The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.
Differential activation of the dorsal striatum by high-calorie visual food stimuli in obese individuals
Abstract
The neural systems regulating food intake in obese individuals remain poorly understood. Previous studies applied positron emission tomography and manipulated hunger and satiety to investigate differences in appetitive processing between obese and normal-weight individuals. However, it is not known whether manipulation of stimulus value may yield different neural activity in obese as compared to control subjects when intrinsic physiological states are kept constant. We used functional magnetic resonance imaging to investigate 13 obese and 13 normal-weight subjects and manipulated food motivation by presenting visual food stimuli differing in their caloric content and energy density. In contrast to controls, obese women selectively activated the dorsal striatum while viewing high-caloric foods. Moreover, in the high-calorie condition body mass index (BMI) predicted activation in the dorsal striatum, anterior insula, claustrum, posterior cingulate, postcentral and lateral orbitofrontal cortex. The results indicate that in obese individuals simple visual stimulation with food stimuli activates regions related to reward anticipation and habit learning (dorsal striatum). Additionally, high-calorie food images yielded BMI-dependent activations in regions associated with taste information processing (anterior insula and lateral orbitofrontal cortex), motivation (orbitofrontal cortex), emotion as well as memory functions (posterior cingulate). Collectively, the results suggest that the observed activation is independent of the physiological states of hunger and satiation, and thus may contribute to pathological overeating and obesity. Some of the observed activations (dorsal striatum, orbitofrontal cortex) are likely to be dopamine-mediated.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Recent studies that used the conventional blood oxygenation level-dependent fMRI have shown selective overactivity in the nucleus accumbens and related brain areas in obese compared with lean individuals when shown imagines of highly palatable food (6)(7)(8)(9)(10)(11)”
From Effects of dietary glycemic index on brain regions related to reward and craving in men (2013) · cites this paper as [8]
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
Prevalence and trends in obesity among US adults, 1999–2000
Flegal, K. M. (2002) · JAMA · doi:10.1001/jama.288.14.1723 · Cited by 6,190
(2005) · CTIT technical reports series · Cited by 5,307
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
Excess Deaths Associated With Underweight, Overweight, and Obesity
Flegal, K. M. (2005) · JAMA · doi:10.1001/jama.293.15.1861 · Cited by 2,811
Wang, G.-J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusll, N., & Fowler, J. S. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03643-6 · Cited by 1,864
Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711
The Orbitofrontal Cortex and Reward
Rolls, E. T. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.284 · Cited by 1,595
The functions of the orbitofrontal cortex
Rolls, E. T. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00277-x · Cited by 1,327
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
Volkow, N. D., Wang, G.-J., Telang, F., Fowler, J. S., Logan, J., Childress, A.-R., Jayne, M., Ma, Y., & Wong, C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1544-06.2006 · Cited by 1,164
Saper, C. B., Chou, T. C., & Elmquist, J. K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00969-8 · Cited by 1,120
Multisubject fMRI Studies and Conjunction Analyses
Friston, K. J., Holmes, A. P., Price, C. J., Büchel, C., & Worsley, K. J. (1999) · NeuroImage · doi:10.1006/nimg.1999.0484 · Cited by 1,090
How can drug addiction help us understand obesity?
Volkow, N. D., & Wise, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1452 · Cited by 1,089
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076
Kelley, A. E. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.015 · Cited by 942
Elliott, R. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.308 · Cited by 887
Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854
Cerebral Representation of One’s Own Past: Neural Networks Involved in Autobiographical Memory
Fink, G. R., Markowitsch, H. J., Reinkemeier, M., Bruckbauer, T., Kessler, J., & Heiss, W.-D. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-13-04275.1996 · Cited by 803
What is the function of the claustrum?
