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Neuroanatomical analysis of the BTBR mouse model of autism using magnetic resonance imaging and diffusion tensor imaging
Open accessAbstract
Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits, and repetitive behaviors with restricted interests. Autism-relevant phenotypes in the inbred mouse strain BTBR T+tf/J (BTBR) offer translational tools to discover biological mechanisms underlying unusual mouse behaviors analogous to symptoms of autism. Two of the most consistent findings with BTBR are lack of sociability as measured by the three-chamber social approach task and increased amount of time engaged in self-grooming in an empty cage. Here we evaluated BTBR as compared to two typical inbred strains with high sociability and low self-grooming, C57BL/6J (B6) and FVB/AntJ (FVB), on both the automated three-chambered social approach task and repetitive self-grooming assays. Brains from the behaviorally tested mice were analyzed using magnetic resonance imaging and diffusion tensor imaging to investigate potential neuroanatomical abnormalities throughout the brain; specifically, to discover neuroanatomical mechanisms which could explain the autism-relevant behavioral abnormalities. Significant differences in volume and white matter microstructure were detected in multiple anatomical regions throughout the brain of BTBR compared to B6 and FVB. Further, significant correlations were found between behavioral measures and areas of the brain known to be associated with those behaviors. For example, striatal volume was strongly correlated to time spent in self-grooming across strains. Our findings suggest that neuropathology exists in BTBR beyond the previously reported white matter abnormalities in the corpus callosum and hippocampal commissure and that these brain differences may be related to the behavioral abnormalities seen in BTBR.
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“The most striking neuroanatomical features of BTBR mice are the absence of corpus callosum and the extremely reduced hippocampal commissure, observed by diffusion tensor tractography and on histologic preparations [87, 96, 367].”
From Autism spectrum disorder: neuropathology and animal models (2017) · cites this paper as [96]
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Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Diagnostic and Statistical Manual of Mental Disorders.
Widiger, T. A. (2000) · Oxford University Press eBooks · doi:10.1037/10518-009 · Cited by 19,766
Thresholding of statistical maps in functional neuroimaging using the false discovery rate
Genovese, C. R., Lazar, N. A., & Nichols, T. (2002) · NeuroImage · doi:10.1006/nimg.2001.1037 · Cited by 4,923
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space
Collins, D. L., Neelin, P., Peters, T. M., & Evans, A. C. (1994) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199403000-00005 · Cited by 3,431 · cited 2×
“All registrations were performed using a combination of the mni_autoreg tools (Collins et al., 1994) and ANTS (Avants et al.”
MethodThe Social Brain: Neural Basis of Social Knowledge
Adolphs, R. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163514 · Cited by 1,827
Amaral, D. G., Schumann, C. M., & Nordahl, C. W. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2007.12.005 · Cited by 1,492
Behavioural phenotyping assays for mouse models of autism
Silverman, J. L., Yang, M., Lord, C., & Crawley, J. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2851 · Cited by 1,462
Self-citationAutism and Abnormal Development of Brain Connectivity: Figure 1.
Belmonte, M. K., Allen, G., Beckel-Mitchener, A., Boulanger, L. M., Carper, R. A., & Webb, S. J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3340-04.2004 · Cited by 1,217
Agenesis of the corpus callosum: Genetic, developmental and functional aspects of connectivity
Paul, L. K., Brown, W. S., Adolphs, R., Tyszka, J. M., Richards, L. J., Mukherjee, P., & Sherr, E. H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2107 · Cited by 830
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Items 101–135 of 135
Carbamoylated Erythropoietin Rescues Autism-Relevant Social Deficits in BALB/cJ Mice
Street, A. L., Thakkar, V. P., Lemke, S. W., Schoenbeck, L. M., Schumacher, K. M., Sathyanesan, M., Newton, S. S., & Kloth, A. D. (2025) · NeuroSci · doi:10.3390/neurosci6010025 · Cited by 3
Xu, X., Tan, L. H., & Zhang, X. (2025) · ALPHA PSYCHIATRY · doi:10.31083/ap39444 · Cited by 3
Redecker, T. M., Kisko, T. M., Wöhr, M., & Schwarting, R. K. W. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112974 · Cited by 3
Khan, T., Cherkas, K., & Francis, N. A. (2025) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2025.1602205 · Cited by 2
Myelin, white matter, and social deficits in autism spectrum disorder
Kimchi-Feldhorn, O., Nir, A., & Barak, B. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-25-00366 · Cited by 4
Eissa, N., Alwattar, J. K., Jayaprakash, P., Chkier, D., Ahmed, A., Ahmed, A., Rizwan, R., Mujeeb, S., Rahal, M. K., & Sadek, B. S. (2025) · International Journal of Nanomedicine · doi:10.2147/ijn.s509158 · Cited by 2
Pervolaraki, E., Tyson, A. L., Pibiri, F., Poulter, S. L., Reichelt, A. C., Rodgers, R. J., Clapcote, S. J., Lever, C., Andreae, L. C., & Dachtler, J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/300806 · Cited by 2
