Cited by 83Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchDevelopmental Biology and Gene Regulation

Production and organization of neocortical interneurons

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Sultan, Khadeejah T., Brown, Keith N., Shi, Song-Hai·2013·Frontiers in Cellular Neuroscience

Abstract

Inhibitory GABA (γ-aminobutyric acid)-ergic interneurons are a vital component of the neocortex responsible for shaping its output through a variety of inhibitions. Consisting of many flavors, interneuron subtypes are predominantly defined by their morphological, physiological, and neurochemical properties that help to determine their functional role within the neocortex. During development, these cells are born in the subpallium where they then tangentially migrate over long distances before being radially positioned to their final location in the cortical laminae. As development progresses into adolescence, these cells mature and form chemical and electrical connections with both glutamatergic excitatory neurons and other interneurons ultimately establishing the cortical network. The production, migration, and organization of these cells are determined by vast array of extrinsic and intrinsic factors that work in concert in order to assemble a proper functioning cortical inhibitory network. Failure of these cells to undergo these processes results in abnormal positioning and cortical function. In humans, this can bring about several neurological disorders including schizophrenia, epilepsy, and autism spectrum disorders. In this article, we will review previous literature that has revealed the framework for interneuron neurogenesis and migratory behavior as well as discuss recent findings that aim to elucidate the spatial and functional organization of interneurons within the neocortex.

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  1. Armijo J. A. Valdizan E. M. De Las Cuevas I. Cuadrado A. (2002). Advances in the physiopathology of epileptogenesis: molecular aspects. Rev. Neurol. 34 409– 429 12040510
  2. Rudy B. Fishell G. Lee S. Hjerling-Leffler J. (2011). Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons. Dev. Neurobiol. 71 45– 61 10.1002/dneu.20853 21154909 PMC3556905 · DOI · Paper page

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Authors
Sultan, K. T., Brown, K. N., & Shi, S.-H.
Affiliations
Memorial Sloan Kettering Cancer Center (US)
Corresponding author
Shi, Song-Hai
Venue
Frontiers in Cellular Neuroscience
Published
2013
Volume
7
Pages
221-221
ISSN
1662-5102 (ISSN-L)
OpenAlex
W2054754390
Cited by
83
References
176
Citations by year
2025: 2 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 14 · 2016: 12 · 2015: 11 · 2014: 3
FWCI
0.93
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • McKnight Foundation
  • National Institute on Drug Abuse (R01DA024681)
  • National Cancer Institute (P30CA008748)
  • National Institute of Neurological Disorders and Stroke (P01NS048120)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords
neocortical interneurons, GABAergic interneurons, interneuron subtypes, tangential migration, subpallium, cortical development, schizophrenia, epilepsy, autism spectrum disorder

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