Kappa Opioid Receptors Regulate Stress-Induced Cocaine Seeking and Synaptic Plasticity

Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

Everitt, B. J., & Robbins, T. W. (2005) · Nature Neuroscience · doi:10.1038/nn1579 · Cited by 3,785 · see citing works

Dopamine, learning and motivation.

Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · cited 1× · see citing works

Opioids excite dopamine neurons by hyperpolarization of local interneurons

Johnson, S., & North, R. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00483.1992 · Cited by 1,637 · see citing works

How does stress increase risk of drug abuse and relapse?

Sinha, R. (2001) · Psychopharmacology · doi:10.1007/s002130100917 · Cited by 1,505 · see citing works

Synaptic plasticity and addiction

Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397 · see citing works

Drugs of Abuse and Stress Trigger a Common Synaptic Adaptation in Dopamine Neurons

Saal, D., Dong, Y., Bonci, A., & Malenka, R. C. (2003) · Neuron · doi:10.1016/s0896-6273(03)00021-7 · Cited by 1,147 · see citing works

Single cocaine exposure in vivo induces long-term potentiation in dopamine neurons

Ungless, M. A., Whistler, J. L., Malenka, R. C., & Bonci, A. (2001) · Nature · doi:10.1038/35079077 · Cited by 1,106 · see citing works

Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling

Lüscher, C., & Malenka, R. C. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.017 · Cited by 1,105 · see citing works

Regulation of cocaine reward by CREB

Carlezon, W. A., Thome, J., Olson, V. G., Lane-Ladd, S. B., Brodkin, E. S., Hiroi, N., Duman, R. S., Neve, R. L., & Nestler, E. J. (1998) · Science · doi:10.1126/science.282.5397.2272 · Cited by 767 · see citing works

Stress-induced relapse to heroin and cocaine seeking in rats: a review

Shaham, Y., Erb, S. M., & Stewart, J. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00024-2 · Cited by 703 · see citing works

Nonlinear relationship between impulse flow and dopamine released by rat midbrain dopaminergic neurons as studied by in vivo electrochemistry

Gonon, F. G. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90307-7 · Cited by 676 · see citing works

The role of stress in drug self-administration

Piazza, P. V., & Moal, M. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01115-2 · Cited by 674 · see citing works

Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function

Zhao, S., Ting, J. T., Atallah, H. E., Qiu, L., Tan, J., Gloss, B., Augustine, G. J., Deisseroth, K., Luo, M., Graybiel, A. M., et al. (2011) · Nature Methods · doi:10.1038/nmeth.1668 · Cited by 653 · see citing works

GABA Neurons of the VTA Drive Conditioned Place Aversion

Tan, K. R., Yvon, C., Turiault, M., Mirzabekov, J. J., Doehner, J., Labouèbe, G., Deisseroth, K. A., Tye, K. M., & Lüscher, C. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.015 · Cited by 635 · see citing works

Activation of VTA GABA Neurons Disrupts Reward Consumption

van Zessen, R., Phillips, J. L., Budygin, E. A., & Stuber, G. D. (2012) · Neuron · doi:10.1016/j.neuron.2012.02.016 · Cited by 609 · see citing works

The Dysphoric Component of Stress Is Encoded by Activation of the Dynorphin κ-Opioid System

Land, B. B., Bruchas, M. R., Lemos, J. C., Xu, M., Melief, E. J., & Chavkin, C. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4458-07.2008 · Cited by 601 · see citing works

The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors

Bruchas, M. R., Land, B. B., & Chavkin, C. (2010) · Brain Research · doi:10.1016/j.brainres.2009.08.062 · Cited by 544 · see citing works

The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?

Margolis, E. B., Lock, H., Hjelmstad, G. O., & Fields, H. L. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.117069 · Cited by 527 · see citing works

Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats.

Bals-Kubik, R., Ableitner, A., Herz, A., & Shippenberg, T. S. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10296-6 · Cited by 525 · see citing works

Limbic and Motor Circuitry Underlying Footshock-Induced Reinstatement of Cocaine-Seeking Behavior

McFarland, K., Davidge, S. B., Lapish, C. C., & Kalivas, P. W. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4177-03.2004 · Cited by 524 · see citing works

Imaging stress‐ and cue‐induced drug and alcohol craving: association with relapse and clinical implications

SINHA, R., & LI, C. ‐. R. (2007) · Drug and Alcohol Review · doi:10.1080/09595230601036960 · Cited by 497 · see citing works

Dynorphin, stress, and depression

Knoll, A. T., & Carlezon, W. A. (2010) · Brain Research · doi:10.1016/j.brainres.2009.09.074 · Cited by 465 · see citing works

Neurobiological substrates for the dark side of compulsivity in addiction

Koob, G. F. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.043 · Cited by 458 · see citing works

κ Opioid Receptor Antagonism and Prodynorphin Gene Disruption Block Stress-Induced Behavioral Responses

McLaughlin, J. P., Marton-Popovici, M., & Chavkin, C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-13-05674.2003 · Cited by 432 · see citing works

Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period

Erb, S. M., Shaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/s002130050150 · Cited by 406 · see citing works

Stress-induced craving and stress response in cocaine dependent individuals

Sinha, R., Catapano, D., & O’Malley, S. S. (1999) · Psychopharmacology · doi:10.1007/s002130050898 · Cited by 403 · see citing works

The role of the dynorphin–κ opioid system in the reinforcing effects of drugs of abuse

Wee, S., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1825-8 · Cited by 398 · see citing works

Stress, vulnerability and adult alcohol relapse.

Brown, S. A., Vik, P. W., Patterson, T. L., Grant, I., & Schuckit, M. A. (1995) · Journal of Studies on Alcohol · doi:10.15288/jsa.1995.56.538 · Cited by 380 · see citing works

Neuronal adaptation to amphetamine and dopamine: Molecular mechanisms of prodynorphin gene regulation in rat striatum

Cole, R. L., Konradi, C. L., DOUGLASS, J. O., & Hyman, S. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90225-2 · Cited by 365 · see citing works

Pathways to relapse: the neurobiology of drug- and stress-induced relapse to drug-taking.

