Anterior hippocampus: the anatomy of perception, imagination and episodic memory
Open accessAbstract
The brain creates a model of the world around us. We can use this representation to perceive and comprehend what we see at any given moment, but also to vividly re-experience scenes from our past and imagine future (or even fanciful) scenarios. Recent work has shown that these cognitive functions--perception, imagination and recall of scenes and events--all engage the anterior hippocampus. In this Opinion article, we capitalize on new findings from functional neuroimaging to propose a model that links high-level cognitive functions to specific structures within the anterior hippocampus.
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Other fMRI studies have linked hippocampal activity during imagining to scene construction, encoding of episodic simulations into long-term memory, and detail recombination.
“Other fMRI studies have linked hippocampal activity during imagining to the process of scene construction (61–62), encoding of episodic simulations into long-term memory (63), and detail recombination (64).”
From Episodic Future Thinking: Mechanisms and Functions (2017) · cites this paper as [62]
Questions about the precise role of the hippocampus in episodic future thinking continue to be debated, with evidence suggesting different hippocampal subregions make distinct contributions to particular subprocesses.
“questions concerning the precise role of the hippocampus in episodic future thinking continue to be debated, with the evidence suggesting that different subregions of the hippocampus make distinct contributions to particular subprocesses that comprise episodic future thinking and related phenomena (59–60, 62).”
From Episodic Future Thinking: Mechanisms and Functions (2017) · cites this paper as [62]
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Past Experience Modulates the Neural Mechanisms of Episodic Memory Formation
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Decoding the cognitive map: ensemble hippocampal sequences and decision making
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The hippocampus extrapolates beyond the view in scenes: an fMRI study of boundary extension
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Intrinsic connections of the macaque monkey hippocampal formation: II. CA3 connections
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Activation of the ventral striatum during aversive contextual conditioning in humans
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Pattern of hippocampal shape and volume differences in blind subjects
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A Comparison of Two fMRI Protocols for Eliciting Hippocampal Activation
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Remembering Preservation in Hippocampal Amnesia
Clark, I. A., & Maguire, E. A. (2015) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033739 · Cited by 60 · see citing works
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Alterations in right posterior hippocampus in early blind individuals
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Memory, Perception, and the Medial Temporal Lobe: A Synthesis of Opinions
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Existence of a potential neurogenic system in the adult human brain
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Some Cell and Fibre Peculiarities of Uncal Hippocampus
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Default Network Connectivity in Medial Temporal Lobe Amnesia
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Brain Genomics Superstruct Project (GSP)
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Intrinsic connections of the macaque monkey hippocampal formation: I. Dentate gyrus
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The neural correlates of navigation beyond the hippocampus
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Memory consolidation in humans: new evidence and opportunities
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Self-citationCounterfactual thinking in patients with amnesia
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Self-citationFunctional MRI Studies of the Hippocampus
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Episodic Future Thinking: Mechanisms and Functions
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The hippocampus and related neocortical structures in memory transformation
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Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery
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False memories with age: neural and cognitive underpinnings
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Two distinct scene processing networks connecting vision and memory
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Exercise Induces Tissue-Specific Adaptations to Enhance Cardiometabolic Health
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Dark control: The default mode network as a reinforcement learning agent
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Metacognitive ability correlates with hippocampal and prefrontal microstructure
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How the Brain’s Navigation System Shapes Our Visual Experience
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Consciousness, Representation, Action: The Importance of Being Goal-Directed
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Oxytocin effects on self-referential processing: behavioral and neuroimaging evidence
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Selective neural coding of object, feature, and geometry spatial cues in humans
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A place with a view: A first‐person perspective in the hippocampal memory space
Wirth, S. (2023) · Hippocampus · doi:10.1002/hipo.23537 · Cited by 11 · see citing works
Ziegler, M. G., Liu, Z.-X., Arsenault, J., Dang, C., Grady, C., Rosenbaum, R. S., & Moscovitch, M. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad272 · Cited by 6 · see citing works
- Authors
- Zeidman, P., & Maguire, E. A.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- Corresponding author
- Maguire, Eleanor A.
- Venue
- Nature Reviews Neuroscience
- Published
- 2016-02-11
- Volume
- 17
- Issue
- 3
- Pages
- 173-182
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- PMC
- PMC5358751
- OpenAlex
- W2269022733
- Cited by
- 542
- References
- 130
- Citations by year
- 2026: 33 · 2025: 51 · 2024: 67 · 2023: 61 · 2022: 54 · 2021: 52 · 2020: 55 · 2019: 62 · 2018: 50 · 2017: 45 · 2016: 10
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (091593, 101759)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Keywords
- anterior hippocampus, perception, imagination, episodic memory, scene memory, cognitive mapping, functional neuroimaging, hippocampal subfields
- MeSH terms
- Animals, Hippocampus, Humans, Imagination, Perception, Memory, Episodic
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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