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Flow of Cortical Activity Underlying a Tactile Decision in Mice
Open accessAbstract
Perceptual decisions involve distributed cortical activity. Does information flow sequentially from one cortical area to another, or do networks of interconnected areas contribute at the same time? Here we delineate when and how activity in specific areas drives a whisker-based decision in mice. A short-term memory component temporally separated tactile "sensation" and "action" (licking). Using optogenetic inhibition (spatial resolution, 2 mm; temporal resolution, 100 ms), we surveyed the neocortex for regions driving behavior during specific behavioral epochs. Barrel cortex was critical for sensation. During the short-term memory, unilateral inhibition of anterior lateral motor cortex biased responses to the ipsilateral side. Consistently, barrel cortex showed stimulus-specific activity during sensation, whereas motor cortex showed choice-specific preparatory activity and movement-related activity, consistent with roles in motor planning and movement. These results suggest serial information flow from sensory to motor areas during perceptual decision making.
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“Hence, peak 4 is likely to reflect participation of the primary somatosensory cortex in motor preparatory activity, often observed in higher motor cortices (12–14).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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“Serial transformation of sensory inputs along bottom–up hierarchical pathways has been observed in rodents engaged in whisker-discrimination tasks (8, 9) with an increasingly stronger association with perceptual choice in S2 (10, 11) and premotor areas (12–14) rather than whisker-related wS1 (9).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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“Therefore, this global regulation is unlikely to originate directly from frontal cortical premotor areas (12–14) since frontal cortices have a high degree of symmetry for both ipsilateral and contralateral projections (59).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [12]
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Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
Benjamini, Y., & Hochberg, Y. (1995) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/j.2517-6161.1995.tb02031.x · Cited by 109,482
Distributed hierarchical processing in the primate cerebral cortex
Felleman, D. J., & Van Essen, D. C. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.1.1 · Cited by 7,783
The subcellular organization of neocortical excitatory connections
Petreanu, L., Mao, T., Sternson, S. M., & Svoboda, K. (2009) · Nature · doi:10.1038/nature07709 · Cited by 1,047
Self-citationNeuronal correlates of parametric working memory in the prefrontal cortex
Romo, R., Brody, C. D., Hernández, A., & Lemus, L. (1999) · Nature · doi:10.1038/20939 · Cited by 822
Multiple dynamic representations in the motor cortex during sensorimotor learning
Huber, D., Gutnisky, D. A., Peron, S., O’Connor, D. H., Wiegert, J. S., Tian, L., Oertner, T. G., Looger, L. L., & Svoboda, K. (2012) · Nature · doi:10.1038/nature11039 · Cited by 540
Self-citationInfluence of the thalamus on spatial visual processing in frontal cortex
Sommer, M. A., & Wurtz, R. H. (2006) · Nature · doi:10.1038/nature05279 · Cited by 520
Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice
Komiyama, T., Sato, T. R., O’Connor, D. H., Zhang, Y.-X., Huber, D., Hooks, B. M., Gabitto, M., & Svoboda, K. (2010) · Nature · doi:10.1038/nature08897 · Cited by 447
Self-citationMicrostimulation of inferotemporal cortex influences face categorization
Afraz, S.-R., Kiani, R., & Esteky, H. (2006) · Nature · doi:10.1038/nature04982 · Cited by 363
Separate Signals for Target Selection and Movement Specification in the Superior Colliculus
Horwitz, G. D., & Newsome, W. T. (1999) · Science · doi:10.1126/science.284.5417.1158 · Cited by 346
Temporal gating of neural signals during performance of a visual discrimination task
Seidemann, E., Zohary, E., & Newsome, W. T. (1998) · Nature · doi:10.1038/27906 · Cited by 103
Flagged first, then by citations
Research works printed but not linked: 54
- Aravanis, 2007, An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology, J. Neural Eng., 4, S143, 10.1088/1741-2560/4/3/S02 · DOI
- Armstrong-James, 1992, Flow of excitation within rat barrel cortex on striking a single vibrissa, J. Neurophysiol., 68, 1345, 10.1152/jn.1992.68.4.1345 · DOI
- Bisley, 2001, Microstimulation of cortical area MT affects performance on a visual working memory task, J. Neurophysiol., 85, 187, 10.1152/jn.2001.85.1.187 · DOI · Paper page
- Brecht, 2011, Movement, confusion, and orienting in frontal cortices, Neuron, 72, 193, 10.1016/j.neuron.2011.10.002 · DOI
- Brecht, 2002, Dynamic representation of whisker deflection by synaptic potentials in spiny stellate and pyramidal cells in the barrels and septa of layer 4 rat somatosensory cortex, J. Physiol., 543, 49, 10.1113/jphysiol.2002.018465 · DOI
- Clack, 2012, Automated tracking of whiskers in videos of head fixed rodents, PLoS Comput. Biol., 8, e1002591, 10.1371/journal.pcbi.1002591 · DOI
- Curtis, 2009, Phase-to-rate transformations encode touch in cortical neurons of a scanning sensorimotor system, Nat. Neurosci., 12, 492, 10.1038/nn.2283 · DOI
- de Lafuente, 2005, Neuronal correlates of subjective sensory experience, Nat. Neurosci., 8, 1698, 10.1038/nn1587 · DOI
