Glia transmit negative valence information during aversive learning in Drosophila
Abstract
During Drosophila aversive olfactory conditioning, aversive shock information needs to be transmitted to the mushroom bodies (MBs) to associate with odor information. We report that aversive information is transmitted by ensheathing glia (EG) that surround the MBs. Shock induces vesicular exocytosis of glutamate from EG. Blocking exocytosis impairs aversive learning, whereas activation of EG can replace aversive stimuli during conditioning. Glutamate released from EG binds to N -methyl- d -aspartate receptors in the MBs, but because of Mg 2+ block, Ca 2+ influx occurs only when flies are simultaneously exposed to an odor. Vesicular exocytosis from EG also induces shock-associated dopamine release, which plays a role in preventing formation of inappropriate associations. These results demonstrate that vesicular glutamate released from EG transmits negative valence information required for associative learning.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Central excitatory glutamatergic transmission has also been reported.
“However, central excitatory glutamatergic transmission has also been reported.93,95,116,117”
From Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster (2024) · cites this paper as [116]
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566 · see citing works
Magnesium gates glutamate-activated channels in mouse central neurones
Nowak, L. M., Bregestovski, P. D., Ascher, P., Herbet, A., & Prochiantz, A. (1984) · Nature · doi:10.1038/307462a0 · Cited by 4,033 · see citing works
Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones
Mayer, M. L., Westbrook, G. L., & Guthrie, P. B. (1984) · Nature · doi:10.1038/309261a0 · Cited by 2,906 · see citing works
A rapid, sensitive, and specific method for the determination of protein in dilute solution
Schaffner, W., & Weissmann, C. (1973) · Analytical Biochemistry · doi:10.1016/0003-2697(73)90217-0 · Cited by 2,527 · see citing works
Mushroom body memoir: from maps to models
Heisenberg, M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1074 · Cited by 1,286 · see citing works
Classical conditioning and retention in normal and mutantDrosophila melanogaster
Tully, T., & Quinn, W. G. (1985) · Journal of Comparative Physiology A · doi:10.1007/bf01350033 · Cited by 1,189 · see citing works
An internal thermal sensor controlling temperature preference in Drosophila
Hamada, F. N., Rosenzweig, M. R., Kang, K., Pulver, S. R., Ghezzi, A., Jegla, T. J., & Garrity, P. (2008) · Nature · doi:10.1038/nature07001 · Cited by 1,076 · see citing works
The neuronal architecture of the mushroom body provides a logic for associative learning
Aso, Y., Hattori, D., Yu, Y., Johnston, R. M., Iyer, N. A., Ngo, T.-T., Dionne, H., Abbott, L., Axel, R., Tanimoto, H., et al. (2014) · eLife · doi:10.7554/elife.04577 · Cited by 1,051 · see citing works
Astrocyte calcium signaling: the third wave
Bazargani, N., & Attwell, D. (2016) · Nature Neuroscience · doi:10.1038/nn.4201 · Cited by 949 · see citing works
Kitamoto, T. (2001) · Journal of Neurobiology · doi:10.1002/neu.1018 · Cited by 868 · see citing works
Sun, F., Zeng, J., Jing, M., Zhou, J., Feng, J., Owen, S. F., Luo, Y., Li, F., Wang, H., Yamaguchi, T., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.042 · Cited by 837 · see citing works
