Lhx6 directly regulates Arx and CXCR7 to determine cortical interneuron fate and laminar position
Open accessAbstract
Cortical GABAergic interneurons have essential roles for information processing and their dysfunction is implicated in neuropsychiatric disorders. Transcriptional codes are elucidating mechanisms of interneuron specification in the MGE (a subcortical progenitor zone), which regulate their migration, integration, and function within cortical circuitry. Lhx6, a LIM-homeodomain transcription factor, is essential for specification of MGE-derived somatostatin and parvalbumin interneurons. Here, we demonstrate that some Lhx6⁻/⁻ MGE cells acquire a CGE-like fate. Using an in vivo MGE complementation/transplantation assay, we show that Lhx6-regulated genes Arx and CXCR7 rescue divergent aspects of Lhx6⁻/⁻ cell-fate and laminar mutant phenotypes and provide insight into a neonatal role for CXCR7 in MGE-derived interneuron lamination. Finally, Lhx6 directly binds in vivo to an Arx enhancer and to an intronic CXCR7 enhancer that remains active in mature interneurons. These data define the molecular identity of Lhx6 mutants and introduce technologies to test mechanisms in GABAergic interneuron differentiation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Loss of ARX severely impairs interneuron development because Arx is a repressor that orchestrates interneuron differentiation.
“Loss of ARX severely impairs interneuron development (Vogt et al., 2014), as Arx is a repressor that functions to orchestrate interneuron differentiation.”
From Unifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops (2016) · cites this paper as Vogt et al., 2014
A transcription cascade involving Nkx2.1 and Lhx6 drives the MGE clade but not the CGE clade of interneurons.
“In particular, a transcription cascade involving Nkx2.1 and Lhx6 drives the MGE clade but not the CGE clade of interneurons31,34,35.”
From The diversity of GABAergic neurons and neural communication elements (2019) · cites this paper as [35]
Embryonic MGE-derived interneurons lacking Cxcr7 transplanted into the cortex at PN1 fail to migrate to layer 5 and instead accumulate in the superficial layers in adult animals.
“when embryonic MGE-derived interneurons lacking Cxcr7 are transplanted into the cortex at PN1, they fail to migrate to layer 5 and instead accumulate in the superficial layers in adult animals”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1176]
In postnatal cortex, Cxcl12 and Cxcr7 expression are maintained preferentially in layer 5.
“In the postnatal cortex, Cxcl12 and Cxcr7 expression are maintained preferentially in layer 5”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [1176]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works
Model of autism: increased ratio of excitation/inhibition in key neural systems
Rubenstein, J. L. R., & Merzenich, M. M. (2003) · Genes, Brain and Behavior · doi:10.1034/j.1601-183x.2003.00037.x · Cited by 2,768 · see citing works
Self-citationNeocortical excitation/inhibition balance in information processing and social dysfunction
Yizhar, O., Fenno, L. E., Prigge, M., Schneider, F., Davidson, T. J., O’Shea, D. J., Sohal, V. S., Goshen, I., Finkelstein, J., Paz, J. T., et al. (2011) · Nature · doi:10.1038/nature10360 · Cited by 2,454 · see citing works
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on <i>Dlx</i> Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462 · see citing works
Self-citationThree groups of interneurons account for nearly 100% of neocortical GABAergic neurons
Rudy, B., Fishell, G., Lee, S., & Hjerling‐Leffler, J. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20853 · Cited by 1,420 · see citing works
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
Chao, H.-T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., Neul, J. L., Gong, S., Lu, H.-C., Heintz, N., et al. (2010) · Nature · doi:10.1038/nature09582 · Cited by 1,168 · see citing works
Self-citationThe origin and specification of cortical interneurons
Wonders, C. P., & Anderson, S. A. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1954 · Cited by 980 · see citing works
Sussel, L., Marin, O., Kimura, S., & Rubenstein, J. L. R. (1999) · Development · doi:10.1242/dev.126.15.3359 · Cited by 873 · see citing works
Self-citationAutistic-like behaviour in Scn1a+/− mice and rescue by enhanced GABA-mediated neurotransmission