- Ding, 2010, Caudate encodes multiple computations for perceptual decisions, J. Neurosci., 30, 15747, 10.1523/JNEUROSCI.2894-10.2010 · DOI
- Erlich, 2011, A cortical substrate for memory-guided orienting in the rat, Neuron, 72, 330, 10.1016/j.neuron.2011.07.010 · DOI · Paper page
- Ferezou, 2007, Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice, Neuron, 56, 907, 10.1016/j.neuron.2007.10.007 · DOI
- Fuster, 1971, Neuron activity related to short-term memory, Science, 173, 652, 10.1126/science.173.3997.652 · DOI · Paper page
- Gold, 2002, Banburismus and the brain: decoding the relationship between sensory stimuli, decisions, and reward, Neuron, 36, 299, 10.1016/S0896-6273(02)00971-6 · DOI
- Goldman-Rakic, 1995, Cellular basis of working memory, Neuron, 14, 477, 10.1016/0896-6273(95)90304-6 · DOI · Paper page
- Harvey, 2012, Choice-specific sequences in parietal cortex during a virtual-navigation decision task, Nature, 484, 62, 10.1038/nature10918 · DOI
- Helmstaedter, 2009, L2/3 interneuron groups defined by multiparameter analysis of axonal projection, dendritic geometry, and electrical excitability, Cereb. Cortex, 19, 951, 10.1093/cercor/bhn130 · DOI
- Hernández, 2010, Decoding a perceptual decision process across cortex, Neuron, 66, 300, 10.1016/j.neuron.2010.03.031 · DOI
- Hikosaka, 1985, Modification of saccadic eye movements by GABA-related substances. I. Effect of muscimol and bicuculline in monkey superior colliculus, J. Neurophysiol., 53, 266, 10.1152/jn.1985.53.1.266 · DOI
- Hippenmeyer, 2005, A developmental switch in the response of DRG neurons to ETS transcription factor signaling, PLoS Biol., 3, e159, 10.1371/journal.pbio.0030159 · DOI
- Hoffer, 2005, Functional circuits mediating sensorimotor integration: quantitative comparisons of projections from rodent barrel cortex to primary motor cortex, neostriatum, superior colliculus, and the pons, J. Comp. Neurol., 488, 82, 10.1002/cne.20579 · DOI
- Hooks, 2013, Organization of cortical and thalamic input to pyramidal neurons in mouse motor cortex, J. Neurosci., 33, 748, 10.1523/JNEUROSCI.4338-12.2013 · DOI
- Hutson, 1986, The sensory contribution of a single vibrissa’s cortical barrel, J. Neurophysiol., 56, 1196, 10.1152/jn.1986.56.4.1196 · DOI
- Kawaguchi, 1993, Groupings of nonpyramidal and pyramidal cells with specific physiological and morphological characteristics in rat frontal cortex, J. Neurophysiol., 69, 416, 10.1152/jn.1993.69.2.416 · DOI
- Kleinfeld, 2011, Neuronal basis for object location in the vibrissa scanning sensorimotor system, Neuron, 72, 455, 10.1016/j.neuron.2011.10.009 · DOI · Paper page
- Knutsen, 2006, Haptic object localization in the vibrissal system: behavior and performance, J. Neurosci., 26, 8451, 10.1523/JNEUROSCI.1516-06.2006 · DOI
- Koralek, 1988, Evidence for two complementary patterns of thalamic input to the rat somatosensory cortex, Brain Res., 463, 346, 10.1016/0006-8993(88)90408-8 · DOI
- Lin, 2013, ReaChR: a red-shifted variant of channelrhodopsin enables deep transcranial optogenetic excitation, Nat. Neurosci., 16, 1499, 10.1038/nn.3502 · DOI
- Long, 2008, Using temperature to analyse temporal dynamics in the songbird motor pathway, Nature, 456, 189, 10.1038/nature07448 · DOI
- Lu, 1993, Thalamic afferents of the rat barrel cortex: a light- and electron-microscopic study using Phaseolus vulgaris leucoagglutinin as an anterograde tracer, Somatosens. Mot. Res., 10, 1, 10.3109/08990229309028819 · DOI
- Luo, 2008, Genetic dissection of neural circuits, Neuron, 57, 634, 10.1016/j.neuron.2008.01.002 · DOI
- Mao, 2011, Long-range neuronal circuits underlying the interaction between sensory and motor cortex, Neuron, 72, 111, 10.1016/j.neuron.2011.07.029 · DOI
- Masino, 1993, Characterization of functional organization within rat barrel cortex using intrinsic signal optical imaging through a thinned skull, Proc. Natl. Acad. Sci. USA, 90, 9998, 10.1073/pnas.90.21.9998 · DOI
- Matyas, 2010, Motor control by sensory cortex, Science, 330, 1240, 10.1126/science.1195797 · DOI
- McCormick, 1985, Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex, J. Neurophysiol., 54, 782, 10.1152/jn.1985.54.4.782 · DOI
- Mountcastle, 1990, Frequency discrimination in the sense of flutter: psychophysical measurements correlated with postcentral events in behaving monkeys, J. Neurosci., 10, 3032, 10.1523/JNEUROSCI.10-09-03032.1990 · DOI
- O’Connor, 2009, Reverse engineering the mouse brain, Nature, 461, 923, 10.1038/nature08539 · DOI
- O’Connor, 2010, Vibrissa-based object localization in head-fixed mice, J. Neurosci., 30, 1947, 10.1523/JNEUROSCI.3762-09.2010 · DOI
- O’Connor, 2010, Neural activity in barrel cortex underlying vibrissa-based object localization in mice, Neuron, 67, 1048, 10.1016/j.neuron.2010.08.026 · DOI
- O’Connor, 2013, Neural coding during active somatosensation revealed using illusory touch, Nat. Neurosci., 16, 958, 10.1038/nn.3419 · DOI · Paper page
- Packer, 2012, Two-photon optogenetics of dendritic spines and neural circuits, Nat. Methods, 9, 1202, 10.1038/nmeth.2249 · DOI
- Pammer, 2013, The mechanical variables underlying object localization along the axis of the whisker, J. Neurosci., 33, 6726, 10.1523/JNEUROSCI.4316-12.2013 · DOI
- Ponce, 2008, Integrating motion and depth via parallel pathways, Nat. Neurosci., 11, 216, 10.1038/nn2039 · DOI
- Ritt, 2008, Embodied information processing: vibrissa mechanics and texture features shape micromotions in actively sensing rats, Neuron, 57, 599, 10.1016/j.neuron.2007.12.024 · DOI