Stewart, J. (2000) · PubMed Central · Cited by 361 · see citing works

Cocaine but Not Natural Reward Self-Administration nor Passive Cocaine Infusion Produces Persistent LTP in the VTA

Chen, B. T., Bowers, M. S., Martín, M., Hopf, F. W., Guillory, A. M., Carelli, R. M., Chou, J., & Bonci, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.024 · Cited by 353 · see citing works

Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location

Ford, C. P., Mark, G. P., & Williams, J. T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4331-05.2006 · Cited by 339 · see citing works

κ opioids selectively control dopaminergic neurons projecting to the prefrontal cortex

Margolis, E. B., Lock, H., Chefer, V. I., Shippenberg, T. S., Hjelmstad, G. O., & Fields, H. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511159103 · Cited by 326 · see citing works

Properties and Plasticity of Excitatory Synapses on Dopaminergic and GABAergic Cells in the Ventral Tegmental Area

Bonci, A., & Malenka, R. C. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-03723.1999 · Cited by 318 · see citing works

Molecular alterations in the neostriatum of human cocaine addicts

Hurd, Y. L., & Herkenham, M. A. (1993) · Synapse · doi:10.1002/syn.890130408 · Cited by 316 · see citing works

Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats

Beardsley, P. M., Howard, J. L., Shelton, K. L., & Carroll, F. I. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0167-4 · Cited by 312 · see citing works

Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking

Land, B. B., Bruchas, M. R., Schattauer, S., Giardino, W. J., Aita, M., Messinger, D., Hnasko, T. S., Palmiter, R. D., & Chavkin, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910705106 · Cited by 301 · see citing works

Opioids block long-term potentiation of inhibitory synapses

Nugent, F. S., Penick, E. C., & Kauer, J. A. (2007) · Nature · doi:10.1038/nature05726 · Cited by 297 · see citing works

Blockade of Stress-Induced But Not Cocaine-Induced Reinstatement by Infusion of Noradrenergic Antagonists into the Bed Nucleus of the Stria Terminalis or the Central Nucleus of the Amygdala

Leri, F., Flores, J., Rodaros, D., & Stewart, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05713.2002 · Cited by 292 · see citing works

A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats

Salmaso, N., Rodaros, D., Stewart, J., & Erb, S. (2001) · Psychopharmacology · doi:10.1007/s002130000642 · Cited by 291 · see citing works

Stress-Induced p38 Mitogen-Activated Protein Kinase Activation Mediates κ-Opioid-Dependent Dysphoria

Bruchas, M. R., Land, B. B., Aita, M., Xu, M., Barot, S. K., Li, S., & Chavkin, C. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3769-07.2007 · Cited by 282 · see citing works

κ-Opioid Agonists Directly Inhibit Midbrain Dopaminergic Neurons

Margolis, E. B., Hjelmstad, G. O., Bonci, A., & Fields, H. L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-31-09981.2003 · Cited by 276 · see citing works

Selective p38α MAPK Deletion in Serotonergic Neurons Produces Stress Resilience in Models of Depression and Addiction

Bruchas, M. R., Schindler, A. G., Shankar, H., Messinger, D. I., Miyatake, M., Land, B. B., Lemos, J. C., Hagan, C. E., Neumaier, J. F., Quintana, A., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.011 · Cited by 266 · see citing works

Cocaine-but not food-seeking behavior is reinstated by stress after extinction

Ahmed, S. H., & Koob, G. F. (1997) · Psychopharmacology · doi:10.1007/s002130050347 · Cited by 257 · see citing works

Kappa opioid inhibition of morphine and cocaine self-administration in rats

Glick, S. D., Maisonneuve, I. M., Raucci, J., & Sydney, A. (1995) · Brain Research · doi:10.1016/0006-8993(95)00306-b · Cited by 245 · see citing works

Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system

Redila, V. A., & Chavkin, C. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1122-y · Cited by 234 · see citing works

Midbrain Dopamine Neurons: Projection Target Determines Action Potential Duration and Dopamine D 2 Receptor Inhibition

Margolis, E. B., Mitchell, J., Ishikawa, J., Hjelmstad, G. O., & Fields, H. L. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1526-08.2008 · Cited by 232 · see citing works

Effects of Naltrexone and Fluoxetine on Alcohol Self-Administration and Reinstatement of Alcohol Seeking Induced by Priming Injections of Alcohol and Exposure to Stress

Lê, A. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00024-x · Cited by 228 · see citing works

Prior Activation of Kappa Opioid Receptors by U50,488 Mimics Repeated Forced Swim Stress to Potentiate Cocaine Place Preference Conditioning

McLaughlin, J. P., Land, B. B., Li, S., Pintar, J. E., & Chavkin, C. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300860 · Cited by 226 · see citing works

The Synaptic Framework for Chemical Signaling in Nucleus Accumbens

Meredith, G. E. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09266.x · Cited by 215 · see citing works

Extremely long-lasting antagonistic actions of nor-binaltorphimine (nor-BNI) in the mouse tail-flick test.

Horan, P. J., Taylor, J., Yamamura, H. I., & Porreca, F. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11434-1 · Cited by 215 · see citing works

Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition

Shaban, H., Humeau, Y., Herry, C., Casassus, G., Shigemoto, R., Ciocchi, S., Barbieri, S., van der Putten, H., Kaupmann, K., Bettler, B., et al. (2006) · Nature Neuroscience · doi:10.1038/nn1732 · Cited by 208 · see citing works

Stress-induced relapse to cocaine seeking: roles for the CRF2 receptor and CRF-binding protein in the ventral tegmental area of the rat

Wang, B., You, Z., Rice, K. C., & Wise, R. A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0782-3 · Cited by 207 · see citing works

Nor-binaltorphimine: a potent and selective kappa-opioid receptor antagonist with long-lasting activity in vivo.

