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Finding thalamic BOLD correlates to posterior alpha EEG
Open accessAbstract
Oscillatory electrical brain activity in the alpha (8-13 Hz) band is a prominent feature of human electroencephalography (EEG) during alert wakefulness, and is commonly thought to arise primarily from the occipital and parietal parts of the cortex. While the thalamus is considered to play a supportive role in the generation and modulation of cortical alpha rhythms, its precise function remains controversial and incompletely understood. To address this, we evaluated the correlation between the blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) signals in the thalamus and the spontaneous modulation of posterior alpha rhythms based on EEG-fMRI data acquired concurrently during an eyes-closed task-free condition. We observed both negative and positive correlations in the thalamus. The negative correlations were mostly seen within the visual thalamus, with a preference for the pulvinar over lateral geniculate nuclei. The positive correlations were found at the anterior and medial dorsal nuclei. Through functional connectivity analysis of the fMRI data, the pulvinar was found to be functionally associated with the same widespread cortical visual areas where the fMRI signals were negatively correlated with the posterior alpha modulation. In contrast, the dorsal nuclei were part of a distinct functional network that included brain stem, cingulate cortex and cerebellum. These observations are consistent with previous animal electrophysiology studies and the notion that the visual thalamus, and the pulvinar in particular, is intimately involved in the generation and spontaneous modulation of posterior alpha rhythms, facilitated by its reciprocal and widespread interaction with the cortical visual areas. We further postulate that the anterior and medial dorsal nuclei, being part of the ascending neuromodulatory system, may indirectly modulate cortical alpha rhythms by affecting vigilance and arousal levels.
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“This circuit could serve as an alpha generator for extrastriate cortex [68], through a mechanism analogous to the geniculocortical loop through layers 4 and 6 of V1 [69], and modulate the effectiveness of the output from one area to another distant cortical region.”
From Cerebral hierarchies: predictive processing, precision and the pulvinar (2015) · cites this paper as [68]
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“Studies have shown that the alpha-band power is correlated to the fMRI signal from visual and sensorimotor cortices (163), attention network (164, 165), and thalamic nuclei (166).”
From Electrophysiological source imaging: A noninvasive window to brain dynamics (2018) · cites this paper as [166]
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Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Brain stem reticular formation and activation of the EEG
Moruzzi, G., & Magoun, H. W. (1949) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(49)90219-9 · Cited by 4,307
Über das Elektrenkephalogramm des Menschen
Berger, H. (1929) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/bf01797193 · Cited by 4,266
Thalamocortical oscillations in the sleeping and aroused brain
Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
Behrens, T. E. J., Johansen-Berg, H., Woolrich, M. W., Smith, S. M., Wheeler-Kingshott, C. A. M., Boulby, P. A., Barker, G. J., Sillery, E. L., Sheehan, K., Ciccarelli, O., et al. (2003) · Nature Neuroscience · doi:10.1038/nn1075 · Cited by 2,330
Pessoa, L., & Adolphs, R. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2920 · Cited by 1,794
Thut, G., Nietzel, A., Brandt, S., & Pascual-Leone, Á. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0875-06.2006 · Cited by 1,662
Simultaneous EEG and fMRI of the alpha rhythm
Goldman, R. I., Stern, J. M., Engel, J., & Cohen, M. S. (2002) · Neuroreport · doi:10.1097/00001756-200212200-00022 · Cited by 1,131
THE ASCENDING CHOLINERGIC RETICULAR SYSTEM: NEOCORTICAL, OLFACTORY AND SUBCORTICAL PROJECTIONS
Shute, C. C. D., & Lewis, P. R. (1967) · Brain · doi:10.1093/brain/90.3.497 · Cited by 1,120
EEG-correlated fMRI of human alpha activity
Laufs, H., Kleinschmidt, A., Beyerle, A., Eger, E., Salek-Haddadi, A., Preibisch, C., & Krakow, K. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00286-6 · Cited by 1,025
Lewis, P. R., & Shute, C. C. D. (1967) · Brain · doi:10.1093/brain/90.3.521 · Cited by 969
Simultaneous EEG and fMRI of the alpha rhythm
Stern (2002) · Neuroreport · doi:10.1097/01.wnr.0000047685.08940.d0 · Cited by 945
A shift of visual spatial attention is selectively associated with human EEG alpha activity
Sauseng, P., Klimesch, W., Stadler, W., Schabus, M., Doppelmayr, M. M., Hanslmayr, S., Gruber, W. R., & Birbaumer, N. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04482.x · Cited by 847
Prestimulus Oscillatory Activity in the Alpha Band Predicts Visual Discrimination Ability
van Dijk, H., Schoffelen, J., Oostenveld, R., & Jensen, O. B. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1853-07.2008 · Cited by 831
