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Flow of Cortical Activity Underlying a Tactile Decision in Mice
Open accessAbstract
Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? Here we delineate when and how activity in specific areas drives a whisker-based decision in mice. A short-term memory component temporally separated tactile "sensation" and "action" (licking). Using optogenetic inhibition (spatial resolution, 2 mm; temporal resolution, 100 ms), we surveyed the neocortex for regions driving behavior during specific behavioral epochs. Barrel cortex was critical for sensation. During the short-term memory, unilateral inhibition of anterior lateral motor cortex biased responses to the ipsilateral side. Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex showed choice-specific preparatory activity and movement-related activity, consistent with roles in motor planning and movement. These results suggest serial information flow from sensory to motor areas during perceptual decision making.
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“Hence, peak 4 is likely to reflect participation of the primary somatosensory cortex in motor preparatory activity, often observed in higher motor cortices (12–14).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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“Serial transformation of sensory inputs along bottom–up hierarchical pathways has been observed in rodents engaged in whisker-discrimination tasks (8, 9) with an increasingly stronger association with perceptual choice in S2 (10, 11) and premotor areas (12–14) rather than whisker-related wS1 (9).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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“Therefore, this global regulation is unlikely to originate directly from frontal cortical premotor areas (12–14) since frontal cortices have a high degree of symmetry for both ipsilateral and contralateral projections (59).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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Bitzidou, M., Bale, M., & Maravall, M. (2018) · Neuron · doi:10.1016/j.neuron.2018.04.002 · Cited by 3
“…several studies have appeared to suggest that PPC is necessary for tasks involving accumulation of evidence based on vision but – judging from optogenetic manipulation – not on hearing or touch (Harvey et al., 2012; Guo et al., 2014; Raposo et al., 2014; Goard et al., 2016; Licata et al., 2017).”
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“As expected 55 , the activated neurons were predominantly fast-spiking, whereas the putative pyramidal neurons were predominantly inactivated (Fig.”
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Nakano, K., Koga, K., Kadoya, M., Yamada, A., Kobayashi, K., Pickering, A. E., Koyama, H., & Furue, H. (2026) · iScience · doi:10.1016/j.isci.2026.114750 · Cited by 1
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“SC integrates visual and tactile information and contributes to orienting behavior [38, 5, 10], whereas ALM encodes preparatory and choice-related activity during decision-making tasks [18, 28].”
Inter- and intrahemispheric sources of vestibular signals to V1
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“This approach silences the vast majority of endogenous activity in projection neurons at least down through layer 5 ( Miri et al., 2017 ; Guo et al., 2014b ), including those projecting to the brainstem and spinal cord; we show below that direct optogenetic effects were only seen in the targeted…”
Huang, J., Crochet, S., Sandi, C., & Petersen, C. C. H. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37831 · Cited by 1
Rule-based modulation of a sensorimotor transformation across cortical areas
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“…hits but not false alarms were rewarded (proportions of neurons showing a significant difference in mean response between tHit and tactile false alarms: S1 (0/177); S2 (2/162); MM (0/140); ALM (6/256); permutation tests on PSTHs with Bonferroni correction for multiple comparisons; Materials…”
BackgroundMethodInfluentialPanniello, M., Gillon, C. J., Maffulli, R., Celotto, M., Richards, B. A., Panzeri, S., & Kohl, M. M. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114244 · Cited by 6
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“Moreover, most multi-regional WM data have been collected from head-fixed mice 30–33 .”
BackgroundRecording Forelimb Muscle Activity in Head-Fixed Mice with Chronically Implanted EMG Electrodes
Kristl, A. C., Akay, T., & Miri, A. (2024) · Journal of Visualized Experiments · doi:10.3791/66584 · Cited by 2
“Common experimental approaches involve head-fixed mice performing motor tasks alongside the monitoring and/or perturbation of neural activity 1, 2, 3, 4, 5 .”