Endoh, T., Matsuura, H., Tanaka, C., & Nagase, H. (1992) · PubMed · Cited by 206 · see citing works

Effect of Selective Blockade of μ1 or δ Opioid Receptors on Reinstatement of Alcohol-Seeking Behavior by Drug-Associated Stimuli in Rats,

Ciccocioppo, R. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00302-0 · Cited by 203 · see citing works

Urges to smoke during the first month of abstinence: relationship to relapse and predictors

Doherty, K., Kinnunen, T., Militello, F. S., & Garvey, A. J. (1995) · Psychopharmacology · doi:10.1007/bf02246158 · Cited by 198 · see citing works

Effects of opioid and dopamine receptor antagonists on relapse induced by stress and re-exposure to heroin in rats

Shaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/bf02246022 · Cited by 194 · see citing works

Addiction: Making the Connection Between Behavioral Changes and Neuronal Plasticity in Specific Pathways

Wolf, M. E. (2002) · Molecular Interventions · doi:10.1124/mi.2.3.146 · Cited by 185 · see citing works

Restraint increases dopaminergic burst firing in awake rats

Anstrom, K. K., & Woodward, D. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300730 · Cited by 181 · see citing works

Affinity profiles of morphine, codeine, dihydrocodeine and their glucuronides at opioid receptor subtypes

Mignat, C., Wille, U., & Ziegler, A. (1995) · Life Sciences · doi:10.1016/0024-3205(95)00010-4 · Cited by 179 · see citing works

Effects of Kappa Opioids on Cocaine Self-Administration by Rhesus Monkeys

Negus, S. S., Mello, N. K., Portoghese, P. S., & Lin, C. E. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36769-2 · Cited by 169 · see citing works

Projections from the rhomboid nucleus of the bed nuclei of the stria terminalis: Implications for cerebral hemisphere regulation of ingestive behaviors

Dong, H., & Swanson, L. W. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10758 · Cited by 168 · see citing works

Cocaine-induced potentiation of synaptic strength in dopamine neurons: Behavioral correlates in GluRA(–/–) mice

Dong, Y., Saal, D., Thomas, M., Faust, R., Bonci, A., Robinson, T., & Malenka, R. C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401553101 · Cited by 158 · see citing works

The kappa-opioid receptor is primarily postsynaptic: combined immunohistochemical localization of the receptor and endogenous opioids.

Arvidsson, U., Riedl, M. S., Chakrabarti, S., Vulchanova, L., LEE, J., Nakano, A. H., Lin, X., Loh, H. H., Law, P., & Wessendorf, M. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.5062 · Cited by 154 · see citing works

Immunohistochemical localization of the cloned κ1 receptor in the rat CNS and pituitary

Mansour, A., Burke, S., Pavlic, R., Akil, H., & Watson, S. J. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00464-5 · Cited by 150 · see citing works

Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area

Niehaus, J. L., Murali, M., & Kauer, J. A. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07256.x · Cited by 140 · see citing works

Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn

Carey, A. N., Borozny, K., Aldrich, J. V., & McLaughlin, J. P. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.05.007 · Cited by 140 · see citing works

Postsynaptic control of hippocampal long-term potentiation.

Wigström, H., & Gustafsson, B. (1986) · PubMed · Cited by 137 · see citing works

Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration

Sperling, R. E., Gomes, S. M., Sypek, E. I., Carey, A. N., & McLaughlin, J. P. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1844-5 · Cited by 127 · see citing works

Molecular and genetic substrates linking stress and addiction

Briand, L. A., & Blendy, J. A. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.002 · Cited by 125 · see citing works

Neuroanatomical characterization of endogenous opioids in the bed nucleus of the stria terminalis

Poulin, J.-F., Arbour, D., Laforest, S., & Drolet, G. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.06.021 · Cited by 125 · see citing works

Making a bad thing worse: adverse effects of stress on drug addiction

Cleck, J. N., & Blendy, J. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33946 · Cited by 122 · see citing works

Phosphorylation-Dependent Trafficking of GluR2-Containing AMPA Receptors in the Nucleus Accumbens Plays a Critical Role in the Reinstatement of Cocaine Seeking

Famous, K. R., Kumaresan, V., Sadri‐Vakili, G., Schmidt, H. D., Mierke, D. F., Cha, J.-H. J., & Pierce, R. C. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1221-08.2008 · Cited by 119 · see citing works

Stress-Induced Activation of the Dynorphin/κ-Opioid Receptor System in the Amygdala Potentiates Nicotine Conditioned Place Preference

Smith, J. S., Schindler, A. G., Martinelli, E., Gustin, R. M., Bruchas, M. R., & Chavkin, C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2980-11.2012 · Cited by 102 · see citing works

κ Agonist-Induced Reinstatement of Cocaine Seeking in Squirrel Monkeys: A Role for Opioid and Stress-Related Mechanisms

Valdez, G. R., Platt, D. M., Rowlett, J. K., Rüedi-Bettschen, D., & Spealman, R. D. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.125484 · Cited by 99 · see citing works

Role of Mu- and Delta-Opioid Receptors in the Nucleus Accumbens in Cocaine-Seeking Behavior

Simmons, D. L., & Self, D. W. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.28 · Cited by 89 · see citing works

Effects of the kappa opioid agonist U50,488 and the kappa opioid antagonist nor-binaltorphimine on choice between cocaine and food in rhesus monkeys

Negus, S. S. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1878-7 · Cited by 86 · see citing works

Kappa Opioid Inhibition of Somatodendritic Dopamine Inhibitory Postsynaptic Currents

Ford, C., Beckstead, M. J., & Williams, J. T. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00963.2006 · Cited by 84 · see citing works

Effects of Frequency and Pattern of Medial Forebrain Bundle Stimulation on Caudate Dialysate Dopamine and Serotonin

Manley, L. D., Kuczenski, R. T., Segal, D. S., Young, S. J., & Groves, P. M. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb11369.x · Cited by 83 · see citing works

Dynorphin-containing pathways in the substantia nigra and ventral tegmentum: A double labeling study using combined immunofluorescence and retrograde tracing

Fallon, J. H., Leslie, F. M., & Cone, R. I. (1985) · Neuropeptides · doi:10.1016/0143-4179(85)90053-8 · Cited by 82 · see citing works

Potentially functional polymorphism in the promoter region of prodynorphin gene may be associated with protection against cocaine dependence or abuse.