- Romo, 2013, Conversion of sensory signals into perceptual decisions, Prog. Neurobiol., 103, 41, 10.1016/j.pneurobio.2012.03.007 · DOI
- Sanders, 2012, Choice ball: a response interface for two-choice psychometric discrimination in head-fixed mice, J. Neurophysiol., 108, 3416, 10.1152/jn.00669.2012 · DOI
- Schwarz, 2010, The head-fixed behaving rat—procedures and pitfalls, Somatosens. Mot. Res., 27, 131, 10.3109/08990220.2010.513111 · DOI
- Simons, 1978, Response properties of vibrissa units in rat SI somatosensory neocortex, J. Neurophysiol., 41, 798, 10.1152/jn.1978.41.3.798 · DOI
- Tanji, 1976, Anticipatory activity of motor cortex neurons in relation to direction of an intended movement, J. Neurophysiol., 39, 1062, 10.1152/jn.1976.39.5.1062 · DOI
- Travers, 1997, Motor and premotor mechanisms of licking, Neurosci. Biobehav. Rev., 21, 631, 10.1016/S0149-7634(96)00045-0 · DOI
- Voigts, 2008, Unsupervised whisker tracking in unrestrained behaving animals, J. Neurophysiol., 100, 504, 10.1152/jn.00012.2008 · DOI
- von Heimendahl, 2007, Neuronal activity in rat barrel cortex underlying texture discrimination, PLoS Biol., 5, e305, 10.1371/journal.pbio.0050305 · DOI
- Woolsey, 1970, The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex. The description of a cortical field composed of discrete cytoarchitectonic units, Brain Res., 17, 205, 10.1016/0006-8993(70)90079-X · DOI · Paper page
- Zainos, 1997, Role of primary somatic sensory cortex in the categorization of tactile stimuli: effects of lesions, Exp. Brain Res., 115, 357, 10.1007/PL00005704 · DOI
- Zhao, 2011, Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function, Nat. Methods, 8, 745, 10.1038/nmeth.1668 · DOI · Paper page
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A cerebellar-thalamocortical pathway drives behavioral context-dependent movement initiation
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“11 , two-sample t test) (Figure S5I) (Catanese and Jaeger, 2021; Guo et al., 2014; Inagaki et al., 2020).”
BackgroundMouse Motor Cortex Coordinates the Behavioral Response to Unpredicted Sensory Feedback
Heindorf, M., Arber, S., & Keller, G. B. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.046 · Cited by 147
“We implanted cranial windows over left and right motor cortices in transgenic mice that express channelrhodopsin-2 in inhibitory neurons (vGAT::ChR2(H134R)EYFP), a strategy previously used successfully to inhibit neuronal activity in cortex (Guo et al., 2014).”
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“To test whether activity in dorsal posterior cortex had a causal relationship with the behavior required for the task, we inhibited small volumes of cortex by optogenetically activating GABAergic interneurons (Guo et al., 2014; Zhao et al., 2011).”
MethodLong distance projections of cortical pyramidal neurons
Gerfen, C. R., Economo, M. N., & Chandrashekar, J. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23978 · Cited by 132
The essential role of recurrent processing for figure-ground perception in mice
Kirchberger, L., Mukherjee, S., Schnabel, U. H., van Beest, E. H., Barsegyan, A., Levelt, C. N., Heimel, J. A., Lorteije, J. A. M., van der Togt, C., Self, M. W., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe1833 · Cited by 85
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Zatka-Haas, P., Steinmetz, N. A., Carandini, M., & Harris, K. D. (2021) · eLife · doi:10.7554/elife.63163 · Cited by 122
Akhlaghpour, H., Wiskerke, J., Choi, J. Y., Taliaferro, J. P., Au, J., & Witten, I. B. (2016) · eLife · doi:10.7554/elife.19507 · Cited by 112
“…contribute to maintaining the memory (Arnsten, 2011; Baeg et al., 2003; Erlich et al., 2015; Funahashi et al., 1989; Fuster and Alexander, 1971; Guo et al., 2014; Hanks et al., 2015; Harvey et al., 2012; Horst and Laubach, 2012; Jung et al., 1998; Kojima and Goldman-Rakic, 1982; Lak et al.,…”
BackgroundCortical Synaptic AMPA Receptor Plasticity during Motor Learning
Roth, R. H., Cudmore, R. H., Tan, H. L., Hong, I., Zhang, Y., & Huganir, R. L. (2019) · Neuron · doi:10.1016/j.neuron.2019.12.005 · Cited by 106
An Accumulation-of-Evidence Task Using Visual Pulses for Mice Navigating in Virtual Reality
Pinto, L., Koay, S. A., Engelhard, B., Yoon, A. M., Deverett, B., Thiberge, S. Y., Witten, I. B., Tank, D. W., & Brody, C. D. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00036 · Cited by 95
“…to record from and manipulate circuits with great spatiotemporal and genetic specificity in behaving animals (Svoboda and Yasuda, 2006; Dombeck et al., 2007; Luo et al., 2008; Deisseroth, 2011; Chen et al., 2013; Guo et al., 2014; Rickgauer et al., 2014; Sofroniew et al., 2016; Song et al., 2017).”
BackgroundMethodLow-noise encoding of active touch by layer 4 in the somatosensory cortex
Andrew Hires, S., Gutnisky, D. A., Yu, J., O'Connor, D. H., & Svoboda, K. (2015) · eLife · doi:10.7554/elife.06619 · Cited by 79
“A detailed description of the behavioral apparatus, headplate installation, water-restriction schedule and training paradigm has been described (O’Connor et al., 2010; Guo et al., 2014).”
BackgroundMethodSelf-citationLow-Dimensional Spatio-Temporal Dynamics Underlie Cortex-Wide Neural Activity
MacDowell, C. J., & Buschman, T. J. (2020) · bioRxiv · doi:10.1101/2020.01.05.895177 · Cited by 95
“For example, sequential activation of primary sensory and then higher-order cortical regions underlies perceptual decision making in both mice [4] and monkeys [5, 6].”
