Oxytocin Shapes the Neural Circuitry of Trust and Trust Adaptation in Humans

In the citing paper

“In agreement, neuroimaging studies demonstrate that intranasal administration of oxytocin attenuates amygdala activation following stressful and fearful stimuli (Baumgartner et al., 2008; Domes et al., 2007; Kirsch et al., 2005; Labuschagne et al., 2010).”

In the citing paper

“Functioning as both a neurotransmitter and a hormone, oxytocin's targets are widespread and include the hippocampus and the amygdala (10–12).”

In the citing paper

“We noticed that Kosfeld’s [1] seminal finding was not always replicated either. Indeed, Baumgartner et al. [7] found no significant effect of OT on the pre-betrayal trust game. More recently, two independent studies also failed to replicate Kosfeld’s findings [20] [21].”

In the citing paper

“adapted version of the well‐established trust game.[ 21 ]”

In the citing paper

“There is no doubt that oxytocin is implicated in the development of trust (10, 18), empathy, and prosociality (11), but these tendencies appear limited to individuals belonging to one's in-group (16, 17).”

In the citing paper

“Previous studies on amygdala responses to fearful faces and fearful/threatening scenes (14 -17, 30) and social risk (31) have also indicated that OXT may induce sex-dependent changes in amygdala activation to emotional stimuli.”

In the citing paper

“An earlier study by Baumgartner et al. (2008) reported that participants in a trust game tend to discount feedback information regarding their partner's unreciprocal behavior more so when they are given intranasal OT compared with a placebo.”

In the citing paper

“On the other hand, there are several reports that OT reduces social anxiety by attenuating the amygdala response to fearful social signals (Kirsch et al., 2005;Baumgartner et al., 2008).”

In the citing paper

“Intriguingly, intranasal application of OT has been shown to increase trusting behavior in humans [20], [21], identification of others' affective states [22] and amygdala responses to emotional faces [23].”

In the citing paper

“Consistent with this evidence, functional magnetic imaging (fMRI) studies with healthy volunteers have shown that intranasal OXT administration dampens amygdala reactivity to threatening facial expressions (Domes et al, 2007;Kirsch et al, 2005), and naturalistic social interactions (Baumgartner et al, 2008).”

In the citing paper

“attenuating activation of amygdala to social stimuli (Baumgartner et al, 2008;Domes et al, 2007a;Gamer et al, 2010;Kirsch et al, 2005)”

In the citing paper

“human studies have prevalently used acute administration of OXT in healthy subjects”

In the citing paper

“IN-OT increases trust by reducing the BOLD activity of amygdala and midbrain regions, neural systems that mediate fear processing (Baumgartner et al. 2008).”

In the citing paper

“Of the six studies that entered the meta-analysis in Nave et al.21 -in addition to the Kosfeld 8 et al. study -four studies had fictional partners [25][26][27][28] , one was completely devoid of human contact with other participants 29 , and participants' previous experience in a dictator game was likely to confound the decision to trust in the sixth study 30 .”

In the citing paper

“Human functional neuroimaging studies have shown that inhaling OT reduces BOLD (blood-oxygen-level dependent) activation in the amygdala when viewing or associating aversive social stimuli (Kirsch, 2005; Petrovic et al., 2008), during trust formation (Baumgartner et al., 2008), in response to pain (Singer et al., 2008), and in response to infant crying (Riem et al., 2011).”

In the citing paper

“Consistently, previous studies showed that OT reduced recognition of and affective responses to negative signals, and failed to change behavior after the receipt of negative information (i.e., social betrayal; ref. 17).”

In the citing paper

“Oxytocin, the hypothalamic neuropeptide important for social cognition and behavior, has been shown to promote prosocial approach, such as trust and cooperative behaviors (16, 21, 22, but also see ref. 23)”

In the citing paper

“Oxytocin, the hypothalamic neuropeptide important for social cognition and behavior, has been shown to promote prosocial approach, such as trust and cooperative behaviors (16, 21, 22, but also see ref. 23)”

In the citing paper

“subsequent neuroimaging work provided indications that the effects of exogenously administered OT on trust and trust adaptation were associated with reductions in neural activity of brain regions that are implicated in fear processing (amygdala and midbrain regions) (Baumgartner et al., 2008).”

In the citing paper

“Further research utilizing cooperative economic games has shown that the prior reputation of a partner alters striatum responses to reciprocated or non-reciprocated cooperation and influences decisions to cooperate or not 75–79.”

In the citing paper

“Further research utilizing cooperative economic games has shown that the prior reputation of a partner alters striatum responses to reciprocated or non-reciprocated cooperation and influences decisions to cooperate or not 75–79.”

In the citing paper

“Decisions to cooperate with another person are colored by the information we have learnt about the person thus far.”

In the citing paper

“and some previous findings that OT-induced alterations on human social behavior are associated with increased activity in the striatum and AI (Baumgartner et al., 2008; Strathearn et al., 2009; Striepens et al., 2011; Yao et al., 2018).”

In the citing paper

“To conform with prior research showing that effects of oxytocin peak after ∼30–40 min (10, 16, 18), after 38–42 min, the computer switched to the experimental task (lasting 15–20 min).”