Cited by 810Functional Brain Connectivity StudiesNeural dynamics and brain functionAdvanced Neuroimaging Techniques and Applications

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

The salience network is responsible for switching between the default mode network and the central executive network: Replication from DCM

Open access

Goulden, Nia, Khusnulina, Aygul, Davis, Nicholas J., Bracewell, Robert M., Bokde, Arun L., McNulty, Jonathan P., Mullins, Paul G.·2014·NeuroImage

DOI 10.1016/j.neuroimage.2014.05.052

Open this paper in CoChat — free account Open PDF

Abstract

With the advent of new analysis methods in neuroimaging that involve independent component analysis (ICA) and dynamic causal modelling (DCM), investigations have focused on measuring both the activity and connectivity of specific brain networks. In this study we combined DCM with spatial ICA to investigate network switching in the brain. Using time courses determined by ICA in our dynamic causal models, we focused on the dynamics of switching between the default mode network (DMN), the network which is active when the brain is not engaging in a specific task, and the central executive network (CEN), which is active when the brain is engaging in a task requiring attention. Previous work using Granger causality methods has shown that regions of the brain which respond to the degree of subjective salience of a stimulus, the salience network, are responsible for switching between the DMN and the CEN (Sridharan et al., 2008). In this work we apply DCM to ICA time courses representing these networks in resting state data. In order to test the repeatability of our work we applied this to two independent datasets. This work confirms that the salience network drives the switching between default mode and central executive networks and that our novel technique is repeatable.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2014.05.052

Cites

47 of 47 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
An Information-Maximization Approach to Blind Separation and Blind Deconvolution
Bell, A. J., & Sejnowski, T. J. (1995) · Neural Computation · doi:10.1162/neco.1995.7.6.1129 · Cited by 8,986
Independent component analysis: algorithms and applications
Hyvärinen, A., & Erkki Oja, A. (2000) · Neural Networks · doi:10.1016/s0893-6080(00)00026-5 · Cited by 8,926
Independent component analysis, A new concept?
Comon, P. (1994) · Signal Processing · doi:10.1016/0165-1684(94)90029-9 · Cited by 8,324
A fast diffeomorphic image registration algorithm
Ashburner, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.007 · Cited by 8,122
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426
How do you feel? Interoception: The sense of the physiological condition of the body
Craig, A. D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn894 · Cited by 6,006
Saliency, switching, attention and control: a network model of insula function
Menon, V., & Uddin, L. Q. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0262-0 · Cited by 5,592
Dynamic causal modelling
Friston, K. J., Harrison, L., & Penny, W. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00202-7 · Cited by 4,583