Spatiotemporal Gene Expression Targeting with the TARGET and Gene-Switch Systems in Drosophila
McGuire, S. E., Mao, Z., & Davis, R. L. (2004) · Science s STKE · doi:10.1126/stke.2202004pl6 · Cited by 762 · see citing works
Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory Enhancement
Adamsky, A., Kol, A., Kreisel, T., Doron, A., Ozeri-Engelhard, N., Melcer, T., Refaeli, R., Horn, H., Regev, L., Groysman, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.002 · Cited by 631 · see citing works
Writing Memories with Light-Addressable Reinforcement Circuitry
Claridge-Chang, A., Roorda, R. D., Vrontou, E., Sjulson, L., Li, H., Hirsh, J., & Miesenböck, G. (2009) · Cell · doi:10.1016/j.cell.2009.08.034 · Cited by 484 · see citing works
Dubnau, J., Grady, L., Kitamoto, T., & Tully, T. (2001) · Nature · doi:10.1038/35078077 · Cited by 455 · see citing works
Agarwal, A., Wu, P.-H., Hughes, E. G., Fukaya, M., Tischfield, M. A., Langseth, A. J., Wirtz, D., & Bergles, D. E. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.034 · Cited by 441 · see citing works
Coordinated and compartmentalized neuromodulation shapes sensory processing in Drosophila
Cohn, R., Morantte, I., & Ruta, V. (2015) · Cell · doi:10.1016/j.cell.2015.11.019 · Cited by 430 · see citing works
Distinct Endocytic Pathways Control the Rate and Extent of Synaptic Vesicle Protein Recycling
Voglmaier, S. M., Kam, K., Yang, H., Fortin, D. L., Hua, Z., Nicoll, R. A., & Edwards, R. H. (2006) · Neuron · doi:10.1016/j.neuron.2006.05.027 · Cited by 425 · see citing works
Sequential Use of Mushroom Body Neuron Subsets during Drosophila Odor Memory Processing
Krashes, M. J., Keene, A. C., Leung, B., Armstrong, J. D., & Waddell, S. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.021 · Cited by 422 · see citing works
Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR
Marvin, J. S., Scholl, B., Wilson, D. E., Podgorski, K., Kazemipour, A., Müller, J. A., Schoch, S., Quiroz, F. J. U., Rebola, N., Bao, H., et al. (2018) · Nature Methods · doi:10.1038/s41592-018-0171-3 · Cited by 412 · see citing works
Metabolic Control of Vesicular Glutamate Transport and Release
Juge, N., Gray, J. A., Omote, H., Miyaji, T., Inoue, T., Hara, C., Uneyama, H., Edwards, R. H., Nicoll, R. A., & Moriyama, Y. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.002 · Cited by 401 · see citing works
Self-citationA connectome of a learning and memory center in the adult Drosophila brain
Takemura, S.-Y., Aso, Y., Hige, T., Wong, A., Lu, Z., Xu, C. S., Rivlin, P. K., Hess, H., Zhao, T., Parag, T., et al. (2017) · eLife · doi:10.7554/elife.26975 · Cited by 367 · see citing works
Punishment Prediction by Dopaminergic Neurons in Drosophila
Riemensperger, T. D., Völler, T., Stock, P., Buchner, E., & Fiala, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.09.042 · Cited by 350 · see citing works
Synapse-specific astrocyte gating of amygdala-related behavior
Martin-Fernandez, M., Jamison, S., Robin, L. M., Zhao, Z., Martin, E. D., Aguilar, J., Benneyworth, M. A., Marsicano, G., & Araque, A. (2017) · Nature Neuroscience · doi:10.1038/nn.4649 · Cited by 345 · cited 1× · see citing works
“Glia are known to regulate neural and synaptic plasticity and play a critical role in regulating behavioral changes ( 35 – 39 ).”
