, S. (2017) · Current Obesity Reports · doi:10.1007/s13679-017-0282-7 · Cited by 13
van Ruiten, C. C., Veltman, D. J., Nieuwdorp, M., & IJzerman, R. G. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.863592 · Cited by 13
Brain function predictors and outcome of weight loss and weight loss maintenance
Szabo‐Reed, A. N., Breslin, F. J., Lynch, A. M., Patrician, T. M., Martin, L. E., Lepping, R. J., Powell, J. N., Yeh, H., Befort, C. A., Sullivan, D. K., et al. (2014) · Contemporary Clinical Trials · doi:10.1016/j.cct.2014.12.008 · Cited by 13
“In obese individuals, as compared to healthy weight individuals, findings suggest that activation in the anterior insula, amygdala, striatum, and OFC occurs in response to the sight of food [14, 16, 32-41].”
Addictive Aspects of Eating Disorders and Obesity
Kim, Y., Cho, S., & Moon, J.-J. (2012) · 신경정신의학 · doi:10.4306/jknpa.2012.51.1.36 · Cited by 13
Obesity and acute stress modulate appetite and neural responses in food word reactivity task
Carnell, S., Benson, L., Papantoni, A., Chen, L., Huo, Y., Wang, Z., Peterson, B. S., & Geliebter, A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0271915 · Cited by 15
Beitrag der Suchtforschung zum Verständnis der Adipositas
Kiefer, F., & Grosshans, M. (2009) · Der Nervenarzt · doi:10.1007/s00115-009-2743-z · Cited by 13
Impaired Brain Satiety Responses After Weight Loss in Children With Obesity
Roth, C. L., Melhorn, S. J., Leon, M. R. B. D., Rowland, M. G., Elfers, C., Huang, A., Saelens, B. E., & Schur, E. A. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac299 · Cited by 14
Devoto, F., Coricelli, C., Paulesu, E., & Zapparoli, L. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.954523 · Cited by 12
Ooi, C. L., Kennedy, J. L., & Levitan, R. D. (2012) · Behavioral Neuroscience · doi:10.1037/a0028600 · Cited by 14
Baek, H.-S., Kim, G.-W., Sundaram, T., Park, K., & Jeong, G. (2019) · Sexual Medicine · doi:10.1016/j.esxm.2019.06.013 · Cited by 12
“In addition, activation of the globus pallidus, which is one of the structures constituting the basal nuclei, can be integrated into the dorsal striatum to determine its possible association with the brain’s reward system.(36)”
BackgroundNo evidence for an association between obesity and milkshake liking
Wall, K. M., Farruggia, M. C., Perszyk, E. E., Kanyamibwa, A., Fromm, S. P., Davis, X. S., Dalenberg, J. R., DiFeliceantonio, A. G., & Small, D. M. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0583-x · Cited by 12
He, Y., von Deneen, K. M., Li, G., Jing, B., Zhou, Y., Zhang, K., Zhang, Y., & Ren, Y. (2021) · Brain Imaging and Behavior · doi:10.1007/s11682-021-00519-3 · Cited by 11
Janssen, L. K., Duif, I., Speckens, A. E. M., van Loon, I., Wegman, J., de Vries, J. H. M., Cools, R., & Aarts, E. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1115727 · Cited by 11
Imaging methodologies and applications for nutrition research: what can functional MRI offer?
Francis, S., & Eldeghaidy, S. (2014) · Proceedings of The Nutrition Society · doi:10.1017/s0029665114001530 · Cited by 11
Preliminary evidence for genetic overlap between body mass index and striatal reward response
Lancaster, T. M., Ihssen, I., Brindley, L. M., & Linden, D. E. J. (2018) · Translational Psychiatry · doi:10.1038/s41398-017-0068-4 · Cited by 11
Neural correlates of executive functions in patients with obesity
Ho, M., Chen, V. C., Chao, S., Fang, C.-T., Liu, Y., & Weng, J. (2018) · PeerJ · doi:10.7717/peerj.5002 · Cited by 13
“3A) and middle occipital gyrus (MidOG) (Fig.”