Show all 47 references

Sorted by citations

Items 201–300 of 809

Neural antagonistic mechanism between default-mode and task-positive networks
Cheng, X., Yuan, Y., Wang, Y., & Wang, R. (2020) · Neurocomputing · doi:10.1016/j.neucom.2020.07.079 · Cited by 39
Targeting the Salience Network: A Mini-Review on a Novel Neuromodulation Approach for Treating Alcohol Use Disorder
Padula, C. B., Tenekedjieva, L., McCalley, D. M., Al-Dasouqi, H., Hanlon, C. A., Williams, L. M., Kozel, F. A., Knutson, B. D., Durazzo, T. C., Yesavage, J. A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.893833 · Cited by 36
Altered intrinsic local activity and cognitive dysfunction in HIV patients: A resting-state fMRI study
Bak, Y., Jun, S., Choi, J. Y., Lee, Y., Lee, S., Han, S. H., & Shin, N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0207146 · Cited by 31
The list-composition effect in memory for emotional and neutral pictures: Differential contribution of ventral and dorsal attention networks to successful encoding
Barnacle, G. E., Montaldi, D., Talmi, D., & Sommer, T. (2016) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2016.06.023 · Cited by 35
“Although our investigation was particularly focussed on neural attentional effects, it should be acknowledged that our study may also provide supporting evidence for a task-switching function executed by the insula (Goulden et al., 2014; Sridharan et al., 2008).”
Aesthetic experience models human learning
Starr, G. G. (2023) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2023.1146083 · Cited by 43
Weakened effective connectivity between salience network and default mode network during resting state in adolescent depression
Willinger, D., Häberling, I. S., Ilioska, I., Berger, G. E., Walitza, S., & Brem, S. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1386984 · Cited by 30
A Combination of Essential Fatty Acids, Panax Ginseng Extract, and Green Tea Catechins Modifies Brain fMRI Signals in Healthy Older Adults
Carmichael, O. T., Pillai, S. R., Shankapal, P., McLellan, A., Kay, D. G., Gold, B. T., & Keller, J. N. (2018) · The journal of nutrition health & aging · doi:10.1007/s12603-018-1028-2 · Cited by 32
“Conversely, the default mode network shows highly structured, temporally synchronous patterns of BOLD signal fluctuations in the absence of an overt cognitive or sensory task (78), and this synchrony reduces markedly during performance of tasks (79-81).”
Aberrations of anterior insular cortex functional connectivity in nontreatment-seeking alcoholics
Halcomb, M., Chumin, E. J., Goñi, J., Džemidžić, M., & Yoder, K. K. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2018.12.016 · Cited by 33
Differential aberrant connectivity of precuneus and anterior insula may underpin the diagnosis of schizophrenia and mood disorders
Aryutova, K., Paunova, R., Kandilarova, S., Stoyanova, K., Maes, M. H. J., & Stoyanov, D. (2021) · World Journal of Psychiatry · doi:10.5498/wjp.v11.i12.1274 · Cited by 30
Impulsive Internet Game Play Is Associated With Increased Functional Connectivity Between the Default Mode and Salience Networks in Depressed Patients With Short Allele of Serotonin Transporter Gene
Hong, J. S., Kim, S. M., Bae, S., & Han, D. H. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00125 · Cited by 30
Large-Scale Network Connectivity and Cognitive Function Changes After Exercise Training in Older Adults with Intact Cognition and Mild Cognitive Impairment
Won, J., Nielson, K. A., & Smith, J. C. (2023) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-220062 · Cited by 34
“For example, the DMN is responsible for introspection and self-generated thoughts [8, 10], the FPN is responsible for higher-order cognitive processes [11], and the SAL is responsible for detecting and integrating relevant sensory information and the facilitation of switching between DMN and FPN engagement [12].”
Cortical and subcortical functional connectivity and cognitive impairment in Parkinson’s disease
Yeager, B. E., Twedt, H. P., Bruss, J., Schultz, J. L., & Narayanan, N. S. (2024) · NeuroImage Clinical · doi:10.1016/j.nicl.2024.103610 · Cited by 35
“…(SAL); frontoparietal network (FPN); and default mode network (DMN) (Aracil-Bola ˜ nos et al., 2019; Baggio et al., 2014, 2015; Chen et al., 2022; Goulden et al., 2014; Lewis et al., 2012; Lucas-Jim ´ enez et al., 2016; Putcha et al., 2015, 2016)) were selected for further analysis based on our…”
Altered functional connectivity of anterior cingulate cortex in chronic insomnia: A resting-state fMRI study
Wang, T., Ye, Y., Li, S., & Jiang, G. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.11.036 · Cited by 29
Pupillary response is associated with the reset and switching of functional brain networks during salience processing
He, H., Hong, L., & Sajda, P. (2023) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1011081 · Cited by 30
Letting the good times roll: adolescence as a period of reduced inhibition to appetitive social cues
Perino, M. T., Miernicki, M. E., & Telzer, E. H. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw096 · Cited by 33
“This finding is interesting as it broadly fits into the social-detection network as defined by Nelson et al. (2005) and has also been implicated as a key region involved in salience monitoring (Goulden et al. , 2014).”
Background
Neural Correlates of Outcome of the Psychotherapy Compared to Antidepressant Therapy in Anxiety and Depression Disorders: A Meta-Analysis
Kalsi, N., Altavilla, D., Tambelli, R., Aceto, P., Trentini, C., Di Giorgio, C., & Lai, C. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00927 · Cited by 26
“…cingulate and insula are involved in the Salience Network (Ham et al., 2013) which is responsible for switching between the default mode network (the network which is active during the rest when the brain is not engaged in a specific task) and the central executive network (Goulden et al., 2014).”
Background
The Forest versus the Trees: Creativity, Cognition and Imagination
Abraham, A. (2018) · Cambridge University Press eBooks · doi:10.1017/9781316556238.012 · Cited by 27
Levodopa Changes Functional Connectivity Patterns in Subregions of the Primary Motor Cortex in Patients With Parkinson’s Disease
