Production and organization of neocortical interneurons
Open accessAbstract
Inhibitory GABA (γ-aminobutyric acid)-ergic interneurons are a vital component of the neocortex responsible for shaping its output through a variety of inhibitions. Consisting of many flavors, interneuron subtypes are predominantly defined by their morphological, physiological, and neurochemical properties that help to determine their functional role within the neocortex. During development, these cells are born in the subpallium where they then tangentially migrate over long distances before being radially positioned to their final location in the cortical laminae. As development progresses into adolescence, these cells mature and form chemical and electrical connections with both glutamatergic excitatory neurons and other interneurons ultimately establishing the cortical network. The production, migration, and organization of these cells are determined by vast array of extrinsic and intrinsic factors that work in concert in order to assemble a proper functioning cortical inhibitory network. Failure of these cells to undergo these processes results in abnormal positioning and cortical function. In humans, this can bring about several neurological disorders including schizophrenia, epilepsy, and autism spectrum disorders. In this article, we will review previous literature that has revealed the framework for interneuron neurogenesis and migratory behavior as well as discuss recent findings that aim to elucidate the spatial and functional organization of interneurons within the neocortex.
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FMRP may regulate parvalbumin cell fate through translational control of transcription factors necessary for GABAergic neuron differentiation.
“FMRP may regulate PV cell fate through translational control of transcription factors necessary for GABAergic neuron differentiation (reviewed in Sultan et al. 2013).”
From Genetic Reduction of Matrix Metalloproteinase-9 Promotes Formation of Perineuronal Nets Around Parvalbumin-Expressing Interneurons and Normalizes Auditory Cortex Responses in Developing Fmr1 Knock-Out Mice (2018) · cites this paper as Sultan et al. 2013
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- Authors
- Sultan, K. T., Brown, K. N., & Shi, S.-H.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Shi, Song-Hai
- ORCID
- Shi, Song-Hai
- Venue
- Frontiers in Cellular Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2013
- Volume
- 7
- Pages
- 221-221
- ISSN
- 1662-5102 (ISSN-L)
- PMC
- PMC3836051
- OpenAlex
- W2054754390
- Cited by
- 83
- References
- 176
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 5 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 14 · 2016: 12 · 2015: 11 · 2014: 3
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- McKnight Foundation
- National Institute on Drug Abuse (R01DA024681)
- National Cancer Institute (P30CA008748)
- National Institute of Neurological Disorders and Stroke (P01NS048120)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- neocortical interneurons, GABAergic interneurons, interneuron subtypes, tangential migration, subpallium, cortical development, schizophrenia, epilepsy, autism spectrum disorder
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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