Cited by 193Gambling Behavior and TreatmentsNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

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Striatal dopamine D2/D3 receptor binding in pathological gambling is correlated with mood-related impulsivity

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Clark, Luke, Stokes, Paul R., Wu, Kit, Michalczuk, Rosanna, Benecke, Aaf, Watson, Ben J., Egerton, Alice, Piccini, Paola, Nutt, David J., Bowden-Jones, Henrietta, Lingford-Hughes, Anne R.·2012·NeuroImage

DOI 10.1016/j.neuroimage.2012.06.067PMC PMC3438449

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Abstract

Pathological gambling (PG) is a behavioural addiction associated with elevated impulsivity and suspected dopamine dysregulation. Reduced striatal dopamine D(2)/D(3) receptor availability has been reported in drug addiction, and may constitute a premorbid vulnerability marker for addictive disorders. The aim of the present study was to assess striatal dopamine D(2)/D(3) receptor availability in PG, and its association with trait impulsivity. Males with PG (n=9) and male healthy controls (n=9) underwent [11C]-raclopride positron emission tomography imaging and completed the UPPS-P impulsivity scale. There was no significant difference between groups in striatal dopamine D(2)/D(3) receptor availability, in contrast to previous reports in drug addiction. However, mood-related impulsivity ('Urgency') was negatively correlated with [11C]-raclopride binding potentials in the PG group. The absence of a group difference in striatal dopamine binding implies a distinction between behavioural addictions and drug addictions. Nevertheless, our data indicate heterogeneity in dopamine receptor availability in disordered gambling, such that individuals with high mood-related impulsivity may show differential benefits from dopamine-based medications.

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Authors: Clark, L., Stokes, P. R., Wu, K., Michalczuk, R., Benecke, A., Watson, B. J., Egerton, A., Piccini, P., Nutt, D. J., Bowden-Jones, H., & Lingford-Hughes, A. R.
Affiliations: University of Cambridge (GB)
Imperial College London (GB)
University of Bristol (GB)
King's College London (GB)
Central and North West London NHS Foundation Trust (GB)
Corresponding author: Clark, Luke
ORCID: Clark, Luke
Stokes, Paul R.
Egerton, Alice
Piccini, Paola
Nutt, David J.
Lingford-Hughes, Anne R.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2012-10
Volume: 63
Issue: 1
Pages: 40-46
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2012.06.067
PMC: PMC3438449
OpenAlex: W2084587642
Cited by: 193
References: 65
Citations by year: 2026: 2 · 2025: 5 · 2024: 4 · 2023: 11 · 2022: 4 · 2021: 3 · 2020: 55 · 2019: 13 · 2018: 14 · 2017: 10 · 2016: 17 · 2015: 21 · 2014: 15 · 2013: 15 · 2012: 3
FWCI: 19.64
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/3.0/ (vor, 288 d)
Locations: NeuroImage (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Wellcome Trust
Medical Research Council (G0400575, G0802725)
Responsible Gambling Fund
Topics: Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: gambling addiction, dopamine D2/D3 receptors, impulsivity, urgency, [11C]raclopride PET, behavioral addiction, dopamine dysregulation
MeSH terms: Adult, Affect, Corpus Striatum, Female, Gambling, Humans, Impulsive Behavior, Male, Middle Aged, Statistics as Topic, Receptors, Dopamine D2, Positron-Emission Tomography, Receptors, Dopamine D3

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Striatal dopamine D2/D3 receptor binding in pathological gambling is correlated with mood-related impulsivity

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