Shen, Y., Hu, J., Chen, Y., Liu, W., Li, Y., Yan, L., Xie, C., Zhang, W., Yu, M., & Liu, W. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00647 · Cited by 28
A role for the anterior insular cortex in the global neuronal workspace model of consciousness
Michel, M. (2017) · Consciousness and Cognition · doi:10.1016/j.concog.2017.02.004 · Cited by 30
“The aI was recently supposed to take a functional role, along with the anterior cingulate cortex, as a part of a ‘‘Salience Network” (Chen et al., 2016; Goulden et al., 2014; Menon, 2015; Menon & Uddin, 2010; Uddin, 2014).”
Background
Increased Resting State Triple Network Functional Connectivity in Undergraduate Problematic Cannabis Users: A Preliminary EEG Coherence Study
Imperatori, C., Massullo, C., Carbone, G. A., Panno, A., Giacchini, M., Capriotti, C., Lucarini, E., Ramella-Zampa, B., Murillo‐Rodríguez, E., Machado, S. E. D. C., et al. (2020) · Brain Sciences · doi:10.3390/brainsci10030136 · Cited by 27
“, between task‐based and task‐free states) is assured by the regular activity of the SN [25,26], which includes the dorsal anterior cingulate cortex (dACC) and bilateral anterior insula [20].”
Background
Racial Differences in Insular Connectivity and Thickness and Related Cognitive Impairment in Hypertension
Chand, G. B., Wu, J., Qiu, D., & Hajjar, I. M. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00177 · Cited by 25
Executive Impairment in Alcohol Use Disorder Reflects Structural Changes in Large-Scale Brain Networks: A Joint Independent Component Analysis on Gray-Matter and White-Matter Features
Crespi, C., Galandra, C., Manera, M. R., Basso, G., Poggi, P., & Canessa, N. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02479 · Cited by 28
Acute effects of different types of cannabis on young adult and adolescent resting-state brain networks
Ertl, N., Freeman, T. P., Mokrysz, C., Ofori, S., Borissova, A., Petrilli, K., Curran, H. V., Lawn, W., & Wall, M. B. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01891-6 · Cited by 26
Insula-Medial Prefrontal Cortex Functional Connectivity Modulated by Transcutaneous Auricular Vagus Nerve Stimulation: An fMRI Study
Zhang, Y., Lin, P., Wang, R., Zhou, J., Xu, X., Jiang, W., Pu, X., & Ge, S. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3423019 · Cited by 27
“The insula, as a key component of the SN, is involved in regulating the balance between the DMN and the central executive network [42].”
Background
Potential Neural Mediators of Mom Power Parenting Intervention Effects on Maternal Intersubjectivity and Stress Resilience
Ho, S.-H. S., Muzik, M., Rosenblum, K. L., Morelen, D. M., Nakamura, Y., & Swain, J. E. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.568824 · Cited by 29
“The roles of the salience network in (a) conflict monitoring (49), (b) switching dynamic oscillations between the frontoparietal network (overlapping with the mirroring system) and the default-mode network (overlapping with the mentalizing system) during resting (66), and (c) representing signed prediction errors of r…”
BackgroundResult
Deep learning for sex classification in resting-state and task functional brain networks from the UK Biobank
Leming, M., & Suckling, J. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118409 · Cited by 20
Decreased Functional Connectivities of Low-Degree Level Rich Club Organization and Caudate in Post-stroke Cognitive Impairment Based on Resting-State fMRI and Radiomics Features
Miao, G., Rao, B., Wang, S., Fang, P., Chen, Z., Chen, L., Zhang, X., Zheng, J., Xu, H., & Liao, W. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.796530 · Cited by 29
Interaction of the salience network, ventral attention network, dorsal attention network and default mode network in neonates and early development of the bottom-up attention system
Onofrj, V., Chiarelli, A. M., Wise, R. G., Colosimo, C., & Caulo, M. (2022) · Brain Structure and Function · doi:10.1007/s00429-022-02477-y · Cited by 30
Sliding-window analysis tracks fluctuations in amygdala functional connectivity associated with physiological arousal and vigilance during fear conditioning
Bączkowski, B. M., Johnstone, T., Walter, H., Erk, S., & Veer, I. M. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.03.022 · Cited by 27
“…the detection of behaviorally salient events and has been implicated in dynamic switching between the DMN and the central executive network (Chen et al., 2013; Goulden et al., 2014; Jilka et al., 2014), which can be tracked by a physiological index of arousal (i.e., heart rate; Young et al., 2016).”
The cortical organization of language: distilling human connectome insights for supratentorial neurosurgery
Poologaindran, A., Lowe, S. R., & Sughrue, M. E. (2020) · Journal of neurosurgery · doi:10.3171/2020.5.jns191281 · Cited by 26
Altered Functional Connectivity Observed at Rest in Children and Adolescents Prenatally Exposed to Alcohol
Little, G. E., Reynolds, J. N., & Beaulieu, C. (2018) · Brain Connectivity · doi:10.1089/brain.2017.0572 · Cited by 24
“More recently, it has been suggested that the salience network modulates the switching between the DMN and the executive function network (Goulden et al., 2014), suggesting that the lower connectivity in FASD in both the salience and frontoparietal networks could be interrelated.”
Connections that characterize callousness: Affective features of psychopathy are associated with personalized patterns of resting-state network connectivity
Dotterer, H. L., Hyde, L. W., Shaw, D. S., Rodgers, E. L., Forbes, E. E., & Beltz, A. M. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102402 · Cited by 24
“A few studies have used a region of interest approach to examine connectivity among a priori, albeit differential, nodes within the DMN, SN, and CEN.”
Influential
Altered anterior insula functional connectivity in adolescent and young women with endometriosis-associated pain: Pilot resting-state fMRI study
Szabó, E., Timmers, I., Borsook, D., Simons, L. E., & Sieberg, C. B. (2022) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2022.10.004 · Cited by 24
The Insidious Influence of Stress: An Integrated Model of Stress, Executive Control, and Psychopathology
Quinn, M. E., & Shields, G. S. (2023) · Clinical Psychological Science · doi:10.1177/21677026221149736 · Cited by 28