Han, S., Tai, C., Westenbroek, R. E., Yu, F. H., Cheah, C. S., Potter, G. B., Rubenstein, J. L., Scheuer, T., de la Iglesia, H. O., & Catterall, W. A. (2012) · Nature · doi:10.1038/nature11356 · Cited by 643 · see citing works
Self-citationSierro, F., Biben, C., Martínez‐Muñoz, L., Mellado, M., Ransohoff, R. M., Li, M., Woehl, B., Leung, H., Groom, J. R., Batten, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0702229104 · Cited by 625 · see citing works
Lee, S., Hjerling-Leffler, J., Zagha, E., Fishell, G., & Rudy, B. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1869-10.2010 · Cited by 600 · see citing works
Maroof, A. M., Keros, S., Tyson, J. A., Ying, S.-W., Ganat, Y. M., Merkle, F. T., Liu, B., Goulburn, A., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.04.008 · Cited by 596 · see citing works
Alcántara, S., Ruiz, M., D’Arcangelo, G., Ezan, F., de Lecea, L., Curran, T., Sotelo, C., & Soriano, E. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07779.1998 · Cited by 568 · see citing works
Fate mapping Nkx2.1‐lineage cells in the mouse telencephalon
Xu, Q., Tam, M., & Anderson, S. A. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21529 · Cited by 560 · see citing works
Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., Sousa, V. H., Butt, S. J. B., Battiste, J., Johnson, J. E., Machold, R. P., & Fishell, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4515-09.2010 · Cited by 559 · see citing works
Nicholas, C. R., Chen, J., Tang, Y., Southwell, D. G., Chalmers, N., Vogt, D. L., Arnold, C. M., Chen, Y.-J. J., Stanley, E. G., Elefanty, A. G., et al. (2013) · Cell stem cell · doi:10.1016/j.stem.2013.04.005 · Cited by 513 · see citing works
Self-citationMice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy
Cobos, I., Calcagnotto, M. E., Vilaythong, A. J., Thwin, M. T., Noebels, J. L., Baraban, S. C., & Rubenstein, J. L. R. (2005) · Nature Neuroscience · doi:10.1038/nn1499 · Cited by 502 · see citing works
Self-citationChoi, G. B., Dong, H.-W., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Swanson, L. W., & Anderson, D. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.04.011 · Cited by 462 · see citing works
CXCR4 Regulates Interneuron Migration in the Developing Neocortex
Stumm, R. K., Zhou, C., Ara, T., Lazarini, F., Dubois-Dalcq, M. E., Nagasawa, T., Höllt, V., & Schulz, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05123.2003 · Cited by 450 · see citing works
Self-citationLiodis, P., Denaxa, M., Grigoriou, M., Akufo-Addo, C., Yanagawa, Y., & Pachnis, V. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3055-06.2007 · Cited by 377 · see citing works
Ara, T., Tokoyoda, K., Sugiyama, T., Egawa, T., Kawabata, K., & Nagasawa, T. (2003) · Immunity · doi:10.1016/s1074-7613(03)00201-2 · Cited by 369 · see citing works
Self-citationZerucha, T., Stühmer, T., Hatch, G., Park, B. K., Long, Q., Yu, G. K., Gambarotta, A., Schultz, J. R., Rubenstein, J. L. R., & Ekker, M. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-02-00709.2000 · Cited by 360 · see citing works
Self-citationMouse in red: Red fluorescent protein expression in mouse ES cells, embryos, and adult animals
Vintersten, K., Monetti, C., Gertsenstein, M., Zhang, P., László, L., Biechele, S., & Nagy, A. (2004) · genesis · doi:10.1002/gene.20095 · Cited by 319 · see citing works
Grigoriou, M. E., Tucker, A. S., Sharpe, P. T., & Pachnis, V. (1998) · Development · doi:10.1242/dev.125.11.2063 · Cited by 307 · see citing works
GABA progenitors grafted into the adult epileptic brain control seizures and abnormal behavior
Hunt, R. F., Girskis, K. M., Rubenstein, J. L. R., Álvarez-Buylla, A., & Baraban, S. C. (2013) · Nature Neuroscience · doi:10.1038/nn.3392 · Cited by 300 · see citing works
Self-citationA Blueprint for the Spatiotemporal Origins of Mouse Hippocampal Interneuron Diversity
Tricoire, L., Pelkey, K. A., Erkkila, B. E., Jeffries, B. W., Yuan, X., & McBain, C. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0323-11.2011 · Cited by 292 · see citing works
CXCR4 and CXCR7 Have Distinct Functions in Regulating Interneuron Migration
Wang, Y., Li, G., Stanco, A., Long, J. E., Crawford, D., Potter, G. B., Pleasure, S. J., Behrens, T., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.005 · Cited by 290 · see citing works
Self-citationCxcr7 controls neuronal migration by regulating chemokine responsiveness
Sánchez-Alcañiz, J. A., Haege, S., Mueller, W., Pla, R., Mackay, F., Schulz, S., López-Bendito, G., Stumm, R., & Marín, O. (2011) · Neuron · doi:10.1016/j.neuron.2010.12.006 · Cited by 290 · see citing works
