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Cited by 259Pain Management and TreatmentDeep Brain Stimulation and Movement DisordersPain Mechanisms and Treatments

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Motor cortex stimulation for neuropathic pain: From phenomenology to mechanisms

Garcia-Larrea, Luis, Peyron, Roland·2007·NeuroImage
DOI 10.1016/j.neuroimage.2007.05.062
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Abstract

Motor cortex stimulation (MCS) is relatively recent neurosurgical technique for pain control, the use of which is growing steadily since its description in the last decade. While clinical series show that at least 50% of patients with chronic, pharmacoresistant neuropathic pain may benefit from this technique, the mechanisms of action of MCS remain elusive. In this review, we synthesise a number of studies that, combining electrophysiology and functional imaging, have permitted to proceed from phenomenology to models that may account for part of such mechanisms. MCS appears to trigger rapid and phasic activation in the lateral thalamus, which leads to a cascade of events of longer time-course in medial thalamus, anterior cingulate/orbitofrontal cortices and periaqueductal grey matter. Activity in these latter structures is delayed relative to actual cortical neurostimulation and becomes maximal during the hours that follow MCS arrest. Current hypotheses suggest that MCS may act through at least two mechanisms: activation of perigenual cingulate and orbitofrontal areas may modulate the emotional appraisal of pain, rather than its intensity, while top down activation of brainstem PAG may lead to descending inhibition toward the spinal cord. Recent evidence also points to a possible secretion of endogenous opioids triggered by chronic MCS. This, along with the delayed and long-lasting activation of several brain structures, is consistent with the clinical effects of MCS, which m…

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Research works printed but not linked: 63