Zhang, K., Germann, J., Matin, R., Mithani, K., Ellegood, J., Suresh, H., Wong, S., Lerch, J. P., Nieman, B. J., Taylor, M. J., et al. (2026) · Science Advances · doi:10.1126/sciadv.aeb5842 · Cited by 1
Self-citationNeuroimaging Phenotypes in Zebrafish
Ullmann, J. F. P., & Janke, A. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-33774-6_13 · Cited by 1
Bolivar, V. J. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.012 · Cited by 1
Rodent Models for ASD Biomarker Development
Lee, H. H. C., & Şahin, M. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-69491-2_8 · Cited by 2
Kosaki, Y., & Mihara, R. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115752 · Cited by 1
Multiscale comparative connectomics
Gopalakrishnan, V., Chung, J., Bridgeford, E., Pedigo, B. D., Arroyo, J., Upchurch, L., Johnson, G. A., Wang, N., Park, Y., Priebe, C. E., et al. (2025) · Imaging Neuroscience · doi:10.1162/imag.a.2 · Cited by 2
Acetaminophen Associated Neurotoxicity and its Relevance to Neurodevelopmental Disorders
Kim, S.-H. (2017) · Digital Commons - University of South Florida (University of South Florida) · Cited by 1
Heritability of the Mouse Brain ConnectomePreprint
Wang, N., Anderson, R. J., Ashbrook, D. G., Gopalakrishnan, V., Park, Y., Priebe, C. E., Qi, Y. P., Vogelstein, J. T., Williams, R. W., & Johnson, G. A. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/701755 · Cited by 1
Social dysfunction and mental retardation
Pietropaolo, S., Sluyter, F., & Crusio, W. E. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107360556.010
Transitive inference task in mice using a touchscreen assay
Ago, Y. (2014) · Folia Pharmacologica Japonica · doi:10.1254/fpj.144.45
Imaging mouse models of neurodegeneration using multi-parametric MRI
Holmes, H. (2015) · UCL Discovery (University College London)
Ford, A. (2017) · OpenCommons - UConn (University of Connecticut)
Rendall, A. R. (2017) · OpenCommons at University of Connecticut (University of Connecticut)
Ellegood, J., Petkova, S. P., Kinman, A. I., Qiu, L. R., Wade, A. A., Fernandes, D., Lindenmaier, Z., Crieghton, A., Nutter, L. M. J., Nord, A. S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.31.017905
Self-citationChromatin Dynamics and Genetic Variation Combine to Regulate Innate Immune Memory.
Kim, J. S., & Ciernia, A. V. (2020) · PubMed
Molecular mechanisms underlying malformations of cortical development
Oishi, S. (2020) · The University of Queensland · doi:10.14264/uql.2020.1023
Richards, K., Coulthard, L. I., Rome, C., Collyer, T. A., Karle, T. J., Beare, R. J., & Petrou, S. (2021) · Neuroimage Reports · doi:10.1016/j.ynirp.2021.100023
The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease
So, P., Ashraf, A., Durieux, A. M. S., Crum, W. R., & Bell, J. D. (2018) · Springer eBooks · doi:10.1007/978-3-319-28388-3_95 · Cited by 1
The Application of In Vivo MRI and MRS in Phenomic Studies of Murine Models of Disease
So, P., Ashraf, A., Durieux, A. M. S., Crum, W. R., & Bell, J. D. (2017) · Springer eBooks · doi:10.1007/978-3-319-28275-6_95-1
Effect of draxin manipulation on BTBR mouse brain and behavior
Blau, A. (2020) · Scholars Archive - University at Albany (University at Albany, State University of New York) · doi:10.54014/pfxg-99pj
Fantegrossi, W. E., Shaw, H. E., Fagot, S. A., Thomas, K., & Kaur, H. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06908-6
Choi, S. E., Ayoub, T., Lee, G., Wheeler, A. L., Guger, S., Weksberg, R., Ito, S., Schachar, R. J., Hitzler, J. K., & Nieman, B. J. (2025) · NeuroToxicology · doi:10.1016/j.neuro.2025.103363
Kawamura, A., Abe, Y., Seki, F., Katayama, Y., Nishiyama, M., Takata, N., Tanaka, K. F., Okano, H., & Nakayama, K. I. (2020) · Figshare · doi:10.6084/m9.figshare.13279529
Filiz, K. D., Abate, N., Pizzella, A., Ferraro, M. G., Speranza, L., Cristiano, C., Mollica, M. P., Giaimo, R. D., Miniaci, M. C., Lacivita, E., et al. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.178689
Tsybko, A. S., Ilchibaeva, T. V., Petrovskii, D., Silvanovich, E. K., Kim, V., Хоцкин, Н. В., Romashchenko, A. V., & Naumenko, V. S. (2026) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2026.111656
Metadata
- Authors
- Ellegood, J., Babineau, B. A., Henkelman, R. M., Lerch, J. P., & Crawley, J. N.
- Affiliations
- Hospital for Sick Children (CA)
- National Institute of Mental Health (US)
- University of Toronto (CA)
- Corresponding author
- Ellegood, Jacob
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 70
- Pages
- 288-300
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3595420
- OpenAlex
- W2096358139
- Cited by
- 135
- References
- 87
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 5 · 2023: 5 · 2022: 9 · 2021: 7 · 2020: 15 · 2019: 9 · 2018: 14 · 2017: 12 · 2016: 9 · 2015: 11 · 2014: 17 · 2013: 5
- FWCI
- 5.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ontario Mental Health Foundation
- Canadian Institute for Health Research
- National Institute of Mental Health Intramural Research Program
- Ontario Brain Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, sociability, self-grooming, repetitive behavior, striatal volume, white matter microstructure, corpus callosum, hippocampal commissure, brain volume, inbred mouse strains
- MeSH terms
- Animals, Autistic Disorder, Behavior, Animal, Brain, Disease Models, Animal, Female, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Mice, Inbred Strains, Mice, Diffusion Tensor Imaging
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