Development of GABA innervation in the cerebral and cerebellar cortices
Huang, Z. J., Cristo, G. D., & Ango, F. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2188 · Cited by 281 · see citing works
Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning
Vokes, S. A., Ji, H., McCuine, S., Tenzen, T., Giles, S., Zhong, S., Longabaugh, W. J. R., Davidson, E. H., Wong, W. H., & McMahon, A. P. (2007) · Development · doi:10.1242/dev.001966 · Cited by 270 · see citing works
Dlx transcription factors promote migration through repression of axon and dendrite growth
Cobos, I., Borello, U., & Rubenstein, J. L. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.024 · Cited by 246 · see citing works
Miyoshi, G., & Fishell, G. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq155 · Cited by 230 · see citing works
Zhao, Y., Marín, O., Hermesz, E., Powell, A., Flames, N., Palkovits, M., Rubenstein, J. L. R., & Westphal, H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1537759100 · Cited by 227 · see citing works
Self-citationNKX2.1 specifies cortical interneuron fate by activatingLhx6
Du, T., Xu, Q., Ocbina, P. J. R., & Anderson, S. A. (2008) · Development · doi:10.1242/dev.015123 · Cited by 220 · see citing works
The Cell-Intrinsic Requirement of Sox6 for Cortical Interneuron Development
Batista-Brito, R., Rossignol, E., Hjerling-Leffler, J., Denaxa, M., Wegner, M., Lefebvre, V., Pachnis, V., & Fishell, G. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.005 · Cited by 214 · cited 4× · see citing works
“Rescue of Lhx6PLAP/PLAP MGE Interneuron Fate via Transduction of Lhx6-Regulated Genes Lhx6 is necessary for the expression of Arx and Sox6 TFs and the CXCR7 cytokine receptor (Batista-Brito et al., 2009; Flandin et al., 2011; Zhao et al., 2008).”
InfluentialTiveron, M.-C., Rossel, M., Moepps, B., Zhang, Y. L., Seidenfaden, R., Favor, J., König, N., & Cremer, H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4162-06.2006 · Cited by 207 · see citing works
Zhao, Y., Flandin, P., Long, J. E., Cuesta, M. D., Westphal, H., & Rubenstein, J. L. R. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21772 · Cited by 207 · see citing works
Self-citationSOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development
Azim, E., Jabaudon, D., Fame, R. M., & Macklis, J. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2387 · Cited by 202 · see citing works
Cortical Inhibition Modified by Embryonic Neural Precursors Grafted into the Postnatal Brain
Álvarez‐Dolado, M., Calcagnotto, M. E., Karkar, K. M., Southwell, D. G., Jones, D. M., Estrada, R. C., Rubenstein, J. L. R., Álvarez-Buylla, A., & Baraban, S. C. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1540-06.2006 · Cited by 189 · see citing works
Self-citationA wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
Gelman, D., Griveau, A., Dehorter, N., Teissier, A., Varela, C., Pla, R., Pierani, A., & Marín, O. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4068-11.2011 · Cited by 179 · see citing works
Long, J. E., Cobos, I., Potter, G. B., & Rubenstein, J. L. R. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp045 · Cited by 178 · see citing works
Self-citationRegulatory Roles of Conserved Intergenic Domains in Vertebrate Dlx Bigene ClustersPreprint
Ghanem, N., Jarinova, O., Amores, A., Long, Q., Hatch, G., Park, B. K., Rubenstein, J. L. R., & Ekker, M. (2003) · Genome Research · doi:10.1101/gr.716103 · Cited by 177 · see citing works
Self-citationFlandin, P., Kimura, S., & Rubenstein, J. L. R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4228-09.2010 · Cited by 176 · see citing works
Self-citationSynaptic interactions of late-spiking neocortical neurons in layer 1
Chu, Z., Galarreta, M., & Hestrin, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00096.2003 · Cited by 172 · see citing works
Common Origins of Hippocampal Ivy and Nitric Oxide Synthase Expressing Neurogliaform Cells
Tricoire, L., Pelkey, K. A., Daw, M. I., Sousa, V. H., Miyoshi, G., Jeffries, B., Cauli, B., Fishell, G., & McBain, C. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5123-09.2010 · Cited by 171 · see citing works
Kanatani, S., Yozu, M., Tabata, H., & Nakajima, K. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2132-08.2008 · Cited by 163 · see citing works
Flandin, P., Zhao, Y., Vogt, D., Jeong, J., Long, J., Potter, G., Westphal, H., & Rubenstein, J. L. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.04.020 · Cited by 155 · see citing works
