Cited by 403Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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Genomic Anatomy of the Hippocampus

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Thompson, Carol L., Pathak, Sayan D., Jeromin, Andreas, Ng, Lydia L., MacPherson, Cameron R., Mortrud, Marty T., Cusick, Allison, Riley, Zackery L., Sunkin, Susan M., Bernard, Amy, Puchalski, Ralph B., Gage, Fred H., Jones, Allan R., Bajic, Vladimir B., Hawrylycz, Michael J., Lein, Ed S.·2008·Neuron

DOI 10.1016/j.neuron.2008.12.008

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Abstract

Availability of genome-scale in situ hybridization data allows systematic analysis of genetic neuroanatomical architecture. Within the hippocampus, electrophysiology and lesion and imaging studies demonstrate functional heterogeneity along the septotemporal axis, although precise underlying circuitry and molecular substrates remain uncharacterized. Application of unbiased statistical component analyses to genome-scale hippocampal gene expression data revealed robust septotemporal molecular heterogeneity, leading to the identification of a large cohort of genes with robust regionalized hippocampal expression. Manual mapping of heterogeneous CA3 pyramidal neuron expression patterns demonstrates an unexpectedly complex molecular parcellation into a relatively coherent set of nine expression domains in the septal/temporal and proximal/distal axes with reciprocal, nonoverlapping boundaries. Unique combinatorial profiles of adhesion molecules within these domains suggest corresponding differential connectivity, which is demonstrated for CA3 projections to the lateral septum using retrograde labeling. This complex, discrete molecular architecture provides a novel paradigm for predicting functional differentiation across the full septotemporal extent of the hippocampus.

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Gene Ontology: tool for the unification of biology
Ashburner, M., Ball, C. A., Blake, J. A., Botstein, D., Butler, H., Cherry, J. M., Davis, A. P., Dolinski, K., Dwight, S. S., Eppig, J. T., et al. (2000) · Nature Genetics · doi:10.1038/75556 · Cited by 43,206
The Elements of Statistical Learning
Hastie, T., Tibshirani, R., & Friedman, J. (2009) · Springer Series in Statistics · doi:10.1007/978-0-387-84858-7 · Cited by 25,970
Learning the parts of objects by non-negative matrix factorization
Lee, D. D., & Seung, H. S. (1999) · Nature · doi:10.1038/44565 · Cited by 14,137
The Elements of Statistical Learning: Data Mining, Inference, and Prediction
Lu, Z. Q. J. (2010) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.1111/j.1467-985x.2010.00646_6.x · Cited by 12,916
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859
DAVID: Database for Annotation, Visualization, and Integrated Discovery
Dennis, G., Sherman, B. T., Hosack, D. A., Yang, J., Gao, W., Lane, H. C., & Lempicki, R. A. (2003) · Genome Biology · doi:10.1186/gb-2003-4-5-p3 · Cited by 9,327
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Self-citation
On the Statistical Analysis of Dirty Pictures
Besag, J. E. (1986) · Journal of the Royal Statistical Society Series B (Statistical Methodology) · doi:10.1111/j.2517-6161.1986.tb01412.x · Cited by 4,204
The “independent components” of natural scenes are edge filters
Bell, A. J., & Sejnowski, T. J. (1997) · Vision Research · doi:10.1016/s0042-6989(97)00121-1 · Cited by 2,201
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180