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Huang, E.-M., Xu, D., Zhu, H.-G., Chen, Z.-Q., Chen, Y.-L., Zhang, X.-X., & Li, C.-Y. T. (2023) · bioRxiv · doi:10.1101/2023.10.08.561458 · Cited by 2
Prefrontal projections modulate recurrent circuitry in insular cortex to support short-term memory
Yao, J., Hou, R.-Q., Fan, H.-M., Hou, J., Cheng, Q., & Li, C.-Y. T. (2023) · bioRxiv · doi:10.1101/2023.04.28.538791 · Cited by 2
Superior colliculus cell types bidirectionally modulate choice activity in frontal cortexPreprint
Thomas, A. M., Yang, W., Wang, C. K., Tipparaju, S. L., Chen, G., Sullivan, B. J., Swiekatowski, K. R., Tatam, M., Gerfen, C. R., & Li, N. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.22.537884 · Cited by 2
Self-citationA novel task to investigate vibrotactile detection in mice
Müller, M., Pennartz, C. M. A., Bosman, C. A., & Olcese, U. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284735 · Cited by 3
“This transgenic line is often used in studies in which area-specific optogenetic inactivation is used, and has been successfully used as an experimental model to study sensory processing and decision making— see e.g. [8, 37, 40].”
MethodA parcellation scheme of mouse isocortex based on reversals in connectivity gradientsPreprint
Reimann, M. W., & Guyonnet-Hencke, T. (2023) · bioRxiv · doi:10.1101/2022.08.30.505842 · Cited by 2
“…this was mostly visible in the efferents of SSs. Finally, the split of motor regions into subregions is arguably consistent with functional data: Guo et al. (2014) described a role of specifically the anterolateral motor areas (ALM) in an object location discrimination task that is not shared…”
BackgroundResultPanniello, M., Gillon, C. J., Maffulli, R., Celotto, M., Panzeri, S., Richards, B., & Kohl, M. (2022) · bioRxiv · doi:10.1101/2022.12.04.518156 · Cited by 2
Zareian, B., Lam, A., & Zagha, E. (2022) · bioRxiv · doi:10.1101/2022.03.03.482906 · Cited by 2
“Prior representational and causal studies implicate the involvement of both MC and DLS in whisker detection/discrimination tasks (Aruljothi et al., 2020; Guo et al., 2014; Hong et al., 2018; Lee et al., 2019; Li et al., 2015; Li et al., 2016; Sippy et al., 2015; Zagha et al., 2015; Zareian et al., 2021).”
BackgroundInvestigation of Neural Substrates of Erroneous Behavior in a Delayed-Response Task
Chae, S., Sohn, J.-W., & Kim, S.-P. (2022) · eNeuro · doi:10.1523/eneuro.0490-21.2022 · Cited by 2
“A spike was extracted from the filtered trace by visual inspection with a spike width calculated as a trough-to-peak interval in the average spike waveform (Guo et al., 2014).”
BackgroundMethodFunctional maps of the primate cortex revealed by through-skull wide-field optical imaging
Song, X.-Y., Guo, Y.-Q., Li, H., Chen, C., Schmidt, Z. W., & Wang, X.-Q. (2020) · bioRxiv · doi:10.1101/2020.12.05.413047 · Cited by 2
Inhibitory midbrain neurons mediate decision making
Essig, J., Hunt, J. B., & Felsen, G. (2020) · bioRxiv · doi:10.1101/2020.02.25.965699 · Cited by 2
Kalemaki, K., Velli, A., Christodoulou, O., Denaxa, M., Karagogeos, D., & Sidiropoulou, K. (2020) · bioRxiv · doi:10.1101/2020.01.21.913913 · Cited by 2
The Essential Role of Feedback Processing for Figure-Ground Perception in MicePreprint
Kirchberger, L., Mukherjee, S., Schnabel, U. H., van Beest, E. H., Barsegyan, A., Levelt, C. N., Alexander, H. J., Lorteije, J. A. M., van der Togt, C., Self, M. W., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3441074 · Cited by 3
Medial prefrontal cortex guides goal-directed decision-making about hunger and thirstPreprint
Eiselt, A.-K., Chen, J. H., Arnold, J., Kim, T., & Sternson, S. M. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/620690 · Cited by 2
Gu, X., & Li, C. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/568055 · Cited by 2
“A hallmark of WM-related activity is the ability of coding the maintained information during the delay period (19, 24, 26, 27, 30, 34, 43-46).”