  1. Adams, 1974, Stimulation of internal capsule for relief of chronic pain, J. Neurosurg., 41, 740, 10.3171/jns.1974.41.6.0740 · DOI
  2. An, 1998, Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in macaque monkeys, J. Comp. Neurol., 401, 455, 10.1002/(SICI)1096-9861(19981130)401:4<455::AID-CNE3>3.0.CO;2-6 · DOI · Paper page
  3. Andersen, 1962, Presynaptic inhibitory action of cerebral cortex on the spinal cord, Nature, 194, 740, 10.1038/194740a0 · DOI
  4. Carmichael, 1995, Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys, J. Comp. Neurol., 363, 615, 10.1002/cne.903630408 · DOI · Paper page
  5. Carroll, 2000, Motor cortex stimulation for chronic neuropathic pain: a preliminary study of 10 cases, Pain, 84, 431, 10.1016/S0304-3959(99)00245-6 · DOI
  6. Cruccu, G., Aziz, T.Z., Garcia-Larrea, L., Hansson, P., Jensen, T.S., Lefaucheur, J.-P., Simpson, B.A., Taylor, R.S., in press. EFNS guidelines on neurostimulation therapy for neuropathic pain. Eur. J. Neurology.
  7. Davis, 2000, Activation of the anterior cingulate cortex by thalamic stimulation in patients with chronic pain: a positron emission tomography study, J. Neurosurg., 92, 64, 10.3171/jns.2000.92.1.0064 · DOI
  8. Derbyshire, 2000, Exploring the pain “neuromatrix”, Curr. Rev. Pain, 4, 467, 10.1007/s11916-000-0071-x · DOI · Paper page
  9. Ducreux, 2006, Mechanisms of central neuropathic pain: a combined psychophysical and fMRI study in syringomyelia, Brain, 129, 963, 10.1093/brain/awl016 · DOI
  10. Duncan, 1998, Stimulation of human thalamus for pain relief: possible modulatory circuits revealed by Positron Emission Tomography, J. Neurophysiol., 80, 3326, 10.1152/jn.1998.80.6.3326 · DOI
  11. Faymonville, 2003, Increased cerebral functional connectivity underlying the antinociceptive effects of hypnosis, Brain Res. Cogn. Brain Res., 17, 255, 10.1016/S0926-6410(03)00113-7 · DOI
  12. Fields, 1974, Pain after cortical injury relieved by electrical stimulation of the internal capsule, Brain, 97, 169, 10.1093/brain/97.1.169 · DOI
  13. Firestone, 1996, Human brain activity response to fentanyl imaged by positron emission tomography, Anesth. Analg., 82, 1247
  14. Foltz, 1962, Pain “relief” by frontal cingulumotomy, J. Neurosurg., 19, 89, 10.3171/jns.1962.19.2.0089 · DOI · Paper page
  15. Frankenstein, 2001, Distraction modulates anterior cingulate gyrus activations during the cold pressor test, NeuroImage, 14, 827, 10.1006/nimg.2001.0883 · DOI
  16. Frederikson, 1995, Affective and attentive neural networks in humans: a PET study of Pavlovian conditioning, NeuroReport, 7, 97, 10.1097/00001756-199512000-00023 · DOI
  17. Freedman, 2000, Subcortical projections of area 25 (subgenual cortex) of the macaque monkey, J. Comp. Neurol., 421, 172, 10.1002/(SICI)1096-9861(20000529)421:2<172::AID-CNE4>3.0.CO;2-8 · DOI
  18. Friston, 1996, Functional topography: multidimensional scaling and functional connectivity in the brain, Cereb. Cortex, 6, 156, 10.1093/cercor/6.2.156 · DOI
  19. Friston, 1997, Psychophysiological and modulatory interactions in neuroimaging, NeuroImage, 6, 218, 10.1006/nimg.1997.0291 · DOI · Paper page
  20. Garcia-Larrea, 1999, Electrical stimulation of motor cortex for pain control: a combined PET-scan and electrophysiological study, Pain, 83, 259, 10.1016/S0304-3959(99)00114-1 · DOI
  21. Garcia-Larrea, 2000, Functional imaging and neurophysiological assessment of spinal and brain therapeutic modulation in humans, Arch. Med. Res., 31, 248, 10.1016/S0188-4409(00)00083-7 · DOI
  22. Garcia-Larrea, 2003, Brain generators of laser-evoked potentials: from dipoles to functional significance, Neurophysiol. Clin., 33, 279, 10.1016/j.neucli.2003.10.008 · DOI · Paper page
  23. Holsheimer, 1997, Effectiveness of spinal cord stimulation in the management of chronic pain: analysis of technical drawbacks and solutions, Neurosurgery, 40, 990, 10.1097/00006123-199705000-00023 · DOI
  24. Hsieh, 1995, Central representation of chronic ongoing neuropathic pain studied by positron emission tomography, Pain, 63, 225, 10.1016/0304-3959(95)00048-W · DOI