Xie, Y., Chan, A. W., McGirr, A., Xue, S., Xiao, D., Zeng, H., & Murphy, T. H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.2744-15.2016 · Cited by 98
“We used longitudinal mesoscopic imaging of iGluSnFR expressed in the dorsal cerebral cortex using an intact skull chronic window preparation (Guo et al., 2014a; Silasi and Murphy, 2014; Vanni and Murphy, 2014). iGluSnFR reports extracellular glutamate concentration that we interpret as a surrogate…”
BackgroundMethodYamashita, T., & Petersen, C. C. (2016) · eLife · doi:10.7554/elife.15798 · Cited by 96
“Interestingly, S2 has been suggested to be reciprocally connected to a tongue/jaw-related M1/M2 area (also termed anterior lateral motor cortex, ALM) a neocortical region known to be involved in goal-directed licking (Oh et al., 2014; Guo et al., 2014; Li et al., 2015).”
Targeted photostimulation uncovers circuit motifs supporting short-term memory
Daie, K., Svoboda, K., & Druckmann, S. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00776-3 · Cited by 103
Self-citationHigh-throughput automated home-cage mesoscopic functional imaging of mouse cortex
Murphy, T. H., Boyd, J. D., Bolaños, F., Vanni, M. P., Silasi, G., Haupt, D., & LeDue, J. M. (2016) · Nature Communications · doi:10.1038/ncomms11611 · Cited by 90
Genetic Dissection of Neural Circuits: A Decade of Progress
Luo, L., Callaway, E. M., & Svoboda, K. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.004 · Cited by 90
“This regime corresponds to ‘‘photoinhibition,’’ a method in which GABAergic neurons are photostimulated to silence a brain region (Guo et al., 2014).”
Self-citationAn integrated calcium imaging processing toolbox for the analysis of neuronal population dynamics
Romano, S. A., Pérez-Schuster, V., Jouary, A., Boulanger-Weill, J., Candeo, A., Pietri, T., & Sumbre, G. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005526 · Cited by 107
Movement Initiation Signals in Mouse Whisker Motor Cortex
Sreenivasan, V., Esmaeili, V., Kiritani, T., Galan, K., Crochet, S., & Petersen, C. C. H. (2016) · Neuron · doi:10.1016/j.neuron.2016.12.001 · Cited by 112
“In these mice, local photo-activation of ChR2-expressing GABAergic neurons suppresses activity in nearby pyramidal cells (Guo et al., 2014).”
BackgroundMethodUnderwood, C. F., & Parr‐Brownlie, L. C. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105159 · Cited by 100
“evolution of subsequent movement (Churchland and Shenoy, 2007a; Guo et al., 2014; Li et al., 2015) and is thought to represent a neural correlate of movement planning (Churchland et”
Context-dependent decision making in a premotor circuit
Wu, Z., Litwin-Kumar, A., Shamash, P., Taylor, A., Axel, R., & Shadlen, M. (2019) · bioRxiv · doi:10.1101/757104 · Cited by 89
Esmaeili, V., Tamura, K., Muscinelli, S. P., Modirshanechi, A., Boscaglia, M., Lee, A. B., Oryshchuk, A., Foustoukos, G., Liu, Y., Crochet, S., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.005 · Cited by 115
“Essential causal neuronal delay-period activity therefore appears to be predominantly localized to ALM (Figures 8A and 8B), in good agreement with previous closely related tasks (Guo et al., 2014; Li et al., 2015).”
InfluentialNikbakht, N., Tafreshiha, A., Zoccolan, D., & Diamond, M. E. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.003 · Cited by 104
“Pub This is an open access article under the CC BY-NC-ND license (http:// 2004; Battaglia et al., 2003; Ernst and Banks, 2002; Fetsch et al., 2009; Guo et al., 2014; Jacobs, 1999; Raposo et al., 2012).”
MethodVisual Evidence Accumulation Guides Decision-Making in Unrestrained Mice
Odoemene, O., Pisupati, S., Nguyen, H., & Churchland, A. K. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3478-17.2018 · Cited by 91
“Mice were weighed daily and checked for signs of dehydration throughout training period (Guo et al. 2014b).”
BackgroundInfluentialThe Challenge of Understanding the Brain: Where We Stand in 2015
Lisman, J. E. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.032 · Cited by 92
Decision-making behaviors: weighing ethology, complexity, and sensorimotor compatibility
Juavinett, A. L., Erlich, J. C., & Churchland, A. K. (2018) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.11.001 · Cited by 82
Kauvar, I., Machado, T. A., Yuen, E., Kochalka, J., Choi, M., Allen, W. E., Wetzstein, G., & Deisseroth, K. A. (2020) · Neuron · doi:10.1016/j.neuron.2020.04.023 · Cited by 92
Metastable attractors explain the variable timing of stable behavioral action sequencesPreprint
Recanatesi, S., Pereira, U., Murakami, M., Mainen, Z., & Mazzucato, L. (2020) · bioRxiv · doi:10.1101/2020.01.24.919217 · Cited by 82
“No statistical methods were used to pre-determine sample sizes, but sample sizes were similar to previous studies [48, 77].”
Circuits in the rodent brainstem that control whisking in concert with other orofacial motor actions
McElvain, L. E., Friedman, B., Karten, H. J., Svoboda, K., Wang, F., Deschênes, M., & Kleinfeld, D. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2017.08.034 · Cited by 82
“ALM cor- tex appears to be a hub that plans and executes voluntary licking under sensorimotor learning tasks (Guo et al., 2014a,b; Li et al., 2015, 2016), however it is notable that licking related to food and water consumption is retained in decerebrate animals (Woods, 1964).”
Self-citationStrengthened Inputs from Secondary Motor Cortex to Striatum in a Mouse Model of Compulsive Behavior
Corbit, V. L., Manning, E. E., Gittis, A. H., & Ahmari, S. E. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1728-18.2018 · Cited by 80
“Similar to SMA/pre-SMA in humans and primates (Isoda and Hikosaka, 2007), M2 in mice is involved in behavioral planning and movement preparation during behavioral selection (Gremel and Costa, 2013; Guo et al., 2014; Cao et al., 2015; Li et al., 2015; Rothwell et al., 2015; Barthas and Kwan, 2017).”
