Control of Cognition and Adaptive Behavior by the GLP/G9a Epigenetic Suppressor Complex
Open accessAbstract
The genetic basis of cognition and behavioral adaptation to the environment remains poorly understood. Here we demonstrate that the histone methyltransferase complex GLP/G9a controls cognition and adaptive responses in a region-specific fashion in the adult brain. Using conditional mutagenesis in mice, we show that postnatal, neuron-specific deficiency of GLP/G9a leads to derepression of numerous nonneuronal and neuron progenitor genes in adult neurons. This transcriptional alteration is associated with complex behavioral abnormalities, including defects in learning, motivation, and environmental adaptation. The behavioral changes triggered by GLP/G9a deficiency are similar to key symptoms of the human 9q34 mental retardation syndrome that is associated with structural alterations of the GLP/EHMT1 gene. The likely causal role of GLP/G9a in mental retardation in mice and humans suggests a key role for the GLP/G9a-controlled histone H3K9 dimethylation in regulation of brain function through maintenance of the transcriptional homeostasis in adult neurons.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Mutation or deletion of one copy of the GLP gene in humans leads to Kleefstra syndrome, characterized by social behavior impairment, impulsivity, aggression, and mental retardation.
“Researchers have reported that postnatal knockout of G9a reduced the anxiety phenotype in mice, while mutation or deletion of one copy of the GLP gene in humans leads to Kleefstra syndrome, characterized by social behavior impairment, impulsivity, aggression, and mental retardation (Schaefer et al., 2009).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Schaefer et al., 2009
The Results report that mice with postnatal G9a deficiency spent more time in the open arms of an elevated plus maze, consistent with reduced anxiety-like behavior, although the paper does not label this a reduced anxiety phenotype. The Results and Discussion associate alteration of a single GLP allele with a human mental retardation syndrome, but describe apathy and reduced activity rather than the claimed social impairment, impulsivity, and aggression. Page numbers were not supplied in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredThe HMT complex G9a/G9a-like protein (GLP) is involved in the monomethylation and dimethylation of H3K9.
“The HMT complex G9a/G9a-like protein (GLP), composed of the HMT euchromatic histone-lysine N-methyltransferase 2 (EHMT2) or G9a and G9a-like protein (GLP or EHMT1), has been shown to be involved in the monomethylation and dimethylation of H3K9 (Schaefer et al., 2009).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Schaefer et al., 2009
The Introduction states that the G9a/GLP histone methyltransferase complex catalyzes H3K9 dimethylation, and the Results report that loss of either protein reduces euchromatic H3K9me2. Our copy does not state that the complex is involved in H3K9 monomethylation (searched: H3K9me1, monomethylation). (LLM, conf=0.88)
Experimental — accuracy not yet measuredPostnatal knockout of G9a reduced the anxiety phenotype in mice.
“Researchers have reported that postnatal knockout of G9a reduced the anxiety phenotype in mice, while mutation or deletion of one copy of the GLP gene in humans leads to Kleefstra syndrome, characterized by social behavior impairment, impulsivity, aggression, and mental retardation (Schaefer et al., 2009).”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Schaefer et al., 2009
The Results section (page unavailable) reports that mice with postnatal forebrain-specific G9a ablation entered and spent more time in the open arms of an elevated plus maze than controls, consistent with reduced anxiety-like avoidance. The paper interprets this as a lack of apparent awareness of danger, rather than explicitly diagnosing reduced anxiety. Its Results and Discussion associate alterations of one GLP allele with a human intellectual-disability syndrome, but do not substantiate the sentence’s specific list of social impairment, impulsivity, and aggression. (LLM, conf=0.84)
Experimental — accuracy not yet measuredG9a/GLP seems to exert temporal effects on developmental histone methylation.
“Thus, G9a/GLP seems to exert temporal effects on developmental histone methylation.”
From The Epigenetics of Anxiety Pathophysiology: A DNA Methylation and Histone Modification Focused Review (2023) · cites this paper as Schaefer et al., 2009
The Results section, “Conditional ablation of GLP and G9a in postnatal neurons erases euchromatic H3K9 dimethylation” (page unavailable), reports that postnatal GLP or G9a deficiency reduces a histone methylation mark. It does not establish temporal changes in histone methylation across developmental stages; its developmental-stage finding concerns gene expression in adult neurons. (LLM, conf=0.82)
Experimental — accuracy not yet measuredThe sample sizes used in the study were similar to those reported in previous publications.
“No statistical methods were used to pre-determine sample sizes but our sample sizes are similar to those reported in previous publications19,31,95,99,108.”