Chen, A. H. Y., Laforge, K., Ho, A., Mchugh, P., Kellogg, S., Bell, K., Schluger, R. P., Leal, S., & Kreek, M. (2002) · American journal of medical genetics · doi:10.1002/ajmg.10362 · Cited by 80 · see citing works

Desipramine Reduces Stress-Activated Dynorphin Expression and CREB Phosphorylation in NAc Tissue

Chartoff, E. H., Papadopoulou, M., MacDonald, M. L., Parsegian, A., Potter, D. N., Konradi, C. L., & Carlezon, W. A. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051417 · Cited by 79 · see citing works

Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations

Nabeshima, T., Katoh, A., Wada, M., & Kameyama, T. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90077-3 · Cited by 75 · see citing works

PKG and PKA Signaling in LTP at GABAergic Synapses

Nugent, F. S., Niehaus, J. L., & Kauer, J. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.5 · Cited by 73 · see citing works

Effects of buprenorphine and naltrexone on reinstatement of cocaine-reinforced responding in rats.

Comer, S. D., Lac, S. T., Curtis, L. K., & Carroll, M. E. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39443-7 · Cited by 73 · see citing works

Opiate and cocaine addiction: from bench to clinic and back to the bench

Kreek, M. J., Zhou, Y., Butelman, E. R., & Levran, O. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.016 · Cited by 68 · see citing works

NMDA receptors in the rat VTA: a critical site for social stress to intensify cocaine taking

Covington, H. E., Tropea, T. F., Rajadhyaksha, A. M., Kosofsky, B. E., & Miczek, K. A. (2007) · Psychopharmacology · doi:10.1007/s00213-007-1024-4 · Cited by 67 · see citing works

The dynorphin/kappa opioid receptor system: a new target for the treatment of addiction and affective disorders?

Shippenberg, T. S. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.165 · Cited by 58 · see citing works

Ethanol Blocks Long-Term Potentiation of GABAergic Synapses in the Ventral Tegmental Area Involving μ-Opioid Receptors

Guan, Y., & Ye, J.-H. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2010.51 · Cited by 57 · see citing works

Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for μ, δ, and κ opioid receptors in mouse brain homogenates

Lewanowitsch, T., & Irvine, R. J. (2003) · Brain Research · doi:10.1016/s0006-8993(02)04117-3 · Cited by 53 · see citing works

GENETIC STUDY: Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence

Williams, T. J., LaForge, K. S., Gordon, D., Bart, G. B., Kellogg, S. H., Ott, J., & Kreek, M. J. (2007) · Addiction Biology · doi:10.1111/j.1369-1600.2007.00069.x · Cited by 48 · see citing works

Further Evidence for the Implication of a κ-Opioid Receptor Mechanism in the Production of Psychological Stress-Induced Analgesia

Takahashi, M., SENDA, T., Tokuyama, S., & KANETO, H. (1990) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.53.487 · Cited by 48 · see citing works

The contribution of drug history and time since termination of drug taking to footshock stress-induced cocaine seeking in rats

Sorge, R. E., & Stewart, J. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0160-y · Cited by 48 · see citing works

Increases of CRF in the amygdala are responsible for reinstatement of methamphetamine-seeking behavior induced by footshock

Nawata, Y., Kitaichi, K., & Yamamoto, T. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.01.003 · Cited by 47 · see citing works

NBQX, an improved non-NMDA antagonist studied in retinal ganglion cells

Yu, W., & Miller, R. F. (1995) · Brain Research · doi:10.1016/0006-8993(95)00665-d · Cited by 46 · see citing works

Stress-induced, glucocorticoid-dependent strengthening of glutamatergic synaptic transmission in midbrain dopamine neurons

Daftary, S. S., Panksepp, J., Dong, Y., & Saal, D. B. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.070 · Cited by 46 · see citing works

Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence

Dahl, J. P., Weller, A. E., Kampman, K. M., Oslin, D. W., Lohoff, F. W., Ferraro, T. N., O’Brien, C. P., & Berrettini, W. H. (2005) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30238 · Cited by 44 · see citing works

Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus

Mott, D. D., Lewis, D. V., Ferrari, C. M., Wilson, W. A., & Swartzwelder, H. S. (1990) · Neuroscience Letters · doi:10.1016/0304-3940(90)90307-u · Cited by 43 · see citing works

Persistent Increases in Cocaine-Seeking Behavior After Acute Exposure to Cold Swim Stress

Conrad, K. L., McCutcheon, J. E., Cotterly, L. M., Ford, K. A., Beales, M., & Marinelli, M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.030 · Cited by 43 · see citing works

Effectiveness of analogs of the kappa opioid receptor antagonist (3R)-7-Hydroxy-N-((1S)-1-{[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl}-2-methylpropyl)-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide (JDTic) to reduce U50,488-induced diuresis and stress-induced cocaine reinstatement in rats

Beardsley, P. M., Pollard, G. T., Howard, J. L., & Carroll, F. I. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1846-3 · Cited by 40 · see citing works

MK-801 interaction with the 5-HT transporter: a real-time study in brain slices using fast cyclic voltammetry

Iravani, M. M., Muscat, R., & Kruk, Z. L. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19990601)32:3 · Cited by 27 · see citing works

Opioid receptors in midbrain dopaminergic regions of the rat II. Kappa and delta receptor autoradiography

Speciale, S. G., Manaye, K. F., Sadeq, M., & German, D. C. (1993) · Journal of Neural Transmission · doi:10.1007/bf01244918 · Cited by 27 · see citing works

Regulation of cocaine-reinstated drug-seeking behavior by κ-opioid receptors in the ventral tegmental area of rats

Sun, W., Xue, Y.-Q., Huang, Z., & Steketee, J. D. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1812-0 · Cited by 20 · see citing works

The Neuroscience of Drug Reward and Addiction

Volkow, N. D., Michaelides, M., & Baler, R. (2019) · Physiological Reviews · doi:10.1152/physrev.00014.2018 · Cited by 863 · see citing works

Altering the course of schizophrenia: progress and perspectives

Millan, M. J., Andrieux, A., Bartzokis, G., Cadenhead, K., Dazzan, P., Fusar-Poli, P., Gallinat, J., Giedd, J., Grayson, D. R., Heinrichs, M., et al. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.28 · Cited by 516 · see citing works

Stress-induced reinstatement of drug seeking: 20 years of progress

Mantsch, J. R., Baker, D. A., Funk, D., Lê, A. D., & Shaham, Y. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.142 · Cited by 438 · see citing works