BackgroundMorrissette, A. E., Chen, P.-H., Bhamani, C., Borden, P. Y., Waiblinger, C., Stanley, G. B., & Jaeger, D. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/360818 · Cited by 1
Ready, Steady, Go! Imaging Cortical Activity during Movement Planning and Execution
Banerjee, A., & Long, M. A. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.002 · Cited by 2
“ALM had previously been shown to be a critical node for enabling the transfer of information from sensory to motor regions within the brain (Guo et al., 2014).”
BackgroundLearning to memorize: Shedding new light on prefrontal functions
Xu, N.-L. (2015) · Neuroscience Bulletin · doi:10.1007/s12264-014-1509-1 · Cited by 1
From Perception to Action: A Spatiotemporal Cortical Map
Crochet, S., & Petersen, C. C. H. (2014) · Neuron · doi:10.1016/j.neuron.2013.12.020 · Cited by 3
“1Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland 2INSERM U1028; CNRS UMR5292; Lyon Neuroscience Research Center, Integrative Physiology of Brain Arousal System Team, Lyon F-69000, France *Correspondence:…”
BackgroundInfluentialMitelut, C. (2017) · doi:10.14288/1.0357482 · Cited by 2
“Barrel cortex neurons have STMs that substantially or completely overlapped with regional GCaMP signal changes in barrel and motor cortex, as well as showing signals in homotopic areas of both hemispheres, consistent with the previously observed pattern of long distance mono-synaptic connections (Ferezou et al., 2007;…”
BackgroundMethodFlow of Information Underlying a Tactile Decision in Mice
Li, N., Guo, Z. V., Chen, T., & Svoboda, K. (2016) · Research and perspectives in neurosciences · doi:10.1007/978-3-319-28802-4_3 · Cited by 2
“Figure adapted from Guo et al. (2014a)”
BackgroundMethodInfluentialSelf-citationGeneration of BAC Transgenic Mice for Functional Analysis of Neural Circuits
Ting, J. T., & Feng, G. (2014) · Neuromethods · doi:10.1007/978-1-4939-1963-5_9 · Cited by 1
Self-citationFunctional Principles of Whisker-Mediated Touch Perception
Maravall, M., & Diamond, M. E. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2975-7_8 · Cited by 2
Neural correlates of perceptual decision-making in the primary somatosensory cortex
Armstrong, A. G., & Vlasov, Y. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2514107123 · Cited by 1
“Hence, peak 4 is likely to reflect participation of the primary somatosensory cortex in motor preparatory activity, often observed in higher motor cortices (12–14).”
Reciprocal connections dynamically build consensus between neocortical areas
Javadzadeh, M., Schimel, M., Hofer, S. B., Ahmadian, Y., & Hennequin, G. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02437-3 · Cited by 6
“Silencing was achieved by photo-activation of PV + inhibitory interneurons expressing ChR2, following established approaches 42,43 .”
Open source laser-scanning photostimulation for neuroscience with Zapit
Lohse, M., Gauld, O. M., Quigley, M. T., Masood, A., Bao, C.-F., Li, J.-J., Miska, N. J., Nabbefeld, G., Pajot-Moric, Q., Townsend, S., et al. (2026) · bioRxiv · doi:10.1101/2024.02.12.579892 · Cited by 1
“Nevertheless, post hoc histology is strongly recommended to assess tissue integrity and confirm opsin expression.”
InfluentialDistinct Orbitofrontal Feedback Signals Shape Sensory Behavioral Strategies during Flexible LearningPreprint
Teutsch, J., Rao, R., Humphries, M. D., Maggi, S., & Banerjee, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.15.737076
“The S1 is classically considered to predominantly encode features of tactile stimuli 48-50 .”
Majumder, S., Hirokawa, K., Yang, Z., Jain, A., Paletzki, R. F., Gerfen, C. R., Fontolan, L., Romani, S., Yasuda, R., & Inagaki, H. (2026) · Nature Communications · doi:10.1038/s41467-026-74869-1 · Cited by 5
Shen, J., Rungratsameetaweemana, N., Sharma, P., Peterka, D. S., Wu, Z., & Shadlen, M. N. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117456 · Cited by 2
“7,9,14,15 These results support the hypothesis that intact ALM activity during the context and delay periods is necessary to configure the circuit appropriately so that the test odor elicits the correct response.”
