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The salience network is responsible for switching between the default mode network and the central executive network: Replication from DCM
Open accessAbstract
With the advent of new analysis methods in neuroimaging that involve independent component analysis (ICA) and dynamic causal modelling (DCM), investigations have focused on measuring both the activity and connectivity of specific brain networks. In this study we combined DCM with spatial ICA to investigate network switching in the brain. Using time courses determined by ICA in our dynamic causal models, we focused on the dynamics of switching between the default mode network (DMN), the network which is active when the brain is not engaging in a specific task, and the central executive network (CEN), which is active when the brain is engaging in a task requiring attention. Previous work using Granger causality methods has shown that regions of the brain which respond to the degree of subjective salience of a stimulus, the salience network, are responsible for switching between the DMN and the CEN (Sridharan et al., 2008). In this work we apply DCM to ICA time courses representing these networks in resting state data. In order to test the repeatability of our work we applied this to two independent datasets. This work confirms that the salience network drives the switching between default mode and central executive networks and that our novel technique is repeatable.
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“The SN has been implicated in switching between these networks and in processing self-relevant emotional information (Goulden et al., 2014; Kaiser et al., 2015b).”
From Understanding and predicting future relapse in depression from resting state functional connectivity and self-referential processing (2023) · cites this paper as Goulden et al., 2014
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“Together, the VLPFC-anterior insula have been shown to form a fronto-insular functional node implicated in switching between salience and executive control networks (Goulden et al., 2014; Sridharan et al., 2008).”
From Neural correlates of emotion acceptance vs worry or suppression in generalized anxiety disorder (2017) · cites this paper as Goulden et al., 2014
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“This switching is crucial for directing attention to either internal or external stimuli, ensuring efficient cognitive processing 25 .”
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“Although structural atrophy and white matter decline are common across multiple brain systems in aging, the SN may be particularly sensitive to disruptions in structure–function integration due to its pivotal role in network switching and brain state transitions [104–106].”
Iordan, A. D. (2016) · Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign) · Cited by 2
Neuroimaging Studies of Effects of Psychotherapy in Depression
Bauer, I. E., & Meyer, T. D. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.021 · Cited by 2
Recovering Hidden Responder Groups in Individuals Receiving Neurofeedback for Tinnitus
Riha, C., Güntensperger, D., Kleinjung, T., & Meyer, M. E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.867704 · Cited by 2
Network based Identification of Dementia Onsets Using Structural MRI Network Signature
Adebisi, A. T., Gonuguntla, V., Lee, H., Hahm, M. H., & Veluvolu, K. C. (2022) · IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm55620.2022.9995588 · Cited by 2
“…signature networks are divided into salient, default mode and other region networks, where other region networks are the regions that are neither in salience nor default mode networks based on previous classification of cortical regions into various networks on the basis of their importance [23].”
BackgroundRidder, D. D., Smith, M. L., & Adhia, D. B. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89827-0.00016-4 · Cited by 2
Wang, X., Zhou, X., Li, J., Gong, Y., & Feng, Z. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1253727 · Cited by 2
Markovic, G., Li, T., & Persson, H. (2024) · Journal of Rehabilitation Medicine – Clinical Communications · doi:10.2340/jrmcc.v7.12436 · Cited by 2
“PCC plays a pivotal role in regulating the focus of attention (42) and is reported to be a part of the default mode network (DMN), the task negative network (3, 4).”
BackgroundLei, Z., Jin, Z., Xie, K., Li, S., Feng, L., Zhang, J., & Li, L. (2024) · NeuroImage · doi:10.1016/j.neuroimage.2024.120552 · Cited by 2
“…of a salience network, is responsible for salience-processing systems and switching between large-scale brain networks (e.g., the frontoparietal network and the default mode network) to facilitate the allocation of attentional resources (Bressler and Menon, 2010; Goulden et al., 2014; Uddin, 2015).”
BackgroundThalamocortical dysrhythmia and reward deficiency syndrome as uncertainty disorders
Ridder, D. D., & Vanneste, S. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.11.002 · Cited by 3
Kayış, H., Akyel, B., Yüncü, Z., Bora, E., & Zorlu, N. (2024) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2024.111916 · Cited by 2
Sex differences in resting-state fMRI functional connectivity related to humor styles
Chang, C.-Y., Chan, Y., Chen, I.-F., & Chen, H. (2025) · Biological Psychology · doi:10.1016/j.biopsycho.2025.108983 · Cited by 2
Evans, I. D., Sharpley, C. F., Bitsika, V., Vessey, K. A., Williams, R. J., Jesulola, E., & Agnew, L. L. (2025) · Applied Sciences · doi:10.3390/app15031459 · Cited by 2
Durak, S. F., Tahıllıoğlu, A., Songür, Ç. Y., Çoban, M., Varol, B., & Ercan, E. S. (2025) · Applied Neuropsychology Child · doi:10.1080/21622965.2025.2493812 · Cited by 2
Son, J. J., Rice, D. L., Schantell, M. D., Picci, G., Okelberry, H. J., Coutant, A. T., Ende, G. C., Wang, Y., Stephen, J. M., Calhoun, V. D., et al. (2025) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsaf037 · Cited by 2
“Evidence suggests that the insula-anchored salience network is responsible for evaluating the relevance of stimuli, relating them to goals and output behaviours, and contributing to the relative engagement of the frontoparietal and default mode networks (Menon 2011, Goulden et al. 2014).”