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Li, Y., Chen, H., Jiang, X., Li, X., Lv, J., Li, M., Peng, H., Tsien, J. Z., & Liu, T. (2017) · Neuroinformatics · doi:10.1007/s12021-017-9333-1 · Cited by 9
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Lei, H., Lv, J., Zhang, F., Wei, L., Shi, K., Liu, J., He, T., Xiong, R., Sun, F., Zhong, T., et al. (2025) · Translational Neurodegeneration · doi:10.1186/s40035-025-00473-w · Cited by 9
Septotemporal variation in modulation of synaptic transmission, paired-pulse ratio and frequency facilitation/depression by adenosine and GABA B receptors in the rat hippocampus
Samara, M. A., Oikonomou, G. D., Trompoukis, G., Madarou, G., Adamopoulou, M., & Papatheodoropoulos, C. (2022) · Brain and Neuroscience Advances · doi:10.1177/23982128221106315 · Cited by 8
A circuit from the basolateral amygdala to hippocampal CA3 regulates social behavior
Li, M., Jiang, Y., & Sun, Q. (2025) · Current Biology · doi:10.1016/j.cub.2025.07.059 · Cited by 8
METscout: a pathfinder exploring the landscape of metabolites, enzymes and transporters
Geffers, L., Tetzlaff, B., Cui, X. X., Yan, J., & Gregor Eichele, C. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks886 · Cited by 8
Rethinking Functional Segregation: Gradients of Gene Expression in Area CA1
Tushev, G., & Schuman, E. M. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.002 · Cited by 9
Hippocampal asymmetry and regional dispersal of nAChRs alpha4 and alpha7 subtypes in the adult rat
Baradaran, R., Anbarkeh, F. R., Delavar, A., Khorasgani, E. M., Rahimian, N., Abbasi, Y., & Jaberi, N. (2021) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2021.101977 · Cited by 8
Circuits underlying social function and dysfunction
Wang, Z., Yueh, H., Chau, M., Veenstra-VanderWeele, J. M., & O’Reilly, K. C. (2023) · Autism Research · doi:10.1002/aur.2978 · Cited by 9
Age-Related Neuronal Deterioration Specifically Within the Dorsal CA1 Region of the Hippocampus in a Mouse Model of Late Onset Alzheimer’s Disease
Mehder, R. H., Bennett, B. M., & Andrew, R. D. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201024 · Cited by 8
Anatomically guided examination of extrinsic connectivity gradients in the human hippocampus
Poppenk, J. (2019) · Cortex · doi:10.1016/j.cortex.2019.11.013 · Cited by 7
Multimodal gradient mapping of rodent hippocampus
Gunnarsdóttir, B., Zerbi, V., & Kelly, C. A. M. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119082 · Cited by 13
Maturation of hippocampus-medial prefrontal cortex projections defines a pathway-specific sensitive period for cognitive flexibility
Cruz-Sanchez, A., LaDouceur, K. E., Abdusalom, A., Chasiotis, H., Gugustea, R., Inayat, M., Mumtaz, U., Hasantash, M., Anacker, C., & Arruda-Carvalho, M. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116812 · Cited by 11
Hippocampal CA3 inhibitory neurons receive extensive noncanonical synaptic inputs from CA1 and subicular complex
Lin, X., Cyrus, N., Avila, B., Holmes, T. C., & Xu, X. (2023) · The Journal of Comparative Neurology · doi:10.1002/cne.25510 · Cited by 8
Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation
Giralt, A., Brito, V., Pardo, M., Rubio, S. E., Marion‐Poll, L., Martín‐Ibáñez, R., Zamora‐Moratalla, A., Bosch, C., Ballesteros, J. J., Blasco, E., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113095 · Cited by 7
DNA repair enzyme NEIL3 enables a stable neural representation of space by shaping transcription in hippocampal neurons
Kunath, N., Bugaj, A. M., Bigonah, P., Fernández-Berrocal, M. S., Bjørås, M., & Ye, J. (2021) · iScience · doi:10.1016/j.isci.2021.103470 · Cited by 7
Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions
Blume, M., Inoguchi, F., Sugiyama, T., Owada, Y., Osumi, N., Aimi, Y., Taki, K., & Katsuyama, Y. (2017) · Development Growth & Differentiation · doi:10.1111/dgd.12393 · Cited by 7
WITHDRAWN: Developmental regulation and lateralization of GABA receptors in the rat hippocampus
Khoshdel‐Sarkarizi, H., Hami, J., Mohammadipour, A., Sadr‐Nabavi, A., Mahmoudi, M., Kheradmand, H., Peyvandi, M., Nourmohammadi, E., & Haghir, H. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.01.002 · Cited by 7
Retracted
The dorsal hippocampal CA3 regulates spatial reference memory through the CtBP2/GluR2 pathway
Han, J., Wen, C., Sun, R. Q., Tang, M., Li, X., & Lian, H. (2022) · The FASEB Journal · doi:10.1096/fj.202101609rr · Cited by 6
Physical Activity Dynamically Regulates the Hippocampal Proteome along the Dorso-Ventral Axis
Frey, S., Schieweck, R., Forné, I., Imhof, A., Straub, T., Popper, B., & Kiebler, M. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103501 · Cited by 7
Modifying Factors of Adult Hippocampal Neurogenesis: A Dorsoventral Perspective in Health and Disease
Erginousakis, I., & Papatheodoropoulos, C. (2025) · Cells · doi:10.3390/cells15010059 · Cited by 6
Hippocampal architecture viewed through the eyes of methodological development
Zhao, L., & Palomero‐Gallagher, N. (2025) · Anatomical Science International · doi:10.1007/s12565-025-00878-7 · Cited by 8
Genome-scale investigation of olfactory system spatial heterogeneity
Noto, T., Barnagian, D., & Castro, J. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178087 · Cited by 5
‘A picture is worth a thousand words’: The use of microscopy for imaging neuroinflammation
de Fraga, L. S., Tassinari, I. D., Jantsch, J., Guedes, R. P., & Bambini-Júnior, V. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13669 · Cited by 5
Non-Canonical Projections from Ventral CA1 and Subicular Complex to CA3 Augments the Feedforward Hippocampal Trisynaptic PathwayPreprint
Lin, X., Amalraj, M., Blanton, C., Avila, B., Holmes, T. C., Nitz, D. A., & Xu, X. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.01.429124 · Cited by 5