A hybrid micro-ECoG for functionally targeted multi-site and multi-scale investigation
Jendritza, P., Liljemalm, R., Stieglitz, T., Fries, P., & Lewis, C. M. (2026) · Cell Reports Methods · doi:10.1016/j.crmeth.2026.101481 · Cited by 1
“…89,90,93–97 31,98–101 The combination of electrical recording with optical methods, such as imaging, 16,94,102 or optical perturbations 27,96,103,104 can permit fined-grained investigations that further reveal the cellular processes underlying coordinated dynamics and inter-areal interactions.”
Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making
Ghaderi, P., Crochet, S., & Petersen, C. C. H. (2026) · Nature Communications · doi:10.1038/s41467-026-73622-y · Cited by 1
“…of activity in different corticalregions to distinct task epochs, we applied blue light to transgenic mice expressing channelrhodopsin-2 (ChR2) in inhibitory neurons (VGAT-ChR2 mice 36 ) allowing local suppression of activity in excitatory neo-cortical neurons with temporal speci fi city 25,37 .”
Inherent coupling of perceptual judgments to actions in the mouse cortex
Sokoletsky, M., Nikitina, A. A., Waychal, K., Katz, Y., & Lampl, I. (2026) · bioRxiv · doi:10.1101/2025.10.30.685660 · Cited by 1
The midbrain reticular formation in contextual control of perceptual decisions
Shaker, J. R., Schroeter, J., Birman, D., & Steinmetz, N. A. (2026) · Neuron · doi:10.1016/j.neuron.2026.04.003 · Cited by 1
Aligned recordings of neural spiking activity and licking behavior in thirsty mice
Xu, Z.-H., Hong, B., Li, L., Xie, T., Chen, Z., Yao, H.-S., & Zhang, T.-L. (2026) · bioRxiv · doi:10.64898/2026.04.21.720009 · Cited by 1
“Nine mice were divided into three experimental groups targeted anterior lateral motor cortex(ALM) [12] inhibition: VGAT-ChR2 [13] mice ( n = 3), VGAT-Cre mice with AAV-FLEX-ChrimsonR ( n = 3), and C57BL/6 mice [14] with AAV-CaMKII α -GtACR2 ( n = 3).”
Peretz‐Rivlin, N., Marsh‐Yvgi, I., Fatal, Y., Levin, S., Atlan, G., & Citri, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.05.697827 · Cited by 1
“As these tasks grow more sophisticated, incorporating delayed responses, dynamic contingencies, or sensory uncertainty, the demands placed on behavioral training rise accordingly (Aguillon-Rodriguez et al., 2021; Guo et al., 2014).”
Cortex-wide circuits for multisensory evidence accumulation and choice formationPreprint
Nabbefeld, G., Rachid, S. A., Lenzi, I., Cravo, E., Musall, S., & Kampa, B. M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.23.696238 · Cited by 2
“In line with earlier work, we found roughly equal proportions of ipsi-and contralateral choice selective cells 73,75,76 .”
Task-similarity dependent reconfiguration of compositional modules and geometry in frontal cortexPreprint
Chen, X., Yao, X., Yin, X., & Guo, Z. V. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.06.687080 · Cited by 1
Self-citationMapping neural subspace dynamics onto the structure of the mouse descending motor systemPreprint
Hasnain, M. A., Han, Y., & Economo, M. N. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.17.682917 · Cited by 3
Neural Correlates of Perceptual Decision Making in Primary Somatosensory Cortex
Armstrong, A. G., & Vlasov, Y. D. (2025) · bioRxiv · doi:10.1101/2025.03.29.646003 · Cited by 1
“Therefore, this global regulation is unlikely to originate directly from frontal cortical pre-motor areas 24-26 since frontal cortices have a very high degree of symmetry for both ipsilateral and contralateral projections 57 .”