Psychopathic traits associated with abnormal hemodynamic activity in salience and default mode networks during auditory oddball task
Anderson, N. E., Maurer, J. M., Steele, V. R., & Kiehl, K. A. (2018) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-018-0588-2 · Cited by 25
Opposing patterns of neuronal variability in the sensorimotor network mediate cyclothymic and depressive temperaments
Conio, B., Magioncalda, P., Martino, M., Tumati, S., Capobianco, L., Escelsior, A., Adavastro, G., Russo, D., Amore, M., Inglese, M., et al. (2018) · Human Brain Mapping · doi:10.1002/hbm.24453 · Cited by 25
The interplay between insomnia symptoms and Alzheimer’s disease across three main brain networks
Elberse, J. D., Saberi, A., Ahmadi, R., Changizi, M., Bi, H., Hoffstaedter, F., Mander, B. A., Eickhoff, S. B., Tahmasian, M., & Initiative, A. D. N. (2024) · SLEEP · doi:10.1093/sleep/zsae145 · Cited by 25
“DMN hyperactivity may some-times be a result of inadequate downregulation by the SN, i.e. the inadequate suppression of mind wandering and rumination when required [56].”
BackgroundInfluential
The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research
Li, X., Kass, G., Wiers, C. E., & Shi, Z. (2024) · Current Addiction Reports · doi:10.1007/s40429-024-00593-9 · Cited by 28
“The seminal paper by Sridharan et al. [16], later replicated by Goulden et al. using a different methodology [ 17], evidenced the role of the SN in cognitive flexibility, facilitating the switch between DMN and CEN in response to internally and externally salient stimuli, respectively [8, 9, 13,…”
Method
Excessive Functional Coupling With Less Variability Between Salience and Default Mode Networks in Autism Spectrum Disorder
Chen, Y., Uljarević, M., Neal, J., Greening, S. G., Yim, H., & Lee, T. (2021) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2021.11.016 · Cited by 29
Structural disconnectome mapping of cognitive function in poststroke patients
Kolskår, K. K., Ulrichsen, K. M., Richard, G., Dørum, E. S., de Schotten, M. T., Rokicki, J., Sánchez, J. M., Engvig, A., Hansen, H. I., Nordvik, J. E., et al. (2022) · Brain and Behavior · doi:10.1002/brb3.2707 · Cited by 24
“Importantly, these network nodes are suggested to mediate regulation and differentiation between the frontoparietal, ventral attention, and default mode networks (Goulden et al., 2014; Menon & Uddin, 2010).”
Background
Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects
Mallio, C. A., Bernetti, C., Agostini, F., Mangone, M., Paoloni, M., Santilli, G., Martina, F. M., Quattrocchi, C. C., Zobel, B. B., & Bernetti, A. (2022) · Diagnostics · doi:10.3390/diagnostics13010054 · Cited by 24
“It is responsible for integrating external information, previous experiences, and a concurrent homeostatic state, in order to orient attention [64].”
Background
Working memory load-dependent changes in cortical network connectivity estimated by machine learning
Eryilmaz, H., Dowling, K. F., Hughes, D., Rodriguez-Thompson, A., Tanner, A. S., Huntington, C., Coon, W. G., & Roffman, J. L. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116895 · Cited by 24
“High prevalence of VAN connectivity with DMN, DAN, and FPCN among the primary discriminative features is also consistent with the putative salience network function of switching between large-scale networks to facilitate access to attentional resources (Goulden et al., 2014; Menon and Uddin, 2010).”
Altered spontaneous neuronal activity and functional connectivity pattern in primary angle-closure glaucoma: a resting-state fMRI study
Wang, R., Tang, Z., Liu, T., Sun, X., Wu, L., & Xiao, Z. (2020) · Neurological Sciences · doi:10.1007/s10072-020-04577-1 · Cited by 23
Evoked and intrinsic brain network dynamics in children with autism spectrum disorder
Kupis, L. B., Romero, C., Dirks, B., Hoang, S., Parlade, M. V., Beaumont, A. L., Cardona, S. M., Alessandri, M., Chang, C., Nomi, J. S., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102396 · Cited by 22
Increased decision latency in alcohol use disorder reflects altered resting-state synchrony in the anterior salience network
Canessa, N., Basso, G., Carne, I., Poggi, P., & Gianelli, C. (2021) · Scientific Reports · doi:10.1038/s41598-021-99211-1 · Cited by 22
Triple Network Functional Connectivity During Acute Stress in Adolescents and the Influence of Polyvictimization
Corr, R., Glier, S., Bizzell, J., Pelletier‐Baldelli, A., Campbell, A., Killian-Farrell, C., & Belger, A. (2022) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2022.03.003 · Cited by 23
“impaired ability to switch between these networks during stress (46).”
Background
Attentional switch to memory: An early and critical phase of the cognitive cascade allowing autobiographical memory retrieval
Servais, A., Hurter, C., & Barbeau, E. J. (2023) · Psychonomic Bulletin & Review · doi:10.3758/s13423-023-02270-w · Cited by 22
“According to the third proposal, the right fronto-insular cortex also plays a critical role in switching between distinct brain states (Tang et al., 2012), particularly between the DAN and the DMN (Goulden et al., 2014; Sridharan et al., 2008).”
Interactions of Insula Subdivisions-Based Networks with Default-Mode and Central-Executive Networks in Mild Cognitive Impairment
Chand, G. B., Wu, J., Hajjar, I. M., & Qiu, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00367 · Cited by 21
Neural substrate of quality of life in patients with schizophrenia: a magnetisation transfer imaging study
Faget, C., Boyer, L., Wirsich, J., Ranjeva, J., Richieri, R. M., Soulier, E., Sylviane Confort-gouny, A., Auquier, P., Guye, M., & Lançon, C. (2015) · Scientific Reports · doi:10.1038/srep17650 · Cited by 22
Disentangling early versus late audiovisual integration in adult ADHD: a combined behavioural and resting-state connectivity study
Schulze, M., Aslan, B., Stöcker, T., Stirnberg, R., Lux, S., & Philipsen, A. (2021) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.210017 · Cited by 25
Individual and combined effects of cannabidiol and Δ 9 -tetrahydrocannabinol on striato-cortical connectivity in the human brain
Wall, M. B., Freeman, T. P., Hindocha, C., Demetriou, L., Ertl, N., Freeman, A. M., Jones, A., Lawn, W., Pope, R. A., Mokrysz, C., et al. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221092506 · Cited by 24