BackgroundOrganization and Postembryonic Development of Glial Cells in the Adult Central Brain of Drosophila
Awasaki, T., Lai, S.-L., Ito, K., & Lee, T. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4844-08.2008 · Cited by 345 · see citing works
Daniels, R. W., Collins, C. A., Gelfand, M. V., Dant, J., Brooks, E. S., Krantz, D. E., & DiAntonio, A. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3001-04.2004 · Cited by 333 · see citing works
Specific Dopaminergic Neurons for the Formation of Labile Aversive Memory
Aso, Y., Siwanowicz, I., Bräcker, L. B., Ito, K., Kitamoto, T., & Tanimoto, H. (2010) · Current Biology · doi:10.1016/j.cub.2010.06.048 · Cited by 324 · see citing works
Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability
Aso, Y., Herb, A., Ogueta, M., Siwanowicz, I., Templier, T., Friedrich, A. B., Ito, K., Scholz, H., & Tanimoto, H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002768 · Cited by 320 · see citing works
Dopaminergic neurons write and update memories with cell-type-specific rules
Aso, Y., & Rubin, G. M. (2016) · eLife · doi:10.7554/elife.16135 · Cited by 306 · see citing works
The glia of the adult D rosophila nervous system
Kremer, M. C., Jung, C., Batelli, S., Rubin, G. M., & Gaul, U. (2017) · Glia · doi:10.1002/glia.23115 · Cited by 297 · see citing works
Reinforcement signalling in Drosophila; dopamine does it all after all
Waddell, S. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.01.005 · Cited by 287 · see citing works
Specialized astrocytes mediate glutamatergic gliotransmission in the CNS
Ceglia, R. D., Ledonne, A., Litvin, D. G., Lind, B. L., Carriero, G., Latagliata, E. C., Bindocci, E., Castro, M. A. D., Savtchouk, I., Vitali, I., et al. (2023) · Nature · doi:10.1038/s41586-023-06502-w · Cited by 285 · see citing works
Kol, A., Adamsky, A., Groysman, M., Kreisel, T., London, M., & Goshen, I. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0679-6 · Cited by 283 · see citing works
Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour
Ma, Z., Stork, T., Bergles, D. E., & Freeman, M. R. (2016) · Nature · doi:10.1038/nature20145 · Cited by 247 · see citing works
NMDA Receptors Mediate Olfactory Learning and Memory in Drosophila
Xia, S., Miyashita, T., Fu, T., Lin, W., Wu, C., Pyzocha, L., Lin, I.-R., Saitoe, M., Tully, T., & Chiang, A. (2005) · Current Biology · doi:10.1016/j.cub.2005.02.059 · Cited by 226 · see citing works
Self-citationMacpherson, L. J., Zaharieva, E. E., Kearney, P. J., Alpert, M. H., Lin, T., Turan, Z., Lee, C., & Gallio, M. (2015) · Nature Communications · doi:10.1038/ncomms10024 · Cited by 214 · see citing works
Linking Hebb's coincidence-detection to memory formation
Tsien, J. Z. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00070-2 · Cited by 205 · see citing works
Visualizing glutamatergic cell bodies and synapses in Drosophila larval and adult CNS
Daniels, R. W., Gelfand, M. V., Collins, C. A., & DiAntonio, A. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21670 · Cited by 186 · see citing works
Aging Specifically Impairs amnesiac-Dependent Memory in Drosophila
Tamura, T., Chiang, A., Ito, N., Liu, H., Horiuchi, J., Tully, T., & Saitoe, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00732-3 · Cited by 171 · see citing works
Self-citationDopamine reveals neural circuit mechanisms of fly memory
Waddell, S. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.07.001 · Cited by 162 · see citing works
Kondo, S., Takahashi, T., Yamagata, N., Imanishi, Y., Katow, H., Hiramatsu, S., Lynn, K., Abe, A., Kumaraswamy, A., & Tanimoto, H. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.018 · Cited by 154 · see citing works
Pharmacogenetic rescue in time and space of the rutabaga memory impairment by using Gene-Switch
