Reliable individual differences in fine-grained cortical functional architecture
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Abstract
Fine-grained functional organization of cortex is not well-conserved across individuals. As a result, individual differences in cortical functional architecture are confounded by topographic idiosyncrasies-i.e., differences in functional-anatomical correspondence. In this study, we used hyperalignment to align information encoded in topographically variable patterns to study individual differences in fine-grained cortical functional architecture in a common representational space. We characterized the structure of individual differences using three common functional indices, and assessed the reliability of this structure across independent samples of data in a natural vision paradigm. Hyperalignment markedly improved the reliability of individual differences across all three indices by resolving topographic idiosyncrasies and accommodating information encoded in spatially fine-grained response patterns. Our results demonstrate that substantial individual differences in cortical functional architecture exist at fine spatial scales, but are inaccessible with anatomical normalization alone.
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- Authors
- Feilong, M., Nastase, S. A., Guntupalli, J. S., & Haxby, J. V.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Haxby, James V.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2018-12
- Volume
- 183
- Pages
- 375-386
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC12551967
- OpenAlex
- W2949433222
- Cited by
- 68
- References
- 64
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 7 · 2023: 9 · 2022: 9 · 2021: 10 · 2020: 11 · 2019: 5 · 2018: 1
- FWCI
- 4.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- NeuroImage (publishedVersion, cc-by-nc-nd)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- Funders
- National Science Foundation (NSF1607845)
- National Institute of Mental Health (5R01MH075706)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- individual differences, hyperalignment, reliability statistics, functional markers
- MeSH terms
- Adult, Brain Mapping, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Individuality, Magnetic Resonance Imaging, Male, Reproducibility of Results, Young Adult
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