The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research

Bossert, J. M., Marchant, N. J., Calu, D. J., & Shaham, Y. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3120-y · Cited by 453 · see citing works

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Ting, J. T., Lee, B. R., Chong, P., Soler-Llavina, G. J., Cobbs, C., Christof Koch, A., Zeng, H., & Lein, E. S. (2018) · Journal of Visualized Experiments · doi:10.3791/53825 · Cited by 315 · see citing works

Ventral tegmental area dopamine revisited: effects of acute and repeated stress

Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265 · see citing works

Role of kappa-opioid receptors in stress and anxiety-related behavior

Veer, A. V., & Carlezon, W. A. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3195-5 · Cited by 254 · see citing works

The Kappa Opioid Receptor: From Addiction to Depression, and Back

Lalanne, L., Ayrancı, G., Kieffer, B. L., & Lutz, P.-É. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00170 · Cited by 227 · see citing works

Stress-induced plasticity and functioning of ventral tegmental dopamine neurons

Douma, E. H., & de Kloet, E. R. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.015 · Cited by 226 · see citing works

VTA GABA Neurons at the Interface of Stress and Reward

Bouarab, C., Thompson, B. V., & Polter, A. M. (2019) · Frontiers in Neural Circuits · doi:10.3389/fncir.2019.00078 · Cited by 224 · see citing works

Long-Term Plasticity of Neurotransmitter Release: Emerging Mechanisms and Contributions to Brain Function and Disease

Monday, H. R., Younts, T. J., & Castillo, P. E. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-062155 · Cited by 175 · see citing works

Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure

Juarez, B., & Han, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.32 · Cited by 165 · see citing works

Suicide Risk and Addiction: The Impact of Alcohol and Opioid Use Disorders

Rizk, M., Herzog, S., Dugad, S., & Stanley, B. (2021) · Current Addiction Reports · doi:10.1007/s40429-021-00361-z · Cited by 175 · see citing works

Functions of p38 MAP Kinases in the Central Nervous System

Asih, P. R., Prikas, E., Stefanoska, K., Tan, A. R. P., Ahel, H. I., & Ittner, A. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.570586 · Cited by 158 · see citing works

Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain

Reeves, K. C., Shah, N., Muñoz, B., & Atwood, B. K. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.919773 · Cited by 156 · see citing works

Stress and VTA synapses: implications for addiction and depression

Polter, A. M., & Kauer, J. A. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12490 · Cited by 141 · see citing works

Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction

Chartoff, E. H., & Mavrikaki, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00466 · Cited by 134 · see citing works

Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment

Crowley, N. A., & Kash, T. L. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.01.001 · Cited by 132 · see citing works

Untitled work

Karkhanis (2017) · doi:10.1016/bs.irn.2017.08.001 · Cited by 113 · see citing works

The effects of psychosocial stress on dopaminergic function and the acute stress response

Bloomfield, M. A., McCutcheon, R. A., Kempton, M., Freeman, T. P., & Howes, O. (2019) · eLife · doi:10.7554/elife.46797 · Cited by 112 · see citing works

Dynorphin/kappa-opioid receptor control of dopamine dynamics: Implications for negative affective states and psychiatric disorders

Tejeda, H. A., & Bonci, A. (2018) · Brain Research · doi:10.1016/j.brainres.2018.09.023 · Cited by 112 · see citing works

Social Support and Resilience as Mediators Between Stress and Life Satisfaction Among People With Substance Use Disorder in China

Yang, C., Xia, M., Han, M., & Liang, Y. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00436 · Cited by 111 · see citing works

Targeting opioid dysregulation in depression for the development of novel therapeutics

Browne, C. A., & Lucki, I. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.04.009 · Cited by 97 · see citing works

Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms

Farrell, M. R., Schoch, H., & Mahler, S. V. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.01.002 · Cited by 85 · see citing works

Substance use modulates stress reactivity: Behavioral and physiological outcomes

Fosnocht, A. Q., & Briand, L. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.024 · Cited by 80 · see citing works

Role of the Dynorphin/Kappa Opioid Receptor System in the Motivational Effects of Ethanol

Anderson, R. I., & Becker, H. C. (2017) · Alcoholism: Clinical and Experimental Research · doi:10.1111/acer.13406 · Cited by 79 · see citing works

Modulation of 5-HT release by dynorphin mediates social deficits during opioid withdrawal

Pomrenze, M. B., Pinto, D. F. C., Neumann, P. A., Llorach, P., Tucciarone, J., Morishita, W., Eshel, N., Heifets, B. D., & Malenka, R. C. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.024 · Cited by 75 · see citing works

Poststress Block of Kappa Opioid Receptors Rescues Long-Term Potentiation of Inhibitory Synapses and Prevents Reinstatement of Cocaine Seeking

Polter, A. M., Bishop, R. A., Briand, L. A., Graziane, N., Pierce, R. C., & Kauer, J. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.019 · Cited by 64 · see citing works

Orexin Signaling in the VTA Gates Morphine-Induced Synaptic Plasticity

Baimel, C., & Borgland, S. L. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.4385-14.2015 · Cited by 65 · see citing works

Optogenetic stimulation of lateral hypothalamic orexin/dynorphin inputs in the ventral tegmental area potentiates mesolimbic dopamine neurotransmission and promotes reward-seeking behaviours

Thomas, C. S., Mohammadkhani, A., Rana, M., Qiao, M., Baimel, C., & Borgland, S. L. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01196-y · Cited by 62 · see citing works

Pharmacology and anti‐addiction effects of the novel κ opioid receptor agonist M esyl S al B , a potent and long‐acting analogue of salvinorin A

Simonson, B., Morani, A. S., Ewald, A. W. M., Walker, L. C., Kumar, N., Simpson, D. S., Miller, J. H., Prisinzano, T. E., & Kivell, B. M. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12692 · Cited by 62 · see citing works

Locus Coeruleus Kappa-Opioid Receptors Modulate Reinstatement of Cocaine Place Preference Through a Noradrenergic Mechanism

Al‐Hasani, R., McCall, J. G., Foshage, A. M., & Bruchas, M. R. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.151 · Cited by 60 · see citing works

A trigger for opioid misuse: chronic pain and stress dysregulate the mesolimbic pathway and kappa opioid system