ResultChronic, cortex-wide imaging of specific cell populations during behavior
Couto, J., Musall, S., Sun, X. R., Khanal, A., Gluf, S., Saxena, S., Kinsella, I., Abe, T., Cunningham, J. P., Paninski, L., et al. (2021) · Nature Protocols · doi:10.1038/s41596-021-00527-z · Cited by 111
Spatiotemporal refinement of signal flow through association cortex during learning
Gilad, A., & Helmchen, F. (2020) · Nature Communications · doi:10.1038/s41467-020-15534-z · Cited by 90
Causal contributions of parietal cortex to perceptual decision-making during stimulus categorization
Zhong, L., Zhang, Y., Duan, C. A., Deng, J., Pan, J., & Xu, N.-L. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0383-6 · Cited by 96
Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention
Chen, Z. S., Wimmer, R. D., Wilson, M. A., & Halassa, M. M. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00083 · Cited by 79
“The TRN is also known to be involved in attentional processing (McAlonan et al., 2006; Wimmer et al., 2015), and manipulating the TRN causes changes in both attention (Halassa et al., 2014; Ahrens et al., 2015; Wimmer et al., 2015) and sleep (Kim et al., 2012).”
BackgroundMethodResultInfluentialCompeting Neural Ensembles in Motor Cortex Gate Goal-Directed Motor Output
Zagha, E., Ge, X., & McCormick, D. A. (2015) · Neuron · doi:10.1016/j.neuron.2015.09.044 · Cited by 84
REM sleep is associated with distinct global cortical dynamics and controlled by occipital cortex
Wang, Z., Fei, X., Liu, X., Wang, Y., Hu, Y., Peng, W., Wang, Y.-W., Zhang, S., & Xu, M. (2022) · Nature Communications · doi:10.1038/s41467-022-34720-9 · Cited by 73
The role of forelimb motor cortex areas in goal directed action in mice
Morandell, K., & Huber, D. (2017) · Scientific Reports · doi:10.1038/s41598-017-15835-2 · Cited by 90
Self-citationAttractor dynamics in networks with learning rules inferred from in vivo data
Pereira, U., & Brunel, N. (2017) · bioRxiv · doi:10.1101/199521 · Cited by 78
“, 1989; Goldman-Rakic, 1995) and rodents (Liu et al., 2014; Guo et al., 2014; Inagaki et al., 2017).”
Tactile frequency discrimination is enhanced by circumventing neocortical adaptation
Musall, S., von der Behrens, W., Mayrhofer, J. M., Weber, B., Helmchen, F., & Haiss, F. (2014) · Nature Neuroscience · doi:10.1038/nn.3821 · Cited by 69
Characterizing Cortex-Wide Dynamics with Wide-Field Calcium Imaging
Ren, C., & Komiyama, T. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.3003-20.2021 · Cited by 91
“, 2020); however, systematic optogenetic inactivation generally localizes behavioral effects to only a few regions (Guo et al., 2014; Goard et al., 2016; Allen et al., 2017; Pinto et al., 2019; Zatka-Haas et al., 2020).”
BackgroundGuo, K., Yamawaki, N., Svoboda, K., & Shepherd, G. M. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.1333-18.2018 · Cited by 133
“The ALM coordinates (Komiyama et al., 2010; Guo et al., 2014) were as follows: 2.4 –2.6 mm anterior; 1.4 –1.6 mm lateral; and 0.1–1.7 mm deep.”
BackgroundMethodInfluentialSelf-citationDiverse Long-Range Axonal Projections of Excitatory Layer 2/3 Neurons in Mouse Barrel Cortex
Yamashita, T., Vavladeli, A., Pala, A., Galan, K., Crochet, S., Petersen, S. S. A., & Petersen, C. C. H. (2018) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2018.00033 · Cited by 100
“Excitatory projection neurons in wS1 make monosynaptic connections to other neurons in many parts of the brain where sensory information is further processed to achieve sensory perception and sensorimotor coordination required for specific behaviors (Ferezou et al., 2007; Mao et al., 2011; Chen et al., 2013, 2015; Yam…”
BackgroundMayrhofer, J. M., El‐Boustani, S., Foustoukos, G., Auffret, M., Tamura, K., & Petersen, C. C. H. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.008 · Cited by 106
“Neuronal activity in wS1 has been shown to be involved in whisker-based decision-making tasks (Guo et al., 2014; Miyashita and Feldman, 2013; Sachidhanandam et al., 2013; Yang et al., 2016), thus providing a well-defined starting point for cortical processing of whisker-related information.”
InfluentialWhisker-Mediated Touch System in Rodents: From Neuron to Behavior
Adibi, M. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00040 · Cited by 110
Neural Correlates of Optimal Multisensory Decision MakingPreprint
Hou, H., Zheng, Q., Zhao, Y., Pouget, A., & Gu, Y. (2018) · bioRxiv · doi:10.1101/480178 · Cited by 76
“The apparent role of rodent posterior parietal cortex turns out to depend on confounding factors such as sensory modality (Guo et al., 2014; Raposo et al., 2014; Erlich et al., 2015; Hanks et al., 2015; Licata et al., 2017), learning process (Zhong et al.”
Background50 years of mnemonic persistent activity: quo vadis?
Wang, X. (2021) · Trends in Neurosciences · doi:10.1016/j.tins.2021.09.001 · Cited by 106
“First, optogenetic inactivation performed systematically across the cortex demonstrated that ALM is the crucial node for maintaining short-term memory [60].”
Layer-Specific Refinement of Sensory Coding in Developing Mouse Barrel Cortex
van der Bourg, A., Yang, J., Reyes‐Puerta, V., Laurenczy, B., Wieckhorst, M., Stüttgen, M. C., Luhmann, H. J., & Helmchen, F. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw280 · Cited by 98
“For each neuron 2 parameters were calculated, which have been shown to reliably separate between the 2 identified neuronal populations in adult rodents in vivo (Guo et al. 2014; Reyes-Puerta et al. 2015): (1) the onset to (late) peak latency, and (2) the asymmetry index.”