Borrell, L. R., Venezia, A. C., & Smith, J. C. (2025) · Brain Structure and Function · doi:10.1007/s00429-025-02952-2 · Cited by 2
“In line with predictions of the triple network model, increased connectivity between the DMN and CEN was observed in conjunction with increased degree (i.e., high number of connections) of the right anterior insula, a critical hub of SAL.”
InfluentialInvestigating Neural Dynamics in Tinnitus Using Constrained Independent Component Analysis
Altunkaya, S., Özmen, G., & Babür, E. (2025) · Brain Connectivity · doi:10.1177/21580014251362839 · Cited by 2
“…ICA algorithm was executed in the Group ICA of the fMRI Toolbox (GIFT, https://trendscenter.org/software/ gift/) using fi ve different RSN templates de fi ned by (Shirer et al., 2012) as prior spatial locations (Altunkaya et al., 2021; Chand et al., 2017; Goulden et al., 2014; Shirer et al., 2012).”
Study of extravisual resting-state networks in pituitary adenoma patients with vision restoration
Wang, F., Zhou, T., Wang, P., Li, Z., Meng, X., & Jiang, J. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00701-3 · Cited by 2
“Some studies have shown that the SN plays a role in the dynamic switching of antagonistic activity between the DMN and CEN in cognitively normal young brains [91, 98, 99].”
BackgroundNeuroimaging and the At-Risk Mental State
Lin, Y.-S., Fusar‐Poli, P., & Borgwardt, S. (2019) · Springer eBooks · doi:10.1007/978-3-319-97307-4_6 · Cited by 2
Functional Brain Imagery and Jungian Analytical Psychology: An Interesting Dance?
Petchkovsky, L., Petchkovsky, M., Morris, P., Dickson, P., Montgomery, D. T., Dwyer, J., Burnett, P., & Robertson-Gillam, K. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82414 · Cited by 2
Electrophysiological Biomarkers for Mood Disorders
Ramakrishnan, N., Murphy, N., Selvaraj, S., & Cho, R. Y. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108623018.015 · Cited by 2
Kamal, F., Morrison, C., Campbell, K. B., & Taler, V. (2021) · Neuroimage Reports · doi:10.1016/j.ynirp.2021.100074 · Cited by 2
“A separate salience network computes the salience of unattended stimulus inputs, forwarding this information to the frontoparietal network (Goulden et al., 2014).”
The default mode of chronic pain: What does it mean and how should we frame it to our patients?
Johansson, E., Coppieters, I., & Nijs, J. (2023) · Journal of Spine Practice (JSP) · doi:10.18502/jsp.v2i2.12678 · Cited by 2
Connectomic Networks and Their Impact on Clinical Outcomes in Glioma Treatment: A Review
Rawanduzy, C. A., Earl, E. R., Brooks, J. B., Khan, M., Dadario, N. B., Sughrue, M. E., & Karsy, M. J. (2023) · Indian Journal of Neurosurgery · doi:10.1055/s-0043-1771214 · Cited by 2
Sbaihat, H., Rajkumar, R., Ramkiran, S., Assi, A. A., Shah, N. J., Veselinović, T., & Neuner, I. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.26.428223 · Cited by 2
Chand, G. B., Thakuri, D. S., & Soni, B. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.03.471183 · Cited by 2
“This approach renders better representation of networks compared to choosing an average or first eigen-variate of a template (Chand et al., 2018; Craddock et al., 2012; Goulden et al., 2014; Shirer et al., 2012; Smith et al., 2011).”
BackgroundMethodInfluentialAltered Brain Network Functional Connectivity One Month Following Pediatric ConcussionPreprint
Healey, K., Fang, Z., Smith, A., Zemek, R. L., & Ledoux, A. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4055849 · Cited by 2
Metadata
- Authors
- Goulden, N., Khusnulina, A., Davis, N. J., Bracewell, R. M., Bokde, A. L., McNulty, J. P., & Mullins, P. G.
- Affiliations
- Bangor University (GB)
- Trinity College Dublin (IE)
- University College Dublin (IE)
- Corresponding author
- Goulden, Nia
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 99
- Pages
- 180-190
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2066208486
- Cited by
- 810
- References
- 47
- Citations by year
- 2026: 65 · 2025: 101 · 2024: 83 · 2023: 85 · 2022: 79 · 2021: 112 · 2020: 67 · 2019: 58 · 2018: 62 · 2017: 34 · 2016: 37 · 2015: 20 · 2014: 6
- FWCI
- 18.03
- Type
- journal article
- Language
- en
- Open access
- green
- e-space.mmu.ac.uk
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- e-space (Manchester Metropolitan University) (submittedVersion, other-oa)
- Funders
- European Regional Development Fund
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- salience network, default mode network, frontoparietal network, network switching, dynamic causal modeling, independent component analysis, resting state, Granger causality, reproducibility, brain connectivity
- MeSH terms
- Adult, Bayes Theorem, Brain Mapping, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Models, Neurological, Nerve Net, Rest, Stochastic Processes, Executive Function
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