Massaly, N., Morón, J. A., & Al-Hasani, R. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00480 · Cited by 59 · see citing works

Closing the gap: long-term presynaptic plasticity in brain function and disease

Monday, H. R., & Castillo, P. E. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.05.011 · Cited by 57 · see citing works

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

Ting, J. T., Lee, B. R., Chong, P., Soler-Llavina, G. J., Cobbs, C., Christof Koch, A., Zeng, H., & Lein, E. S. (2018) · Journal of Visualized Experiments · doi:10.3791/53825-v · Cited by 55 · see citing works

Synaptic function and plasticity in identified inhibitory inputs onto VTA dopamine neurons

Polter, A. M., Barcomb, K., Tsuda, A. C., & Kauer, J. A. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13879 · Cited by 52 · see citing works

Dopaminergic cellular and circuit contributions to kappa opioid receptor mediated aversion

Margolis, E. B., & Karkhanis, A. N. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104504 · Cited by 51 · see citing works

Endogenous opiates and behavior: 2013

Bodnar, R. J. (2014) · Peptides · doi:10.1016/j.peptides.2014.09.013 · Cited by 52 · see citing works

Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release

Chartoff, E. H., Ebner, S. R., Sparrow, A. M., Potter, D. N., Baker, P. M., Ragozzino, M. E., & Roitman, M. F. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.226 · Cited by 49 · see citing works

Periaqueductal Gray and Rostromedial Tegmental Inhibitory Afferents to VTA Have Distinct Synaptic Plasticity and Opiate Sensitivity

Laurent, R. S., Damonte, V. M., Tsuda, A. C., & Kauer, J. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.02.029 · Cited by 51 · see citing works

Exposure to chronic mild stress prevents kappa opioid-mediated reinstatement of cocaine and nicotine place preference

Al‐Hasani, R., McCall, J. G., & Bruchas, M. R. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00096 · Cited by 49 · see citing works

Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

Polter, A. M., Barcomb, K., Chen, R. W., Dingess, P. M., Graziane, N., Brown, T. E., & Kauer, J. A. (2017) · eLife · doi:10.7554/elife.23785 · Cited by 50 · see citing works

Opiates and Plasticity in the Ventral Tegmental Area

Langlois, L. D., & Nugent, F. S. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00281 · Cited by 47 · see citing works

What does the Fos say? Using Fos-based approaches to understand the contribution of stress to substance use disorders

McReynolds, J. R., Christianson, J. P., Blacktop, J. M., & Mantsch, J. R. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.05.004 · Cited by 42 · see citing works

Drug withdrawal conceptualized as a stressor

Chartoff, E. H., & Carlezon, W. A. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000080 · Cited by 43 · see citing works

Changing the tune: plasticity and adaptation of retrograde signals

Iremonger, K. J., Cusulin, J. I. W., & Bains, J. S. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.007 · Cited by 42 · see citing works

Bidirectional role of acupuncture in the treatment of drug addiction

Lee, M. Y., Lee, B. H., Kim, H. Y., & Yang, C. H. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.04.004 · Cited by 41 · see citing works

Acupuncture reduces relapse to cocaine‐seeking behavior via activation of GABA neurons in the ventral tegmental area

Jin, W., Kim, M. S., Jang, E. Y., Lee, J. Y., Lee, J. G., Kim, H. Y., Yoon, S. S., Lee, B. H., Chang, S., Kim, J. H., et al. (2017) · Addiction Biology · doi:10.1111/adb.12499 · Cited by 39 · see citing works

Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine‐seeking behaviour

Brice‐Tutt, A. C., Wilson, L., Eans, S. O., Stacy, H. M., Simons, C. A., Simpson, G. G., Coleman, J. S., Ferracane, M. J., Aldrich, J. V., & McLaughlin, J. P. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15165 · Cited by 38 · see citing works

Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol

Ostroumov, A., & Dani, J. A. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052735 · Cited by 35 · see citing works

Differential regulation of mGlu5R and ΜOPr by priming‐ and cue‐induced reinstatement of cocaine‐seeking behaviour in mice

Georgiou, P., Zanos, P., Ehteramyan, M., Hourani, S. M. O., Kitchen, I., Maldonado, R. J., & Bailey, A. (2014) · Addiction Biology · doi:10.1111/adb.12208 · Cited by 35 · see citing works

Neurobiological mechanisms underlying relapse to cocaine use: contributions of CRF and noradrenergic systems and regulation by glucocorticoids

McReynolds, J. R., Peña, D. F., Blacktop, J. M., & Mantsch, J. R. (2013) · Stress · doi:10.3109/10253890.2013.872617 · Cited by 33 · see citing works

The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving

de Laat, B., Goldberg, A., Shi, J. M., Tetrault, J. M., Nabulsi, N., Zheng, M., Najafzadeh, S., Gao, H., Kapinos, M., Ropchan, J. R., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.021 · Cited by 35 · see citing works

Early life stress dysregulates kappa opioid receptor signaling within the lateral habenula

Simmons, S. C., Shepard, R. D., Gouty, S., Langlois, L. D., Flerlage, W. J., Cox, B. M., & Nugent, F. S. (2020) · Neurobiology of Stress · doi:10.1016/j.ynstr.2020.100267 · Cited by 32 · see citing works

Anti-stress neuropharmacological mechanisms and targets for addiction treatment: A translational framework

Greenwald, M. K. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.08.003 · Cited by 32 · see citing works

Crosstalk Between Kappa Opioid and Dopamine Systems in Compulsive Behaviors

Escobar, A. P., Casanova, J. P., Andrés, M. E., & Fuentealba, J. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00057 · Cited by 31 · see citing works

Paradoxical changes in brain reward status during oxycodone self‐administration in a novel test of the negative reinforcement hypothesis

Nguyen, J. D., Grant, Y., & Taffe, M. A. (2021) · British Journal of Pharmacology · doi:10.1111/bph.15520 · Cited by 30 · see citing works

Opioid addiction and withdrawal differentially drive long-term depression of inhibitory synaptic transmission in the hippocampus

Han, H., Dong, Z., Jia, Y., Mao, R., Zhou, Q., Yang, Y., Wang, L., Xu, L., & Cao, J. (2015) · Scientific Reports · doi:10.1038/srep09666 · Cited by 29 · see citing works