“The insula is a key hub in the salience network (Goulden et al., 2014; Seeley et al., 2007; Uddin, 2014), and recent work using combined PET and fMRI methods has identified a link between mesolimbic dopamine systems and the salience network (McCutcheon et al., 2019b).”
Characterizing the temporal dynamics of intrinsic brain activities in depressed adolescents with prior suicide attempts
Cheng, X., Chen, J., Zhang, X., Wang, T., Sun, J., Zhou, Y., Yang, R., Xiao, Y., Chen, A., Song, Z., et al. (2023) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-023-02242-4 · Cited by 22
“…and impaired decision-making and planning[7, The insula cortex is a key hub of the salience network that mediates or switches between the extended ventromedial prefrontal cortex and dorsal prefrontal cortex/IFG system [65, 66], which possibly facilitates the transition from SI to attempt [7].”
Background
Frequency-Dependent Spatial Distribution of Functional Hubs in the Human Brain and Alterations in Major Depressive Disorder
Ries, A., Hollander, M., Glim, S., Meng, C., Sorg, C., & Wohlschläger, A. M. (2019) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2019.00146 · Cited by 23
“switching between the DMN and CEN, thus, dynamically gates saliency allocation and behavioral response toward either internally or externally driven content (Sridharan et al., 2008; Menon and Uddin, 2010; Goulden et al., 2014).”
Background
Increased Functional Segregation Related to the Salience Network in Unaffected Siblings of Youths With Attention-Deficit/Hyperactivity Disorder
Lin, H., Kessler, D. A., Tseng, W. I., & Gau, S. S. (2019) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2019.11.012 · Cited by 21
Test–retest stability of spontaneous brain activity and functional connectivity in the core resting‐state networks assessed with ultrahigh field 7‐Tesla resting‐state functional magnetic resonance imaging
Sbaihat, H., Rajkumar, R., Ramkiran, S., Assi, A. A., Felder, J., Shah, N. J., Veselinović, T., & Neuner, I. (2022) · Human Brain Mapping · doi:10.1002/hbm.25771 · Cited by 20
Multiscale fMRI analysis reveals hierarchical network disruptions underlying disorders of consciousness
Kurkin, S., Mayorova, L. A., Khorev, V. S., Николаевна, П. Е., Radutnaya, M., Леонидовна, Б. Е., & Hramov, A. E. (2025) · Chaos Solitons & Fractals · doi:10.1016/j.chaos.2025.117008 · Cited by 20
Glioma-Induced Disruption of Resting-State Functional Connectivity and Amplitude of Low-Frequency Fluctuations in the Salience Network
Yang, J., Gohel, S., Zhang, Z., Hatzoglou, V., Holodny, A. I., & Vachha, B. A. (2020) · American Journal of Neuroradiology · doi:10.3174/ajnr.a6929 · Cited by 22
Compassion As an Intervention to Attune to Universal Suffering of Self and Others in Conflicts: A Translational Framework
Ho, S.-H. S., Nakamura, Y., & Swain, J. E. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.603385 · Cited by 25
“…detrimental effects on health (Umberson and Montez, 2010) and positive association with cellular aging (Uchino et al., 2012); an animal model suggested that when conflicts resulted in social defeat, individuals are prone for substance abuse and social emotional disorders (Hammels et al., 2015).”
Background
Pharmaco-Magnetic Resonance as a Tool for Monitoring the Medication-Related Effects in the Brain May Provide Potential Biomarkers for Psychotic Disorders
Aryutova, K., & Stoyanov, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179309 · Cited by 20
Salience network anatomical and molecular markers are linked with cognitive dysfunction in mild cognitive impairment
Chand, G. B., Thakuri, D. S., & Soni, B. (2022) · Journal of Neuroimaging · doi:10.1111/jon.12980 · Cited by 19
Altered effective connectivity among core brain networks in patients with bipolar disorder
Zhang, Z., Bo, Q., Li, F., Zhao, L., Wang, Y., Liu, R., Chen, X., Wang, C., & Zhou, Y. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.06.031 · Cited by 21
Adolescent depression and resting-state fMRI brain networks: a scoping review of longitudinal studies
Macedo, M., Sato, J. R., Bressan, R. A., & Pan, P. M. (2022) · Brazilian Journal of Psychiatry · doi:10.47626/1516-4446-2021-2032 · Cited by 22
Small Changes, But Huge Impact? The Right Anterior Insula's Loss of Connection Strength during the Transition of Old to Very Old Age
Muller, A. M., Mérillat, S., & Jäncke, L. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00086 · Cited by 20
“…influential output hubs of the brain (Sridharan et al., 2008) because it is causally initiating the switching from the brain’s internal modus operandi to the external modus operandi vital for all successful goaldirected behavior (Sridharan et al., 2008; Menon and Uddin, 2010; Goulden et al., 2014).”
Background
ADORA2A genotype modulates interoceptive and exteroceptive processing in a fronto-insular network
Geiger, M. J., Domschke, K., Homola, G. A., Schulz, S. M., Nowak, J., Akhrif, A., Pauli, P., Deckert, J., & Neufang, S. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2016.05.007 · Cited by 22
Intrinsic functional neurocircuitry associated with treatment response to transdiagnostic CBT in bipolar disorder with anxiety
Ellard, K., Gosai, A., Bernstein, E. E., Kaur, N., Sylvia, L., Camprodon, J., Dougherty, D., Nierenberg, A., & Deckersbach, T. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.06.002 · Cited by 18
“We selected the anterior insula as the seed region as this region has been identified as a key neural hub implicated in flexible switching between processing modes (external, goal directed processing via ECN; internally focused processing via the DMN, and salience processing via SN), representing an important componen…”
BackgroundMethod
The Neural Mechanisms of Associative Memory Revisited: fMRI Evidence from Implicit Contingency Learning
Caviezel, M. P., Reichert, C., Bahmani, D. S., Linnemann, C., Liechti, C., Bieri, O., Borgwardt, S., Leyhe, T., & Melcher, T. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01002 · Cited by 21
“In a broader context, this supposed neural inhibition may be part of the functional interaction between the salience network (SAL) and the default mode network (DMN) of which the aIC and the PMR represent primary hubs, respectively (60, 61).”
Background