Neural responses prior to licking onset in the striatal matrix compartment in mice
Ishimaru, Y., Yoshizawa, T., Kimoto, T., Inui, T., Yawaka, Y., & Funahashi, M. (2025) · bioRxiv · doi:10.1101/2025.05.23.655747 · Cited by 1
Perception and neural representation of intermittent odor stimuli in mice
Boero, L. E., Wu, H., Zak, J. D., Masset, P., Pashakhanloo, F., Jayakumar, S., Tolooshams, B., Ba, D. E., & Murthy, V. N. (2026) · Nature Communications · doi:10.1038/s41467-026-72445-1 · Cited by 5
Inter- and Intrahemispheric Sources of Vestibular Signals to V1
Bouvier, G., Sanzeni, A., Hamada, E. C., Brunel, N., & Scanziani, M. (2024) · bioRxiv · doi:10.1101/2024.11.18.624137 · Cited by 1
“Cortical silencing was achieved by expressing channelrhodopsin-2 (ChR2) in inhibitory neurons, a technique previously validated 19–21 , 37 .”
Time-Varying ℓ 0 Optimization for Spike Inference from Multi-Trial Calcium Recordings
Shen, T., Du, M., Johnston, K., Grieco, S. F., Crary, R., Guzowski, J. F., Lür, G., Xu, X., Ombao, H., Guindani, M., et al. (2024) · Data Science in Science · doi:10.1080/26941899.2024.2407770
Divergent subregional information processing in mouse prefrontal cortex during working memory
Sonneborn, A., Bartlett, L., Olson, R. J., Milton, R., & Abbas, A. I. (2024) · Communications Biology · doi:10.1038/s42003-024-06926-8 · Cited by 3
“Moreover, mostmulti-regionalWMdatahavebeencollectedfromhead-fi xedmice 30 – 33 .”
Jodar, T. O., Prat-Ortega, G., Li, C., Dalmau, J. O., Compte, A., & de la Rocha, J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.18.579447
“First, ALM coordinates +2.5AV ± 1.5M (Guo et al. 2014) were marked and a really thin layer of transparent cement applied on top of it.”
MethodInfluentialMagnetic voluntary head-fixation in transgenic rats enables lifetime imaging of hippocampal neurons
Rich, P. D., Thiberge, S., Scott, B. B., Guo, C., Tervo, D. G., Brody, C., Karpova, A., Daw, N., & Tank, D. W. (2023) · bioRxiv · doi:10.1101/2023.08.17.553594 · Cited by 1
Cell-type-specific plasticity shapes neocortical dynamics for motor learningPreprint
Majumder, S., Hirokawa, K., Yang, Z., Paletzki, R. F., Gerfen, C. R., Fontolan, L., Romani, S., Jain, A., Yasuda, R., & Inagaki, H. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.09.552699 · Cited by 4
“Next, we examined whether synaptic plasticity in the anterior-lateral motor cortex (ALM; AP 2.5mm ML 1.5 mm from Bregma), a premotor cortical area responsible for orofacial movement 5,57 , is required for this learning.”
InfluentialThe Secondary Somatosensory Cortex Gates Mechanical and Thermal Sensitivity
Taub, D., Jiang, Q., Pietrafesa, F., Su, J.-F., Greene, C. A., Blanchard, M., Jain, A., El-Rifai, M., Callen, A., Yager, K., et al. (2023) · Research Square · doi:10.21203/rs.3.rs-2976953/v1 · Cited by 1
The Secondary Somatosensory Cortex Gates Mechanical and Thermal SensitivityPreprint
Taub, D. G., Jiang, Q., Pietrafesa, F., Su, J., Greene, C. A., Blanchard, M. R., Jain, A., El-Rifai, M., Callen, A., Yager, K., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.19.541449
Mouse frontal cortex nonlinearly encodes sensory, choice and outcome signals
Wool, L. E., Lak, A., Carandini, M., & Harris, K. (2023) · bioRxiv · doi:10.1101/2023.05.11.539851 · Cited by 1
“Inactivation of MOs affects performance in multiple tasks, involving multiple sensory modalities and behavioral outputs (Erlich et al., 2011, 2015; Sul et al., 2011; Guo et al., 2014; Hanks et al., 2015; Goard et al., 2016; Coen et al., 2021; Kondo and Matsuzaki, 2021; Zatka-Haas et al., 2021; Atilgan et al., 2022).”