Self-citationMcKinsey, G. L., Lindtner, S., Trzcinski, B., Visel, A., Pennacchio, L. A., Huylebroeck, D., Higashi, Y., & Rubenstein, J. L. R. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.035 · Cited by 153 · see citing works
Self-citationJeong, J., Li, X., McEvilly, R. J., Rosenfeld, M. G., Lufkin, T., & Rubenstein, J. L. R. (2008) · Development · doi:10.1242/dev.019778 · Cited by 151 · see citing works
Self-citationColasante, G., Collombat, P., Raimondi, V., Bonanomi, D., Ferrai, C., Maira, M., Yoshikawa, K., Mansouri, A., Valtorta, F., Rubenstein, J. L. R., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1283-08.2008 · Cited by 150 · see citing works
Self-citationClose, J., Xu, H., De Marco García, N., Batista-Brito, R., Rossignol, E., Rudy, B., & Fishell, G. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.3583-12.2012 · Cited by 141 · see citing works
Schönemeier, B., Kolodziej, A., Schulz, S., Jacobs, S., Hoellt, V., & Stumm, R. (2008) · Journal of Comparative Neurology · doi:10.1002/cne.21780 · Cited by 141 · see citing works
Fragkouli, A., van Wijk, N. V., Lopes, R., Kessaris, N., & Pachnis, V. (2009) · Development · doi:10.1242/dev.038083 · Cited by 135 · see citing works
Potter, G. B., Petryniak, M. A., Shevchenko, E., McKinsey, G. L., Ekker, M., & Rubenstein, J. L. R. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.10.003 · Cited by 122 · see citing works
Self-citationMaturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons
Denaxa, M., Kalaitzidou, M., Garefalaki, A., Achimastou, A., Lasrado, R., Maes, T., & Pachnis, V. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.10.003 · Cited by 105 · see citing works
Armstrong, C., Szabadics, J., Tamás, G., & Soltesz, I. (2011) · Journal of Comparative Neurology · doi:10.1002/cne.22577 · Cited by 86 · see citing works
Elshatory, Y. M., & Gan, L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5730-07.2008 · Cited by 80 · see citing works
Ma, T., Zhang, Q., Cai, Y., You, Y., Rubenstein, J. L. R., & Yang, Z. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr296 · Cited by 79 · see citing works
Self-citationCai, Y., Zhang, Q., Wang, C., Zhang, Y., Ma, T., Zhou, X., Tian, M., Rubenstein, J. L. R., & Yang, Z. (2012) · The Journal of Comparative Neurology · doi:10.1002/cne.23186 · Cited by 53 · see citing works
Self-citationPueyo, J. I., & Couso, J. P. (2004) · Development · doi:10.1242/dev.01161 · Cited by 34 · see citing works
The homeobox gene Arx is a novel positive regulator of embryonic myogenesis
Biressi, S., Messina, G., Collombat, P., et al. (2007) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4402230 · Cited by 33 · see citing works
Chen, Y.-J. J., Vogt, D. L., Wang, Y., Visel, A., Silberberg, S. N., Nicholas, C. R., Danjo, T., Pollack, J. L., Pennacchio, L. A., Anderson, S. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061956 · Cited by 30 · see citing works
Self-citationRapid Kinetics and Inward Rectification of Miniature EPSCs in Layer I Neurons of Rat Neocortex
Zhou, F.-M., & Hablitz, J. J. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.5.2416 · Cited by 28 · see citing works
A Brain Region-Specific Gene Product Lhx6.1 Interacts with Ldbl through Tandem LIM-Domains
Kimura, N., Ueno, M., Nakashima, K., & Taga, T. (1999) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022420 · Cited by 20 · see citing works
Arguello, A., Yang, X., Vogt, D. L., Stanco, A., Rubenstein, J. L. R., & Cheyette, B. N. R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067679 · Cited by 19 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain
Lake, B. B., Ai, R., Kaeser, G. E., Salathia, N. S., Yung, Y. C., Liu, R., Wildberg, A., Gao, D., Fung, H.-L., Chen, S., et al. (2016) · Science · doi:10.1126/science.aaf1204 · Cited by 957 · see citing works
Hippocampal GABAergic Inhibitory Interneurons
Pelkey, K. A., Chittajallu, R., Craig, M. T., Tricoire, L., Wester, J. C., & McBain, C. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00007.2017 · Cited by 889 · see citing works
Development and Functional Diversification of Cortical Interneurons
Lim, L., Mi, D., Llorca, A., & Marín, O. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.009 · Cited by 714 · see citing works
“Meis2+ neurons reside in the white matter and extend axons to deep layers of the cortex and striatum (Frazer et al., 2017; von Engelhardt et al., 2011).”