Neural connectivity biotypes: associations with internalizing problems throughout adolescence
Chahal, R., Weissman, D. G., Hallquist, M. N., Robins, R. W., Hastings, P. D., & Guyer, A. E. (2020) · Psychological Medicine · doi:10.1017/s003329172000149x · Cited by 20
“Given the role of the CCN in executive control and the DMN in self-referential introspective processing (Barrett & Satpute, 2013; Buckner, AndrewsHanna, & Schacter, 2008), these two networks typically show negatively correlated activity (Goulden et al., 2014).”
Background
Reconfiguration of Directed Functional Connectivity Among Neurocognitive Networks with Aging: Considering the Role of Thalamo-Cortical Interactions
Das, M., Singh, V., Uddin, L. Q., Banerjee, A., & Roy, D. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa334 · Cited by 19
Adolescents with a concussion have altered brain network functional connectivity one month following injury when compared to adolescents with orthopedic injuries
Healey, K., Fang, Z., Smith, A., Zemek, R., & Ledoux, A.-A. (2022) · NeuroImage: Clinical · doi:10.1016/j.nicl.2022.103211 · Cited by 19
Role of the right anterior insula for the emergence of flow—A combined task-based fMRI activation and connectivity study
Martin, U., Niemann, F., & Grön, G. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.1067968 · Cited by 19
“Given the right anterior insula’s role as a causal hub mediating engagement and disengagement of the CEN and DMN, respectively (Goulden et al., 2014; Menon, 2015; Chand and Dhamala, 2016; Krönke et al., 2020; Shaw et al., 2021; Molnar-Szakacs and Uddin, 2022), the relatively increased functional coupling during flow b…”
Result
EEG Evidence of Acute Stress Enhancing Inhibition Control by Increasing Attention
Yan, B., Wang, Y., Yang, Y., Wu, D., Sun, K., & Xiao, W. (2024) · Brain Sciences · doi:10.3390/brainsci14101013 · Cited by 20
The Motivation-Based Promotion of Proactive Control: The Role of Salience Network
Qiao, L., Xu, L., Che, X., Zhang, L., Li, Y., Xue, G., Li, H., & Chen, A. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00328 · Cited by 21
Structural, functional, and neurochemical neuroimaging of methamphetamine-associated psychosis: A systematic review
Chen, C., Hsu, F., Li, C., & Huang, M. (2019) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2019.06.002 · Cited by 20
The pathoconnectivity network analysis of the insular cortex: A morphometric fingerprinting
Nani, A., Manuello, J., Mancuso, L., Liloia, D., Costa, T., Vercelli, A., Duca, S., & Cauda, F. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117481 · Cited by 19
Differentiating dementia with Lewy bodies from Alzheimer's disease and Parkinson's disease dementia: an update on imaging modalities
Orad, R. I., & Shiner, T. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10402-2 · Cited by 19
The resting-state cerebro-cerebellar function connectivity and associations with verbal working memory performance
Li, Y., Yang, L., Li, L., Xie, Y., & Fang, P. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113586 · Cited by 19
Structure and Dynamics of Large‐Scale Cognitive Networks in Huntington's Disease
Aracil‐Bolaños, I., Martínez‐Horta, S., Gónzalez‐de‐Echávarri, J. M., Sampedro, F., Pérez‐Pérez, J., Horta‐Barba, A., Campolongo, A., Izquierdo, C., Gómez‐Ansón, B., Pagonabarraga, J., et al. (2021) · Movement Disorders · doi:10.1002/mds.28839 · Cited by 18
“44 Second — and perhaps more important given its clinical repercussion — although patients with HD show a higher frequency of DMN-CEN connections, their variability seems to be decreased across different dynamic factors.”
Stationary EEG pattern relates to large-scale resting state networks – An EEG-fMRI study connecting brain networks across time-scales
Arzate-Mena, J. D., Abela, E., Olguín-Rodríguez, P. V., Ríos-Herrera, W. A., Alcauter, S., Schindler, K. A., Wiest, R., Müller, M., & Rummel, C. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118763 · Cited by 19
Neural functional connectivity during rumination in individuals with adverse childhood experiences
Sokołowski, A., Kowalski, J., & Dragan, M. (2022) · European Journal of Psychotraumatology · doi:10.1080/20008198.2022.2057700 · Cited by 25
“between other large-scale networks (Goulden et al., 2014; Menon & Uddin, 2010), one interpretation of our results may be that ACEs are related to alterations in switching between intrinsic connectivity networks.”
Background
Reviewing the neurobiology of electroconvulsive therapy on a micro- meso- and macro-level
Belge, J.-B., Mulders, P. C. R., van Diermen, L., Sienaert, P. A., Sabbe, B., Abbott, C., Tendolkar, I., Schrijvers, D. L., & van Eijndhoven, P. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110809 · Cited by 21
Working memory performance in disordered gambling and gaming: A systematic review
Ngetich, R. K., Burleigh, T. L., Czakó, A., Vékony, T., Németh, D., & Demetrovics, Z. (2023) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2023.152408 · Cited by 25
Gradient Organization of Space, Time, and Numbers in the Brain: A Meta-analysis of Neuroimaging Studies
Cona, G., Wiener, M., Allegrini, F., & Scarpazza, C. (2023) · Neuropsychology Review · doi:10.1007/s11065-023-09609-z · Cited by 20
“The salience network responds indeed to the degree of subjective salience, whether cognitive, emotional, or homeostatic (Goulden et al., 2014), and, based on such “salience,” this network drives the switching between the default mode network (DMN), which is active when the brain is not involved in…”
Background
Dysregulated Salience Network Control over Default-Mode and Central-Executive Networks in Schizophrenia Revealed Using Stochastic Dynamical Causal Modeling
Thakuri, D. S., Bhattarai, P., Wong, D. F., & Chand, G. B. (2024) · Brain Connectivity · doi:10.1089/brain.2023.0054 · Cited by 22
“…we chose stochastic DCM due to the following reasons: ﬁrst, to test whether SN-based controlling mechanisms in healthy controls replicate in this data set using stochastic DCM, similar to previous studies from our group (Chand et al., 2017a; Chand et al., 2017b) and others (Goulden et al., 2014).”
Influential
Brain function associated with reaction time after sport-related concussion
Churchill, N. W., Hutchison, M. G., Graham, S. J., & Schweizer, T. A. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00349-9 · Cited by 22