  25. Hsieh, 1999, Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study, Neurosci. Lett., 262, 61, 10.1016/S0304-3940(99)00060-9 · DOI · Paper page
  26. Jing, 2001, Effects of high frequency repetitive transcranial magnetic stimulation on P300 event-related potentials, Clin. Neurophysiol., 112, 304, 10.1016/S1388-2457(00)00540-X · DOI
  27. Jones, 2004, Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [11C]diprenorphine binding and PET, Eur. J. Pain, 8, 479, 10.1016/j.ejpain.2003.11.017 · DOI
  28. Katayama, 1988, Corticospinal direct responses in humans: identification of the motor cortex during intracranial surgery under general anesthesia, J. Neurol. Neurosurg. Psychiatry, 51, 50, 10.1136/jnnp.51.1.50 · DOI
  29. Kuhar, 1973, Regional distribution of opiate receptor binding in monkey and human brain, Nature, 245, 447, 10.1038/245447a0 · DOI
  30. Lindblom, 1957, Influence of pyramidal stimulation upon the relay of coarse cutaneous afferents in the dorsal horn, Acta Physiol. Scand., 38, 309, 10.1111/j.1748-1716.1957.tb01394.x · DOI
  31. Lopez-Larson, 2002, Regional prefrontal gray and white matter abnormalities in bipolar disorder, Biol. Psychiatry, 52, 93, 10.1016/S0006-3223(02)01350-1 · DOI
  32. Maarrawi, 2007, Differential brain opioid receptor availability in central and peripheral neuropathic pain, Pain, 127, 183, 10.1016/j.pain.2006.10.013 · DOI
  33. Maarrawi, J., Peyron, R., Mertens, P., Costes, N., Magnin, M., Sindou, M., Laurent, B., Garcia-Larrea, L., in press. Motor cortex stimulation for pain control induces changes in the endogenous opioid system. Neurology.
  34. Mertens, 1999, Precentral cortex stimulation for the treatment of central neuropathic pain: results of a prospective study in a 20-patient series, Stereotact. Funct. Neurosurg., 73, 122, 10.1159/000029769 · DOI
  35. Meyerson, 1993, Motor cortex stimulation as treatment of trigeminal neuropathic pain, Acta Neurochir., Suppl. (Wien), 58, 150
  36. Montes, 2002, Cognitive effects of precentral cortical stimulation for pain control: an ERP study, Neurophysiol. Clin./Clin. Nurophysiol., 32, 313, 10.1016/S0987-7053(02)00340-4 · DOI
  37. Morris, 1998, A neuromodulatory role for the human amygdala in processing emotional facial expressions, Brain, 121, 47, 10.1093/brain/121.1.47 · DOI · Paper page
  38. Nguyen, 2000, Motor cortex stimulation in the treatment of central and neuropathic pain, Arch. Med. Res., 31, 263, 10.1016/S0188-4409(00)00078-3 · DOI
  39. Nowak, 1998, Axons, but not cell bodies, are activated by electrical stimulation of the cortical grey matter: II. Evidence from selective inactivation of cell bodies and axon initial segments, Exp. Brain Res., 118, 489, 10.1007/s002210050305 · DOI
  40. Nuti, 2005, Motor cortex stimulation for refractory neuropathic pain: a study of long-term outcome and possible predictors of efficacy, Pain, 118, 43, 10.1016/j.pain.2005.07.020 · DOI
  41. Petrovic, 2002, Placebo and opioid analgesia—imaging a shared neuronal network, Science, 295, 1737, 10.1126/science.1067176 · DOI · Paper page
  42. Peyron, 1995, Electrical stimulation of precentral cortical area in the treatment of central pain: electrophysiological and PET study, Pain, 62, 275, 10.1016/0304-3959(94)00211-V · DOI
  43. Peyron, 1998, Allodynia after lateral-medullary (Wallenberg) infarct. A Positron Emission Tomography (PET) study, Brain, 121, 345, 10.1093/brain/121.2.345 · DOI
  44. Peyron, 1999, Haemodynamic brain responses to acute pain in humans: sensory and attentional networks, Brain, 122, 1765, 10.1093/brain/122.9.1765 · DOI
  45. Peyron, 1999, Temporal pattern of cerebral blood flow (CBF) in patients with electrical motor cortex stimulation (MCS) for pain control, Abstr. - Soc. Neurosci., Miami
  46. Peyron, 2000, Functional imaging of brain responses to pain. A review and meta-analysis, Neurophysiol. Clin., 30, 263, 10.1016/S0987-7053(00)00227-6 · DOI · Paper page
  47. Peyron, 2007, Motor cortex stimulation in neuropathic pain. Long term effects and their correlation with protracted brain activations. A PET study, NeuroImage, 34, 310, 10.1016/j.neuroimage.2006.08.037 · DOI