BackgroundUnraveling the therapeutic mechanism of deep-brain stimulationPreprint
van den Boom, B. J. G., Fernandez, A. E., Rasmussen, P. A., van Beest, E. H., Parthasarathy, A., Denys, D. A. J. P., & Willuhn, I. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.12.23.521799 · Cited by 1
“5 However, mOFC and DS predominantly recruited neurons by exciting their activity, 135 independent of genotype (Factor direction, mOFC: F(3,32)=14.”
BackgroundThe Future of Neurotoxicology: A Neuroelectrophysiological Viewpoint
Herr, D. W. (2021) · Frontiers in Toxicology · doi:10.3389/ftox.2021.729788 · Cited by 2
“Optogenetic inhibition has been used to study the flow of neural network information from sensory to motor areas of the cortex in mice (Guo et al., 2014).”
Cognitive experience alters cortical involvement in navigation decisions
Arlt, C., Barroso-Luque, R., Kira, S., Bruno, C. A., Xia, N., Chettih, S. N., Soares, S., Pettit, N. L., & Harvey, C. D. (2021) · bioRxiv · doi:10.1101/2021.12.10.472106 · Cited by 1
“Across studies, the necessity of cortical areas has been tested during a variety of 24 decision-making tasks that involve different sensory, behavioral, and cognitive features (Ceballo et al., 25 2019; Erlich et al., 2011; Fischer et al., 2020; Goard et al., 2016; Guo et al., 2014; Harvey et al., 2012; 26 Inagaki et a…”
BackgroundMethodInfluentialNeurometric correlates to sensitive high-frequency sound amplitude modulation detection by mice
van den Berg, M., Busscher, E., Borst, J. G., & Wong, A. (2021) · doi:10.1101/2021.11.02.466979 · Cited by 1
“…the gap between 61 neurometric and psychometric factors is filled by non-sensory factors (Kettner and Thompson 1985; de 62 Lafuente and Romo 2006; Guo et al. 2014; Goris et al. 2017; Stringer et al. 2021), but we argue here that 63 sensory performance in some behavioral tasks may also be easily…”
BackgroundResta, F., Montagni, E., Devito, G., Scaglione, A., Mascaro, A., & Pavone, F. (2021) · bioRxiv · doi:10.1101/2021.07.15.452461 · Cited by 1
Fast-spiking interneurons of the premotor cortex contribute to action planning
Giordano, N., Alia, C., Fruzzetti, L., Pasquini, M., Mazzoni, A., Micera, S., Fogassi, L., Bonini, L., & Caleo, M. (2021) · bioRxiv · doi:10.1101/2021.05.14.443822 · Cited by 1
“Here we recorded premotor neuronal activity from the anterior-lateral motor cortex (ALM, Chen et al., 2017; Guo et al., 2014b; Komiyama et al., 2010), which partially overlaps with the rostral forelimb area (RFA, Tennant et al., 2011; Vallone et al., 2016) in head-restrained mice allowed to either…”
BackgroundMethodFrom an invariant sensory code to a perceptual categorical code in second somatosensory cortexPreprint
Rossi-Pool, R., Zainos, A., Álvarez, M., & Romo, R. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.31.018879 · Cited by 1
Similar visual perception in GCaMP6 transgenic mice despite differences in learning and motivationPreprint
Groblewski, P. A., Ollerenshaw, D. R., Kiggins, J. T., Garrett, M., Mochizuki, C., Casal, L., Cross, S., Mace, K. D., Swapp, J., Manavi, S., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.18.954990 · Cited by 1
“…of perception and action across multiple sensory modalities and cognitive systems (Chen et al., 2013; Glickfeld et al., 2013; Goard et al., 2016; Z. Guo et al., 2014; Harvey et al., 2012; Huber et al., 2012; Li et al., 2016; O’Connor et al., 2013; Peron et al., 2015; Petreanu et al., 2012; Pinto…”
BackgroundIndependent representations of reward-predicting cues and reward history in frontal cortical neurons
Kondo, M., & Matsuzaki, M. (2020) · bioRxiv · doi:10.1101/2020.01.23.916460 · Cited by 1
Convergence of unisensory-evoked signals via multiple pathways to the cerebellum
Shimuta, M., Sugihara, I., & Ishikawa, T. (2019) · bioRxiv · doi:10.1101/769000 · Cited by 1
“ChR2 can suppress the activity of specific areas of the neocortex (Guo et al., 2014; Li et al., 2015, 327 2016).”