Resting state functional atlas and cerebral networks in mouse lemur primates at 11.7 Tesla
Garin, C. M., Nadkarni, N. A., Landeau, B., Chételat, G., Picq, J., Bougacha, S., & Dhénain, M. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117589 · Cited by 19
Is there a “g-neuron”? Establishing a systematic link between general intelligence (g) and the von Economo neuron
Bruton, O. J. (2021) · Intelligence · doi:10.1016/j.intell.2021.101540 · Cited by 20
Prior Cocaine Exposure Increases Firing to Immediate Reward While Attenuating Cue and Context Signals Related to Reward Value in the Insula
Pribut, H. J., Vázquez, D., Brockett, A. T., Wei, A. D., Tennyson, S. S., & Roesch, M. R. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3025-20.2021 · Cited by 19
Specificity of anhedonic alterations in resting-state network connectivity and structure: A transdiagnostic approach
Geller, W. N., Liu, K., & Warren, S. L. (2021) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2021.111349 · Cited by 18
Dynamic lag analysis reveals atypical brain information flow in autism spectrum disorder
Raatikainen, V., Korhonen, V., Borchardt, V., Huotari, N., Helakari, H., Kananen, J., Raitamaa, L., Joskitt, L., Loukusa, S., Hurtig, T., et al. (2020) · Autism Research · doi:10.1002/aur.2218 · Cited by 19
“The salience network is thought to be involved in switching between the default mode network and central executive network [Goulden et al., 2014], and salience network dysfunction has been linked to autism [Uddin & Menon, 2009; Uddin et al.”
Background
Transcutaneous auricular vagus nerve stimulation in disorders of consciousness: A mini-narrative review
Jang, S. H., & Cho, M. J. (2022) · Medicine · doi:10.1097/md.0000000000031808 · Cited by 18
“[24,40,43] The salience network (SN), which connects the ventrolateral prefrontal cortex, anterior insula, and dorsal anterior cingulate cortex, is known to be involved in switching between the EXN and DMN.[24,42,43,46,54] In their review, Briand et al[24] have elaborated on the key brain areas and networks of conscio…”
Functional Connectivity Analysis of Transcutaneous Vagus Nerve Stimulation (tVNS) Using Magnetoencephalography (MEG)
Keatch, C., Lambert, É., Kameneva, T., & Woods, W. (2023) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2023.3297736 · Cited by 17
“poles, the putamen, thalamus and ventral striatum [44].”
Background
Age differences in the neural processing of semantics, within and beyond the core semantic network
Wu, W., & Hoffman, P. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.07.022 · Cited by 18
Associations between regular cannabis use and brain resting-state functional connectivity in adolescents and adults
Ertl, N., Lawn, W., Mokrysz, C., Freeman, T. P., Alnagger, N., Borissova, A., Fernandez‐Vinson, N., Lees, R., Ofori, S., Petrilli, K., et al. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231189441 · Cited by 18
“The salience network (SN) is thought to be the mediator between these two networks as well as facilitating attention and detection of emotional and sensory stimuli (Goulden et al., 2014).”
Background
A systematic review of quantitative EEG findings in Fibromyalgia, Chronic Fatigue Syndrome and Long COVID
Silva-Passadouro, B., Tamasauskas, A., Khoja, O., Casson, A. J., Delis, I., Brown, C. A., & Sivan, M. (2024) · Clinical Neurophysiology · doi:10.1016/j.clinph.2024.04.019 · Cited by 17
Stimulant medications affect arousal and reward, not attention networks
Kay, B. P., Wheelock, M. D., Siegel, J. S., Raut, R. V., Chauvin, R. J., Metoki, A., Rajesh, A., Eck, A., Pollaro, J., Wang, A., et al. (2025) · Cell · doi:10.1016/j.cell.2025.11.039 · Cited by 25
Learning induces coordinated neuronal plasticity of metabolic demands and functional brain networks
Klug, S., Godbersen, G. M., Rischka, L., Wadsak, W., Pichler, V., Klöbl, M., Hacker, M., Lanzenberger, R. R., & Hahn, A. (2022) · Communications Biology · doi:10.1038/s42003-022-03362-4 · Cited by 21
“As part of the SN, the right anterior insula mediates switching between task-irrelevant networks and the activation of task-specific networks that convey externally oriented attention (Sridharan et al., 2008; Menon & Uddin, 2010; Goulden et al., 2014; Uddin, 2015).”
Association Between White Matter Networks and the Pattern of Striatal Dopamine Depletion in Patients With Parkinson Disease
Chung, S. J., Kim, Y. J., Kim, Y. J., Lee, H. S., Jeong, S. H., Hong, J., Sohn, Y. H., Yun, M., Jeong, Y., & Lee, P. H. (2022) · Neurology · doi:10.1212/wnl.0000000000201269 · Cited by 17
“For example, the anterior cingulate cortex is a key component of the salience network that modulates the activation of the default mode network and central executive network.(46) The anterior portion of the putamen acts as an integrative hub through the convergence of multiple distal cortical inputs and seems to be as…”
The influence of childhood maltreatment on trait depression in patients with major depressive disorder: A moderated mediation model of rumination and mindful attention awareness
Mao, L., Wu, Y., Xin, H., Li, P., Yuan, X., & Hu, M. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.03.052 · Cited by 18
Longitudinal neurofunctional changes in medication overuse headache patients after mindfulness practice in a randomized controlled trial (the MIND-CM study)
Fedeli, D., Ciullo, G., Demichelis, G., Medina, J. P., Bruzzone, M. G., Ciusani, E., Erbetta, A., Ferraro, S., Grisoli, M., Guastafierro, E., et al. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01803-5 · Cited by 17
“The SN drives the switching between DMN and FPN [21].”
Background
Moderating Effects of Harm Avoidance on Resting-State Functional Connectivity of the Anterior Insula
Huggins, A. A., Belleau, E. L., Miskovich, T. A., Pedersen, W. S., & Larson, C. L. (2018) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2018.00447 · Cited by 17
“…extant literature suggests that the right anterior insula, in particular, is critical in switching between the DMN and CEN (Sridharan et al., 2008; Goulden et al., 2014), several studies have indicated left hemispheric effects related to trait and state anxiety (Dennis et al., 2011; Baur et al.,…”
BackgroundMethodResultInfluential