Combined early life stressors: prenatal nicotine and maternal deprivation interact to influence behavioral phenotypes in rats

Bassey, R., & Gondré-Lewis, M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.07.022 · Cited by 23 · see citing works

Spike timing‐dependent plasticity at GABAergic synapses in the ventral tegmental area

Jayaraj, K. N., Dacher, M., Authement, M. E., & Nugent, F. S. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.257873 · Cited by 27 · see citing works

Cocaine conditioning induces persisting changes in ventral hippocampus synaptic transmission, long-term potentiation, and radial arm maze performance in the mouse

Preston, C. J., Brown, K. A., & Wagner, J. J. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.02.033 · Cited by 27 · see citing works

A role for kappa-, but not mu-opioid, receptor activation in acute food deprivation-induced reinstatement of heroin seeking in rats

Sedki, F., Eigenmann, K., Gelinas, J., Schouela, N., Courchesne, S., & Shalev, U. (2014) · Addiction Biology · doi:10.1111/adb.12133 · Cited by 26 · see citing works

Prefrontal cortical dynorphin peptidergic transmission constrains threat-driven behavioral and network states

Wang, H., Flores, R. J., Yarur, H. E., Limoges, A., Bravo-Rivera, H., Casello, S. M., Loomba, N., Enríquez-Traba, J., Arenivar, M. A., Wang, Q., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.03.015 · Cited by 25 · see citing works

Differential expression of long-term potentiation among identified inhibitory inputs to dopamine neurons

Simmons, D. V., Petko, A. K., & Paladini, C. A. (2017) · Journal of Neurophysiology · doi:10.1152/jn.00270.2017 · Cited by 24 · see citing works

Opioid modulation of cognitive impairment in depression

Jacobson, M. L., Wulf, H. A., Browne, C. A., & Lucki, I. (2018) · Progress in brain research · doi:10.1016/bs.pbr.2018.07.007 · Cited by 24 · see citing works

Stress-induced anxiety-related behavior in mice is driven by enhanced excitability of ventral tegmental area GABA neurons

Mitten, E. H., Souders, A., de Velasco, E. M. F., & Wickman, K. D. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1425607 · Cited by 19 · see citing works

Neural Plasticity Is Involved in Physiological Sleep, Depressive Sleep Disturbances, and Antidepressant Treatments

Zhang, M., Li, R., Wang, Y., & Huang, Z. (2017) · Neural Plasticity · doi:10.1155/2017/5870735 · Cited by 19 · see citing works

Antagonism of GABA-B but not GABA-A receptors in the VTA prevents stress- and intra-VTA CRF-induced reinstatement of extinguished cocaine seeking in rats

Blacktop, J. M., Vranjkovic, O., Mayer, M., Hoof, M. V., Baker, D. L., & Mantsch, J. R. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.11.013 · Cited by 17 · see citing works

The Role of the Kappa Opioid System in Comorbid Pain and Psychiatric Disorders: Function and Implications

Ji, M., Yang, J., Gao, Z., Zhang, L., & Liu, C. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.642493 · Cited by 17 · see citing works

Stressed and wired: The effects of stress on the VTA circuits underlying motivated behavior

Lowes, D. C., & Harris, A. Z. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100388 · Cited by 18 · see citing works

Learned avoidance requires VTA KOR-mediated reductions in dopamine

Robble, M. A., Bozsik, M., Wheeler, D. S., & Wheeler, R. A. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107996 · Cited by 17 · see citing works

VTA dopamine neuron plasticity – the unusual suspects

Xin, W., Edwards, N., & Bonci, A. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13425 · Cited by 17 · see citing works

A single, extinction-based treatment with a kappa opioid receptor agonist elicits a long-term reduction in cocaine relapse

Heinsbroek, J. A., Furbish, A. B., & Peters, J. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-017-0006-4 · Cited by 16 · see citing works

Hypocretin/Orexin and Plastic Adaptations Associated with Drug Abuse

Baimel, C., & Borgland, S. L. (2016) · Current topics in behavioral neurosciences · doi:10.1007/7854_2016_44 · Cited by 15 · see citing works

Consideration of sex as a biological variable in the translation of pharmacotherapy for stress-associated drug seeking

Martin, E. L., Doncheck, E. M., Reichel, C. M., & McRae‐Clark, A. L. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100364 · Cited by 14 · see citing works

Dichotomous regulation of striatal plasticity by dynorphin

Yang, R., Lalchandani, R. R., Hwang, F.-J., Bloodgood, D. W., Kong, D., & Ding, J. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01885-0 · Cited by 14 · see citing works

The Neurocircuitry of Substance Use Disorder, Treatment, and Change: A Resource for Clinical Psychiatrists

Imperio, C. G., LEVIN, F. R., & Martínez, D. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20231023 · Cited by 13 · see citing works

Dysregulation of Dopaminergic Regulatory Factors TH, Nurr1, and Pitx3 in the Ventral Tegmental Area Associated with Neuronal Injury Induced by Chronic Morphine Dependence

Shi, W., Zhang, Y., Zhao, G., Wang, S., Zhang, G., Ma, C., Li, Y., & Cong, B. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20020250 · Cited by 13 · see citing works

Neuroplasticity in cholinergic neurons of the laterodorsal tegmental nucleus contributes to the development of cocaine addiction

Kaneda, K. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13962 · Cited by 13 · see citing works

Dual motor responses elicited by ethanol in the posterior VTA: Consequences of the blockade of μ-opioid receptors

Martí‐Prats, L., Orrico‐Sánchez, A., Polache, A., & Granero, L. M. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881115598337 · Cited by 12 · see citing works

Co-targeting the kappa opioid receptor and dopamine transporter reduces motivation to self-administer cocaine and partially reverses dopamine system dysregulation

Estave, P. M., Albertson, S. E., Karkhanis, A. N., & Jones, S. R. (2024) · Scientific Reports · doi:10.1038/s41598-024-53463-9 · Cited by 11 · see citing works

Short-Term Consequences of Single Social Defeat on Accumbal Dopamine and Behaviors in Rats

Nemets, V. V., Deal, A. L., Sobolev, V. E., Grinevich, V. P., Gainetdinov, R. R., & Budygin, E. A. (2022) · Biomolecules · doi:10.3390/biom13010035 · Cited by 11 · see citing works

Mechanical allodynia induced by optogenetic sensory nerve excitation activates dopamine signaling and metabolism in medial nucleus accumbens

Sugiyama, E., Kondo, T., Kuzumaki, N., Honda, K., Yamanaka, A., Narita, M., Suematsu, M., & Sugiura, Y. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104494 · Cited by 11 · see citing works

How Does Stress-Induced Activation of the Kappa Opioid System Increase Addiction Risk?