  48. Phillips, 2003, Neurobiology of emotion perception II: implications for major psychiatric disorders, Biol. Psychiatry, 54, 515, 10.1016/S0006-3223(03)00171-9 · DOI · Paper page
  49. Ploghaus, 2003, Neural circuitry underlying pain modulation: expectation, hypnosis, placebo, Trends Cogn. Sci., 7, 197, 10.1016/S1364-6613(03)00061-5 · DOI
  50. Porro, 2002, Does anticipation of pain affect cortical nociceptive systems?, J. Neurosci., 22, 3206, 10.1523/JNEUROSCI.22-08-03206.2002 · DOI · Paper page
  51. Powell, 1967, The interpretation of the degenerative changes in the intralaminar nuclei of the thalamus, J. Neurol. Neurosurg. Psychiatry, 30, 140, 10.1136/jnnp.30.2.140 · DOI
  52. Rajkowska, 2002, Cell pathology in bipolar disorder, Bipolar Disord., 4, 105, 10.1034/j.1399-5618.2002.01149.x · DOI
  53. Schweinhardt, 2006, An fMRI study of cerebral processing of brush-evoked allodynia in neuropathic pain patients, NeuroImage, 32, 256, 10.1016/j.neuroimage.2006.03.024 · DOI
  54. Senapati, 2005, Spinal dorsal horn neuron response to mechanical stimuli is decreased by electrical stimulation of the primary motor cortex, Brain Res., 1036, 173, 10.1016/j.brainres.2004.12.043 · DOI
  55. Simpson, 2001, Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety, Proc. Natl. Acad. Sci. U. S. A., 98, 688, 10.1073/pnas.98.2.688 · DOI
  56. Talbot, 1995, Evaluation of pain perception after anterior capsulotomy: a case report, Somatosens. Motor Res., 12, 115, 10.3109/08990229509101503 · DOI
  57. Tölle, 1999, Region-specific encoding of sensory and affective components of pain in the human brain: a Positron Emission Tomography correlation analysis, Ann. Neurol., 45, 40, 10.1002/1531-8249(199901)45:1<40::AID-ART8>3.0.CO;2-L · DOI
  58. Tsubokawa, 1991, Treatment of thalamic pain by chronic motor cortex stimulation, Pacing Clin. Electrophysiol., 14, 131, 10.1111/j.1540-8159.1991.tb04058.x · DOI
  59. Tsubokawa, 1993, Chronic motor cortex stimulation in patients with thalamic pain, J. Neurosurg., 78, 393, 10.3171/jns.1993.78.3.0393 · DOI
  60. Vogt, 1996, Pain processing in four regions of human cingulate cortex localized with co-registered PET and MR imaging, Eur. J. Neurosci., 8, 1461, 10.1111/j.1460-9568.1996.tb01608.x · DOI
  61. Vogt, 2003, Structural and functional dichotomy of human midcingulate cortex, Eur. J. Neurosci., 18, 3134, 10.1111/j.1460-9568.2003.03034.x · DOI · Paper page
  62. Wallace, 2004, Deep brain stimulation for the treatment of chronic, intractable pain, Neurosurg. Clin. N. Am., 15, 343, 10.1016/j.nec.2004.03.004 · DOI
  63. Willoch, 2003, Analgesia by electrostimulation of the trigeminal ganglion in patients with trigeminopathic pain: a PET activation study, Pain, 103, 119, 10.1016/s0304-3959(02)00423-2 · DOI

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Metadata

Authors
Garcia-Larrea, L., & Peyron, R.
Affiliations
Inserm (FR)
ORCID
Peyron, Roland
Venue
NeuroImage
Publisher
Elsevier BV
Published
2007
Volume
37
Pages
S71-S79
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2007.05.062
OpenAlex
W2029045410
Cited by
259
References
75
Citations by year
2026: 8 · 2025: 4 · 2024: 12 · 2023: 13 · 2022: 15 · 2021: 20 · 2020: 14 · 2019: 18 · 2018: 11 · 2017: 11 · 2016: 17 · 2015: 21 · 2014: 16 · 2013: 13 · 2012: 15
FWCI
2.15
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
Fondation pour la Recherche Médicale
Topics
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Keywords
motor cortex stimulation, neuropathic pain, chronic pain, mechanism of action, lateral thalamus, medial thalamus, periaqueductal gray, anterior cingulate cortex, orbitofrontal cortex, descending pain inhibition, endogenous opioids, pain management
MeSH terms
Animals, Cerebrovascular Circulation, Chronic Disease, Endorphins, Humans, Magnetic Resonance Imaging, Motor Cortex, Pain, Peripheral Nervous System Diseases, Neurosurgical Procedures, Positron-Emission Tomography, Pain Management

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