Mitra, P. P., & Bokil, H. (2007) · doi:10.1093/acprof:oso/9780195178081.001.0001 · Cited by 827
Kelly, S. P., Lalor, E. C., Reilly, R. B., & Foxe, J. J. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01234.2005 · Cited by 715
Influence of heart rate on the BOLD signal: The cardiac response function
Chang, C., Cunningham, J. P., & Glover, G. H. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.029 · Cited by 682
Birn, R. M., Smith, M. A., Jones, T. B., & Bandettini, P. A. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.059 · Cited by 651
Exploring the Thalamus and Its Role in Cortical Function
Sherman, S. M., & Guillery, R. W. (2005) · The MIT Press eBooks · doi:10.7551/mitpress/2940.001.0001 · Cited by 646
High-field MRI of brain cortical substructure based on signal phase
Duyn, J. H., van Gelderen, P., Li, T., de Zwart, J. A., Koretsky, A. P., & Fukunaga, M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610821104 · Cited by 641
Self-citationPhysiological basis of the alpha rhythm
Purpura, D. P. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90182-5 · Cited by 599
Correlates of alpha rhythm in functional magnetic resonance imaging and near infrared spectroscopy
Moosmann, M., Ritter, P., Krastel, I., den Brink, A. M.-V., Thees, S., Blankenburg, F., Taskin, B., Obrig, H., & Villringer, A. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00344-6 · Cited by 595
Johansen‐Berg, H., Behrens, T. E. J., Sillery, E., Ciccarelli, O., Thompson, A. J., Smith, S. M., & Matthews, P. M. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh105 · Cited by 571
Thalamic Mechanisms of EEG Alpha Rhythms and Their Pathological Implications
Hughes, S. W., & Crunelli, V. (2005) · The Neuroscientist · doi:10.1177/1073858405277450 · Cited by 565
Parieto-occipital ∼1 0Hz activity reflects anticipatory state of visual attention mechanisms
Foxe, J. J., Simpson, G. V., & Ahlfors, S. P. (1998) · NeuroReport · doi:10.1097/00001756-199812010-00030 · Cited by 543
Physiological Basis of the Alpha Rhythm
Andersen, P. N., & Andersson, S. A. (1968) · Medical Entomology and Zoology · Cited by 540
Sadaghiani, S., Scheeringa, R., Lehongre, K., Morillon, B., Giraud, A.-L., & Kleinschmidt, A. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1004-10.2010 · Cited by 504
Cognitive and Perceptual Functions of the Visual Thalamus
Saalmann, Y. B., & Kästner, S. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.027 · Cited by 461
Intrinsic functional relations between human cerebral cortex and thalamus
Zhang, D., Snyder, A. Z., Fox, M. D., Sansbury, M. W., Shimony, J. S., & Raichle, M. E. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90463.2008 · Cited by 437
Lopes, F. H. D. S., Vos, J. E., Mooibroek, J. J., & van Rotterdam, A. (1980) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(80)90011-5 · Cited by 425
The functional logic of cortico-pulvinar connections
Shipp, S. (2003) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2002.1213 · Cited by 411 · cited 1×
“6a) and anatomical (Shipp, 2003) connections between Pul and the cortex make Pul well suitable to behave as a thalamic control unit for the widespread cortical alpha activity.”
A new method for improving functional-to-structural MRI alignment using local Pearson correlation
Saad, Z. S., Glen, D. R., Chen, G., Beauchamp, M. S., Desai, R., & Cox, R. W. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.09.037 · Cited by 405
Alpha rhythms as physiological and abnormal phenomena
Niedermeyer, E. (1997) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(97)00754-x · Cited by 376
EEG-vigilance and BOLD effect during simultaneous EEG/fMRI measurement
Olbrich, S., Mulert, C., Karch, S., Trenner, M. U., Leicht, G., Pogarell, O. M., & Hegerl, U. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.014 · Cited by 368
Cortical and Subcortical Correlates of Electroencephalographic Alpha Rhythm Modulation
Feige, B., Scheffler, K., Esposito, F., Salle, F. D., Hennig, J., & Seifritz, E. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00721.2004 · Cited by 362
Arousal--Revisiting the Reticular Activating System
Steriade, M. (1996) · Science · doi:10.1126/science.272.5259.225 · Cited by 350
Temporal Framing of Thalamic Relay-Mode Firing by Phasic Inhibition during the Alpha Rhythm
Lörincz, M. L., Kékesi, K. A., Juhász, G. D., Crunelli, V., & Hughes, S. W. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.012 · Cited by 348
Pulvinar contributions to the dorsal and ventral streams of visual processing in primates
Kaas, J. H., & Lyon, D. C. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.02.008 · Cited by 344
Distinct functions for direct and transthalamic corticocortical connections
Sherman, S. M., & Guillery, R. W. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00429.2011 · Cited by 336
Stereotactic Atlas of the Human Thalamus and Basal Ganglia
Morel, A. (2007) · CRC Press eBooks · doi:10.3109/9781420016796 · Cited by 329
Organization of thalamic and cortical alpha rhythms: Spectra and coherences
Lopes, F. H. D. S., van Lierop, T. H. M. T., Schrijer, C. F., & van Leeuwen, W. S. (1973) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(73)90216-2 · Cited by 326