Chavkin, C., & Ehrich, J. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.015 · Cited by 10 · see citing works

Synaptic Plasticity at Inhibitory Synapses in the Ventral Tegmental Area Depends upon Stimulation Site

Laurent, R. S., & Kauer, J. A. (2019) · eNeuro · doi:10.1523/eneuro.0137-19.2019 · Cited by 9 · see citing works

Alleviation of Cocaine Withdrawal and Pertinent Interactions between Salvinorin-Based Antagonists and Kappa Opioid Receptor

Akins, N. S., Mohammed, S., Pandey, P., Kim, S. J., Mahdi, F., Khan, M. I. H., Moss, E. M., Worth, C. J., Keane, M. M., Chittiboyina, A. G., et al. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00806 · Cited by 9 · see citing works

Incisional Injury Modulates Morphine Reward and Morphine-Primed Reinstatement: A Role of Kappa Opioid Receptor Activation

Nwaneshiudu, C. A., Shi, X., & Clark, J. D. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004142 · Cited by 9 · see citing works

KOR agonists for the treatment and/or prevention of opioid use disorder and cocaine use disorder

Liu‐Chen, L., & Huang, P. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.174056 · Cited by 6 · see citing works

Accumbal Dopamine Responses Are Distinct between Female Rats with Active and Passive Coping Strategies

Nemets, V. V., Виноградова, Е. П., Zavialov, V. A., Grinevich, V. P., Budygin, E. A., & Gainetdinov, R. R. (2024) · Biomolecules · doi:10.3390/biom14101280 · Cited by 6 · see citing works

Enhanced psychostimulant response, but not social avoidance, depends on GluA1 AMPA receptors in VTA dopamine neurons following intermittent social defeat stress in rats

Rudolph, M. L., Neve, R. L., Hammer, R. P., & Nikulina, E. M. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14884 · Cited by 5 · see citing works

G protein‐coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects

Littlepage‐Saunders, M., Hochstein, M. J., Chang, D. S., & Johnson, K. A. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16151 · Cited by 5 · see citing works

Untangling the multifaceted VTA responses to stress

Skupio, U., Harris, A. Z., & Polter, A. M. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.06.004 · Cited by 4 · see citing works

The effect of different durations of morphine exposure on mesencephalic dopaminergic neurons in morphine dependent rats

Shi, W., Ma, C., Qian, Q., Liu, L., Bi, H., Cong, B., & Li, Y. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.09.005 · Cited by 4 · see citing works

Pharmacological Treatment of Substance Abuse Disorders

Raby, W. N., Mariani, J. J., LEVIN, F. R., & Nunes, E. V. (2015) · Wiley eBooks · doi:10.1002/9781118753378.ch113 · Cited by 4 · see citing works

G Protein Inactivation as a Mechanism for Addiction Treatment

Neiswanger, C., Ruiz, M. V., Kimball, K., Lee, C. J., Land, B. B., Berndt, A., & Chavkin, C. (2025) · Biological Psychiatry · doi:10.1016/j.biopsych.2025.03.021 · Cited by 3 · see citing works

Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking

Damonte, V. M., Bailey, L. G., Thakar, A., Stralka, J., Brown, T. E., & Kauer, J. A. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1233-25.2025 · Cited by 3 · see citing works

Long-Term Measurements

Graziane, N., & Dong, Y. (2016) · Neuromethods · doi:10.1007/978-1-4939-3274-0_12 · Cited by 3 · see citing works

A method for evaluating cocaine-induced social preference in rats

Dingess, P. M., Deters, M. J., Darling, R. A., Yarborough, E. A., & Brown, T. E. (2017) · Journal of Biological Methods · doi:10.14440/jbm.2017.145 · Cited by 3 · see citing works

BDNF restores impaired long-term potentiation of GABAergic synapses induced by chronic ethanol exposure in the VTA and attenuates reward-seeking behavior

Xiong, J., Dou, M.-Y., Wang, Y., Zeng, T., Qi, X., Wei, J.-N., Shi, X., Cui, D.-D., Dai, H.-Z., Du, C.-Y., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03532-4 · Cited by 2 · see citing works

Long-term potentiation in the brain: a synaptic memory mechanism

Moreno, A. R., & Paulsen, O. (2026) · Physiological Reviews · doi:10.1152/physrev.00028.2025 · Cited by 2 · see citing works

Poststress Block of Kappa Opioid Receptors Rescues Long-Term Potentiation of Inhibitory Synapses and Prevents Reinstatement of Cocaine Seeking

Polter, A. M., Bishop, R. A., Briand, L. A., Graziane, N., Pierce, R. C., & Kauer, J. A. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.04.019 · Cited by 64 · see citing works

Kappa Opioid Receptors Control a Stress-Sensitive Brain Circuit and Drive Cocaine Seeking

Damonte, V. M., Bailey, L. G., Thakar, A., Stralka, J., Brown, T. E., & Kauer, J. A. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1233-25.2025 · Cited by 3 · see citing works

How Does Stress-Induced Activation of the Kappa Opioid System Increase Addiction Risk?

Chavkin, C., & Ehrich, J. M. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.015 · Cited by 10 · see citing works

Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress

Polter, A. M., Barcomb, K., Chen, R. W., Dingess, P. M., Graziane, N., Brown, T. E., & Kauer, J. A. (2017) · eLife · doi:10.7554/elife.23785 · Cited by 50 · see citing works

Exposure to chronic mild stress prevents kappa opioid-mediated reinstatement of cocaine and nicotine place preference

Al‐Hasani, R., McCall, J. G., & Bruchas, M. R. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00096 · Cited by 49 · see citing works