Mao, Z., Roman, G., Zong, L., & Davis, R. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306128101 · Cited by 153 · see citing works
Imaging a Population Code for Odor Identity in the Drosophila Mushroom Body
Campbell, R. A. A., Honegger, K. S., Qin, H., Li, W., Demir, E., & Turner, G. C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0682-12.2013 · Cited by 129 · see citing works
Vesicular Glutamate Transporter Contains Two Independent Transport Machineries
Juge, N., Yoshida, Y., Yatsushiro, S., Omote, H., & Moriyama, Y. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607670200 · Cited by 124 · see citing works
Self-citationLong-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling
Miyashita, T., Kikuchi, E., Horiuchi, J., & Saitoe, M. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.022 · Cited by 108 · see citing works
Self-citationMiyashita, T., Oda, Y., Horiuchi, J., Yin, J. C. P., Morimoto, T., & Saitoe, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.039 · Cited by 102 · see citing works
Self-citationCervantes-Sandoval, I., Phan, A., Chakraborty, M., & Davis, R. L. (2017) · eLife · doi:10.7554/elife.23789 · Cited by 96 · see citing works
Raccuglia, D., Huang, S., Ender, A., Heim, M. ‐., Laber, D., Suárez-Grimalt, R., Liotta, A., Sigrist, S. J., Geiger, J. R. P., & Owald, D. (2019) · Current Biology · doi:10.1016/j.cub.2019.08.070 · Cited by 87 · see citing works
The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan
Yamazaki, D., Horiuchi, J., Nakagami, Y., Nagano, S., Tamura, T., & Saitoe, M. (2007) · Nature Neuroscience · doi:10.1038/nn1863 · Cited by 78 · see citing works
Self-citationFlyception: imaging brain activity in freely walking fruit flies
Grover, D., Katsuki, T., & Greenspan, R. J. (2016) · Nature Methods · doi:10.1038/nmeth.3866 · Cited by 67 · see citing works
Combinatorial Pharyngeal Taste Coding for Feeding Avoidance in Adult Drosophila
Chen, Y., Park, S. J., Joseph, R. M., Ja, W. W., & Dahanukar, A. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.036 · Cited by 66 · see citing works
Complementary encoding of spatial information in hippocampal astrocytes
Curreli, S., Bonato, J., Romanzi, S., Panzeri, S., & Fellin, T. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001530 · Cited by 66 · see citing works
The Role of Dopamine in Associative Learning in Drosophila: An Updated Unified Model
Adel, M., & Griffith, L. C. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00665-0 · Cited by 64 · see citing works
Glial Dysfunction Causes Age-Related Memory Impairment in Drosophila
Yamazaki, D., Horiuchi, J., Ueno, K., Ueno, T., Saeki, S., Matsuno, M., Naganos, S., Miyashita, T., Hirano, Y., Nishikawa, H., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.039 · Cited by 62 · see citing works
Self-citationCombinatorial Method for Overexpression of Membrane Proteins in Escherichia coli
Ben‐Arye, S. L., Sawada, K., Moriyama, Y., & Nelson, N. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.125492 · Cited by 57 · see citing works
Self-citationLong-term optical brain imaging in live adult fruit flies
Huang, C., Maxey, J. R., Sinha, S., Savall, J., Gong, Y., & Schnitzer, M. J. (2018) · Nature Communications · doi:10.1038/s41467-018-02873-1 · Cited by 48 · see citing works
Ueno, K., Naganos, S., Hirano, Y., Horiuchi, J., & Saitoe, M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.242909 · Cited by 39 · see citing works
Self-citationUeno, K., Suzuki-Sawano, E., Naganos, S., Ofusa, K., Horiuchi, J., & Saitoe, M. (2017) · eLife · doi:10.7554/elife.21076 · Cited by 31 · see citing works
Self-citationNew tools for the analysis of glial cell biology in Drosophila
Awasaki, T., & Lee, T. (2011) · Glia · doi:10.1002/glia.21133 · Cited by 31 · see citing works
Drosophila Memory: Dopamine Signals Punishment?