BackgroundMethodMao, H., Yuan, Y., & Si, J. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00950.2016 · Cited by 2
“…on distributed neural circuits that are involved in a multitude of cognitive processes including perceptual and attentional processing of sensory input as well as goal setting and behavioral adaptation (Dayan et al. 2000; Gottlieb 2012; Gottlieb et al. 2014; Grossberg 1999; Guo et al. 2014).”
BackgroundDual brain cortical calcium imaging reveals social interaction-specific correlated activity in micePreprint
Michelson, N. J., Bolaños, F., Bolaños, L. A., Balbi, M., LeDue, J. M., & Murphy, T. H. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.20383/101.0303 · Cited by 4
“V Guo et al., 2014) and rodents can even be trained to restrain 422 themselves (Aoki, Tsubota, Goya, & Benucci, 2017; Murphy et al., 2020; Scott, Brody, & Tank, 423 2013).”
BackgroundDifferent inhibitory interneuron cell classes make distinct contributions to visual perceptionPreprint
Cone, J. J., Scantlen, M. D., Histed, M., & Maunsell, J. H. R. (2018) · bioRxiv · doi:10.1101/275172 · Cited by 1
“Our behavioral results are supported by prior work examining the role of PV neurons in visual and somatosensory cortex (Glickfeld et al., 2013; Guo et al., 2014).”
BackgroundResultCell type-specific variation of somatotopic precision across corticostriatal projectionsPreprint
Hooks, B. M., Papale, A. E., Paletzki, R. F., Feroze, M. W., Eastwood, B. S., Couey, J. J., Winnubst, J., Chandrashekar, J. V., & Gerfen, C. R. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/261446 · Cited by 1
Medial frontal theta is entrained to rewarded actionsPreprint
Amarante, L. M., Caetano, M. S., & Laubach, M. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/144550 · Cited by 2
Aberration in 3-Photon Transcranial Calcium Imaging of Cortical Activity
Takasaki, K., Valley, M. T., Liu, R., & Waters, J. (2017) · Optics in the Life Sciences · doi:10.1364/boda.2017.jtu4a.14 · Cited by 1
Armstrong, A. G., & Vlasov, Y. (2026) · The Journal of Neuroscience · doi:10.1523/jneurosci.0930-25.2026 · Cited by 1
The Nigro-Thalamic Projection contributes to the Control of Action Initiation TimingPreprint
Catanese, J., & Jaeger, D. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.01.12.903500 · Cited by 4
Santra, K., Logiacco, F., Frechou, A., Barber, K., Bellafard, A., Liou, J., & Vaziri, A. (2026) · bioRxiv · doi:10.64898/2026.10.16.759624
Wu, C., Liu, X., Yan, M., Zhang, C., & Yang, Z. (2026) · Precision medicine and engineering. · doi:10.1016/j.preme.2026.100094
Scheib, J., Newman, Z. L., Gable, J., Farinella, D. M., Head, M., Bliese, S., Dougen, B., Jayakumar, H., Young, S., Miller, N., et al. (2026) · eLife · doi:10.7554/elife.111876 · Cited by 2
“Mice were trained to perform an auditory-cued directional licking task ( Figure 1A ; Guo et al., 2014b ; Inagaki et al., 2018 ) with two target lickports approximately equidistant from the mouth ( Figure 1A and B ).”