From Epigenetic regulation of brain region-specific microglia clearance activity (2018) · cites this paper as [95]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
Chromatin modifications and their function
Kouzarides, T. (2007) · Cell · doi:10.1016/j.cell.2007.02.005 · Cited by 10,883 · see citing works
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756 · see citing works
Role of Histone H3 Lysine 27 Methylation in Polycomb-Group Silencing
Cao, R., Wang, L., Wang, H., Xia, L., Erdjument-Bromage, H., Tempst, P., Jones, R. S., & Zhang, Y. (2002) · Science · doi:10.1126/science.1076997 · Cited by 3,775 · see citing works
An efficient recombination system for chromosome engineering in Escherichia coli
Yu, D., Ellis, H. M., Lee, E.-C., Jenkins, N. A., Copeland, N. G., & Court, D. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100127597 · Cited by 1,688 · see citing works
Zhang, Y., & Reinberg, D. (2001) · Genes & Development · doi:10.1101/gad.927301 · Cited by 1,534 · see citing works
Tachibana, M., Sugimoto, K., Nozaki, M., Ueda, J., Ohta, T., Ohki, M., Fukuda, M., Takeda, N., Niida, H., Kato, H., et al. (2002) · Genes & Development · doi:10.1101/gad.989402 · Cited by 1,261 · see citing works
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsPreprint
Bracken, A. P., Dietrich, N., Pasini, D., Hansen, K. H., & Helin, K. (2006) · Genes & Development · doi:10.1101/gad.381706 · Cited by 1,258 · see citing works
Lee, E.-C., Yu, D., de Velasco, J. M., Tessarollo, L., Swing, D. A., Court, D. L., Jenkins, N. A., & Copeland, N. G. (2001) · Genomics · doi:10.1006/geno.2000.6451 · Cited by 1,179 · see citing works
High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP
Rodríguez, C. I., Buchholz, F., Galloway, J. L., Sequerra, R., Kasper, J. S., Ayala, R., Stewart, A. F., & Dymecki, S. M. (2000) · Nature Genetics · doi:10.1038/75973 · Cited by 1,162 · see citing works
Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin
Peters, A. H. F. M., Kubicek, S., Mechtler, K., O’Sullivan, R. J., Derijck, A. A. H. A., Perez-Burgos, L., Kohlmaier, A., Opravil, S., Tachibana, M., Shinkai, Y., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00477-5 · Cited by 1,148 · see citing works
A translational profiling approach for the molecular characterization of CNS cell types
Heiman, M., Schaefer, A., Gong, S., Peterson, J. D., Day, M., Ramsey, K. E., Suárez-Fariñas, M., Schwarz, C., Stephan, D. A., Surmeier, D. J., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.028 · Cited by 1,134 · see citing works
Self-citationGong, S., Doughty, M., Harbaugh, C. R., Cummins, A., Hatten, M. E., Heintz, N., & Gerfen, C. R. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2707-07.2007 · Cited by 977 · see citing works
Application of a translational profiling approach for the comparative analysis of CNS cell types
Doyle, J. P., Dougherty, J. D., Heiman, M., Schmidt, E. F., Stevens, T. R., Ma, G., Bupp, S., Shrestha, P., Shah, R. D., Doughty, M. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.10.029 · Cited by 912 · see citing works
Self-citationThe functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
Cao, R., & Zhang, Y. (2004) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2004.02.001 · Cited by 907 · see citing works
Tachibana, M., Ueda, J., Fukuda, M., Takeda, N., Ohta, T., Iwanari, H., Sakihama, T., Kodama, T., Hamakubo, T., & Shinkai, Y. (2005) · Genes & Development · doi:10.1101/gad.1284005 · Cited by 853 · see citing works
Rice, J. C., Briggs, S. D., Ueberheide, B. M., Barber, C. M., Shabanowitz, J., Hunt, D. F., Shinkai, Y., & Allis, C. D. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00479-9 · Cited by 828 · see citing works
Coordinated histone modifications mediated by a CtBP co-repressor complex
Shi, Y. G., Sawada, J.-I., Sui, G., Affar, E. B., Whetstine, J. R., Lan, F., Ogawa, H., Luke, M. P.-S., Nakatani, Y., & Shi, Y. (2003) · Nature · doi:10.1038/nature01550 · Cited by 799 · see citing works
Tachibana, M., Sugimoto, K., Fukushima, T., & Shinkai, Y. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101914200 · Cited by 784 · see citing works
A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G 0 Cells
Ogawa, H., Ishiguro, K., Gaubatz, S., Livingston, D. M., & Nakatani, Y. (2002) · Science · doi:10.1126/science.1069861 · Cited by 769 · see citing works
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement
Su, I.-H., Basavaraj, A., Krutchinsky, A. N., Hobert, O., Ullrich, A., Chait, B. T., & Tarakhovsky, A. (2002) · Nature Immunology · doi:10.1038/ni876 · Cited by 614 · see citing works
Self-citationDichotomous Anatomical Properties of Adult Striatal Medium Spiny Neurons
Gertler, T. S., Chan, C. S., & Surmeier, D. J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2660-08.2008 · Cited by 469 · see citing works
Self-citationHirabayashi, Y., Suzki, N., Tsuboi, M., Endo, T. A., Toyoda, T., Shinga, J., Koseki, H., Vidal, M., & Gotoh, Y. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.021 · Cited by 447 · see citing works
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
Tahiliani, M., Mei, P., Fang, R., Leonor, T., Rutenberg, M. S., Shimizu, F., Li, J., Rao, A., & Shi, Y. G. (2007) · Nature · doi:10.1038/nature05823 · Cited by 429 · see citing works
Cerebellar neurodegeneration in the absence of microRNAs
