The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Lake-Front Property: A Unique Germinal Niche by the Lateral Ventricles of the Adult Brain
Open accessAbstract
Summary New neurons and glial cells are generated in an extensive germinal niche adjacent to the walls of the lateral ventricles in the adult brain. The primary progenitors (B1 cells) have astroglial characteristics, but retain important neuroepithelial properties. Recent work shows how B1 cells contact all major compartments of this niche. They share the “shoreline” on the ventricles with ependymal cells, forming a unique adult ventricular zone (VZ). In the subventricular zone (SVZ), B1 cells contact transit amplifying (Type C) cells, chains of young neurons (A cells), and blood vessels. How signals from these compartments influence the behavior of B1 or C cells remains largely unknown, but recent work highlights growth factors, neurotransmitters, morphogens, and the extracellular matrix as key regulators of this niche. The integration of emerging molecular and anatomical clues forecasts an exciting new understanding of how the germ of youth is actively maintained in the adult brain.
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“Type B1 cells have several characteristics that are reminiscent of their radial glial progenitors – a thin apical process with a primary cilium extending into the ventricular lumen, a basal process that extends to reach blood vessels, and behavior that is reminiscent of the interkinetic nuclear migration observed in t…”
InfluentialmiR-124 regulates adult neurogenesis in the subventricular zone stem cell niche
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Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
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Metadata
- Authors
- Ihrie, R. A., & Álvarez-Buylla, A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 70
- Issue
- 4
- Pages
- 674-686
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2010054551
- Cited by
- 350
- References
- 21
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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