MethodModularity and robustness of frontal cortical networks
Chen, G., Kang, B., Lindsey, J. W., Druckmann, S., & Li, N. (2021) · Cell · doi:10.1016/j.cell.2021.05.026 · Cited by 70
Self-citationBrown, S. T., & Raman, I. M. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.028 · Cited by 77
Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior
Huda, R., Sipe, G. O., Breton‐Provencher, V., Cruz, K. G., Pho, G. N., Adam, E. M., Gunter, L. M., Sullins, A., Wickersham, I. R., & Sur, M. (2020) · Nature Communications · doi:10.1038/s41467-020-19772-z · Cited by 85
A somatosensory circuit for cooling perception in mice
Milenkovic, N., Zhao, W., Walcher, J., Albert, T., Siemens, J., Lewin, G. R., & Poulet, J. F. A. (2014) · Nature Neuroscience · doi:10.1038/nn.3828 · Cited by 84
Contribution of Excitatory and Inhibitory Neuronal Activity to BOLD fMRI
Moon, H. S., Jiang, H., Vo, T. T., Jung, W. B., Vazquez, A. L., & Kim, S. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhab068 · Cited by 85
Through the looking glass: A review of cranial window technology for optical access to the brain
Cramer, S. W., Carter, R. E., Aronson, J. D., Kodandaramaiah, S. B., Ebner, T. J., & Chen, C. C. (2021) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2021.109100 · Cited by 100
“However, optical windows based on full thickness skull clearing, such as the Clear Skull Cap (Allen et al., 2017; Guo et al., 2014) or similar techniques (Silasi et al., 2016) also provide optical access to a large fraction of the dorsal cerebral cortex (~ 49− 81 mm2), with the caveat that transcranial windows are sui…”
MethodInfluentialCell-Type-Specific Contributions of Medial Prefrontal Neurons to Flexible Behaviors
Nakayama, H., Ibáñez-Tallon, I., & Heintz, N. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3537-17.2018 · Cited by 80
“…powers (1.5 mW) has been shown to produce potent and local inhibition of cortical pyramidal neurons within 1 mm radius of the photostimulus center (Guo et al., 2014), we conclude that the higher laser intensity and deeper location of the optical fibers used in our studies produced sufficient…”
BackgroundMethodInfluentialMovement-related activity dominates cortex during sensory-guided decision making
Musall, S., Kaufman, M. T., Juavinett, A., Gluf, S., & Churchland, A. (2018) · bioRxiv · doi:10.1101/308288 · Cited by 71
“Fluorescence was measured through the cleared skull (Guo et al., 2014).”
BackgroundMethodResultInfluentialGenetic Dissection of Neural Circuits: A Decade of Progress
Luo, L., Callaway, E. M., & Svoboda, K. (2018) · Neuron · doi:10.1016/j.neuron.2018.03.040 · Cited by 454
Self-citationDynamic Representation of Taste-Related Decisions in the Gustatory Insular Cortex of Mice
Vincis, R., Chen, K., Czarnecki, L., Chen, J., & Fontanini, A. (2020) · Current Biology · doi:10.1016/j.cub.2020.03.012 · Cited by 70
“Optical stimulation of PV neurons is widely used to inhibit cortical circuits [18, 27– 29].”
InfluentialGallero-Salas, Y., Han, S., Sych, Y., Voigt, F. F., Laurenczy, B., Gilad, A., & Helmchen, F. (2020) · bioRxiv · doi:10.1101/2020.01.13.904284 · Cited by 70
“Both frontal and posterior cortical areas have been implicated in delay activity related to short-term memory (Goard et al., 2016; Guo et al., 2014; Inagaki et al., 2018; Kamigaki and Dan, 2017; Gilad et al., 2018; Harvey et al., 2012; Morcos and Harvey, 2016; Siegel et al., 2015; see also review by Sreenivasan and D’…”
BackgroundMeta-reinforcement learning via orbitofrontal cortex
Hattori, R., Hedrick, N. G., Jain, A., Chen, S., You, H., Hattori, M., Choi, J., Lim, B. K., Yasuda, R., & Komiyama, T. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01485-3 · Cited by 75
“Previous studies have found that unilateral inactivation of several brain areas such as premotor cortex and striatum can lead to a lateralized choice bias toward the direction ipsilateral to the inactivated hemisphere 48,49 .”
BackgroundCortical-subcortical interactions in goal-directed behavior
Cruz, K. G., Leow, Y. N., Le, N. M., Adam, E. M., Huda, R., & Sur, M. (2022) · Physiological Reviews · doi:10.1152/physrev.00048.2021 · Cited by 76
“Most notably, optogenetic inhibition of the fMC during the delay period results in suboptimal choices of animals in many tasks: performance in a visual go/no-go task decreases to chance levels (251), whereas behavior in a bidirectional (left/right) licking task becomes biased toward the ipsilateral side of the inhibit…”
BackgroundDana, H., Novák, O., Guardado-Montesino, M., Fransen, J. W., Hu, A., Borghuis, B. G., Guo, C., Kim, D. S., & Svoboda, K. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205444 · Cited by 87
Self-citationMultiregion neuronal activity: the forest and the trees
Machado, T. A., Kauvar, I., & Deisseroth, K. A. (2022) · Nature reviews. Neuroscience · doi:10.1038/s41583-022-00634-0 · Cited by 71
Cross-hemispheric communication: Insights on lateralized brain functions
Ocklenburg, S., & Guo, Z. V. (2024) · Neuron · doi:10.1016/j.neuron.2024.02.010 · Cited by 85
Self-citationThalamus-driven functional populations in frontal cortex support decision-making
Yang, W., Tipparaju, S. L., Chen, G., & Li, N. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01171-w · Cited by 82
“This classification has been verified by optogenetic tagging of GABAergic neurons (Guo et al. 2014).”
