Cited by 403Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

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Genomic Anatomy of the Hippocampus

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Thompson, Carol L., Pathak, Sayan D., Jeromin, Andreas, Ng, Lydia L., MacPherson, Cameron R., Mortrud, Marty T., Cusick, Allison, Riley, Zackery L., Sunkin, Susan M., Bernard, Amy, Puchalski, Ralph B., Gage, Fred H., Jones, Allan R., Bajic, Vladimir B., Hawrylycz, Michael J., Lein, Ed S.·2008·Neuron

DOI 10.1016/j.neuron.2008.12.008

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Abstract

Availability of genome-scale in situ hybridization data allows systematic analysis of genetic neuroanatomical architecture. Within the hippocampus, electrophysiology and lesion and imaging studies demonstrate functional heterogeneity along the septotemporal axis, although precise underlying circuitry and molecular substrates remain uncharacterized. Application of unbiased statistical component analyses to genome-scale hippocampal gene expression data revealed robust septotemporal molecular heterogeneity, leading to the identification of a large cohort of genes with robust regionalized hippocampal expression. Manual mapping of heterogeneous CA3 pyramidal neuron expression patterns demonstrates an unexpectedly complex molecular parcellation into a relatively coherent set of nine expression domains in the septal/temporal and proximal/distal axes with reciprocal, nonoverlapping boundaries. Unique combinatorial profiles of adhesion molecules within these domains suggest corresponding differential connectivity, which is demonstrated for CA3 projections to the lateral septum using retrograde labeling. This complex, discrete molecular architecture provides a novel paradigm for predicting functional differentiation across the full septotemporal extent of the hippocampus.

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Authors: Thompson, C. L., Pathak, S. D., Jeromin, A., Ng, L. L., MacPherson, C. R., Mortrud, M. T., Cusick, A., Riley, Z. L., Sunkin, S. M., Bernard, A., Puchalski, R. B., Gage, F. H., Jones, A. R., Bajic, V. B., Hawrylycz, M. J., & Lein, E. S.
Affiliations: Allen Institute for Brain Science (US)
University of the Western Cape (ZA)
Salk Institute for Biological Studies (US)
Corresponding author: Lein, Ed S.
ORCID: Thompson, Carol L.
Ng, Lydia L.
MacPherson, Cameron R.
Sunkin, Susan M.
Bernard, Amy
Puchalski, Ralph B.
Gage, Fred H.
Hawrylycz, Michael J.
Lein, Ed S.
Venue: Neuron
Publisher: Elsevier BV
Published: 2008-12
Volume: 60
Issue: 6
Pages: 1010-1021
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2008.12.008
OpenAlex: W2088189569
Cited by: 403
References: 64
Citations by year: 2026: 16 · 2025: 26 · 2024: 16 · 2023: 21 · 2022: 14 · 2021: 31 · 2020: 24 · 2019: 22 · 2018: 25 · 2017: 23 · 2016: 20 · 2015: 24 · 2014: 32 · 2013: 29 · 2012: 31
FWCI: 8.47
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1689 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: hippocampus, septotemporal axis, CA3 pyramidal cells, gene expression domains, adhesion molecules, lateral septum, hippocampal connectivity, functional heterogeneity
MeSH terms: Animals, Animals, Newborn, Brain Mapping, Cholera Toxin, Hippocampus, Male, Mice, Inbred C57BL, Models, Biological, Nerve Tissue Proteins, Neural Pathways, Septum Pellucidum, Temporal Lobe, In Situ Hybridization, Gene Expression Regulation, Developmental, Neural Cell Adhesion Molecules, Imaging, Three-Dimensional, Genomics, Principal Component Analysis, Mice

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