Keene, A. C., & Waddell, S. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.058 · Cited by 22 · see citing works
Ueno, K., Morstein, J., Ofusa, K., Naganos, S., Suzuki-Sawano, E., Minegishi, S., Rezgui, S. P., Kitagishi, H., Michel, B. W., Chang, C. J., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2378-19.2020 · Cited by 19 · see citing works
Self-citationHoriuchi, J. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12567 · Cited by 13 · see citing works
Self-citationA non-canonical on-demand dopaminergic transmission underlying olfactory aversive learning
Saitoe, M., Naganos, S., Miyashita, T., Matsuno, M., & Ueno, K. (2021) · Neuroscience Research · doi:10.1016/j.neures.2021.12.008 · Cited by 7 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Eckstein, N., Bates, A. S., Champion, A., Du, M., Yin, Y., Schlegel, P., Lu, A. K.-Y., Rymer, T., Finley-May, S., Paterson, T., et al. (2024) · Cell · doi:10.1016/j.cell.2024.03.016 · Cited by 233 · see citing works
Norepinephrine changes behavioral state through astroglial purinergic signaling
Chen, A., Duque, M., Rymbek, A., Dhanasekar, M., Wang, V. M., Mi, X., Tocquer, L., Narayan, S., Legorreta, E. M., Eddison, M., et al. (2025) · Science · doi:10.1126/science.adq5233 · Cited by 93 · see citing works
Dynamics of glia and neurons regulate homeostatic rest, sleep and feeding behavior in Drosophila
Flores-Valle, A., Vishniakou, I., & Seelig, J. D. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-01942-1 · Cited by 33 · see citing works
Mohammad, F., Mai, Y., Ho, J., Zhang, X., Ott, S., Stewart, J. C., & Claridge‐Chang, A. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002843 · Cited by 34 · see citing works
Francés, R., Rabah, Y., Préat, T., & Plaçais, P.-Y. (2024) · Nature Communications · doi:10.1038/s41467-024-54778-x · Cited by 11 · see citing works
Norepinephrine changes behavioral state via astroglial purinergic signalingPreprint
Chen, A., Duque, M., Wang, V. M., Dhanasekar, M., Mi, X., Rymbek, A., Tocquer, L., Narayan, S., Prober, D. A., Yu, G., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.23.595576 · Cited by 10 · see citing works
Johnson, M., & Barrett, M. (2025) · Animal · doi:10.1016/j.animal.2025.101501 · Cited by 7 · see citing works
Flores-Valle, A., Vishniakou, I., & Seelig, J. D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.07.07.499175 · Cited by 7 · see citing works
Glial metabolism versatility regulates mushroom body–driven behavioral output inDrosophilaPreprint
Basu, R., Préat, T., & Plaçais, P.-Y. (2024) · Learning & Memory · doi:10.1101/lm.053823.123 · Cited by 7 · see citing works
A LAT1-Like Amino Acid Transporter Regulates Neuronal Activity in the Drosophila Mushroom Bodies
Delescluse, J., Simonnet, M. M., Ziegler, A. B., Piffaretti, K., Alves, G., Grosjean, Y., & Manière, G. (2024) · Cells · doi:10.3390/cells13161340 · Cited by 4 · see citing works
Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila
Backer, J. D., Karges, T., Papst, J., Pınar, Z. N., Coman, C., Ahrends, R., Xu, Y., García‐Cáceres, C., & Kadow, I. C. G. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115765 · Cited by 4 · see citing works
Non-Immune Functions of Innate Immunity Acting on Physiological Processes: Insights from Drosophila
Li, X., Wang, X., Shang, Z., Yang, S., Tang, Y., & Xu, W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26031087 · Cited by 3 · see citing works
Pribbenow, C., & Owald, D. (2024) · Learning & Memory · doi:10.1101/lm.053919.124 · Cited by 3 · see citing works
Cryptochrome interaction networks across different tissues in Drosophila melanogaster