Schaefer, A., O'Carroll, D., Tan, C. L., Hillman, D., Sugimori, M., Llinas, R., & Greengard, P. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070823 · Cited by 426 · see citing works
Self-citationFailure of neuronal homeostasis results in common neuropsychiatric phenotypes
Ramocki, M. B., & Zoghbi, H. Y. (2008) · Nature · doi:10.1038/nature07457 · Cited by 399 · see citing works
Kleefstra, T., Brunner, H. G., Amiel, J., Oudakker, A. R., Nillesen, W. M., Magee, A. C., Geneviève, D., Cormier‐Daire, V., Esch, H. V., Fryns, J., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/505693 · Cited by 395 · see citing works
Gene Expression Nervous System Atlas (GENSAT)
Heintz, N. (2004) · Nature Neuroscience · doi:10.1038/nn0504-483 · Cited by 323 · see citing works
A CamKIIα iCre BAC allows brain‐specific gene inactivation
Casanova, E., Fehsenfeld, S., Mantamadiotis, T., Lemberger, T., Greiner, E. F., Stewart, A. F., & Schütz, G. (2001) · genesis · doi:10.1002/gene.1078 · Cited by 293 · see citing works
Localized Domains of G9a-Mediated Histone Methylation Are Required for Silencing of Neuronal Genes
Roopra, A., Qazi, R., Schoenike, B. A., Daley, T. J., & Morrison, J. F. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.05.026 · Cited by 282 · see citing works
Genetics and pathophysiology of mental retardation
Chelly, J., Khelfaoui, M., Francis, F., Beldjord, C., & Bienvenu, T. (2006) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5201595 · Cited by 266 · see citing works
Molecular and Comparative Genetics of Mental Retardation
Inlow, J. K., & Restifo, L. L. (2004) · Genetics · doi:10.1534/genetics.166.2.835 · Cited by 262 · see citing works
Fyffe, S. L., Neul, J. L., Samaco, R. C., Chao, H.-T., Ben-Shachar, S., Moretti, P., McGill, B. E., Goulding, E. H., Sullivan, E., Tecott, L. H., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.07.030 · Cited by 254 · see citing works
Kleefstra, T., van Zelst-Stams, W. A., Nillesen, W. M., Cormier-Daire, V, Houge, G., Foulds, N., van Dooren, M., Willemsen, M. H., Pfundt, R., Turner, A., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.062950 · Cited by 252 · see citing works
Niyonsaba, F., Ushio, H., Nagaoka, I., Okumura, K., & Ogawa, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1776 · Cited by 246 · see citing works
Sampath, S. C., Marazzi, I., Yap, K. L., Sampath, S. C., Krutchinsky, A. N., Mecklenbräuker, I., Viale, A. J., Rudensky, E., Zhou, M., Chait, B. T., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.06.026 · Cited by 246 · see citing works
Self-citationMediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation
Ding, N., Zhou, H., Estève, P., Chin, H. G., Kim, S., Xu, X., Joseph, S., Friez, M. J., Schwartz, C. E., Pradhan, S., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.05.023 · Cited by 238 · see citing works
Kondo, Y., Shen, L., Ahmed, S., Boumber, Y., Sekido, Y., Haddad, B. R., & Issa, J. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002037 · Cited by 235 · see citing works
Chen, H., Yan, Y., Davidson, T. L., Shinkai, Y., & Costa, M. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0101 · Cited by 222 · see citing works
G9a Histone Methyltransferase Contributes to Imprinting in the Mouse Placenta
Wagschal, A., Sutherland, H. G. E., Woodfine, K., Henckel, A., Chébli, K., Schulz, R., Oakey, R. J., Bickmore, W. A., & Feil, R. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01111-07 · Cited by 181 · see citing works
Laboratory Protocols for Conditional Gene Targeting
Torres, R. M., & Kühn, R. (1997) · doi:10.1093/oso/9780199636778.001.0001 · Cited by 170 · see citing works
Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family.
Lichenstein, H. S., Lyons, D. E., Wurfel, M. M., Johnson, D. A., McGinley, M. D., Leidli, J. C., Trollinger, D. B., Mayer, J. P., Wright, S. D., & Zukowski, M. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32429-8 · Cited by 156 · see citing works
Laminin isoforms in development and disease
Schéele, S., Nyström, A., Durbeej, M., Talts, J. F., Ekblom, M., & Ekblom, P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0182-5 · Cited by 155 · see citing works
Biological functions of maspin
Bailey, C. M., Khalkhali‐Ellis, Z., Seftor, E. A., & Hendrix, M. J. C. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20782 · Cited by 147 · see citing works
Estrogen action: A historic perspective on the implications of considering alternative approaches
Jensen, E. V., Jacobson, H. I., Walf, A. A., & Frye, C. A. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.08.013 · Cited by 133 · see citing works
Oien, K. A., McGregor, F., Butler, S., Ferrier, R. K., Downie, I., Bryce, S. D., Burns, S., & Keith, W. N. (2004) · The Journal of Pathology · doi:10.1002/path.1583 · Cited by 102 · see citing works
Genetic and epigenetic defects in mental retardation
Kramer, J. M., & van Bokhoven, H. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.08.009 · Cited by 87 · see citing works
A Jumonji (Jarid2) Protein Complex Represses cyclin D1 Expression by Methylation of Histone H3-K9
Shirato, H., Ogawa, S., Nakajima, K., Inagawa, M., Kojima, M., Tachibana, M., Shinkai, Y., & Takeuchi, T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804994200 · Cited by 80 · see citing works
Goldstone, A. P., & Beales, P. L. (2008) · Frontiers of hormone research · doi:10.1159/000115336 · Cited by 79 · see citing works
Cryptic terminal deletion of chromosome 9q34: a novel cause of syndromic obesity in childhood?
Cormier‐Daire, V., Molinari, F., Rio, M., Raoul, O., de Blois, M.-C., Romana, S. P., Vekemans, M. J. J., Münnich, A., & Colleaux, L. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.4.300 · Cited by 68 · see citing works
Functional Analysis of Histone Methyltransferase G9a in B and T Lymphocytes
Thomas, L. R., Miyashita, H., Cobb, R. M., Pierce, S. E., Tachibana, M., Hobeika, E., Reth, M. G., Shinkai, Y., & Oltz, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.485 · Cited by 65 · see citing works
Nguyen, T. T. T., Cho, K., Stratton, S. A., & Barton, M. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.6.2147-2157.2005 · Cited by 60 · see citing works
Benarafa, C., Cooley, J., Zeng, W., Bird, P. I., & Remold‐O’Donnell, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207080200 · Cited by 55 · see citing works
Characterization of mouse Dach2 , a homologue of Drosophila dachshund
Davis, R. J., Shen, W., Sandler, Y. I., Heanue, T. A., & Mardon, G. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(01)00307-0 · Cited by 52 · see citing works
Mammalian carboxylesterase 5: Comparative biochemistry and genomics
Holmes, R. S., Cox, L. A., & VandeBerg, J. L. (2008) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2008.05.002 · Cited by 34 · see citing works
Behavioral phenotype in the 9q subtelomeric deletion syndrome: A report about two adult patients
Verhoeven, W. M. A., Kleefstra, T., & Egger, J. I. M. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31015 · Cited by 33 · see citing works
Generation of a conditional allele of the CBP gene in mouse
Zhang, Z., Hofmann, C., Casanova, E., Schütz, G., & Lutz, B. (2004) · genesis · doi:10.1002/gene.20068 · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Epigenetic protein families: a new frontier for drug discovery
Arrowsmith, C. H., Bountra, C., Fish, P. V., Lee, K., & Schapira, M. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3674 · Cited by 1,327 · see citing works
Writing, erasing and reading histone lysine methylations
Hyun, K., Jeon, J., Park, K., & Kim, J. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.11 · Cited by 1,250 · see citing works
H3K9 methyltransferase G9a and the related molecule GLPPreprint
Shinkai, Y., & Tachibana, M. (2011) · Genes & Development · doi:10.1101/gad.2027411 · Cited by 557 · see citing works
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
Vedadi, M., Baršytė-Lovejoy, D., Liu, F., Rival‐Gervier, S., Allali‐Hassani, A., Labrie, V., Wigle, T. J., DiMaggio, P. A., Wasney, G. A., Siarheyeva, A., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.599 · Cited by 547 · see citing works
Padeken, J., Methot, S. P., & Gasser, S. M. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00483-w · Cited by 515 · see citing works
Epigenetic mechanisms in cognition
Day, J. J., & Sweatt, J. D. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.019 · Cited by 510 · see citing works
Histone lysine methyltransferases in biology and disease
Husmann, D., & Gozani, O. (2019) · Nature Structural & Molecular Biology · doi:10.1038/s41594-019-0298-7 · Cited by 469 · see citing works
Epigenetic regulation of brain region-specific microglia clearance activity
Ayata, P., Badimon, A., Strasburger, H. J., Duff, M. K., Montgomery, S. E., Loh, Y.-H. E., Ebert, A., Pimenova, A. A., Ramirez, B. R., Chan, A. T., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0192-3 · Cited by 460 · see citing works
Self-citationGenetic and Epigenetic Networks in Intellectual Disabilities
van Bokhoven, H. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132512 · Cited by 382 · see citing works
Epigenetic regulation of gene expression in physiological and pathological brain processes
Gräff, J., Kim, D., Dobbin, M. M., & Tsai, L.-H. (2011) · Physiological Reviews · doi:10.1152/physrev.00012.2010 · Cited by 373 · see citing works
EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex
Ohno, H., Shinoda, K., Ohyama, K., Sharp, L. Z., & Kajimura, S. (2013) · Nature · doi:10.1038/nature12652 · Cited by 331 · see citing works
Inhibitors of Protein Methyltransferases and Demethylases
Kanıskan, H. Ü., Martini, M. L., & Jin, J. J. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00801 · Cited by 320 · see citing works
SET for life: biochemical activities and biological functions of SET domain-containing proteins
Herz, H.-M., Garruss, A., & Shilatifard, A. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.09.004 · Cited by 314 · see citing works
Brain function and chromatin plasticity
Dulac, C. G. (2010) · Nature · doi:10.1038/nature09231 · Cited by 299 · see citing works
A Role for Repressive Histone Methylation in Cocaine-Induced Vulnerability to Stress
Covington, H. E., Maze, I., Sun, H., Bomze, H. M., DeMaio, K. D., Wu, E. Y., Dietz, D. M., Lobo, M. K., Ghose, S., Mouzon, E., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.007 · Cited by 289 · see citing works
Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP
Liu, F., Baršytė-Lovejoy, D., Li, F., Xiong, Y., Korboukh, V. K., Huang, X., Allali‐Hassani, A., Janzen, W. P., Roth, B. L., Frye, S. V., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm401480r · Cited by 285 · see citing works
Mozzetta, C., Pontis, J., Fritsch, L., Robin, P., Portoso, M., Proux, C., Margueron, R., & Ait‐Si‐Ali, S. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.005 · Cited by 278 · see citing works
An epigenetic framework for neurodevelopmental disorders: From pathogenesis to potential therapy
Millan, M. J. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.015 · Cited by 229 · see citing works
Gupta, S., Franklin, A. V., DeRamus, T. P., Wheelock, M. D., Davis, R. L., McMahon, L. L., & Lubin, F. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0147-12.2012 · Cited by 224 · see citing works
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
von Schimmelmann, M., Feinberg, P. A., Sullivan, J. M., Ku, S. M., Badimon, A., Duff, M. K., Wang, Z., Lachmann, A., Dewell, S., Ma'ayan, A., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4360 · Cited by 225 · see citing works
Self-citationThe epigenetic landscape of addiction
Maze, I. S., & Nestler, E. J. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05893.x · Cited by 223 · see citing works
Liu, F., Chen, X., Allali‐Hassani, A., Quinn, A. M., Wigle, T. J., Wasney, G. A., Dong, A., Senisterra, G. A., Chau, I., Siarheyeva, A., et al. (2010) · Journal of Medicinal Chemistry · doi:10.1021/jm100478y · Cited by 216 · see citing works
General Principals of miRNA Biogenesis and Regulation in the Brain
O'Carroll, D., & Schaefer, A. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.87 · Cited by 205 · see citing works
Self-citationEpigenetic Regulation of Learning and Memory by Drosophila EHMT/G9a
Kramer, J. M., Kochinke, K., Oortveld, M. A. W., Marks, H., Kramer, D., de Jong, E. K., Asztalos, Z., Westwood, J. T., Stunnenberg, H. G., Sokolowski, M. B., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000569 · Cited by 204 · see citing works
Targeting histone lysine methylation in cancer
McGrath, J. P., & Trojer, P. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.01.002 · Cited by 188 · see citing works
How the epigenome integrates information and reshapes the synapse
Campbell, R. R., & Wood, M. A. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0121-9 · Cited by 175 · see citing works
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer’s disease
Zheng, Y., Liu, A., Wang, Z.-J., Cao, Q., Wang, W., Lin, L., Ma, K., Zhang, F., Wei, J., Matas, E., et al. (2019) · Brain · doi:10.1093/brain/awy354 · Cited by 168 · see citing works
What is the degree of segregation between striatonigral and striatopallidal projections?
Bertran‐Gonzalez, J. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00136 · Cited by 173 · see citing works
G9a, a multipotent regulator of gene expression
Shankar, S. R., Bahirvani, A. G., Rao, V. K., Bharathy, N., Ow, J. R., & Taneja, R. (2012) · Epigenetics · doi:10.4161/epi.23331 · Cited by 169 · see citing works
LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control
Wang, J., Telese, F., Tan, Y., Li, W., Jin, C., He, X., Basnet, H., Ma, Q., Merkurjev, D., Zhu, X., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4069 · Cited by 169 · see citing works
High-Resolution Genome-wide Mapping of the Primary Structure of Chromatin
Zhang, Z., & Pugh, B. F. (2011) · Cell · doi:10.1016/j.cell.2011.01.003 · Cited by 163 · see citing works
Kmt1e regulates a large neuron-specific topological chromatin domain
Jiang, Y., Loh, Y., Rajarajan, P., Hirayama, T., Liao, W., Kassim, B. S., Javidfar, B., Hartley, B., Kleofas, L., Park, R. B., et al. (2017) · Nature Genetics · doi:10.1038/ng.3906 · Cited by 128 · see citing works
Self-citationOptimization of Cellular Activity of G9a Inhibitors 7-Aminoalkoxy-quinazolines
Liu, F., Baršytė-Lovejoy, D., Allali‐Hassani, A., He, Y., Herold, J. M., Chen, X., Yates, C. M., Frye, S. V., Brown, P. J., Huang, J. L., et al. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm200903z · Cited by 163 · see citing works
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response
Fang, T., Schaefer, U., Mecklenbräuker, I., Stienen, A., Dewell, S. B., Chen, M. S., Rioja, I., Parravicini, V., Prinjha, R. K., Chandwani, R., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20112343 · Cited by 162 · see citing works
Self-citationKoemans, T. S., Kleefstra, T., Chubak, M. C., Stone, M. H., Reijnders, M. R. F., de Munnik, S., Willemsen, M. H., Fencková, M., Schrander-Stumpel, C. T. R. M., Bok, L. A., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006864 · Cited by 159 · see citing works
Tan, S.-L., Nishi, M., Ohtsuka, T., Matsui, T., Takemoto, K., Kamio-Miura, A., Aburatani, H., Shinkai, Y., & Kageyama, R. (2012) · Development · doi:10.1242/dev.082198 · Cited by 159 · see citing works
UK10K, Riazuddin, S. A., Hussain, M., Razzaq, A., Iqbal, Z., Shahzad, M., Polla, D. L., Song, Y., van Beusekom, E., Khan, A. A., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.109 · Cited by 159 · see citing works
Histone-Methyltransferase MLL2 (KMT2B) Is Required for Memory Formation in Mice
Kerimoglu, C., Agís‐Balboa, R. C., Kranz, A., Stilling, R. M., Bahari‐Javan, S., Benito, E., Halder, R., Burkhardt, S., Stewart, A. F., & Fischer, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3356-12.2013 · Cited by 155 · see citing works
Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder
Yoon, S. H., Choi, J., Lee, W. Y., & Do, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9040966 · Cited by 156 · see citing works
Argonaute 2 in dopamine 2 receptor–expressing neurons regulates cocaine addiction
Schaefer, A., Im, H., Venø, M. T., Fowler, C. D., Min, A. K., Intrator, A., Kjems, J., Kenny, P. J., O’Carroll, D., & Greengard, P. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100451 · Cited by 146 · see citing works
Self-citationREST and CoREST are transcriptional and epigenetic regulators of seminal neural fate decisions
Qureshi, I., Gökhan, Ş., & Mehler, M. F. (2010) · Cell Cycle · doi:10.4161/cc.9.22.13973 · Cited by 143 · see citing works
Diverse Epigenetic Mechanisms of Human Disease
Brookes, E., & Shi, Y. (2014) · Annual Review of Genetics · doi:10.1146/annurev-genet-120213-092518 · Cited by 142 · see citing works
Epigenetic Etiology of Intellectual Disability
Iwase, S., Bérubé, N. G., Zhou, Z., Kasri, N. N., Battaglioli, E., Scandaglia, M., & Barco, Á. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1840-17.2017 · Cited by 137 · see citing works
Neuronal network dysfunction in a model for Kleefstra syndrome mediated by enhanced NMDAR signaling
Frega, M., Linda, K., Keller, J. M., Gümüş-Akay, G., Mossink, B., van Rhijn, J.-R., Negwer, M., Klein Gunnewiek, T., Foreman, K., Kompier, N., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12947-3 · Cited by 137 · see citing works
Epigenetic regulation of female puberty
Lomniczi, A., Wright, H., & Ojeda, S. R. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.08.003 · Cited by 136 · see citing works
Histone Regulation in the CNS: Basic Principles of Epigenetic Plasticity
Maze, I. S., Noh, K., & Allis, C. D. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.124 · Cited by 136 · see citing works
Selective Inhibitors of Protein Methyltransferases
Kanıskan, H. Ü., Konze, K. D., & Jin, J. J. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501234a · Cited by 135 · see citing works
Epigenetic Mechanisms in Memory and Synaptic Function
Sultan, F. A., & Day, J. J. (2011) · Epigenomics · doi:10.2217/epi.11.6 · Cited by 131 · see citing works
Lehnertz, B., Northrop, J. P., Antignano, F., Burrows, K., Hadidi, S., Mullaly, S. C., Rossi, F. M. V., & Zaph, C. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100363 · Cited by 133 · see citing works
Chromatin deregulation in disease
Mirabella, A., Foster, B. M., & Bartke, T. (2015) · Chromosoma · doi:10.1007/s00412-015-0530-0 · Cited by 132 · see citing works
Iwase, S., Brookes, E., Agarwal, S., Badeaux, A. I., Ito, H., Vallianatos, C. N., Tomassy, G. S., Kasza, T., Lin, G. R., Thompson, A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2015.12.091 · Cited by 132 · see citing works
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy
Thienpont, B., Aronsen, J. M., Robinson, E. L., Okkenhaug, H., Loche, E., Ferrini, A., Brien, P., Alkass, K., Tomasso, A., Agrawal, A., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88353 · Cited by 125 · see citing works
Epigenetic Treatments for Cognitive Impairments
Day, J. J., & Sweatt, J. D. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.85 · Cited by 127 · see citing works
Chromatin Landscape Defined by Repressive Histone Methylation during Oligodendrocyte Differentiation
Liu, J., Magri, L., Zhang, F., Marsh, N. O., Albrecht, S., Huynh, J. L., Kaur, J., Kuhlmann, T., Zhang, W., Slesinger, P. A., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.2606-14.2015 · Cited by 123 · see citing works
Scandaglia, M., López‐Atalaya, J. P., Medrano-Fernandez, A., López-Cascales, M. T., del Blanco, B., Lipiński, M., Benito, E., Olivares, R., Iwase, S., Shi, Y., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.09.014 · Cited by 123 · see citing works
Wang, H.-T., Huang, F., Hu, Z., Zhang, W., Qiao, X., Huang, Y., Dai, R., Li, F., & Li, C.-Q. (2017) · Neurotoxicity Research · doi:10.1007/s12640-016-9696-3 · Cited by 121 · see citing works
Mossink, B., Negwer, M., Schubert, D., & Nadif Kasri, N. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03714-5 · Cited by 114 · see citing works
Hamilton, P. J., Burek, D. J., Lombroso, S. I., Neve, R. L., Robison, A. J., Nestler, E. J., & Heller, E. A. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.88 · Cited by 113 · see citing works
Histone Methyltransferase G9a Is Required for Cardiomyocyte Homeostasis and Hypertrophy
Papait, R., Serio, S., Pagiatakis, C., Rusconi, F., Carullo, P., Mazzola, M., Salvarani, N., Miragoli, M., & Condorelli, G. (2017) · Circulation · doi:10.1161/circulationaha.117.028561 · Cited by 110 · see citing works
Balancing histone methylation activities in psychiatric disorders
Peter, C. J., & Akbarian, S. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.02.003 · Cited by 110 · see citing works
Fischer, A. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.038 · Cited by 108 · see citing works
Epigenetic memory: The Lamarckian brain
Fischer, A. (2014) · The EMBO Journal · doi:10.1002/embj.201387637 · Cited by 107 · see citing works
Histone methylation at H3K9: Evidence for a restrictive epigenome in schizophrenia
Chase, K. A., Gavin, D. P., Guidotti, A., & Sharma, R. P. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.06.021 · Cited by 107 · see citing works
Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area
Koo, J. W., Mazei‐Robison, M. S., LaPlant, Q. C., Egervári, G., Braunscheidel, K. M., Adank, D. N., Ferguson, D., Feng, J., Sun, H., Scobie, K. N., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3932 · Cited by 104 · see citing works
The Epigenetic Regulator G9a Mediates Tolerance to RNA Virus Infection in Drosophila
Merkling, S. H., Bronkhorst, A. W., Kramer, J. M., Overheul, G. J., Schenck, A., & van Rij, R. P. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004692 · Cited by 97 · see citing works
Epigenetics of major psychosis: progress, problems and perspectives
Labrie, V., Pai, S., & Petronis, A. (2012) · Trends in Genetics · doi:10.1016/j.tig.2012.04.002 · Cited by 102 · see citing works
Pappano, W. N., Guo, J. Q., He, Y., Ferguson, D. C., Jagadeeswaran, S., Osterling, D. J., Gao, W., Spence, J. K., Pliushchev, M. A., Sweis, R. F., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131716 · Cited by 100 · see citing works
The Epigenetic Landscape of Alcoholism
Krishnan, H. R., Sakharkar, A. J., Teppen, T. L., Berkel, T. D. M., & Pandey, S. C. (2014) · International review of neurobiology · doi:10.1016/b978-0-12-801311-3.00003-2 · Cited by 98 · see citing works
Chaturvedi, C.-P., Somasundaram, B., Singh, K., Carpenedo, R. L., Stanford, W. L., Dilworth, F. J., & Brand, M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213951109 · Cited by 98 · see citing works
Histone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling
Benevento, M., Iacono, G., Selten, M. M., Ba, W., Oudakker, A. R., Frega, M., Keller, J., Mancini, R., Lewerissa, E., Kleefstra, T., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.003 · Cited by 94 · see citing works
A neurodegenerative cellular stress response linked to dark microglia and toxic lipid secretion
Flury, A. G., Aljayousi, L., Park, H.-J., Khakpour, M., Mechler, J., Aziz, S., McGrath, J. D., Deme, P., Sandberg, C., Ibáñez, F. G., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.11.018 · Cited by 98 · see citing works
Subbanna, S., Shivakumar, M., Umapathy, N. S., Saito, M., Mohan, P. S., Kumar, A. R., Nixon, R. A., Verin, A. D., Psychoyos, D., & Basavarajappa, B. S. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.01.022 · Cited by 95 · see citing works
G9a influences neuronal subtype specification in striatum
Maze, I. S., Chaudhury, D., Dietz, D., von Schimmelmann, M. J., Kennedy, P., Lobo, M. K., Daws, S. E., Miller, M. L., Bagot, R. C., Sun, H., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3670 · Cited by 91 · see citing works
Self-citationAlternative Splicing of G9a Regulates Neuronal Differentiation
Fiszbein, A., Giono, L. E., Quaglino, A., Berardino, B. G., Sigaut, L., von Bilderling, C., Schor, I. E., Steinberg, J. H. E., Rossi, M., Pietrasanta, L. I., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.063 · Cited by 88 · see citing works
Subbanna, S., Nagre, N. N., Shivakumar, M., Umapathy, N. S., Psychoyos, D., & Basavarajappa, B. S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.043 · Cited by 86 · see citing works
Griñán‐Ferré, C., Marsal-García, L., Bellver‐Sanchís, A., Kondengaden, S. M., Turaga, R. C., Vázquez, S., & Pallàs, M. (2019) · Aging · doi:10.18632/aging.102558 · Cited by 85 · see citing works
The Lysine Methyltransferase G9a in Immune Cell Differentiation and Function
Scheer, S., & Zaph, C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00429 · Cited by 84 · see citing works
Porter, R. S., Jaamour, F., & Iwase, S. (2017) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2017.10.006 · Cited by 80 · see citing works
Wang, Z.-J., Zhong, P., Ma, K., Seo, J.-S., Yang, F., Hu, Z., Zhang, F., Lin, L., Wang, J., Liu, T., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0351-2 · Cited by 82 · see citing works
Self-citationDiscovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase
Xiong, Y., Li, F., Babault, N., Dong, A., Zeng, H., Wu, H., Chen, X., Arrowsmith, C. H., Brown, P. J., Liu, J., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01645 · Cited by 79 · see citing works
Lubin, F. D., Gupta, S., Parrish, R. R., Grissom, N. M., & Davis, R. L. (2011) · The Neuroscientist · doi:10.1177/1073858411386967 · Cited by 97 · see citing works
G9A promotes gastric cancer metastasis by upregulating ITGB3 in a SET domain-independent manner
Hu, L., Zang, M., Wang, H., Zhang, B.-G., Wang, Z., Fan, Z., Wu, H., Li, J., Su, L., Yan, M., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0322-6 · Cited by 79 · see citing works
“Seq-ing” Insights into the Epigenetics of Neuronal Gene Regulation
Telese, F., Gamliel, A., Skowronska‐Krawczyk, D., García-Bassets, I., & Rosenfeld, M. G. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.034 · Cited by 76 · see citing works
Heterochromatin-Mediated Gene Silencing Facilitates the Diversification of Olfactory Neurons
Lyons, D. B., Magklara, A., Goh, T., Sampath, S. C., Schaefer, A., Schotta, G., & Lomvardas, S. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.001 · Cited by 77 · see citing works
Self-citationBalemans, M. C. M., Kasri, N. N., Kopanitsa, M. V., Afinowi, N. O., Ramakers, G. J. A., Peters, T. A., Beynon, A. J., Janssen, S. M., van Summeren, R. C. J., Eeftens, J. M., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds490 · Cited by 76 · see citing works
Tools and landscapes of epigenetics
Tarakhovsky, A. (2010) · Nature Immunology · doi:10.1038/ni0710-565 · Cited by 73 · see citing works
Self-citationIntegrating Early Life Experience, Gene Expression, Brain Development, and Emergent Phenotypes
Weaver, I. C. G. (2014) · Advances in genetics · doi:10.1016/b978-0-12-800222-3.00011-5 · Cited by 73 · see citing works
Transgenerational epigenetic effects on animal behaviour
Jensen, P. (2013) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2013.01.001 · Cited by 73 · see citing works
Balemans, M. C. M., Ansar, M., Oudakker, A. R., van Caam, A. P. M., Bakker, B., Vitters, E. L., van der Kraan, P. M., de Bruijn, D. R. H., Janssen, S. M., Kuipers, A. J., et al. (2014) · Developmental Biology · doi:10.1016/j.ydbio.2013.12.016 · Cited by 72 · see citing works
The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression
Bian, C., Chen, Q., & Yu, X. (2015) · eLife · doi:10.7554/elife.05606 · Cited by 72 · see citing works
Qiang, M., Denny, A. D., Lieu, M., Carreon, S., & Li, J. (2011) · Epigenetics · doi:10.4161/epi.6.9.16924 · Cited by 71 · see citing works
Rothammer, N., Woo, M. S., Bauer, S., Binkle-Ladisch, L., Liberto, G. D., Égervári, K., Wagner, I., Haferkamp, U., Pleß, O., Merkler, D., et al. (2022) · Science Advances · doi:10.1126/sciadv.abm5500 · Cited by 70 · see citing works
G9a co-suppresses LINE1 elements in spermatogonia
Giacomo, M. D., Comazzetto, S., Sampath, S. C., Sampath, S. C., & O’Carroll, D. (2014) · Epigenetics & Chromatin · doi:10.1186/1756-8935-7-24 · Cited by 70 · see citing works
Self-citationHistone lysine methylation: critical regulator of memory and behavior
Jarome, T. J., & Lubin, F. D. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0008 · Cited by 70 · see citing works
Epigenetic Control of Cytokine Gene Expression
Falvo, J. V., Jasenosky, L. D., Kruidenier, L., & Goldfeld, A. E. (2013) · Advances in immunology · doi:10.1016/b978-0-12-407708-9.00002-9 · Cited by 65 · see citing works
Targeting Neuronal Populations of the Striatum
Durieux, P. F., Schiffmann, S. N., & d’Exaerde, A. D. K. (2011) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2011.00040 · Cited by 64 · see citing works
Homocysteine, Alcoholism, and Its Potential Epigenetic Mechanism
Kamat, P. K., Malonee, C. J., George, A. K., Tyagi, S. C., & Tyagi, N. (2016) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13234 · Cited by 64 · see citing works
Weaver, I. C. G., Korgan, A. C., Lee, K., Wheeler, R. V., Hundert, A. S., & Goguen, D. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00041 · Cited by 64 · see citing works
Milite, C., Feoli, A., Horton, J. R., Rescigno, D., Cipriano, A., Pisapia, V., Viviano, M., Pepe, G., Amendola, G., Novellino, E., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b02008 · Cited by 65 · see citing works
Two definite cases of sudden unexpected death in epilepsy in a family with a DEPDC5 mutation
Nascimento, F. A., Borlot, F., Cossette, P., Minassian, B. A., & Andrade, D. M. (2015) · Neurology Genetics · doi:10.1212/nxg.0000000000000028 · Cited by 64 · see citing works
- Authors
- Schaefer, A., Sampath, S. C., Intrator, A., Min, A., Gertler, T. S., Surmeier, D. J., Tarakhovsky, A., & Greengard, P.
- Affiliations
- Rockefeller University (US)
- Northwestern University (US)
- Corresponding author
- Tarakhovsky, Alexander
- Greengard, Paul
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 64
- Issue
- 5
- Pages
- 678-691
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2814156
- OpenAlex
- W2065364505
- Cited by
- 317
- References
- 57
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 14 · 2023: 11 · 2022: 12 · 2021: 17 · 2020: 16 · 2019: 20 · 2018: 16 · 2017: 24 · 2016: 23 · 2015: 27 · 2014: 28 · 2013: 24 · 2012: 24
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (AG09464, P01AG009464)
- National Institute of Mental Health (MH-074866, F30MH082522, MH082522, P50MH074866)
- National Institute on Drug Abuse (R03DA025962, DA025962)
- National Institute of General Medical Sciences (GM 07739, R01GM112811, T32GM007739)
- National Institute of Allergy and Infectious Diseases (AI068058, R01AI068058)
- National Institute of Neurological Disorders and Stroke (P01NS013742)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- EHMT1, histone methyltransferase, epigenetic regulation, cognition, learning and memory, motivation, environmental adaptation, adult neurons
- MeSH terms
- Enhancer of Zeste Homolog 2 Protein, Adaptation, Physiological, Central Nervous System Stimulants, Animals, Animals, Newborn, Behavior, Animal, Benzazepines, Body Weight, Caffeine, Cognition, Cognition Disorders, Conditioning, Classical, Exploratory Behavior, Fear, Food Preferences, Mice, Inbred DBA, Mice, Transgenic, Motor Activity, Histone-Lysine N-Methyltransferase, Mutagenesis, Dopamine Agonists, Maze Learning, Epigenesis, Genetic, Green Fluorescent Proteins, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Polycomb Repressive Complex 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
