Mg2+ Block of Drosophila NMDA Receptors Is Required for Long-Term Memory Formation and CREB-Dependent Gene Expression
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NMDA receptor (NMDAR) channels allow Ca(2+) influx only during correlated activation of both pre- and postsynaptic cells; a Mg(2+) block mechanism suppresses NMDAR activity when the postsynaptic cell is inactive. Although the importance of NMDARs in associative learning and long-term memory (LTM) formation has been demonstrated, the role of Mg(2+) block in these processes remains unclear. Using transgenic flies expressing NMDARs defective for Mg(2+) block, we found that Mg(2+) block mutants are defective for LTM formation but not associative learning. We demonstrate that LTM-dependent increases in expression of synaptic genes, including homer, staufen, and activin, are abolished in flies expressing Mg(2+) block defective NMDARs. Furthermore, we show that genetic and pharmacological reduction of Mg(2+) block significantly increases expression of a CREB repressor isoform. Our results suggest that Mg(2+) block of NMDARs functions to suppress basal expression of a CREB repressor, thus permitting CREB-dependent gene expression upon LTM induction.
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rs668387, rs2070045, rs11218343 and rs3781834 appear protective, whereas other variants such as rs143571823 aggravate AD pathogenesis.
“For instance, rs668387, rs2070045, rs11218343 and rs3781834 appear to be protective [474, 482], whereas other variants of SORL1, such as rs143571823, aggravate AD pathogenesis [483].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [482]
Reduced Mg2+ levels decrease Ca2+ influx mediated by NMDAR and damage-associated learning and long-term memory deficits in Drosophila.
“Reduced Mg2+ levels can decrease Ca2+ influx mediated by NMDAR and damage-associated learning and long-term memory deficits in Drosophila [482].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [482]
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Glia transmit negative valence information during aversive learning in <i>Drosophila</i>
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NOSA, an Analytical Toolbox for Multicellular Optical Electrophysiology
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F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol‐Induced Behaviors in Drosophila
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- Authors
- Miyashita, T., Oda, Y., Horiuchi, J., Yin, J. C. P., Morimoto, T., & Saitoe, M.
- Affiliations
- Tokyo Metropolitan Institute of Medical Science (JP)
- Tokyo University of Pharmacy and Life Sciences (JP)
- Tokyo Metropolitan University (JP)
- University of Wisconsin–Madison (US)
- Corresponding author
- Saitoe, Minoru
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 74
- Issue
- 5
- Pages
- 887-898
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3651368
- OpenAlex
- W2095940963
- Cited by
- 102
- References
- 54
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 8 · 2021: 5 · 2020: 12 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 5 · 2015: 11 · 2014: 7 · 2013: 12 · 2012: 4
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Takeda Science Foundation
- Uehara Memorial Foundation
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- NMDA receptor, magnesium block, long-term memory, CREB, Drosophila, associative learning, synaptic gene expression, Homer, Staufen, activin, memory formation
- MeSH terms
- Homer Scaffolding Proteins, Analysis of Variance, Animals, Carrier Proteins, Cells, Cultured, Central Nervous System, Conditioning, Psychological, Dose-Response Relationship, Drug, Drosophila, Electric Stimulation, Magnesium, Neurons, Nicotine, Odorants, Olfactory Pathways, Pupa, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Mutagenesis, RNA-Binding Proteins, Long-Term Potentiation, Patch-Clamp Techniques, Excitatory Amino Acid Agonists, Nicotinic Agonists, Mitogen-Activated Protein Kinase Kinases, Activins, Drosophila Proteins, Animals, Genetically Modified, CREB-Binding Protein
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