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Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals
Abstract
The neural systems regulating food intake in obese individuals remain poorly understood. Previous studies applied positron emission tomography and manipulated hunger and satiety to investigate differences in appetitive processing between obese and normal-weight individuals. However, it is not known whether manipulation of stimulus value may yield different neural activity in obese as compared to control subjects when intrinsic physiological states are kept constant. We used functional magnetic resonance imaging to investigate 13 obese and 13 normal-weight subjects and manipulated food motivation by presenting visual food stimuli differing in their caloric content and energy density. In contrast to controls, obese women selectively activated the dorsal striatum while viewing high-caloric foods. Moreover, in the high-calorie condition body mass index (BMI) predicted activation in the dorsal striatum, anterior insula, claustrum, posterior cingulate, postcentral and lateral orbitofrontal cortex. The results indicate that in obese individuals simple visual stimulation with food stimuli activates regions related to reward anticipation and habit learning (dorsal striatum). Additionally, high-calorie food images yielded BMI-dependent activations in regions associated with taste information processing (anterior insula and lateral orbitofrontal cortex), motivation (orbitofrontal cortex), emotion as well as memory functions (posterior cingulate). Collectively, the results suggest that the observed activation is independent of the physiological states of hunger and satiation, and thus may contribute to pathological overeating and obesity. Some of the observed activations (dorsal striatum, orbitofrontal cortex) are likely to be dopamine-mediated.
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“Recent studies that used the conventional blood oxygenation level-dependent fMRI have shown selective overactivity in the nucleus accumbens and related brain areas in obese compared with lean individuals when shown imagines of highly palatable food (6)(7)(8)(9)(10)(11)”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [8]
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
(2005) · CTIT technical reports series · Cited by 5,307
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
Excess Deaths Associated With Underweight, Overweight, and Obesity
Flegal, K. M. (2005) · JAMA · doi:10.1001/jama.293.15.1861 · Cited by 2,811
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864
Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711
The Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595
The functions of the orbitofrontal cortex
Rolls, E. T. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00277-x · Cited by 1,327
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Construir e avaliar um instrumento imagético para orientação alimentar
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Kabisch, S., Schlögl, H., Villringer, A., & Stümvoll, M. (2011) · Journal für Kardiologie (Krause & Pachernegg GmbH)
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Siep, N. (2010) · Research Publications (Maastricht University) · doi:10.26481/dis.20101104ns
Carlin, J. L. (2014) · Scholarly Commons (University of Pennsylvania)
Central lipid detection and the regulation of feeding behavior
Cansell, C., & Luquet, S. H. (2013) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2013.0500
“…2008) whereas they showed greater activation of regions that process palatability and motivation (Nacc, St, orbitofrontal cortex (OFC), AG. . .) when they anticipated consumption (stimulated with pictures of high-calorie food) (Rothemund et al., 2007; Stice et al., 2008; Stoeckel et al., 2008).”
Cansell, C., & Luquet, S. H. (2014) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2013.11.001
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Frank, T. C. (2009) · QSpace (Queen's University Library)
Stice, E. M., Yokum, S., & Burger, K. S. (2014) · Springer eBooks · doi:10.1007/978-3-319-12766-8_6
“Consistent with these theories, obese versus lean humans show greater responsivity of brain regions associated with reward and motivation (striatum, amygdala, OFC) to pictures of high-fat/sugar foods versus low-fat/sugar foods and control images [21–28] and to pictorial cues that signal impending palatable food receip…”
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Yeme Bağimliliğinin Etyolojisi Etiology of Food Addiction
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The influence of visual attention on choice between high versus low energy food items.
