Motor and cognitive stereotypies in the BTBR T+tf/J mouse model of autism
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The BTBR T+tf/J inbred mouse strain displays a variety of persistent phenotypic alterations similar to those exhibited in autism spectrum disorders (ASDs). The unique genetic background of the BTBR strain is thought to underlie its lack of reciprocal social interactions, elevated repetitive self-directed grooming, and restricted exploratory behaviors. In order to clarify the existence, range, and mechanisms of abnormal repetitive behaviors within BTBR mice, we performed detailed analyses of the microstructure of self-grooming patterns and noted increased overall grooming, higher percentages of interruptions in grooming bouts and a concomitant decrease in the proportion of incorrect sequence transitions compared to C57BL/6J inbred mice. Analyses of active phase home-cage behavior also revealed an increase in stereotypic bar-biting behavior in the BTBR strain relative to B6 mice. Finally, in a novel object investigation task, the BTBR mice exhibited greater baseline preference for specific unfamiliar objects as well as more patterned sequences of sequential investigations of those items. These results suggest that the repetitive, stereotyped behavior patterns of BTBR mice are relatively pervasive and reflect both motor and cognitive mechanisms. Furthermore, other pre-clinical mouse models of ASDs may benefit from these more detailed analyses of stereotypic behavior.
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BTBR T+tf/J mice display behavioral phenotypes relevant to all three diagnostic symptoms of autism.
“BTBR T+tf/J (BTBR) is a commercially available inbred strain of mouse that displays behavioral phenotypes relevant to all three diagnostic symptoms of autism (60–62, 64, 66, 68–70, 72, 74–78).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [69]
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Intact and impaired executive abilities in the BTBR mouse model of autism
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Mecp2 Truncation in Male Mice Promotes Affiliative Social Behavior
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Self-citation
- Authors
- Pearson, B. L., Pobbe, R. L. H., Defensor, E. B., Oasay, L., Bolivar, V. J., Blanchard, D. C., & Blanchard, R. J.
- Affiliations
- University of Hawaiʻi at Mānoa (US)
- New York State Department of Health (US)
- Corresponding author
- Pearson, B. L.
- Venue
- Genes, Brain and Behavior
- Publisher
- Wiley
- Published
- 2010-11-04
- Volume
- 10
- Issue
- 2
- Pages
- 228-235
- ISSN
- 1601-183X (ISSN-L)
- 1601-1848
- PMC
- PMC3037433
- OpenAlex
- W2072319418
- Cited by
- 171
- References
- 47
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 4 · 2022: 11 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 11 · 2017: 8 · 2016: 11 · 2015: 18 · 2014: 25 · 2013: 14 · 2012: 19
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Genes Brain & Behavior (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH081845, MH081845)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, mouse models of autism, repetitive behavior, stereotypy, self-grooming, home cage behavior, object preference, C57BL/6J mice, motor stereotypies
- MeSH terms
- Animals, Autistic Disorder, Cognition, Disease Models, Animal, Exploratory Behavior, Grooming, Male, Mice, Inbred C57BL, Mice, Neurologic Mutants, Motor Activity, Video Recording, Stereotypic Movement Disorder, Mice
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