BackgroundInfluentialStriatal Dopamine Responses to Feeding are Altered in People with Obesity
Eisenstein, S. A., BLACK, K. J., Samara, A., Koller, J. M., Dunn, J. P., Hershey, T. G., Klein, S., & Smith, G. I. (2020) · Obesity · doi:10.1002/oby.22753 · Cited by 11
“org images, and this activation is greater than that observed in people who are lean (34,35).”
BackgroundWingrove, J. O., O’Daly, O., Rubio, A. D. L., Hill, S., Swedroska, M., Forbes, B., Amiel, S. A., & Zelaya, F. O. (2022) · Human Brain Mapping · doi:10.1002/hbm.26019 · Cited by 9
“Finally, we were interested in determining whether these data may support or align with theories surrounding food intake that relate to the hyper and hypo-responsiveness of reward related regions in obesity (Davis et al., 2004; Rothemund et al., 2007; Stice et al., 2008).”
BackgroundAppetite, Energy Expenditure, and the Regulation of Energy Balance
ROSENBAUM, M. S. (2023) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2023.03.004 · Cited by 11
Central nervous system biomarkers for antiobesity drug development
Ziauddeen, H., & Fletcher, P. C. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.08.015 · Cited by 10
Altered neurochemical levels in the rat brain following chronic nicotine treatment
Falasca, S., Ranc, V., Petruzziello, F., Khani, A., Kretz, R., Zhang, X., & Rainer, G. (2014) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2014.05.002 · Cited by 10
“The DS acts as an important player in the development and maintenance of drug dependence for nicotine and other drugs of abuse (Everitt and Robbins, 2005; Rothemund et al., 2007; Veeneman et al., 2012; Yamamoto and Zahniser, 2012).”
Computational approaches to predicting treatment response to obesity using neuroimaging
Kozarzewski, L., Maurer, L., Mähler, A., Spranger, J., & Weygandt, M. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09701-w · Cited by 9
Neuroimaging the interaction of mind and metabolism in humans
D’Agostino, A. E., & Small, D. M. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.06.002 · Cited by 11
Yokum, S., & Stice, E. M. (2023) · Nutrients · doi:10.3390/nu15112558 · Cited by 9
“Our results replicate previous evidence that overweight/obesity is associated with an elevated vmPFC and ACC response to food cues [11,43] and food images [10,12,44].”
ResultMoszak, M., Marcickiewicz, J., Pelczyńska, M., & Bogdański, P. (2025) · Nutrients · doi:10.3390/nu17101662 · Cited by 12
“…future perspectives for weight loss and WR. Similarly to drug users, individuals with obesity experience activation of specific areas of the brain associated with reward anticipation and habit learning in response to food stimuli, regardless of physiological states of hunger and satiety [72].”
Vartanian, M., Jahanitabesh, A., Christensen, J. F., Staub, H., Jensen, D. E. A., Villringer, A., & Witte, A. V. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106301 · Cited by 11
“…2008; Luo et al., 2013), middle occipital cortex (Rothemund et al., 2007; Grosshans et al., 2012; Bumb et al., 2021; Luo et al., 2013), hippocampus (Rothemund et al., 2007; Stoeckel et al., 2008; Luo et al., 2013), medial prefrontal cortex (Kaurijoki et al., 2008; Stoeckel et al., 2008; Luo et…”
InfluentialNeuroadaptive processes associated with palatable food intake: present data and future directions
Gilbert, J. R., & Burger, K. S. (2016) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.02.033 · Cited by 9
Le, T. M., Zhornitsky, S., Wang, W., Zhang, S., & Li, C.-S. R. (2019) · Addiction Biology · doi:10.1111/adb.12857 · Cited by 9
Romei, A., Voigt, K., & Verdejo‐García, A. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200309152321 · Cited by 10
Sampaio, C. V. S., Magnavita, G. M., & Ladeia, A. M. T. (2021) · Complementary Therapies in Clinical Practice · doi:10.1016/j.ctcp.2021.101468 · Cited by 10
Okamoto, K., Tanaka, S., Suzuki, Y., Shigematsu, T., Kunieda, K., Hojo, K., Shimizu, A., Ohno, T., & Fujishima, I. (2022) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2022.2137784 · Cited by 9
“The report suggested that the good appearance of food increases cortical activity in regions of the reward system (Berridge 1996; Schultz et al. 1997; Rothemund et al. 2007).”
BackgroundPollack, L. O., & Lundgren, J. D. (2013) · Current Obesity Reports · doi:10.1007/s13679-013-0082-7 · Cited by 9
Zamora, R., Bartholow, J., Green, E., Morgan, C. D., & Murphy, C. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.09.001 · Cited by 9
“Past fMRI research using food pictures (Rothemund et al., 2007) as well as taste stimuli (Green et al., 2011; Stice et al., 2008) has found reduced activation in adults with high BMI compared to low BMI in the reward processing areas of the brain.”
BackgroundNeurobiology of food choices—between energy homeostasis, reward system, and neuroeconomics
Enax, L., & Weber, B. (2016) · e-Neuroforum · doi:10.1007/s13295-015-0020-0 · Cited by 10
Poghosyan, V., Ioannou, S., Al-Amri, K. M., Al-Mashhadi, S. A., Al-Mohammed, F., Al-Otaibi, T., & Al-Saeed, W. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.948063 · Cited by 8
Furukawa, E., Bado, P., da Costa, R. Q. M., Melo, B. R. P., Erthal, P., de Oliveira, I. P., Wickens, J. R., Moll, J., Tripp, G., & Mattos, P. (2022) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2022.111561 · Cited by 8
“In typically developing adults, striatal activation to affiliative (Feldman, 2017; Moll and de Oliveira-Souza, 2009) and food stimuli (Beaver et al., 2006; Cornier et al., 2007; Pursey et al., 2014; Rothemund et al., 2007; Tang et al., 2012) have been reported.”
BackgroundObesity is associated with progressive brain structural changes
Zhou, H., Hu, Y., Li, G., Zhang, W., Ji, W., Feng, Y., La, Z., Li, M., Zhao, Y., Manza, P., et al. (2025) · Obesity · doi:10.1002/oby.24251 · Cited by 8
“The CAU, located in the dorsal striatum, regulates the motivational and incentive properties of food [ 34].”
Dagher, A., Neseliler, S., & Han, J.-E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-805308-9.00032-4 · Cited by 8
Hawkins, M. A. W., Keirns, N. G., Baraldi, A. N., Layman, H. M., Stout, M. E., Smith, C. E., Gunstad, J., Hildebrand, D. A., Vohs, K. D., & Lovallo, W. R. (2021) · Obesity Science & Practice · doi:10.1002/osp4.537 · Cited by 9
“Changes in structural and functional brain integrity are documented at all levels and across the lifespan.(5,6) Although the neurocognitive burden associated with obesity may be reversible with weight loss,(7) this cognitive dysfunction may disrupt an individual's self‐regulation efforts and contribute to the very obe…”
BackgroundLegget, K. T., Cornier, M., Erpelding, C., Lawful, B. P., Bear, J. J., Kronberg, E., & Tregellas, J. R. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac009 · Cited by 8
Cui, K., Zhao, J. L., Li, R., Gao, Y., & Gao, X. (2023) · Appetite · doi:10.1016/j.appet.2023.107048 · Cited by 8
Dürtüsellik ve Aşırı Yeme Arasındaki İlişki: Psikolojik ve Nörobiyolojik Yaklaşımlar
Atalayer, D. (2017) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.358090 · Cited by 10
“It is proposed that impulsivity may be a mediator modulating eating behavior towards obesity and increased food intake (Rydén et al. 2003, Nederkoorn 2006a, 2006b, Guerrieri et al. 2008, Weller et al. 2008, Kavakcı et al. 2011, Jasinska et al. 2012, Murphy et al. 2013), binge eating (Nasser et al.…”
BackgroundDemos, K. E., Williams, S. E., Espeland, M. A., Erickson, K. I., Neiberg, R. H., Wadden, T. A., Bryan, R. N., Desiderio, L. M., Leckie, R. L., Falconbridge, L. H., et al. (2019) · Obesity · doi:10.1002/oby.22496 · Cited by 7
“Studies have also shown differing responsivity in visual- and attention-processing regions in individuals with obesity compared with those with normal weight (4,9,29).”
BackgroundBanerjee, T., Chattaraman, V., Zou, H., & Deshpande, G. (2020) · Scientific Reports · doi:10.1038/s41598-020-71082-y · Cited by 9
Neural underpinnings of food choice and consumption in obesity
Christensen, E., Harding, I. H., Voigt, K., Chong, T. T. ‐., & Verdejo‐García, A. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00974-4 · Cited by 8
Advantageous Object Recognition for High-Fat Food Images
Toepel, U., Knebel, J., Hudry, J., le Coutre, J., & Murray, M. M. (2009) · Frontiers in neuroscience · doi:10.1201/9781420067767-c9 · Cited by 7
The psychological basis of obesity
Tsegaye, A., Kökönyei, G., Baldacchino, A., Urbán, R., Demetrovics, Z., & Logemann, H. N. A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817921-5.00004-7 · Cited by 8
Explicit and Implicit Devaluation Effects of Food-Specific Response Inhibition Training
Tzavella, L., & Chambers, C. (2023) · Journal of Cognition · doi:10.5334/joc.256 · Cited by 6
Obesity, subliminal perception and inhibition: Neuromodulation of the prefrontal cortex
Osimo, S. A., Korb, S., & Aiello, M. (2019) · Behaviour Research and Therapy · doi:10.1016/j.brat.2019.05.005 · Cited by 7
“…to reward processing (Frank et al., 2010; Killgore et al., 2003), and in particular, that individuals with a high BMI show a stronger bias for, and a stronger response towards high calorie foods (Graham, Hoover, Ceballos, & Komogortsev, 2011; Killgore & Yurgelun-Todd, 2005; Rothemund et al., 2007).”
BackgroundClinical evaluation of the on-line Sensicath blood gas monitoring system.
Myklejord, D. J., PRITZKER, M. R., Nicoloff, D. M., Emery, A. M., & Emery, R. W. (1998) · PubMed · Cited by 7
The interplay between white adipose tissue, adipokines, and structural gray matter changes
Okudzhava, L., Schulz, S., Pilorz, V., Oster, H., Fischi-Gómez, E., Girard, G., Machann, J., Thiran, J., Münte, T. F., & Heldmann, M. (2024) · Human Brain Mapping · doi:10.1002/hbm.26752 · Cited by 6
“Functional MRI (fMRI) consistently shows increased activity in the putamen (Put) and Caud in response to appealing food cues in obese individuals compared to normal-weight participants (Pursey et al., 2014; Rothemund et al., 2007).”
Background
Metadata
- Authors
- Rothemund, Y., Preuschhof, C., Bohner, G., Bauknecht, H.-C., Klingebiel, R., Flor, H., & Klapp, B. F.
- Affiliations
- Stiftung Charité (DE)
- Max Planck Society (DE)
- Heidelberg University (DE)
- Corresponding author
- Rothemund, Yvonne
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 37
- Issue
- 2
- Pages
- 410-421
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1976544983
- Cited by
- 679
- References
- 67
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 13 · 2023: 25 · 2022: 34 · 2021: 38 · 2020: 35 · 2019: 43 · 2018: 35 · 2017: 44 · 2016: 45 · 2015: 56 · 2014: 69 · 2013: 50 · 2012: 73
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (FL 156/29)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- obesity, dorsal striatum, food motivation, energy density, reward anticipation, habit learning, anterior insula, orbitofrontal cortex, posterior cingulate cortex, body mass index, dopamine, overeating
- MeSH terms
- Adult, Brain Mapping, Corpus Striatum, Female, Food, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Obesity, Photic Stimulation
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