Damulewicz, M., Gregoris, F., Colaianni, D., Cendron, F., Biscontin, A., Minervini, G., & Mazzotta, G. M. (2025) · Biology Direct · doi:10.1186/s13062-025-00696-x · Cited by 2 · see citing works
Franco‐García, A., Gómez‐Murcia, V., & Núñez, C. (2025) · Behavioral and Brain Functions · doi:10.1186/s12993-025-00313-x · Cited by 2 · see citing works
Revisiting the role of cAMP in Drosophila aversive olfactory memory formationPreprint
Abe, T., Yamazaki, D., Hiroi, M., Ueoka, Y., Maeyama, Y., & Tabata, T. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.26.545795 · Cited by 2 · see citing works
Matsuno, M., Uemura, N., Miyashita, T., Kobayashi, K. S., Liotta, A., Kimura, M., Ofusa, K., Owald, D., Matsuo, N., Saitoe, M., et al. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003752 · Cited by 1 · see citing works
Self-citationAdenosine signaling in glia modulates metabolic state-dependent behavior in DrosophilaPreprint
Backer, J. D., Karges, T., Papst, J., Coman, C., Ahrends, R., Xu, Y., García‐Cáceres, C., & Kadow, I. C. G. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.07.606811 · Cited by 1 · see citing works
Mohammad, F., Mai, Y., Ho, J., Zhang, X., Ott, S., Stewart, J. C., & Claridge‐Chang, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.23.517775
Remembering punishment-related odors: Insights from the Drosophila brain and its inspiration
Li, Q., & Zhong, Y. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-15754-7.00052-3
Transition in “Digital Brain” Researches, and Surrogate-based Generative Model
Okuno, T., Tsukada, H., & Hata, J. (2025) · The Brain & Neural Networks · doi:10.3902/jnns.32.12
Notch canonical activity in a subset of glial cells regulates short-term memory in DrosophilaPreprint
Aguirre, A., Girard, D., Parrot, S., Clugnet, A.-A., Biolchini, X., Li, H., & Seugnet, L. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.10.681599
Migues, P. V., & Hardt, O. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.10.698790
Grik2b and Grik2c kainate receptors regulate oviposition in Bactrocera dorsalis
Liu, B., Yang, J., Ye, L., Xiao, Y., Luo, G., He, M., Smagghe, G., Lu, Y., & Cheng, D. (2026) · PLoS Biology · doi:10.1371/journal.pbio.3003609
Glial mediation of hormonal actions on the Drosophila brain
Imura, E., Okamoto, N., & Yamanaka, N. (2026) · Current Opinion in Insect Science · doi:10.1016/j.cois.2026.101535
Noya, S. B., Yang, J., Yue, Z., Nguyen, A., Guevara, C., GIANANI, S. R., XU, V., Pivarshev, P., Williams, J. A., LU, K., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.02.736189
- Authors
- Miyashita, T., Murakami, K., Kikuchi, E., Ofusa, K., Mikami, K., Endo, K., Miyaji, T., Moriyama, S., Konno, K., Muratani, H., Moriyama, Y., Watanabe, M., Horiuchi, J., & Saitoe, M.
- Affiliations
- Tokyo Metropolitan Institute of Medical Science (JP)
- Okayama University (JP)
- Kurume University (JP)
- Hokkaido University (JP)
- University of Electro-Communications (JP)
- Corresponding author
- Saitoe, Minoru
- ORCID
- Venue
- Science
- Published
- 2023-12-22
- Volume
- 382
- Issue
- 6677
- Pages
- eadf7429-eadf7429
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W4390046017
- Cited by
- 26
- References
- 63
- Citations by year
- 2026: 5 · 2025: 9 · 2024: 9 · 2023: 1 · 2022: 2
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (19H01013, 21K19338, 21K06403, 21K18238, 23K24791)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- ensheathing glia, mushroom body, vesicular glutamate release, NMDA receptor, dopamine release, negative valence, aversive learning, Drosophila, associative learning
- MeSH terms
- Animals, Avoidance Learning, Conditioning, Psychological, Drosophila, Drosophila melanogaster, Glutamates, Neuroglia, Odorants, Smell, Mushroom Bodies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review