Crick, F. C., & Koch, C. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1661 · Cited by 742
Posterior cingulate cortex activation by emotional words: fMRI evidence from a valence decision task
Maddock, R. J., Garrett, A. S., & Buonocore, M. H. (2003) · Human Brain Mapping · doi:10.1002/hbm.10075 · Cited by 695 · cited 2×
“…and Koch, 2005), the posterior cingulate cortex, a region associated with processing of emotionally relevant stimuli and memory-related function (Maddock et al., 2003; Fink et al., 1996), the postcentral gyrus which has been linked to an enhanced resting activity in obese subjects (Wang et al.,…”
BackgroundSmall, D. M., Jones-Gotman, M., & Dagher, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00253-2 · Cited by 632
Hernandez, L., & Hoebel, B. G. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90036-7 · Cited by 627
Decreases in dopamine receptors but not in dopamine transporters in alcoholics
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Hitzemann, R., Ding, Y., Pappas, N., Shea, C., & Piscani, K. (1996) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb05936.x · Cited by 612
Neuroanatomical correlates of hunger and satiation in humans using positron emission tomography
Tataranni, P. A., Gautier, J., Chen, K., Uecker, A., Bandy, D. J., Salbe, A. D., Pratley, R. E., Lawson, M. A., Reiman, E. M., & Ravussin, É. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4569 · Cited by 592
Cortical and limbic activation during viewing of high- versus low-calorie foods
Killgore, W. D. S., Young, A. D., Femia, L. A., Bogorodzki, P., Rogowska, J., & Yurgelun-Todd, D. A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00191-5 · Cited by 581
Differential prefrontal cortex and amygdala habituation to repeatedly presented emotional stimuli
Wright, C. I., Fischer, H., Whalen, P. J., McInerney, S. C., Shin, L. M., & Rauch, S. L. (2001) · Neuroreport · doi:10.1097/00001756-200102120-00039 · Cited by 533
Wang, G.-J., Volkow, N. D., Thanos, P. K., & Fowler, J. S. (2004) · Journal of Addictive Diseases · doi:10.1300/j069v23n03_04 · Cited by 502
Cabeza, R. E. L., Dolcos, F., Graham, R., & Nyberg, L. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1063 · Cited by 466
Volkow, N. D., Wang, G., Fowler, J. S., Logan, J., Jayne, M., Franceschi, D., Wong, C., Gatley, S. J., Gifford, A. N., Ding, Y., et al. (2002) · Synapse · doi:10.1002/syn.10075 · Cited by 452
Hunger selectively modulates corticolimbic activation to food stimuli in humans
LaBar, K. S., Gitelman, D. R., Parrish, T. B., Kim, Y.-H., Nobre, A. C., & Mesulam, M. M. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.493 · Cited by 444
Human cortical gustatory areas: A review of functional neuroimaging data
Small, D. M., Zald, D. H., Jones-Gotman, M., Zatorre, R. J., Pardo, J. V., Frey, S., & Petrides, M. (1999) · NeuroReport · doi:10.1097/00001756-199901180-00002 · Cited by 431
A Theory of Emotion, and its Application to Understanding the Neural Basis of Emotion
Rolls, E. (1990) · Cognition & Emotion · doi:10.1080/02699939008410795 · Cited by 411
Heinz, A., Siessmeier, T., Wrase, J., Hermann, D., Klein, S., Grüsser-Sinopoli, S. M., Flor, H., Braus, D. F., Buchholz, H. G., Gründer, G., et al. (2004) · American Journal of Psychiatry · doi:10.1176/ajp.161.10.1783 · Cited by 408
Exposure to appetitive food stimuli markedly activates the human brain
Wang, G.-J., Volkow, N. D., Telang, F., Jayne, M., Ma, J., Rao, M., Zhu, W., Wong, C. T., Pappas, N. R., Geliebter, A., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.11.026 · Cited by 402
Involvement of the dorsal striatum in cue-controlled cocaine seeking
Vanderschuren, L. J. M. J., Di Ciano, P., & Everitt, B. J. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0925-05.2005 · Cited by 393
Representation in the Human Brain of Food Texture and Oral Fat
de Araujo, I. E., & Rolls, E. T. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0130-04.2004 · Cited by 365
Dopamine Production in the Caudate Putamen Restores Feeding in Dopamine-Deficient Mice
Szczypka, M. S., Kwok, K., Brot, M. D., Marck, B. T., Matsumoto, A. M., Donahue, B. A., & Palmiter, R. D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00319-1 · Cited by 354
O'Doherty, J. P., Buchanan, T. W., Seymour, B., & Dolan, R. J. (2006) · Neuron · doi:10.1016/j.neuron.2005.11.014 · Cited by 322
Reward prediction in primate basal ganglia and frontal cortex
Schultz, W., Tremblay, L., & Hollerman, J. R. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00071-9 · Cited by 318
Martinez, D., Broft, A., Foltin, R. W., Slifstein, M., Hwang, D.-R., Huang, Y., Perez, A., Frankel, W. G., Cooper, T., Kleber, H. D., et al. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300420 · Cited by 306
Differential brain responses to satiation in obese and lean men.