The hemodynamic response of the alpha rhythm: An EEG/fMRI study
de Munck, J. C., Goncalves, S. I., Huijboom, L., Kuijer, J. P. A., Pouwels, P. J. W., Heethaar, R. M., & Lopes, F. H. D. S. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.01.022 · Cited by 260
Functional Imaging of the Human Lateral Geniculate Nucleus and Pulvinar
Kastner, S., O'Connor, D. H., Fukui, M. M., Fehd, H. M., Herwig, U., & Pinsk, M. A. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00553.2003 · Cited by 228
Pulvinar Inactivation Disrupts Selection of Movement Plans
Wilke, M., Turchi, J. N., Smith, K., Mishkin, M., & Leopold, D. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0953-10.2010 · Cited by 191
Michel, C. M., Lehmann, D., Henggeler, B., & Brandeis, D. (1992) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(92)90180-p · Cited by 190
Snow, J. C., Allen, H. A., Rafal, R. D., & Humphreys, G. W. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810086106 · Cited by 188
Neural networks for generation and suppression of alpha rhythm
Sadato, N., Nakamura, S., Oohashi, T., Nishina, E., Fuwamoto, Y., Waki, A., & Yonekura, Y. (1998) · Neuroreport · doi:10.1097/00001756-199803300-00024 · Cited by 158
de Zwart, J. A., van Gelderen, P., Kellman, P., & Duyn, J. H. (2002) · Magnetic Resonance in Medicine · doi:10.1002/mrm.10303 · Cited by 145
Self-citationNeural activity in the visual thalamus reflects perceptual suppression
Wilke, M., Mueller, K.-M., & Leopold, D. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900714106 · Cited by 144
Relations between PET-derived measures of thalamic glucose metabolism and EEG alpha power
Larson, C. L., Davidson, R. J., Abercrombie, H. C., Ward, R. T., Schaefer, S. M., Jackson, D. C., Holden, J. E., & Perlman, S. B. (1998) · Psychophysiology · doi:10.1111/1469-8986.3520162 · Cited by 135
Steriade, M. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90064-6 · Cited by 121
Metzger, C. D. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00138 · Cited by 114
Lindgren, K. A., Larson, C. L., Schaefer, S. M., Abercrombie, H. C., Ward, R. T., Oakes, T. R., Holden, J. E., Perlman, S. B., Benca, R. M., & Davidson, R. J. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00350-3 · Cited by 110
Statistical feature extraction for artifact removal from concurrent fMRI-EEG recordings
Liu, Z., de Zwart, J. A., van Gelderen, P., Kuo, L.-W., & Duyn, J. H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.042 · Cited by 97
Self-citationDavis, B. M., Fundín, B. T., Albers, K. M., Goodness, T. P., Cronk, K. M., & Rice, F. L. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19971103)387:4 · Cited by 90
EEG Alpha Rhythm and Glucose Metabolic Rate in the Thalamus in Schizophrenia
Dános, P., Guich, S., Abel, L., & Buchsbaum, M. S. (2001) · Neuropsychobiology · doi:10.1159/000054901 · Cited by 65
Elias, W. J., Zheng, Z. A., Domer, P., Quigg, M., & Pouratian, N. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.049 · Cited by 54
Buchsbaum, M. S., KESSLER, R. M., King, A. C., Johnson, J., & Cappelletti, J. (1984) · Progress in brain research · doi:10.1016/s0079-6123(08)62182-2 · Cited by 48
A 10 Hz “alpha-like” rhythm in the visual cortex of the waking cat
Chatila, M., Milleret, C., Buser, P., & Rougeul, A. (1992) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(92)90147-a · Cited by 48
Dissociating Vision and Visual Attention in the Human Pulvinar
Smith, A. T., Cotton, P. L., Bruno, A., & Moutsiana, C. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90963.2008 · Cited by 41
EEG-fMRI reciprocal functional neuroimaging
Yang, L., Liu, Z., & He, B. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2010.02.153 · Cited by 31
Self-citationAlpha rhythm in the cat thalamus.
Chatila, M., Milleret, C., Rougeul, A., & Buser, P. (1993) · PubMed · Cited by 30
Lukashevich, I. P., & Sazonova, O. B. (1997) · PubMed · Cited by 12
Glover (2000) · doi:10.1002/1522-2594(200007)44:1
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Tracking brain arousal fluctuations with fMRI
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Metadata
- Authors
- Liu, Z., de Zwart, J. A., Yao, B., van Gelderen, P., Kuo, L.-W., & Duyn, J. H.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Liu, Zhongming
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 63
- Issue
- 3
- Pages
- 1060-1069
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3472152
- OpenAlex
- W1996197465
- Cited by
- 104
- References
- 66
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 7 · 2023: 9 · 2022: 10 · 2021: 8 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 6 · 2016: 7 · 2015: 11 · 2014: 4 · 2013: 3
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke, National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- thalamus, BOLD signal, EEG-fMRI correlation, pulvinar, lateral geniculate nucleus, visual thalamus, functional connectivity, eyes-closed state
- MeSH terms
- Alpha Rhythm, Brain Mapping, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Neural Pathways, Thalamus
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