The DOI matches its Crossref record; 66 of the 67 references it cites were found in a registry or an index.
Bassoon Speeds Vesicle Reloading at a Central Excitatory Synapse
Open accessAbstract
Sustained rate-coded signals encode many types of sensory modalities. Some sensory synapses possess specialized ribbon structures, which tether vesicles, to enable high-frequency signaling. However, central synapses lack these structures, yet some can maintain signaling over a wide bandwidth. To analyze the underlying molecular mechanisms, we investigated the function of the active zone core component Bassoon in cerebellar mossy fiber to granule cell synapses. We show that short-term synaptic depression is enhanced in Bassoon knockout mice during sustained high-frequency trains but basal synaptic transmission is unaffected. Fluctuation and quantal analysis as well as quantification with constrained short-term plasticity models revealed that the vesicle reloading rate was halved in the absence of Bassoon. Thus, our data show that the cytomatrix protein Bassoon speeds the reloading of vesicles to release sites at a central excitatory synapse.
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“Piccolo and bassoon are large proteins specific to vertebrates whose major function appears to be to guide synaptic vesicles from the backfield of the synapse to the active zone (Mukherjee et al., 2010; Hallermann et al., 2010).”
From The Presynaptic Active Zone (2012) · cites this paper as Hallermann et al., 2010
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“Recovery at MF–GC synapses follows a bi‐exponential time course (Hallermann et al., 2010).”
From MicroRNA‐138‐5p suppresses excitatory synaptic strength at the cerebellar input layer (2025) · cites this paper as Hallermann et al., 2010
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“a deletion of the 17 C-terminal residues of bruchpilot (which are part of the plectin-homology region) impaired attachment of synaptic vesicles to t bars in Drosophila synapses and altered synaptic transmission”
From The Presynaptic Active Zone (2012) · cites this paper as Hallermann et al., 2010
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“suggesting that a major contribution to bruchpilot function is derived from the plectin-homology region (Hallermann et al., 2010).”
From The Presynaptic Active Zone (2012) · cites this paper as Hallermann et al., 2010
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Kemna, N. A. (2022) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9052
Targeting ion sensors to synaptic vesicles using a Nanobody against luminal Synaptotagmin 1
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Metadata
- Authors
- Hallermann, S., Fejtova, A., Schmidt, H., Weyhersmüller, A., Silver, R. A., Gundelfinger, E. D., & Eilers, J.
- Affiliations
- Leipzig University (DE)
- University College London (GB)
- Leibniz Institute for Neurobiology (DE)
- Corresponding author
- Hallermann, Stefan
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 68
- Issue
- 4
- Pages
- 710-723
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3004039
- OpenAlex
- W2050878615
- Cited by
- 223
- References
- 67
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 7 · 2023: 12 · 2022: 15 · 2021: 11 · 2020: 16 · 2019: 17 · 2018: 13 · 2017: 16 · 2016: 17 · 2015: 13 · 2014: 17 · 2013: 15 · 2012: 16
- FWCI
- 6.34
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- bassoon, short-term synaptic depression, cerebellum, active zone, quantal analysis, rate coding
- MeSH terms
- Animals, Cells, Cultured, Cerebellum, Hippocampus, Mice, Inbred C57BL, Mice, Transgenic, Nerve Tissue Proteins, Neural Inhibition, Reaction Time, Synapses, Synaptic Vesicles, Time Factors, Mice, Knockout, Excitatory Postsynaptic Potentials, Mice, Mice, 129 Strain
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