Gautier, J., Chen, K., Salbe, A. D., Bandy, D. J., Pratley, R. E., Heiman, M. L., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2000) · Diabetes · doi:10.2337/diabetes.49.5.838 · Cited by 283
Bassareo, V., & Chiara, G. D. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00843.x · Cited by 278
Responses to the Sensory Properties of Fat of Neurons in the Primate Orbitofrontal Cortex
Rolls, E. T., Critchley, H. D., Browning, A. S., Hernadi, I., & Lenard, L. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01532.1999 · Cited by 278
Altered hypothalamic function in response to glucose ingestion in obese humans.
Matsuda, M., Liu, Y., Mahankali, S., Pu, Y., Mahankali, A., Wang, J., DeFronzo, R. A., Fox, P. T., & Gao, J. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1801 · Cited by 272
The Talairach Daemon a database server for talairach atlas labels
Lancaster, J. L., Summerlin, J. L., Rainey, L., Freitas, C., & Fox, P. T. (1997) · NeuroImage · Cited by 261
Mesolimbic dopaminergic system activity as a function of food reward: a microdialysis study
Martel, P. (1996) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(95)00187-5 · Cited by 224
Effect of Satiation on Brain Activity in Obese and Lean Women
Gautier, J., Parigi, A. D., Chen, K., Salbe, A. D., Bandy, D. J., Pratley, R. E., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2001) · Obesity Research · doi:10.1038/oby.2001.92 · Cited by 207
Parigi, A. D., Gautier, J., Chen, K., Salbe, A. D., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2002) · PubMed · Cited by 206
Parigi, A. D., Gautier, J., CHEN, K., Salbe, A. D., Ravussin, É., Reiman, E. M., & Tataranni, P. A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04294.x · Cited by 192
Body weight is regulated by the brain: a link between feeding and emotion
Kishi, T., & Elmquist, J. K. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001638 · Cited by 183
Neural contributions to the motivational control of appetite in humans
Hinton, E. C., Parkinson, J. A., Holland, A. J., Arana, F. S., Roberts, A., & Owen, A. M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03589.x · Cited by 169
Zhang, J. X., Leung, H.-C., & Johnson, M. K. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.016 · Cited by 167
Neural mechanisms underlying food motivation in children and adolescents
Holsen, L. M., Zarcone, J. R., Thompson, T., Brooks, W., Anderson, M. F., Ahluwalia, J., Nollen, N., & Savage, C. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.04.043 · Cited by 164
Richardson, N. R., & Gratton, A. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08160.1996 · Cited by 160
DelParigi, A., Chen, K., Salbe, A. D., Reiman, E. M., & Tataranni, P. A. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.08.035 · Cited by 158
Enhanced resting activity of the oral somatosensory cortex in obese subjects
Wang, G.-J., Volkow, N. D., Felder, C., Fowler, J. S., Levy, A. V., Pappas, N. R., Wong, C. T., Zhu, W., & Netusil, N. (2002) · Neuroreport · doi:10.1097/00001756-200207020-00016 · Cited by 121
Regional cerebral blood flow during food exposure in obese and normal- weight women
Karhunen, L. J. (1997) · Brain · doi:10.1093/brain/120.9.1675 · Cited by 107
Body mass predicts orbitofrontal activity during visual presentations of high-calorie foods
Killgore, W. D. S., & Yurgelun-Todd, D. A. (2005) · NeuroReport · doi:10.1097/00001756-200505310-00016 · Cited by 104
Brain mechanisms in human classical conditioning
Hugdahl, K., Berardi, A., Thompson, W. L., Kosslyn, S. M., Macy, R., Baker, D. P., Alpert, N. M., & LeDoux, J. E. (1995) · Neuroreport · doi:10.1097/00001756-199509000-00005 · Cited by 91
Das Zentralnervensystem des Menschen
Nieuwenhuys, R., Voogd, J., & van Huijzen, C. (1991) · Springer eBooks · doi:10.1007/978-3-642-86091-1 · Cited by 82
Human Cortical Specialization for Food: a Functional Magnetic Resonance Imaging Investigation