A reactivated thalamocortical plasticity window promotes learning and is reshaped by experiencePreprint
Jie, H., Pothayee, N., Deng, Z., Sharer, K., & Koretsky, A. P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.27.747577
Kim, D. W. (2026) · Journal of Space Safety Engineering · doi:10.1016/j.jsse.2026.08.005
Michaud, N. M., ten Haaf, M. R., & Crowder, N. A. (2026) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2026.110897
Projection-defined modules reveal mouse motor cortex architecture
Falasconi, A., Kanodia, H., Lusk, N. A., Yao, S., Costa, R. M., Zeng, H., & Arber, S. (2026) · Cell · doi:10.1016/j.cell.2026.08.046
A stimulus–state geometry in somatosensory cortex reorganizes during inflammatory painPreprint
Schorscher-Petcu, A., Parkes, I., & Browne, L. E. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.11.744145
“…to provide a 1 s pulse of light, time-locked to stimulus onset via the same TTL that initiated the sensory stimulus, modulated as a 40 Hz sinusoid with a peak intensity of 1.5 mW at the fiber tip and linearly attenuated in the final 100 ms to avoid post-stimulus rebound firing (Guo et al., 2014).”
InfluentialOsako, Y., Heller, G. R., Ährlund‐Richter, S., Buschman, T. J., & Sur, M. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02410-0 · Cited by 6
Continuous contributions of the dorsolateral striatum to movement initiation and execution
Cao, J., Zhao, Y., & Yu, J. (2026) · Science Advances · doi:10.1126/sciadv.adt2097
“Our optogenetic approach, which drives inhibitory interneurons to suppress the firing rates of projection neurons ( 49 , 88 ), does not isolate cell type– or pathway-specific effects, as both the direct (striatonigral) and indirect (striatopallidal) pathways are suppressed.”
Closed-loop sensory feedback enables fast and reliable instrumental acquisition in head-fixed micePreprint
Ranganath, A., Hähnke, D., & Jacob, S. N. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.26.740810
“1A ) allows for spatially and temporally precise stimulus delivery and has enabled the use of mice in studies of sensory discrimination behaviors involving visual 13,14 , auditory 15,16 , tactile 17 and odorant 18-20 stimuli.”
Chang, Y.-T., Dasgupta, R., Dong, M., Colonell, J., Karsh, B., Cheng, A. H. R., Hermans, R., Mahmudul, H., Lopez, C. M., Putzeys, J., et al. (2026) · bioRxiv · doi:10.64898/2026.07.23.740388
“30 To accommodate various brain targets, the headpost was positioned posteriorly over the cerebellum in four mice and more anteriorly over Bregma in two mice.”
Lang, L., Zheng, C. Y., Blackwell, J. M., Camera, G. L., & Fontanini, A. (2025) · eLife · doi:10.7554/elife.109313
“The task design is based on a 2AC paradigm ( Guo et al., 2014a ; Churchland and Ditterich, 2012 ; Kogan and Fontanini, 2024 ).”
Wang, Y., Kuo, H.-C., Kuang, X., Yao, S., Lesnar, P., Ng, L., Li, Y., El-Hifnawi, L., Chen, N., Zhang, K., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2026.117469
Metadata
- Authors
- Guo, Z. V., Li, N., Huber, D., Ophir, E., Gutnisky, D., Ting, J. T., Feng, G., & Svoboda, K.
- Affiliations
- Howard Hughes Medical Institute (US)
- McGovern Institute for Brain Research (US)
- Corresponding author
- Svoboda, Karel
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 81
- Issue
- 1
- Pages
- 179-194
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3984938
- OpenAlex
- W2040707073
- Cited by
- 715
- References
- 0
- Citations by year
- 2026: 65 · 2025: 56 · 2024: 74 · 2023: 84 · 2022: 60 · 2021: 64 · 2020: 69 · 2019: 62 · 2018: 57 · 2017: 47 · 2016: 32 · 2015: 27 · 2014: 18
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- perceptual decision making, barrel cortex, anterior lateral motor cortex, short-term memory, optogenetic inhibition, sensorimotor integration, mice
- MeSH terms
- Channelrhodopsins, Action Potentials, Afferent Pathways, Animals, Cerebral Cortex, Conditioning, Operant, Decision Making, Discrimination, Psychological, Female, Male, Mice, Transgenic, Motion Perception, Nerve Net, Neurons, Photic Stimulation, Touch, Vibrissae, Green Fluorescent Proteins, Vesicular Inhibitory Amino Acid Transport Proteins, Mice
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