Authors: Goulden, N., Khusnulina, A., Davis, N. J., Bracewell, R. M., Bokde, A. L., McNulty, J. P., & Mullins, P. G.
Affiliations: Bangor University (GB)
Trinity College Dublin (IE)
University College Dublin (IE)
Corresponding author: Goulden, Nia
ORCID: Goulden, Nia
Davis, Nicholas J.
Bracewell, Robert M.
Bokde, Arun L.
McNulty, Jonathan P.
Mullins, Paul G.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2014-10
Volume: 99
Pages: 180-190
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2014.05.052
OpenAlex: W2066208486
Cited by: 810
References: 47
Citations by year: 2026: 65 · 2025: 101 · 2024: 83 · 2023: 85 · 2022: 79 · 2021: 112 · 2020: 67 · 2019: 58 · 2018: 62 · 2017: 34 · 2016: 37 · 2015: 20 · 2014: 6
FWCI: 18.03
Type: journal article
Language: en
Open access: green
e-space.mmu.ac.uk
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
e-space (Manchester Metropolitan University) (submittedVersion, other-oa)
Funders: European Regional Development Fund
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords: salience network, default mode network, frontoparietal network, network switching, dynamic causal modeling, independent component analysis, resting state, Granger causality, reproducibility, brain connectivity
MeSH terms: Adult, Bayes Theorem, Brain Mapping, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Models, Neurological, Nerve Net, Rest, Stochastic Processes, Executive Function

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The salience network is responsible for switching between the default mode network and the central executive network: Replication from DCM

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks