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Corticospinal Neurons in Macaque Ventral Premotor Cortex with Mirror Properties: A Potential Mechanism for Action Suppression?
Open accessAbstract
The discovery of "mirror neurons" in area F5 of the ventral premotor cortex has prompted many theories as to their possible function. However, the identity of mirror neurons remains unknown. Here, we investigated whether identified pyramidal tract neurons (PTNs) in area F5 of two adult macaques exhibited "mirror-like" activity. About half of the 64 PTNs tested showed significant modulation of their activity while monkeys observed precision grip of an object carried out by an experimenter, with somewhat fewer showing modulation during precision grip without an object or grasping concealed from the monkey. Therefore, mirror-like activity can be transmitted directly to the spinal cord via PTNs. A novel finding is that many PTNs (17/64) showed complete suppression of discharge during action observation, while firing actively when the monkey grasped food rewards. We speculate that this suppression of PTN discharge might be involved in the inhibition of self-movement during action observation.
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“subsequent studies confirmed that sizable proportions, perhaps the majority, of MNs exhibit robust responses to the observation of object-free body movement.”
From Mirror neurons: from origin to function (2014) · cites this paper as Kraskov et al., 2009
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“MN responses start around 250ms after observed movement onset”
From Mirror neurons: from origin to function (2014) · cites this paper as Kraskov et al., 2009
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Cites
Action recognition in the premotor cortex
Gallese, V., Fadiga, L., Fogassi, L., & Rizzolatti, G. (1996) · Brain · doi:10.1093/brain/119.2.593 · Cited by 4,968
Premotor cortex and the recognition of motor actions
Rizzolatti, G., Fadiga, L., Gallese, V., & Fogassi, L. (1996) · Cognitive Brain Research · doi:10.1016/0926-6410(95)00038-0 · Cited by 4,870
Understanding motor events: a neurophysiological study
di Pellegrino, G., Fadiga, L., Fogassi, L., Gallese, V., & Rizzolatti, G. (1992) · Experimental Brain Research · doi:10.1007/bf00230027 · Cited by 3,539
Motor facilitation during action observation: a magnetic stimulation study
Fadiga, L., Fogassi, L., Pavesi, G., & Rizzolatti, G. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.6.2608 · Cited by 2,297
Unsupervised spike detection and sorting with wavelets and superparamagnetic clustering
Quiroga, R. Q., Nadasdy, Z., & Ben-Shaul, Y. (2004) · Neural Computation · doi:10.1162/089976604774201631 · Cited by 2,119
Parietal Lobe: From Action Organization to Intention Understanding
Fogassi, L., Ferrari, P. F., Gesierich, B., Rozzi, S., Chersi, F., & Rizzolatti, G. (2005) · Science · doi:10.1126/science.1106138 · Cited by 1,990
Hearing Sounds, Understanding Actions: Action Representation in Mirror Neurons
Kohler, E., Keysers, C., Umiltà, M. A., Fogassi, L., Gallese, V., & Rizzolatti, G. (2002) · Science · doi:10.1126/science.1070311 · Cited by 1,801
Imitation, empathy, and mirror neurons
Iacoboni, M. (2009) · Annual Review of Psychology · doi:10.1146/annurev.psych.60.110707.163604 · Cited by 1,606
Descending Pathways in Motor Control
Lemon, R. N. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125547 · Cited by 1,599
Self-citationFunctional organization of inferior area 6 in the macaque monkey
Rizzolatti, G., Camarda, R., Fogassi, L., Gentilucci, M., Luppino, G., & Matelli, M. (1988) · Experimental Brain Research · doi:10.1007/bf00248742 · Cited by 1,550
The origin of corticospinal projections from the premotor areas in the frontal lobe
Dum, R., & Strick, P. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-03-00667.1991 · Cited by 1,447
Umiltà, M. A., Kohler, E., Gallese, V., Fogassi, L., Fadiga, L., Keysers, C., & Rizzolatti, G. (2001) · Neuron · doi:10.1016/s0896-6273(01)00337-3 · Cited by 1,192
Localization of grasp representations in humans by PET: 1. Observation versus execution
Rizzolatti, G., Fadiga, L., Matelli, M., Bettinardi, V., Paulesu, E., Perani, D., & Fazio, F. (1996) · Experimental Brain Research · doi:10.1007/bf00227301 · Cited by 1,061
Grafton, S., Arbib, M., Fadiga, L., & Rizzolatti, G. (1996) · Experimental Brain Research · doi:10.1007/bf00227183 · Cited by 1,045
He, S., Dum, R. P., & Strick, P. L. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00952.1993 · Cited by 877
Ferrari, P. F., Gallese, V., Rizzolatti, G., & Fogassi, L. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02601.x · Cited by 728
Subdivisions of primary motor cortex based on cortico-motoneuronal cells
Rathelot, J.-A., & Strick, P. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0808362106 · Cited by 590
Strafella, A. P., & Paus, T. (2000) · NeuroReport · doi:10.1097/00001756-200007140-00044 · Cited by 504
Impairment of actions chains in autism and its possible role in intention understanding
Cattaneo, L., Fabbri‐Destro, M., Boria, S., Pieraccini, C., Monti, A., Cossu, G., & Rizzolatti, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706273104 · Cited by 483
Mirror Neurons and Mirror Systems in Monkeys and Humans
Fabbri‐Destro, M., & Rizzolatti, G. (2008) · Physiology · doi:10.1152/physiol.00004.2008 · Cited by 440
Muscle representation in the macaque motor cortex: An anatomical perspective
Rathelot, J.-A., & Strick, P. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602933103 · Cited by 433
Audiovisual mirror neurons and action recognition
Keysers, C., Kohler, E., Umilt�, M. A., Nanetti, L., Fogassi, L., & Gallese, V. (2003) · Experimental Brain Research · doi:10.1007/s00221-003-1603-5 · Cited by 420
Mirror neurons and their clinical relevance
Rizzolatti, G., Fabbri‐Destro, M., & Cattaneo, L. (2009) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0990 · Cited by 417
Direction of action is represented in the ventral premotor cortex
Kakei, S., Hoffman, D. S., & Strick, P. L. (2001) · Nature Neuroscience · doi:10.1038/nn726 · Cited by 383
Mirror Neurons Differentially Encode the Peripersonal and Extrapersonal Space of Monkeys
Caggiano, V., Fogassi, L., Rizzolatti, G., Thier, P., & Casile, A. (2009) · Science · doi:10.1126/science.1166818 · Cited by 361
Rozzi, S., Ferrari, P. F., Bonini, L., Rizzolatti, G., & Fogassi, L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06395.x · Cited by 354
Neonatal imitation in Rhesus Macaques
Ferrari, P. F., Visalberghi, E., Paukner, A., Fogassi, L., Ruggiero, A., & Suomi, S. J. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040302 · Cited by 354
Localization of grasp representations in humans by PET
Rizzolatti, G., Fadiga, L., Matelli, M., Bettinardi, V., Paulesu, E., Perani, D., & Fazio, F. (1996) · Cited by 340
Neural correlates of mental rehearsal in dorsal premotor cortex
Cisek, P., & Kalaska, J. F. (2004) · Nature · doi:10.1038/nature03005 · Cited by 312
Shimazu, H., Maier, M. A., Cerri, G., Kirkwood, P., & Lemon, R. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4731-03.2004 · Cited by 304
Self-citationCongruent Activity during Action and Action Observation in Motor Cortex
Tkach, D. C., Reimer, J., & Hatsopoulos, N. G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2895-07.2007 · Cited by 297
Ferrari, P. F., Rozzi, S., & Fogassi, L. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929053124910 · Cited by 283
Primate spinal interneurons show pre-movement instructed delay activity
Prut, Y., & Fetz, E. E. (1999) · Nature · doi:10.1038/44145 · Cited by 242
Visalberghi, E. M., & Fragaszy, D. M. (1990) · Cambridge University Press eBooks · doi:10.1017/cbo9780511665486.011 · Cited by 241
Kurata, K. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.69.1.187 · Cited by 232
Modulation of spinal excitability during observation of hand actions in humans
Baldissera, F., Cavallari, P., Craighero, L., & Fadiga, L. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01368.x · Cited by 205
Baker, S. N., Spinks, R. L., Jackson, A., & Lemon, R. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.2.869 · Cited by 198
Self-citationCheney, P. D., Fetz, E. E., & Palmer, S. S. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.53.3.805 · Cited by 196
Gray and white matter changes associated with tool-use learning in macaque monkeys
Quallo, M. M., Price, C. J., Ueno, K., Asamizuya, T., Cheng, K., Lemon, R., & Iriki, A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909751106 · Cited by 185
Self-citationUmiltà, M. A., Brochier, T. G., Spinks, R. L., & Lemon, R. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01094.2006 · Cited by 185
Self-citationMethods for neuronal recording in conscious animals
(1985) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(85)90035-7 · Cited by 184
Cattaneo, L., Caruana, F., Jezzini, A., & Rizzolatti, G. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2605-09.2009 · Cited by 173
Humphrey, D. R., & Corrie, W. S. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.1.216 · Cited by 172
Facilitation From Ventral Premotor Cortex of Primary Motor Cortex Outputs to Macaque Hand Muscles
Cerri, G., Shimazu, H., Maier, M. A., & Lemon, R. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01026.2002 · Cited by 157
Self-citationIriki, A., & Sakura, O. (2008) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2008.2274 · Cited by 142
Patterns of Muscle Activity Underlying Object-Specific Grasp by the Macaque Monkey
Brochier, T. G., Spinks, R. L., Umiltà, M. A., & Lemon, R. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00976.2003 · Cited by 137
Self-citation"Do Monkeys Ape?"—Ten Years After
Visalberghi, E. M., & Fragaszy, D. M. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3676.003.0019 · Cited by 134
Montagna, M., Cerri, G., BORRONI, P. F., & Baldissera, F. G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04336.x · Cited by 125
Multiple single unit recording in the cortex of monkeys using independently moveable microelectrodes
Baker, S. N., Philbin, N., Spinks, R. L., Pinches, E. M., Wolpert, D. M., MacManus, D. G., Pauluis, Q., & Lemon, R. (1999) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(99)00121-1 · Cited by 119
Self-citationDirect and Indirect Cortico-Motoneuronal Pathways and Control of Hand/Arm Movements
Isa, T., Ohki, Y., Alstermark, B., Pettersson, L. ‐., & Sasaki, S. (2007) · Physiology · doi:10.1152/physiol.00045.2006 · Cited by 108
Acquisition and development of monkey tool-use: behavioral and kinematic analyses
Ishibashi, H., Hihara, S., & Iriki, A. (2000) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y00-063 · Cited by 95
Merchant, H., Naselaris, T., & Georgopoulos, A. P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1898-08.2008 · Cited by 93
Prabhu, G., Shimazu, H., Cerri, G., Brochier, T. G., Spinks, R. L., Maier, M. A., & Lemon, R. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.165571 · Cited by 92
Self-citationBoudrias, M., McPherson, R. L., Frost, S. B., & Cheney, P. D. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp084 · Cited by 84
Schmidlin, E., Brochier, T. G., Maier, M. A., Kirkwood, P., & Lemon, R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.0944-08.2008 · Cited by 80
Self-citationOlivier, E., Baker, S. N., Nakajima, K., Brochier, T. G., & Lemon, R. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.4.1573 · Cited by 61
Self-citationKurata, K., & Hoshi, E. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00070.2002 · Cited by 50
Problem of Dural Scarring in Recording From Awake, Behaving Monkeys: A Solution Using 5-Fluorouracil
Spinks, R. L., Baker, S. N., Jackson, A., Khaw, P. T., & Lemon, R. (2003) · Journal of Neurophysiology · doi:10.1152/jn.00169.2003 · Cited by 45
Self-citationZhou, X., & Rush, R. A. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960812)372:1 · Cited by 31
Methods for Neuronal Recording in Conscious Animals
Kerkut, G. A. (1984) · Neurochemistry International · doi:10.1016/0197-0186(84)90016-0 · Cited by 13
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Mukamel, R., Ekstrom, A. D., Kaplan, J., Iacoboni, M., & Fried, I. (2010) · Current Biology · doi:10.1016/j.cub.2010.02.045 · Cited by 1,178
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Metadata
- Authors
- Kraskov, A., Dancause, N., Quallo, M. M., Shepherd, S., & Lemon, R. N.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- Corresponding author
- Lemon, Roger N.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 64
- Issue
- 6
- Pages
- 922-930
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2862290
- OpenAlex
- W1970012077
- Cited by
- 298
- References
- 60
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 10 · 2023: 21 · 2022: 12 · 2021: 13 · 2020: 8 · 2019: 12 · 2018: 20 · 2017: 21 · 2016: 16 · 2015: 18 · 2014: 37 · 2013: 28 · 2012: 26
- FWCI
- 29.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (073920)
- Topics
- Social Sciences › Psychology › Social Psychology › Action Observation and Synchronization
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Primate Behavior and Ecology
- Keywords
- mirror neurons, ventral premotor cortex, pyramidal tract neurons, action observation, precision grip, action suppression, corticospinal neurons, motor inhibition, macaque
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Female, Frontal Lobe, Imitative Behavior, Macaca mulatta, Male, Motor Cortex, Movement, Neural Inhibition, Neurons, Photic Stimulation, Pyramidal Tracts, Reward, Visual Perception, Hand Strength
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