Authors: Thompson, C. L., Pathak, S. D., Jeromin, A., Ng, L. L., MacPherson, C. R., Mortrud, M. T., Cusick, A., Riley, Z. L., Sunkin, S. M., Bernard, A., Puchalski, R. B., Gage, F. H., Jones, A. R., Bajic, V. B., Hawrylycz, M. J., & Lein, E. S.
Affiliations: Allen Institute for Brain Science (US)
University of the Western Cape (ZA)
Salk Institute for Biological Studies (US)
Corresponding author: Lein, Ed S.
ORCID: Thompson, Carol L.
Ng, Lydia L.
MacPherson, Cameron R.
Sunkin, Susan M.
Bernard, Amy
Puchalski, Ralph B.
Gage, Fred H.
Hawrylycz, Michael J.
Lein, Ed S.
Venue: Neuron
Publisher: Elsevier BV
Published: 2008-12
Volume: 60
Issue: 6
Pages: 1010-1021
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2008.12.008
OpenAlex: W2088189569
Cited by: 403
References: 64
Citations by year: 2026: 16 · 2025: 26 · 2024: 16 · 2023: 21 · 2022: 14 · 2021: 31 · 2020: 24 · 2019: 22 · 2018: 25 · 2017: 23 · 2016: 20 · 2015: 24 · 2014: 32 · 2013: 29 · 2012: 31
FWCI: 8.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1689 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: hippocampus, septotemporal axis, CA3 pyramidal cells, gene expression domains, adhesion molecules, lateral septum, hippocampal connectivity, functional heterogeneity
MeSH terms: Animals, Animals, Newborn, Brain Mapping, Cholera Toxin, Hippocampus, Male, Mice, Inbred C57BL, Models, Biological, Nerve Tissue Proteins, Neural Pathways, Septum Pellucidum, Temporal Lobe, In Situ Hybridization, Gene Expression Regulation, Developmental, Neural Cell Adhesion Molecules, Imaging, Three-Dimensional, Genomics, Principal Component Analysis, Mice

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Genomic Anatomy of the Hippocampus

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