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Cited by 352Memory Processes and InfluencesMemory and Neural MechanismsCognitive Functions and Memory

The Eyes Have It: Hippocampal Activity Predicts Expression of Memory in Eye Movements

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Hannula, Deborah E., Ranganath, Charan·2009·Neuron
DOI 10.1016/j.neuron.2009.08.025PMC PMC2747814
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Abstract

Although there is widespread agreement that the hippocampus is critical for explicit episodic memory retrieval, it is controversial whether this region can also support indirect expressions of relational memory when explicit retrieval fails. Here, using functional magnetic resonance imaging (fMRI) with concurrent indirect, eye-movement-based memory measures, we obtained evidence that hippocampal activity predicted expressions of relational memory in subsequent patterns of viewing, even when explicit, conscious retrieval failed. Additionally, activity in the lateral prefrontal cortex and functional connectivity between the hippocampus and prefrontal cortex were greater for correct than for incorrect trials. Together, these results suggest that hippocampal activity can support the expression of relational memory even when explicit retrieval fails and that recruitment of a broader cortical network may be required to support explicit associative recognition.

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  • Prefrontal cortex executive functions mediate processing of anticipatory aspects of behavior and, with the hippocampus, regulate implementation of anticipated memory retrieval and allocation of relevance and expectancies to a memory.

    “Prefrontal cortex executive functions mediate the processing of anticipatory aspects of behavior and, in collaboration with the hippocampus, these prefrontal regions also regulate the implementation of anticipated memory retrieval as well as the allocation of relevance and expectancies to a memory (219, 511, 820, 938).”

    From About Sleep's Role in Memory (2013) · cites this paper as [511]

    The Results report prefrontal activity during the scene cue and increased prefrontal–hippocampal connectivity during accurate associative recognition. The Discussion suggests that prefrontal regions may use hippocampally retrieved information to guide memory decisions. These passages do not establish that prefrontal executive functions mediate anticipatory behavior or allocate relevance and expectancies to a memory; the paper's interpretation is also more tentative than the claim. Page numbers are unavailable in our copy. (LLM, conf=0.85)

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Research works printed but not linked: 35

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Cited by

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Authors
Hannula, D. E., & Ranganath, C.
Affiliations
University of California, Davis (US)
Corresponding author
Hannula, Deborah E.
ORCID
Hannula, Deborah E.
Venue
Neuron
Publisher
Elsevier BV
Published
2009-09
Volume
63
Issue
5
Pages
592-599
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2009.08.025
PMC
PMC2747814
OpenAlex
W2133280872
Cited by
352
References
1
Citations by year
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FWCI
7.77
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • University of California, Davis
  • National Institute of Mental Health (F32MH075513, R01MH068721, MH68721)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
Keywords
hippocampus, relational memory, eye movements, eye tracking, lateral prefrontal cortex, associative recognition memory
MeSH terms
Analysis of Variance, Association Learning, Cues, Eye Movements, Face, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Neural Pathways, Neuropsychological Tests, Photic Stimulation, Reaction Time, Temporal Lobe, Time Factors, Prefrontal Cortex, Recognition, Psychology, Eye Movement Measurements

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