BackgroundSelf-citationRefinement of learned skilled movement representation in motor cortex deep output layer
Li, Q., Ko, H., Qian, Z., Yan, L. Y. C., Chan, D. C. W., Arbuthnott, G. W., Ke, Y., & Yung, W. (2017) · Nature Communications · doi:10.1038/ncomms15834 · Cited by 68
Structural Plasticity within the Barrel Cortex during Initial Phases of Whisker-Dependent Learning
Kuhlman, S. J., O’Connor, D. H., Fox, K. D., & Svoboda, K. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4919-12.2014 · Cited by 62
“This task is known to require the barrel cortex (O’Connor et al., 2010b; Guo et al., 2014).”
Self-citationCortical feedback loops bind distributed representations of working memory
Voitov, I., & Mrsic‐Flogel, T. D. (2022) · Nature · doi:10.1038/s41586-022-05014-3 · Cited by 88
Neural activity in the mouse claustrum in a cross-modal sensory selection task
Chevée, M., Finkel, E. A., Kim, S.-J., O’Connor, D. H., & Brown, S. P. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.013 · Cited by 84
Striatal indirect pathway mediates exploration via collicular competition
Lee, J., & Sabatini, B. L. (2021) · Nature · doi:10.1038/s41586-021-04055-4 · Cited by 73
Neural Circuits for Goal-Directed Sensorimotor Transformations
Crochet, S., Lee, S., & Petersen, C. C. H. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2018.08.011 · Cited by 69
Inhibition of impulsive action by projection-defined prefrontal pyramidal neurons
Li, B., Nguyen, T. P., Ma, C., & Dan, Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2000523117 · Cited by 70
A Role for Mouse Primary Visual Cortex in Motion Perception
Marques, T., Summers, M. T., Fioreze, G. T., Fridman, M. V., Dias, R. F., Feller, M. B., & Petreanu, L. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.012 · Cited by 68
“RDK stimuli were presented monocularly, and mice reported the perceived direction of motion by licking one of two available lickports [25] immediately after stimulus offset.”
Pushing the Boundaries of Neuroimaging with Optoacoustics
Ovsepian, S. V., Olefir, I., Westmeyer, G. G., Razansky, D., & Ntziachristos, V. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.022 · Cited by 64
Behaviorally relevant decision coding in primary somatosensory cortex neurons
Buetfering, C., Zhang, Z., Pitsiani, M., Smallridge, J., Boven, E., McElligott, S., & Häusser, M. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01151-0 · Cited by 59
Temporal controls over inter-areal cortical projection neuron fate diversity
Klingler, E., Tomasello, U., Prados, J., Kebschull, J. M., Contestabile, A., Galiñanes, G. L., Fièvre, S., Santinha, A. J., Platt, R. J., Huber, D., et al. (2021) · Nature · doi:10.1038/s41586-021-04048-3 · Cited by 71
Self-citationMechanisms underlying the response of mouse cortical networks to optogenetic manipulation
Mahrach, A., Chen, G., Li, N., van Vreeswijk, C., & Hansel, D. (2020) · eLife · doi:10.7554/elife.49967 · Cited by 68
Self-citationShared and specialized coding across posterior cortical areas for dynamic navigation decisions
Tseng, S.-Y., Chettih, S. N., Arlt, C., Barroso-Luque, R., & Harvey, C. D. (2022) · Neuron · doi:10.1016/j.neuron.2022.05.012 · Cited by 49
“The inhibition was performed bilaterally, with an estimated effect size of 1-2mm radius on cortex (Guo et al., 2014; Pinto et al., 2019).”
Cortical processing of flexible and context-dependent sensorimotor sequences
Xu, D., Dong, M., Chen, Y., Delgado, A. M., Hughes, N., Zhang, L., & O’Connor, D. H. (2022) · Nature · doi:10.1038/s41586-022-04478-7 · Cited by 87
Large-scale dynamics of perceptual decision information across human cortex
Wilming, N., Murphy, P. R., Meyniel, F., & Donner, T. H. (2020) · Nature Communications · doi:10.1038/s41467-020-18826-6 · Cited by 77
Karube, F., TAKAHASHI, S. Y., Kobayashi, K., & Fujiyama, F. (2019) · eLife · doi:10.7554/elife.49511 · Cited by 66
“The M2 is also involved in the preparatory and movement phases of behavior (Guo et al., 2014; Heindorf, Arber, & Keller, 2018; Li et al., 2015; Murakami et al., 2017; Murakami et al., 2014), and learning of motor tasks (Cao et al., 2015; Kawai et al., 2015).”
Corticostriatal Flow of Action Selection Bias
Hwang, E. J., Link, T. D., Hu, Y. Y., Lu, S., Wang, E. H.-J., Lilascharoen, V., Aronson, S., O’Neil, K., Lim, B. K., & Komiyama, T. (2019) · Neuron · doi:10.1016/j.neuron.2019.09.028 · Cited by 54
“Given that preparatory activity in motor cortex encodes various kinematic features of upcoming movements such as the reaching movement direction, amplitude, and velocity (Crammond and Kalaska, 1994; Churchland et al., 2006; Guo et al., 2014), the PPC-pM2 pathway may be critical for the formation of proper preparatory…”
BackgroundOrsolic, I., Rio, M., Mrsic-Flogel, T., & Znamenskiy, P. (2019) · bioRxiv · doi:10.1101/552026 · Cited by 54
Cone, J. J., Scantlen, M. D., Histed, M. H., & Maunsell, J. H. R. (2019) · eNeuro · doi:10.1523/eneuro.0337-18.2019 · Cited by 48
“Our behavioral results are supported by earlier work examining the role of PV neurons in visual and somatosensory cortex (Glickfeld et al., 2013; Guo et al., 2014).”