St‐Onge, M., Sy, M., Heymsfield, S. B., & Joy Hirsch, C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.5.1014 · Cited by 76
Stimulus-induced craving and startle potentiation in abstinent alcoholics and controls
Grüsser, S. M., Heinz, A., Raabe, A., Wessa, M., Podschus, J., & Flor, H. (2002) · European Psychiatry · doi:10.1016/s0924-9338(02)00666-1 · Cited by 61
Medial Orbitofrontal Cortex: Its Role in Mediating Satiety in the Macaque
Scott, T. R. (2005) · Chemical Senses · doi:10.1093/chemse/bjh178 · Cited by 8
Fatty acid mobilization to 2-deoxyglucose is blocked by globus pallidus lesions
Gunion, M. W., Grijalva, C. V., Novin, D., & Pi-Sunyer, X. (1984) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(84)90073-0 · Cited by 5
Mussell (2000) · doi:10.1002/(sici)1098-108x(200003)27:2
Flagged first, then by citations
1 of the 67 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Nolen-Hoeksema, S., & Watkins, E. R. (2011) · Perspectives on Psychological Science · doi:10.1177/1745691611419672 · Cited by 863
“…intake: neuroimaging studies found greater reactivity in mesocorticolimbic areas in response to food cues in obese than in nonobese participants (Rothemund et al., 2007; Stice, Spoor, Bohon, Veldhuizen, & Small, 2008; Stoeckel et al., 2008), and greater reactivity in this brain area predicted…”
BackgroundWidespread reward-system activation in obese women in response to pictures of high-calorie foods
Stoeckel, L. E., Weller, R. E., Cook, E. W., Twieg, D. B., Knowlton, R. C., & Cox, J. E. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.02.031 · Cited by 857
“Comparisons of activation elicited by food images compared to non-food images for our control participants revealed results generally similar to those of previous neuroimaging studies, which have found activation in response to visual food-related stimuli in similar reward and associated areas (Arana et el., 2003; Bea…”
InfluentialStice, E., Spoor, S., Bohon, C., Veldhuizen, M. G., & Small, D. M. (2008) · Journal of Abnormal Psychology · doi:10.1037/a0013600 · Cited by 779
“, 2008); that obese individuals show greater activation in dorsal striatum, insula, claustrum, and somatosensory cortex in response to food cues than lean individuals (Rothemund et al., 2007); that obese rats have lower basal dopamine levels and reduced D2 receptor expression than lean rats (Fetissov et al.”
Reward mechanisms in obesity: new insights and future directions
Kenny, P. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.016 · Cited by 748
“—George Bernard Shaw”
Neural correlates of food addiction
Gearhardt, A. N. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.32 · Cited by 707
Metadata
- Authors
- Rothemund, Y., Preuschhof, C., Bohner, G., Bauknecht, H.-C., Klingebiel, R., Flor, H., & Klapp, B. F.
- Affiliations
- Stiftung Charité (DE)
- Max Planck Society (DE)
- Heidelberg University (DE)
- Corresponding author
- Rothemund, Yvonne
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 37
- Issue
- 2
- Pages
- 410-421
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1976544983
- Cited by
- 679
- References
- 67
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 13 · 2023: 25 · 2022: 34 · 2021: 38 · 2020: 35 · 2019: 43 · 2018: 35 · 2017: 44 · 2016: 45 · 2015: 56 · 2014: 69 · 2013: 50 · 2012: 73
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (FL 156/29)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- obesity, dorsal striatum, food motivation, energy density, reward anticipation, habit learning, anterior insula, orbitofrontal cortex, posterior cingulate cortex, body mass index, dopamine, overeating
- MeSH terms
- Adult, Brain Mapping, Corpus Striatum, Female, Food, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Obesity, Photic Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
