Structural and functional dichotomy of human midcingulate cortex
Open accessAbstract
Anterior cingulate cortex is comprised of perigenual and midcingulate regions based on cytology, imaging and connections. Its anterior (aMCC) and posterior (pMCC) parts and transition to posterior area 23 were evaluated in six human cingulate gyri with Nissl staining and immunoreactions for neuron-specific nuclear binding protein and intermediate neurofilament proteins (NFP), and their pain and emotion functions evaluated in standard coordinates. Morphological differences included a poorly differentiated layer III with few NFP-expressing neurons in aMCC and a very dense layer Va with small and large pyramids intermingled in pMCC. The density of NFP-positive, layer Vb neurons was higher in pMCC than in aMCC. The junction of pMCC with area 23 had a dysgranular area 23d with clumps of layer IV neurons and a very dense layer Va. Each case was co-registered to standard coordinates and the regional borders identified and measured. Although both regions had overall equivalent activations during noxious cutaneous thermal stimulation, the posterior two-thirds of pMCC was relatively inactive. About 60% of fear-induced activity was in aMCC, sadness and happiness activated perigenual cortex, and neither were activated with non-emotion tasks. Thus, pain activity is coupled to fear in aMCC, while other MCC processing is not related to affect. Beyond midcingulate duality, this is the first report of a very dense layer Va for areas p24' and 23 and the features of transitional area 23d. The M…
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The psychological constructionist hypothesis draws on neuroscience literature showing that pregenual anterior cingulate cortex, subgenual anterior cingulate cortex, and anterior midcingulate cortex take part in distinct psychological operations related to realizing core affect.
“Our psychological constructionist hypothesis draws on the neuroscience literature showing that pACC, sACC, and the more dorsal anterior midcingulate cortex (aMCC) (Vogt 1993; Vogt et al. 2003) take part in distinct psychological operations related to realizing core affect.”
From The brain basis of emotion: a meta-analytic review (2012) · cites this paper as Vogt et al. 2003
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- Authors
- Vogt, B. A., Berger, G. R., & Derbyshire, S. W. G.
- Affiliations
- SUNY Upstate Medical University (US)
- University of Pittsburgh Medical Center (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2003-12
- Volume
- 18
- Issue
- 11
- Pages
- 3134-3144
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC2548277
- OpenAlex
- W1989389824
- Cited by
- 440
- References
- 7
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 20 · 2023: 17 · 2022: 20 · 2021: 17 · 2020: 15 · 2019: 22 · 2018: 18 · 2017: 18 · 2016: 30 · 2015: 19 · 2014: 18 · 2013: 30 · 2012: 24
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- Funders
- Pittsburgh Foundation
- National Institutes of Health (5r01ns038485-04)
- National Institute of Neurological Disorders and Stroke (R01NS044222, NS44222, NS38485)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Keywords
- midcingulate cortex, anterior cingulate cortex, pregenual anterior cingulate cortex, posterior cingulate cortex, neuronal differentiation, pain processing, fear, emotions, noxious thermal stimulation, chronic pain, stress, cingulate motor area
- MeSH terms
- Adult, Animals, Haplorhini, Brain Mapping, Cerebral Cortex, Emotions, Female, Gyrus Cinguli, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Male, Middle Aged, Neural Pathways, Pain, Pain Measurement, Phosphopyruvate Hydratase, Staining and Labeling, Neurofilament Proteins
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