Phosphorylation of AMPA receptors is required for sensory deprivation-induced homeostatic synaptic plasticity
Open accessAbstract
Sensory experience, and the lack thereof, can alter the function of excitatory synapses in the primary sensory cortices. Recent evidence suggests that changes in sensory experience can regulate the synaptic level of Ca(2+)-permeable AMPA receptors (CP-AMPARs). However, the molecular mechanisms underlying such a process have not been determined. We found that binocular visual deprivation, which is a well-established in vivo model to produce multiplicative synaptic scaling in visual cortex of juvenile rodents, is accompanied by an increase in the phosphorylation of AMPAR GluR1 (or GluA1) subunit at the serine 845 (S845) site and the appearance of CP-AMPARs at synapses. To address the role of GluR1-S845 in visual deprivation-induced homeostatic synaptic plasticity, we used mice lacking key phosphorylation sites on the GluR1 subunit. We found that mice specifically lacking the GluR1-S845 site (GluR1-S845A mutants), which is a substrate of cAMP-dependent kinase (PKA), show abnormal basal excitatory synaptic transmission and lack visual deprivation-induced homeostatic synaptic plasticity. We also found evidence that increasing GluR1-S845 phosphorylation alone is not sufficient to produce normal multiplicative synaptic scaling. Our study provides concrete evidence that a GluR1 dependent mechanism, especially S845 phosphorylation, is a necessary pre-requisite step for in vivo homeostatic synaptic plasticity.
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Dark rearing increases the abundance of GluA2-lacking receptors and requires GluA1 phosphorylation.
“In contrast, dark rearing increases the abundance of GluA2-lacking receptors and requires GluA1 phosphorylation, suggesting that these two modes of deprivation may induce different forms of compensatory synaptic plasticity (Goel and Lee 2007;Goel et al. 2011).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Goel et al. 2011
The Results report that two days of dark exposure increased functional calcium-permeable AMPA receptors, consistent with more GluA2-lacking receptors; the Discussion says deprivation-induced synaptic changes require GluA1 phosphorylation. But the Methods specify that mice were raised under normal lighting until postnatal day 21, then exposed to darkness for two days. The paper does not establish these effects for dark rearing from birth. (LLM, conf=0.83)
Experimental — accuracy not yet measuredThese two modes of deprivation may induce different forms of compensatory synaptic plasticity.
“In contrast, dark rearing increases the abundance of GluA2-lacking receptors and requires GluA1 phosphorylation, suggesting that these two modes of deprivation may induce different forms of compensatory synaptic plasticity (Goel and Lee 2007;Goel et al. 2011).”
From Homeostatic Synaptic Plasticity: Local and Global Mechanisms for Stabilizing Neuronal Function (2012) · cites this paper as Goel et al. 2011
Visual deprivation-induced scaling-up in mouse visual cortex involves the recruitment of synaptic CP-AMPARs and increased GluA1 S845 phosphorylation.
“Homeostatic scaling-up has also been observed in the visual cortex in mice in response to visual deprivation, and involves the recruitment of synaptic CP-AMPARs and increased GluA1 S845 phosphorylation (Goel et al., 2006, Goel et al., 2011).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Goel et al., 2011
Visual deprivation-induced scaling-up is absent in GluA1 S845A knock-in mutant mice.
“Like in cultured neurons, visual deprivation-induced scaling-up is absent in GluA1 S845A knock-in mutant mice (Goel et al., 2011).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Goel et al., 2011
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- Authors
- Goel, A., Xu, L. W., Snyder, K. P., Song, L., Goenaga-Vazquez, Y., Megill, A., Takamiya, K., Huganir, R. L., & Lee, H.-K.
- Affiliations
- University of Maryland, College Park (US)
- University of Miyazaki (JP)
- Johns Hopkins University (US)
- Corresponding author
- Lee, Hey-Kyoung
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-03-31
- Volume
- 6
- Issue
- 3
- Pages
- e18264
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3069067
- OpenAlex
- W2090738767
- Cited by
- 103
- References
- 63
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 4 · 2016: 12 · 2015: 5 · 2014: 7 · 2013: 12 · 2012: 8
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health (NS036715)
- Japan Society for the Promotion of Science (22300122)
- National Eye Institute (R01EY014882)
- National Institute of Neurological Disorders and Stroke (R01NS036715)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- AMPA receptor phosphorylation, GluR1, homeostatic plasticity, sensory deprivation, Ca2+-permeable AMPA receptors, protein kinase A, excitatory synaptic transmission, visual cortex
- MeSH terms
- Animals, Electrophoresis, Polyacrylamide Gel, Neuronal Plasticity, Phosphorylation, Sensory Deprivation, Synapses, Immunoblotting, Receptors, AMPA, Mice, In Vitro Techniques
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