Bezemer, M. A. (2016) · Utrecht University Repository (Utrecht University)
Kennedy, J. T. (2013) · OhioLink ETD Center (Ohio Library and Information Network)
da Silva, J. H. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2016.tde-22042015-210949
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Abdullah, A., Hussain, A., & Khan, I. H. (2017) · International Conference on Compute and Data Analysis (ICCDA) · doi:10.1145/3093241.3093286
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van Holst, R. J., Janssen, L. K., van Mierlo, P., Lammers, G. J., Cools, R., Overeem, S., & Aarts, E. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/191544
Lowe, C. J. (2017) · UWSpace (University of Waterloo)
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Cohen, J. (2018) · D-Scholarship@Pitt (University of Pittsburgh)
West, K. M. (2022) · Digital Archive @ GSU · doi:10.57709/12454585
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Joyner, M. A. (2019) · Deep Blue (University of Michigan)
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Eguchi, K., Shirai, S., Matsushima, M., Kano, T., Yamazaki, K., Hamauchi, S., Sasamori, T., Hirata, K., Kitagawa, M., Otsuki, M., et al. (2021) · Research Square · doi:10.21203/rs.3.rs-384471/v1
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Yunker, A. G., Alves, J. M., LUO, S. H., ANGELO, B. C., DEFENDIS, A. W., Pickering, T. A., Jann, K., Monterosso, J. R., & Page, K. A. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.29.446318
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Otero, A. (2001) · Lateral: Revista de Cultura
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Burger, K. S. (2017) · NutriXiv (OSF Preprints) · doi:10.31232/osf.io/4rxkw
Hayek, S. E., Padilla, V. L., Eid, M., & Jovel, A. (2022) · Nutritional neurosciences · doi:10.1007/978-981-19-5021-6_12
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Wong, S. K. W. (2022) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/163576 · Cited by 1
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Barros, L. S. D. A., Melato, D., da Silva, G. F., & Centa, A. (2023) · Seven Editora eBooks · doi:10.56238/ciesaudesv1-106
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Tronieri, J. S., & Wadden, T. A. (2024) · Research Square · doi:10.21203/rs.3.pex-2526/v1
黄, 艾. (2024) · Advances in Psychology · doi:10.12677/ap.2024.144212
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Malmir, N., Ekhtiari, H., Farhoudian, A., Robatmili, S., & Nitsche, M. A. (2025) · Appetite · doi:10.1016/j.appet.2025.108239
Max, S. M., Giel, K. E., Plewnia, C., Weller, S., Fallgatter, A. J., Lossa, V., Zipfel, S., & Schag, K. (2025) · Journal of Eating Disorders · doi:10.1186/s40337-025-01358-z
Leitch, M., Simkus, J., & Geliebter, A. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197688908.003.0005
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BASELINE TRAITS AS PREDICTORS OF SUCCESS IN MEDICAL WEIGHT MANAGEMENT
Bayer, L. A. (2015) · University of Minnesota Digital Conservancy (University of Minnesota)
Polymorphismes génétiques et perception gustative des lipides alimentaires chez les sujets obèses
Plesnik, J. (2017) · theses.fr (ABES) · doi:10.70675/17aadd34z7a30z4c2fz98c9z249e40fcfb47
Gautier, Y. (2018) · theses.fr (ABES) · doi:10.70675/1169b49bz1289z4c70za20dz2e2032cbff00
Triglyceride-sensing in the mesocorticolimbic system and reward-driven behaviour control
Berland, C. (2018) · theses.fr (ABES) · doi:10.70675/3a1dc076z7d5az413czbc66z525614a40de5
“On the other hand, obesity is associated with a greater BOLD response to food-related cues in brain regions associated with reward and motivation (Rothemund et al., 2007a), suggesting that striatal neurons are underactive at baseline in obese individuals but show sensitized responses to food…”
Salles, J. (2021) · theses.fr (ABES) · doi:10.70675/40181baczefeaz416dz8542zd4525164a953
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Metadata
- Authors
- Rothemund, Y., Preuschhof, C., Bohner, G., Bauknecht, H.-C., Klingebiel, R., Flor, H., & Klapp, B. F.
- Affiliations
- Stiftung Charité (DE)
- Max Planck Society (DE)
- Heidelberg University (DE)
- Corresponding author
- Rothemund, Yvonne
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 37
- Issue
- 2
- Pages
- 410-421
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1976544983
- Cited by
- 679
- References
- 67
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 13 · 2023: 25 · 2022: 34 · 2021: 38 · 2020: 35 · 2019: 43 · 2018: 35 · 2017: 44 · 2016: 45 · 2015: 56 · 2014: 69 · 2013: 50 · 2012: 73
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (FL 156/29)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- obesity, dorsal striatum, food motivation, energy density, reward anticipation, habit learning, anterior insula, orbitofrontal cortex, posterior cingulate cortex, body mass index, dopamine, overeating
- MeSH terms
- Adult, Brain Mapping, Corpus Striatum, Female, Food, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Obesity, Photic Stimulation
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