Genetic and activity-dependent mechanisms underlying interneuron diversity
Wamsley, B., & Fishell, G. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.30 · Cited by 290 · see citing works
The diversity of GABAergic neurons and neural communication elements
Huang, Z. J., & Paul, A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0195-4 · Cited by 201 · see citing works
Cortical interneuron development: a tale of time and space
Hu, J. S., Vogt, D., Sandberg, M., & Rubenstein, J. L. (2017) · Development · doi:10.1242/dev.132852 · Cited by 189 · see citing works
Self-citationUnifying Views of Autism Spectrum Disorders: A Consideration of Autoregulatory Feedback Loops
Mullins, C., Fishell, G., & Tsien, R. W. (2016) · Neuron · doi:10.1016/j.neuron.2016.02.017 · Cited by 167 · see citing works
Genomic Perspectives of Transcriptional Regulation in Forebrain Development
Nord, A. S., Pattabiraman, K., Visel, A., & Rubenstein, J. L. R. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.011 · Cited by 152 · see citing works
Self-citationTranscriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons
Sandberg, M., Flandin, P., Silberberg, S., Su-Feher, L., Price, J. D., Hu, J. S., Kim, C., Visel, A., Nord, A. S., & Rubenstein, J. L. R. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.020 · Cited by 129 · see citing works
Self-citationModulation of apoptosis controls inhibitory interneuron number in the cortex
Denaxa, M., Neves, G., Rabinowitz, A., Kemlo, S., Liodis, P., Burrone, J., & Pachnis, V. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.064 · Cited by 112 · see citing works
New Insights Into Cholinergic Neuron Diversity
Ahmed, N. Y., Knowles, R., & Dehorter, N. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00204 · Cited by 108 · see citing works
Neuregulin 3 Mediates Cortical Plate Invasion and Laminar Allocation of GABAergic Interneurons
Bartolini, G., Sánchez-Alcañiz, J. A., Osório, C., Valiente, M., García-Frigola, C., & Marín, O. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.089 · Cited by 74 · see citing works
Silberberg, S. N., Taher, L., Lindtner, S., Sandberg, M., Nord, A. S., Vogt, D., Mckinsey, G. L., Hoch, R., Pattabiraman, K., Zhang, D., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.027 · Cited by 62 · see citing works
Self-citationConserved rules in embryonic development of cortical interneurons
Laclef, C., & Métin, C. (2018) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.09.017 · Cited by 57 · see citing works
The Cytokine CXCL12 Promotes Basket Interneuron Inhibitory Synapses in the Medial Prefrontal Cortex
Wu, P.-R., Cho, K. K. A., Vogt, D., Sohal, V. S., & Rubenstein, J. L. R. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhw230 · Cited by 32 · see citing works
Self-citation
- Authors
- Vogt, D., Hunt, R. F., Mandal, S., Sandberg, M., Silberberg, S. N., Nagasawa, T., Yang, Z., Baraban, S. C., & Rubenstein, J. L. R.
- Affiliations
- University of California, San Francisco (US)
- Kyoto University (JP)
- Fudan University (CN)
- Corresponding author
- Vogt, Daniel
- Rubenstein, John L.R.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 82
- Issue
- 2
- Pages
- 350-364
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4261952
- OpenAlex
- W1985673159
- Cited by
- 129
- References
- 65
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 4 · 2023: 11 · 2022: 9 · 2021: 12 · 2020: 11 · 2019: 13 · 2018: 13 · 2017: 16 · 2016: 10 · 2015: 11 · 2014: 5
- FWCI
- 4.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Autism Speaks
- Weston Havens Foundation
- National Institute of Mental Health (MH049428, MH081880, R37MH049428, R01MH081880)
- National Institute of Neurological Disorders and Stroke (K99NS085046, F32NS077747, R01NS071785)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- Lhx6, ARX, CXCR7, cortical lamination, GABAergic interneurons, somatostatin interneurons, parvalbumin interneurons, LIM-homeodomain transcription factor, enhancer binding
- MeSH terms
- Action Potentials, Age Factors, Animals, Cell Movement, Cerebral Cortex, Embryo, Mammalian, Humans, Interneurons, Luminescent Proteins, Mice, Transgenic, Nerve Tissue Proteins, Stem Cells, Transcription Factors, Homeodomain Proteins, Gene Expression Regulation, Developmental, Stem Cell Transplantation, Mice, Chemokine CXCL1, Receptors, CXCR, HEK293 Cells, LIM-Homeodomain Proteins, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