BackgroundResultInfluentialKira, S., Safaai, H., Morcos, A. S., Panzeri, S., & Harvey, C. D. (2023) · Nature Communications · doi:10.1038/s41467-023-37804-2 · Cited by 52
Romano, V., Propris, L. D., Bosman, L., Warnaar, P., ten Brinke, M. T., Lindeman, S., Ju, C.-H., Velauthapillai, A., Spanke, J. K., Guerra, E. M., et al. (2018) · bioRxiv · doi:10.1101/335489 · Cited by 52
Active information maintenance in working memory by a sensory cortex
Zhang, X., Yan, W., Wang, W., Fan, H., Hou, R., Chen, Y., Chen, Z., Ge, C., Duan, S., Compte, A., et al. (2019) · eLife · doi:10.7554/elife.43191 · Cited by 55
“The VGAT-ChR2 mice have been used extensively in many studies to suppress local excitatory neurons (e.g. Liu et al., 2014; Guo et al., 2014).”
BackgroundMethodA touchscreen based global motion perception task for mice
Stirman, J. N., Townsend, L. B., & Smith, S. L. (2016) · Vision Research · doi:10.1016/j.visres.2016.07.006 · Cited by 53
“Mouse psychophysics can be combined with reversible optogenetic lesions to delineate requisite brain areas [8, 14], and genetically engineered mouse models can be used to link genetic changes to psychophysical performance [15, 16].”
A cortico-basal ganglia-thalamo-cortical channel underlying short-term memory
Wang, Y., Yin, X., Zhang, Z., Li, J., Zhao, W., & Guo, Z. V. (2021) · Neuron · doi:10.1016/j.neuron.2021.08.002 · Cited by 62
Self-citationMouse frontal cortex mediates additive multisensory decisions
Coen, P., Sit, T. P. H., Wells, M. J., Carandini, M., & Harris, K. D. (2023) · Neuron · doi:10.1016/j.neuron.2023.05.008 · Cited by 60
“The implantation method largely followed established methods 60 and has been previously described.”
Secondary Motor Cortex Transforms Spatial Information into Planned Action During Navigation
Olson, J. M., Li, J. K., Montgomery, S. E., & Nitz, D. (2019) · bioRxiv · doi:10.1101/776765 · Cited by 49
Activity map of a cortico-cerebellar loop underlying motor planning
Zhu, J., Hasanbegović, H., Liu, L. D., Gao, Z., & Li, N. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01453-x · Cited by 53
“For cerebellar recordings, initial spike clustering was performed in principal component space 31 .”
BackgroundMethodInfluentialSelf-citationFunctional Organisation of the Mouse Superior Colliculus
Wheatcroft, T., Saleem, A. B., & Solomon, S. G. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.792959 · Cited by 57
Thalamic input to motor cortex facilitates goal-directed action initiation
Takahashi, N., Moberg, S., Zolnik, T. A., Catanese, J., Sachdev, R. N. S., Larkum, M. E., & Jaeger, D. (2021) · Current Biology · doi:10.1016/j.cub.2021.06.089 · Cited by 60
“Thus, our results suggest that VM inputs specifically modulate trained goal-directed responses, which in previous studies has been found to be coded in ALM network activity.(10,12,22)”
Multiple timescales of sensory-evidence accumulation across the dorsal cortex
Pinto, L., Tank, D. W., & Brody, C. D. (2022) · eLife · doi:10.7554/elife.70263 · Cited by 52
“To minimize postinactivation rebounds, the last 100 ms of the laser pulse consisted of a linear rampdown of power (Guo et al., 2014; Pinto et al., 2019).”
BackgroundMethodState-Dependent Subnetworks of Parvalbumin-Expressing Interneurons in Neocortex
García‐Junco‐Clemente, P., Tring, E., Ringach, D. L., & Trachtenberg, J. T. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.005 · Cited by 46
Jung, W. B., Jiang, H., Lee, S., & Kim, S. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113313119 · Cited by 53
“been widely used in circuit/systems neuroscience (15, 35).”
BackgroundMethodCortical signatures of wakeful somatosensory processing
Song, C., Piscopo, D. M., Niell, C. M., & Knöpfel, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-30422-9 · Cited by 54
A rise-to-threshold process for a relative-value decision
Vijayan, V., Wang, F., Wang, K., Chakravorty, A., Adachi, A., Akhlaghpour, H., Dickson, B. J., & Maimon, G. (2023) · Nature · doi:10.1038/s41586-023-06271-6 · Cited by 49
Dynamic causal communication channels between neocortical areas
Javadzadeh, M., & Hofer, S. (2021) · bioRxiv · doi:10.1101/2021.06.28.449892 · Cited by 46
“We thensilencedone of the twoareas for brief timewindows using optogenetic activation of inhibitory parvalbumin-expressing interneuronsexpressingchannelrhodopsin-2 (ChR2) (Cardin et al., 2009; Guo et al., 2014) and measured the instantaneous effect on the recorded neurons in the target area, revealing the causal influ…”
Method
Metadata
- Authors
- Guo, Z. V., Li, N., Huber, D., Ophir, E., Gutnisky, D., Ting, J. T., Feng, G., & Svoboda, K.
- Affiliations
- Howard Hughes Medical Institute (US)
- McGovern Institute for Brain Research (US)
- Corresponding author
- Svoboda, Karel
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 81
- Issue
- 1
- Pages
- 179-194
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3984938
- OpenAlex
- W2040707073
- Cited by
- 715
- References
- 0
- Citations by year
- 2026: 65 · 2025: 56 · 2024: 74 · 2023: 84 · 2022: 60 · 2021: 64 · 2020: 69 · 2019: 62 · 2018: 57 · 2017: 47 · 2016: 32 · 2015: 27 · 2014: 18
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc-nd)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- perceptual decision making, barrel cortex, anterior lateral motor cortex, short-term memory, optogenetic inhibition, sensorimotor integration, mice
- MeSH terms
- Channelrhodopsins, Action Potentials, Afferent Pathways, Animals, Cerebral Cortex, Conditioning, Operant, Decision Making, Discrimination, Psychological, Female, Male, Mice, Transgenic, Motion Perception, Nerve Net, Neurons, Photic Stimulation, Touch, Vibrissae, Green Fluorescent Proteins, Vesicular Inhibitory Amino Acid Transport Proteins, Mice
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