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Striatal dopamine D2/D3 receptor binding in pathological gambling is correlated with mood-related impulsivity
Open accessAbstract
Pathological gambling (PG) is a behavioural addiction associated with elevated impulsivity and suspected dopamine dysregulation. Reduced striatal dopamine D(2)/D(3) receptor availability has been reported in drug addiction, and may constitute a premorbid vulnerability marker for addictive disorders. The aim of the present study was to assess striatal dopamine D(2)/D(3) receptor availability in PG, and its association with trait impulsivity. Males with PG (n=9) and male healthy controls (n=9) underwent [11C]-raclopride positron emission tomography imaging and completed the UPPS-P impulsivity scale. There was no significant difference between groups in striatal dopamine D(2)/D(3) receptor availability, in contrast to previous reports in drug addiction. However, mood-related impulsivity ('Urgency') was negatively correlated with [11C]-raclopride binding potentials in the PG group. The absence of a group difference in striatal dopamine binding implies a distinction between behavioural addictions and drug addictions. Nevertheless, our data indicate heterogeneity in dopamine receptor availability in disordered gambling, such that individuals with high mood-related impulsivity may show differential benefits from dopamine-based medications.
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![Fig. 1 [11C]-raclopride binding potentials (BPND) for the overall striatum region of interest (bilateral) and limbic subdivision, for individual cases with Pathological Gambling and healthy controls.](/paper-figures/811981735bbf491daaf35c08204fd0e7/striatal-dopamine-d2-d3-receptor-binding-in-pathological-gambling-is-correlated-figure-1.jpg)
![Fig. 2 Correlations in Pathological Gamblers between [11C]-raclopride BPND in overall striatum and UPPS-P Negative Urgency (A) and Positive Urgency (B). C: Quadratic relationship between [11C]-raclopride BPND in limbic striatum and Negative Urgency in the pooled group of pathological gamblers (filled circles) and healthy controls (open circles).](/paper-figures/a59d079a8c744d259c81ffec5427a9b3/striatal-dopamine-d2-d3-receptor-binding-in-pathological-gambling-is-correlated-figure-2.jpg)
![Fig. 3 Results of voxelwise regression of [11C]-raclopride BPND in the Pathological Gamblers, showing negative association with Negative Urgency (A) (y = +15, z = − 5) and Positive Urgency (B) (y = +15, z = − 5).](/paper-figures/f71be067b8f64c43a0fc58151d92390a/striatal-dopamine-d2-d3-receptor-binding-in-pathological-gambling-is-correlated-figure-3.jpg)
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“However, it should be noted that decreases in D2 receptor binding are not seen in pathological gamblers compared to control subjects, which also has a significant impulsive component (Boileau et al., 2013; Clark et al., 2012; Joutsa et al., 2012; Linnet et al., 2011).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Clark et al., 2012
In the citing paper
“Nonetheless, two of these studies (Boileau et al., 2013; Clark et al., 2012) did show that low D2 binding correlated with greater impulsivity within the group of gamblers.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Clark et al., 2012
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Self-citationPotenza, M. N., Balodis, I. M., Derevensky, J., Grant, J. E., Petry, N. M., Verdejo-Garcia, A., & Yip, S. W. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0099-7 · Cited by 437
Validation of a short French version of the UPPS-P Impulsive Behavior Scale
Billieux, J., Rochat, L., Ceschi, G., Carré, A., Offerlin-Meyer, I., Defeldre, A.-C., Khazaal, Y., Besche‐Richard, C., & der Linden, M. V. (2011) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2011.09.001 · Cited by 482
Wise, R. A., & Robble, M. A. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-103337 · Cited by 446
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Smith, G. T., & Cyders, M. A. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.08.038 · Cited by 353
Metadata
- Authors
- Clark, L., Stokes, P. R., Wu, K., Michalczuk, R., Benecke, A., Watson, B. J., Egerton, A., Piccini, P., Nutt, D. J., Bowden-Jones, H., & Lingford-Hughes, A. R.
- Affiliations
- University of Cambridge (GB)
- Imperial College London (GB)
- University of Bristol (GB)
- King's College London (GB)
- Central and North West London NHS Foundation Trust (GB)
- Corresponding author
- Clark, Luke
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 63
- Issue
- 1
- Pages
- 40-46
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3438449
- OpenAlex
- W2084587642
- Cited by
- 193
- References
- 65
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 11 · 2022: 4 · 2021: 3 · 2020: 55 · 2019: 13 · 2018: 14 · 2017: 10 · 2016: 17 · 2015: 21 · 2014: 15 · 2013: 15 · 2012: 3
- FWCI
- 19.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- NeuroImage (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust
- Medical Research Council (G0400575, G0802725)
- Responsible Gambling Fund
- Topics
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- gambling addiction, dopamine D2/D3 receptors, impulsivity, urgency, [11C]raclopride PET, behavioral addiction, dopamine dysregulation
- MeSH terms
- Adult, Affect, Corpus Striatum, Female, Gambling, Humans, Impulsive Behavior, Male, Middle Aged, Statistics as Topic, Receptors, Dopamine D2, Positron-Emission Tomography, Receptors, Dopamine D3
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